All Biobank Publications
2025 Scientific Article in Diabetes, Obesity and Metabolism Diabetes Obes. Metab. 27, 338–347 (2025)
Subphenotypes of adult-onset diabetes: Data-driven clustering in the population-based KORA cohort.
2024 Scientific Article in Communications Medicine Commun. Med. 4:265 (2024)
Interpretable multimodal machine learning (IMML) framework reveals pathological signatures of distal sensorimotor polyneuropathy.
2024 Scientific Article in Nature Nature 627, 347-357 (2024)
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.
2024 Scientific Article in Nature Communications Nat. Commun. 15:10061 (2024)
Analyzing longitudinal trait trajectories using GWAS identifies genetic variants for kidney function decline.
2024 Scientific Article in Clinical Epigenetics Clin. Epigenet. 16:149 (2024)
Association analysis between an epigenetic alcohol risk score and blood pressure.
2024 Other: Opinion in Gesundheitswesen, Das Gesundheitswesen, DOI: 10.1055/a-2438-0670 (2024)
Datennutzung für eine bessere Gesundheitsversorgung–Plädoyer für eine kooperative Forschungsdatenplattform der gesetzlichen und privaten Krankenversicherung und dem Netzwerk Universitätsmedizin (NUM).
2024 Scientific Article in Journal of medical internet research J. Med. Internet Res. 26:e50049 (2024)
Creation of standardized common data elements for diagnostic tests in infectious disease studies: Semantic and syntactic mapping.
2024 Scientific Article in Science Advances Sci. Adv. 10:eadl4374 (2024)
Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity.
2024 Scientific Article in BMC Medicine BMC Med. 22:420 (2024)
Association of plasma proteomics with mortality in individuals with and without type 2 diabetes: Results from two population-based KORA cohort studies.
2024 Scientific Article in Diabetologia Diabetologia 67, 2804-2818 (2024)
Role of human plasma metabolites in prediabetes and type 2 diabetes from the IMI-DIRECT study.
2024 Scientific Article in Gesundheitswesen, Das Gesundheitswesen 86, 647-654 (2024)
Integration von Bestandsdaten aus Kohorten- und Registerstudien in ein existierendes Forschungsnetzwerk: Nationales Pandemie Kohorten Netz (NAPKON).
2024 Scientific Article in BMC Public Health BMC Public Health 24:2317 (2024)
Public attitudes towards personal health data sharing in long-term epidemiological research: A Citizen Science approach in the KORA study.
2024 Scientific Article in Lancet, The Lancet 403, 1027-1050 (2024)
Worldwide trends in underweight and obesity from 1990 to 2022: A pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults.
2024 Scientific Article in Kidney international reports Kidney Int. Rep. 9, 1849-1859 (2024)
Prioritization of kidney cell types highlights myofibroblast cells in regulating human blood pressure.
2024 Scientific Article in International Journal of Medical Informatics Int. J. Med. Inform. 190:105545 (2024)
#consented - A semantic consent code to facilitate consistent documentation and implementation of consent in collaborative medical research.
2024 Nature Genetics Nat. Genet. 56, 1763-1764 (2024)
Publisher Correction: Understanding the genetic complexity of puberty timing across the allele frequency spectrum.
2024 Scientific Article in Nature Genetics Nat. Genet. 56, 1397–1411 (2024)
Understanding the genetic complexity of puberty timing across the allele frequency spectrum.
2024 Scientific Article in Diabetes/Metabolism Research and Reviews Diabetes Metab. Res. Rev. 40:e3834 (2024)
Association of transketolase polymorphisms with diabetic polyneuropathy in the general population: The KORA F4 study.
2024 Scientific Article in Metabolites Metabolites 14:258 (2024)
Prediction of myocardial infarction using a combined generative adversarial network model and feature-enhanced loss function.
