Research Group Diabetes and Related Traits (MED ART)

187 loci associated with BMI in a large EWAs published in Wahl et al. Nature 2017

As part of the German Center for Diabetes Research (DZD), our focus is to elucidate molecular mechanisms of diabetes and related traits such as obesity and glycemic traits. Involving a wide range of methods we intent to map molecular disease mechanisms from early stages in disease development to manifest disease and resulting complications. Thus, we aim to identify and validate new biomarkers for early diagnosis and prevention purposes.

We participate in several international consortia on type 2 diabetes and related traits (e.g. DIAGRAM, DIAMANTE, MAGIC, CHARGE, GIANT) in large scale genome and epigenome wide association studies and sequencing approaches (e.g. GoT2D), contributing data/samples from KORA and the Augsburg diabetes family study. Assessment of interactions between environmental factors (e.g. microbiome) and molecular markers is another major focus of our work.

We are located in the Genome Analysis Center (GAC) and can rely on a strong background of state of the art laboratory technologies. This enables combination of different molecular omics data (genomics, epigenomics, transcriptomics, metabolomics, and proteomics) to generate detailed risk marker profiles that can especially be used to identify subgroups in disease progression.

With our research we aims to enable better understanding of metabolic diseases for personalized medicine, as we provide the basis for evaluation of these profiles in mouse models or other human tissue from our Partners and clinical studies especially within the DZD. Evaluated markers will be taken forward to therapeutic testing and will help to lighten the burden of diabetes.