Transport of satiety factors into the CSF

The blood-brain barrier regulates the passage of peripheral hormones from the blood to the brain and informs the brain about the nutritional and energy status.

The aim of this study is to investigate to which extent the hormones are able to overcome the blood-brain barrier and how long this process is prolonged after food intake. Furthermore, the effect of peripheral satiety hormones in the central nervous system and the role of these hormones in the development of obesity are investigated.

The main objective is

  • To find out to what extent and in what timeframe peripheral produced saturation hormones overcome the blood-brain barrier/or blood cerebrospinal fluid barrier.

Project Supervisor

Prof. Dr. Martin Heni

Study Registration

 NCT04038086