2024 Scientific Article in Biomolecules Biomolecules 14:662 (2024)
Smoking-induced DNA hydroxymethylation signature is less pronounced than true DNA methylation: The population-based KORA Fit cohort
2024 Scientific Article in Infection - A Journal of Infectious Disease Infection, DOI: 10.1007/s15010-024-02270-5 (2024)
Comparison of post-COVID-19 symptoms in patients infected with the SARS-CoV-2 variants delta and omicron-results of the Cross-Sectoral Platform of the German National Pandemic Cohort Network (NAPKON-SUEP).
2024 Scientific Article in Nature Genetics Nat. Genet. 56, 1090-1099 (2024)
Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction.
2024 Scientific Article in Cardiovascular Diabetology Cardiovasc. Diabetol. 23:199 (2024)
Bidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i.
2024 Scientific Article in Cardiovascular Diabetology Cardiovasc. Diabetol. 23:181 (2024)
Plasma proteome association with coronary heart disease and carotid intima media thickness: Results from the KORA F4 study.
2024 Scientific Article in Nature Genetics Nat. Genet. 56, 778-791 (2024)
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.
2024 Nature Genetics Nat. Genet. 56, 1032-1033 (2024)
Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
2024 Scientific Article in Nature Communications Nat. Commun. 15:4259 (2024)
Development of a long noncoding RNA-based machine learning model to predict COVID-19 in-hospital mortality.
2024 Scientific Article in Clinical & Experimental Allergy Clin. Exp. Allergy 54, 314-328 (2024)
An integrated molecular risk score early in life for subsequent childhood asthma risk.
2024 Scientific Article in Biopreservation and Biobanking Biopreserv. Biobank., DOI: 10.1089/bio.2023.0074 (2024)
Update of the minimum iinformation about BIobank data sharing (MIABIS) core terminology to the 3rd version.
2024 Scientific Article in Frontiers in Immunology Front. Immunol. 15:1330864 (2024)
Intramuscular vaccination against SARS-CoV-2 transiently induces neutralizing IgG rather than IgA in the saliva.
2024 Scientific Article in Journal of Affective Disorders J. Affect. Disord. 352, 296-305 (2024)
Depression and fatigue six months post-COVID-19 disease are associated with overlapping symptom constellations: A prospective, multi-center, population-based cohort study.
2024 Scientific Article in EBioMedicine EBioMedicine 101:105007 (2024)
Phenotypic and genome-wide studies on dicarbonyls: Major associations to glomerular filtration rate and gamma-glutamyltransferase activity.
2024 Scientific Article in Journal of Infection and Public Health J. Infect. Public Health 17, 642-649 (2024)
Prevalence of infectious diseases, immunity to vaccine-preventable diseases and chronic medical conditions among Ukrainian refugees in Germany - A cross sectional study from the German Network University Medicine (NUM).
2024 Scientific Article in Nature Nature 628, 130-138 (2024)
Genome-wide characterization of circulating metabolic biomarkers.
2024 Scientific Article in International Journal of Biological Macromolecules Int. J. Biol. Macromol. 265:130962 (2024)
Metabolic effects of SGLT2i and metformin on 3-hydroxybutyric acid and lactate in db/db mice.
2024 Scientific Article in Biology of Sex Differences Biol. Sex Differ. 15:26 (2024)
Sex and statin-related genetic associations at the PCSK9 gene locus: Results of genome-wide association meta-analysis.
2024 Scientific Article in Liver International Liver Int. 44, 838-847 (2024)
Penetrance, cancer incidence and survival in HFE haemochromatosis-A population-based cohort study.
2024 Scientific Article in Clinical Epigenetics Clin. Epigenet. 16:29 (2024)
Epigenome-wide association study of dietary fatty acid intake.
2024 Scientific Article in Nature Communications Nat. Commun. 15:888 (2024)
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications.
2023 Scientific Article in Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz Bundesgesundheitsbl.-Gesund. 66, 114-125 (2023)
Das Netzwerk Universitätsmedizin: Technisch-organisatorische Ansätze für Forschungsdatenplattformen.
