Vascular Epigenetics / Sheikh-Lab

What environmental factors impact our risk of developing chronic diseases? What molecular mechanisms are responsible for this?

The Vascular Epigenetics group aims to disentangle how our metabolic environment interacts with our epigenome. By understanding the molecular mechanisms underlying this link, the team works towards identifying novel treatments that could lower the risk of life-threatening chronic disorders. In particular, the lab focuses on these mechanisms in the context of vascular dysfunction, which is typically driven by metabolic disease and underlies numerous diseases such as atherosclerosis, cardiac failure and neurodegeneration.