Effect of Weight Loss on Brain Insulin Sensitivity in Humans (8weeks)

Obesity is known to be associated with brain insulin resistance in humans. This condition has not only implications for the brain but also for whole-body energy homeostasis. Research in rodents indicates that weight loss is able to improve the insulin sensitivity of the brain. The current project will test this hypothesis in humans. Therefore, brain insulin sensitivity will be assessed by fMRI in combination with intranasal insulin administration, using an established protocol. Furthermore, effects of daily administration of insulin nasal spray (versus placebo) over 8 weeks will be assessed as secondary variables.

With this project wir pursue two main objectives

  • Is brain insulin resistance reversible and can brain insulin sensitivity be improved by body weight reduction in obese subjects?
  • Comparison of daily administration of insulin nasal spray (versus placebo) over 8 weeks will be assessed.

Project supervisor

Prof. Dr. Martin Heni

Study registration

NCT02991365

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