2023 Scientific Article in Atherosclerosis Atherosclerosis 386:117384 (2023)
Meta-GWAS on PCSK9 concentrations reveals associations of novel loci outside the PCSK9 locus in White populations.
2023 Scientific Article in Gastroenterology Gastroenterology 165, 946-962.e13 (2023)
HLA-DP on epithelial cells enables tissue damage by NKp44+ natural killer cells in ulcerative colitis.
2023 Scientific Article in Stroke Stroke 54, 810-818 (2023)
Genetic risk Score for intracranial aneurysms: Prediction of subarachnoid hemorrhage and role in clinical heterogeneity.
2023 Scientific Article in Thorax Thorax 78, 496-503 (2023)
Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease.
2023 Scientific Article in Gut (eGut) Gut 72, 2068-2080 (2023)
Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis.
2023 Scientific Article in Nature human behaviour Nat. Hum. Behav. 7, 790-801 (2023)
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.
2023 Scientific Article in Aging Aging 15, 14509-14552 (2023)
Mapping of the gene network that regulates glycan clock of ageing.
2023 Scientific Article in Nature Nature 615, 874-883 (2023)
Diminishing benefits of urban living for children and adolescents’ growth and development.
2023 Scientific Article in Diabetes Diabetes 72, 1870-1880 (2023)
A faecal metabolite signature of impaired fasting glucose: Results from twoindependent population-based cohorts.
2023 Scientific Article in Cardiovascular Research Cardiovasc. Res. 119, 2743-2754 (2023)
Predictive metabolites for incident myocardial infarction: A two-step meta-analysis of individual patient data from six cohorts comprising 7,897 individuals from the the COnsortium of METabolomic Studies.
2023 Scientific Article in BMC Medical Ethics BMC Med. Ethics 24:84 (2023)
Ethical and coordinative challenges in setting up a national cohort study during the COVID-19 pandemic in Germany.
2023 Scientific Article in Clinical Epigenetics Clin. Epigenet. 15:166 (2023)
Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome.
2023 Scientific Article in Frontiers in Genetics Front. Genet. 14:1235337 (2023)
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.
2023 Nature Genetics Nat. Genet. 55, 1778-1779 (2023)
Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk (Nature Genetics, (2023), 55, 3, (410-422), 10.1038/s41588-023-01314-0).
2023 Scientific Article in Studies in Health Technology and Informatics Stud. Health Technol. Inform. 307, 152-158 (2023)
Impact of clinical study implementation on data quality assessments - using contradictions within interdependent health data items as a pilot indicator.
2023 Nature Immunology Nat. Immunol. 24:1960 (2023)
Author Correction: Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets (Nature Immunology, (2023), 24, 9, (1540-1551), 10.1038/s41590-023-01588-w).
2023 Scientific Article in Nature Genetics Nat. Genet. 55, 1448-1461 (2023)
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.
2023 Scientific Article in Annals of the American Thoracic Society Ann. Am. Thorac. Soc. 20, 1124-1135 (2023)
Systemic markers of lung function and forced expiratory volume in 1 second decline across diverse cohorts.
2023 Scientific Article in Scientific Reports Sci. Rep. 13:4805 (2023)
A polygenic and family risk score are both independently associated with risk of type 2 diabetes in a population-based study.
2023 Scientific Article in Nature Genetics Nat. Genet. 55, 410-422 (2023)
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.
2023 Review in Clinical Research in Cardiology Clin. Res. Cardiol. 112, 923-941 (2023)
The DZHK research platform: Maximisation of scientific value by enabling access to health data and biological samples collected in cardiovascular clinical studies.
2023 Nature Biotechnology Nat. Biotechnol. 41:1026 (2023)
Author Correction: Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.
2023 Scientific Article in Nature Aging Nature Aging 3, 450-458 (2023)
Development and validation of DNA methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes.
2023 Scientific Article in Nature Genetics Nat. Genet. 55, 973-983 (2023)
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake.
2023 Scientific Article in BMC Genomic Data BMC Genom Data 24:28 (2023)
Polygenic scores for estimated glomerular filtration rate in a population of general adults and elderly - comparative results from the KORA and AugUR study.
2023 Scientific Article in Infection - A Journal of Infectious Disease Infection 51, 1679-1694 (2023)
Persistent symptoms and risk factors predicting prolonged time to symptom-free after SARS‑CoV‑2 infection: An analysis of the baseline examination of the German COVIDOM/NAPKON-POP cohort.
2023 Scientific Article in Movement Disorders Mov. Disord. 38, 1410-1418 (2023)
Epigenetic association analyses and risk prediction of RLS.
2023 Scientific Article in Studies in Health Technology and Informatics Stud. Health Technol. Inform. 302, 93-97 (2023)
The importance of being FAIR and FAST – The clinical epidemiology and study platform of the German network university medicine (NUKLEUS).
2023 Scientific Article in Nature Communications Nat. Commun. 14:5062 (2023)
Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits.
2023 Scientific Article in Nature Immunology Nat. Immunol. 24, 1540-1551 (2023)
Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.
2023 Scientific Article in Molecular Psychiatry Mol. Psychiatry 28, 3874-3887 (2023)
Circulating metabolites modulated by diet are associated with depression.
2023 Scientific Article in Infection - A Journal of Infectious Disease Infection:12 (2023)
Analysis of acute COVID-19 including chronic morbidity: Protocol for the deep phenotyping National Pandemic Cohort Network in Germany (NAPKON-HAP).
2023 Scientific Article in Nature Biotechnology Nat. Biotechnol. 41, 399-408 (2023)
Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.
2023 Scientific Article in Metabolites Metabolites 13:227 (2023)
Metabolic signatures elucidate the effect of body mass index on type 2 diabetes.
2023 Scientific Article in Thyroid Thyroid 33, 301-311 (2023)
Epigenome-wide association study reveals CpG sites associated with thyroid function and regulatory effects on KLF9.
2023 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 32, 907–916 (2023)
Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.
2022 Scientific Article in International Journal of Systematic and Evolutionary Microbiology Int. J. Syst. Evol. Microbiol. 72:005581 (2022)
Genomic evidence for two pathways of formaldehyde oxidation and denitrification capabilities of the species Paracoccus methylovorus sp. nov.
2022 Scientific Article in Genome Biology Genome Biol. 23:268 (2022)
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
2022 Scientific Article in Nature Nature 612, 720–724 (2022)
Genetic diversity fuels gene discovery for tobacco and alcohol use.
2022 Scientific Article in ACR Open Rheumatology ACR Open Rheumatol. 4, 528-533 (2022)
47XXY and 47XXX in scleroderma and myositis.
2022 Scientific Article in Environmental Science & Technology Environ. Sci. Technol. 56, 17815-17824 (2022)
Higher daily air temperature is associated with shorter leukocyte telomere length: KORA F3 and KORA F4.
2022 Nature Nature 612:E7 (2022)
Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries.
2022 Scientific Article in Journal of Lipid Research J. Lipid Res. 63, 11:100306 (2022)
The kringle IV type 2 domain variant 4925G>A causes the elusive association signal of the LPA pentanucleotide repeat.
2022 Scientific Article in Genome Medicine Genome Med. 14:125 (2022)
Network reconstruction for trans acting genetic loci using multi-omics data and prior information.
2022 Scientific Article in Frontiers in Medicine Front. Med. 9:953643 (2022)
Renal X-inactivation in female individuals with X-linked Alport syndrome primarily determined by age.
2022 Scientific Article in Nature Cardiovascular Research Nat. Cardio. Res. 1, 727–731 (2022)
Triggering of myocardial infarction by heat exposure is modified by medication intake.
2022 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 109, 1366-1387 (2022)
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
2022 Scientific Article in Nature Genetics Nat. Genet. 54, 412-436 (2022)
New insights into the genetic etiology of Alzheimer's disease and related dementias.
2022 Editorial in Frontiers in Microbiology Front. Microbiol. 13:960602 (2022)
Editorial: Acidobacteria - Towards unraveling the secrets of a widespread, though enigmatic, phylum.
2022 Scientific Article in Immunity Immunity 55, 2285-2299.e7 (2022)
Neutrophil "plucking" on megakaryocytes drives platelet production and boosts cardiovascular disease.
2022 Scientific Article in Nature Communications Nat. Commun. 13:6204 (2022)
Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota.
2022 Scientific Article in Neurology Neurology 99, E1738-E1754 (2022)
Contribution of common genetic variants to risk of early onset ischemic stroke.
2022 Scientific Article in Nature Nature 611, 115-123 (2022)
Stroke genetics informs drug discovery and risk prediction across ancestries.
2022 Scientific Article in Nature Genetics Nat. Genet. 54, 1332–1344 (2022)
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.
2022 Scientific Article in Sleep Sleep 45:zsac098 (2022)
Reassessment of candidate gene studies for idiopathic restless legs syndrome in a large GWAS dataset of European ancestry.
2022 Scientific Article in Nature Communications Nat. Commun. 13:5198 (2022)
Identification of risk loci for primary aldosteronism in genome-wide association studies.
2022 Review in European Journal of Epidemiology Eur. J. Epidemiol. 37, 849-870 (2022)
The German National Pandemic Cohort Network (NAPKON): Rationale, study design and baseline characteristics.
2022 Scientific Article in Aging Aging 14, 5620-5627 (2022)
Common electrocardiogram measures are not associated with telomere length.
2022 Scientific Article in Cancers Cancers 14:3363 (2022)
Uncovering the contribution of moderate-penetrance susceptibility genes to breast cancer by whole-exome sequencing and targeted enrichment sequencing of candidate genes in women of European ancestry.
2022 Scientific Article in Stroke Stroke 53, 2331-2339 (2022)
A family and a genome-wide polygenic risk score are independentlyassociated with stroke in a population-based study.
2022 Scientific Article in Pancreatology Pancreatol. 22, 449-456 (2022)
Colocalization analysis of pancreas eQTLs with risk loci from alcoholic and novel non-alcoholic chronic pancreatitis GWAS suggests potential disease causing mechanisms.
2022 Scientific Article in Atherosclerosis Atherosclerosis 349, 151-159 (2022)
The effect of LPA Thr3888Pro on lipoprotein(a) and coronary artery disease is modified by the LPA KIV-2 variant 4925G>A.
2022 Scientific Article in Kidney International Kidney Int. 102, 624-639 (2022)
Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies.
2022 Scientific Article in Nature Genetics Nat. Genet. 54, 560-572 (2022)
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.
2022 Scientific Article in JCI insight JCI insight 7:e157035 (2022)
Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases.
2022 Scientific Article in Communications Biology Comm. Biol. 5:580 (2022)
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.
2022 Scientific Article in Aging Cell Aging Cell:e13608 (2022)
Integrative analysis of clinical and epigenetic biomarkers of mortality.
2022 Scientific Article in Atherosclerosis Atherosclerosis 352, 10-17 (2022)
Association between a polygenic and family risk score on the prevalence and incidence of myocardial infarction in the KORA-F3 study.
2022 Scientific Article in eLife eLife 11:e71802 (2022)
Epigenetic scores for the circulating proteome as tools for disease prediction.
2022 Scientific Article in Circulation Genomic and precision medicine Circ. Genom. Precis. Med. 15:e003489 (2022)
Genome-wide characterization of a highly penetrant form of hyperlipoproteinemia associated with genetically elevated cardiovascular Risk.
2022 Scientific Article in Nature Genetics Nat. Genet. 54, 437-449 (2022)
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals.
2022 Scientific Article in Diagnostics Diagnostics 12:965 (2022)
Validation of the 30-year Framingham Risk Score in a German population-based cohort.
2022 Scientific Article in New Biotechnology New Biotech. 68, 37-47 (2022)
Impact of the pre-examination phase on multicenter metabolomic studies.
2022 Scientific Article in Diabetologia Diabetologia 65, 763-776 (2022)
Epigenome-wide association study of incident type 2 diabetes: A meta-analysis of five prospective European cohorts.
2022 Nature Communications Nat. Commun. 13:1122 (2022)
Author Correction: Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis (Nature Communications, (2022), 13, 1, (143), 10.1038/s41467-021-27706-6).
2022 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 109, 81-96 (2022)
Rare coding variants in 35 genes associate with circulating lipid levels-A multi-ancestry analysis of 170,000 exomes.
2022 Scientific Article in Briefings in Bioinformatics Brief. Bioinform. 23:bbab535 (2022)
TIGER: Technical variation elimination for metabolomics data using ensemble learning architecture.
2022 Scientific Article in Nature Genetics Nat. Genet. 54, 18–29 (2022)
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.
2022 Scientific Article in Nature Communications Nat. Commun. 13:143 (2022)
Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis.
2022 Scientific Article in Pediatric Allergy and Immunology Pediatr. Allergy Immunol. 33:e13721 (2022)
17q12-21 risk-variants influence cord blood immune regulation and multitrigger-wheeze.
2022 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 31, 3367-3376 (2022)
First mitochondrial genome wide association study with metabolomics.
2022 Scientific Article in Infection - A Journal of Infectious Disease Infection 49, 1277-1287 (2022)
Long-term health sequelae and quality of life at least 6 months after infection with SARS-CoV-2: Design and rationale of the COVIDOM-study as part of the NAPKON population-based cohort platform (POP).
2022 Scientific Article in European Journal of Human Genetics Eur. J. Hum. Genet., DOI: 10.1038/s41431-021-00905-x (2022)
Stakeholder engagement to ensure the sustainability of biobanks: A survey of potential users of biobank services.
2022 Scientific Article in Cardiovascular Research Cardiovasc. Res. 118, 1088–1102 (2022)
Cis-epistasis at the LPA locus and risk of cardiovascular diseases.
2021 Scientific Article in Nature Communications Nat. Commun. 12:7173 (2021)
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus.
2021 Scientific Article in Nature Nature 600, 675-679 (2021)
The power of genetic diversity in genome-wide association studies of lipids.
2021 Scientific Article in Nature Communications Nat. Commun. 12:6618 (2021)
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4.
2021 Scientific Article in Brain: A Journal of Neurology Brain, DOI: 10.1093/brain/awab360 (2021)
Blood DNA methylation provides an accurate biomarker of KMT2B-related dystonia and predicts onset.
2021 Scientific Article in Nature human behaviour Nat. Hum. Behav. 5, 1717-1730 (2021)
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.
2021 Scientific Article in Scientific Reports Sci. Rep. 11:19365 (2021)
Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function.
2021 Scientific Article in Epilepsia Epilepsia 62, 1518-1527 (2021)
Shared genetic basis between genetic generalized epilepsy and background electroencephalographic oscillations.
2021 Scientific Article in Lancet, The Lancet 398, 957-980 (2021)
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: A pooled analysis of 1201 population-representative studies with 104 million participants.
2021 Scientific Article in Nature Nature 596, 393-397 (2021)
Genetic insights into biological mechanisms governing human ovarian ageing.
2021 Scientific Article in Journal of Hypertension J. Hypertens. 39, 2527-2533 (2021)
N-glycosylation of immunoglobulin G predicts incident hypertension.
2021 Scientific Article in Genome Biology Genome Biol. 22:194 (2021)
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.
2021 Scientific Article in Clinical Chemistry Clin. Chem. 67, 1153-1155 (2021)
Metabolomic fingerprints in large population cohorts: Impact of preanalytical heterogeneity.
2021 Nature Communications Nat. Commun. 12:4256 (2021)
Publisher Correction: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.
2021 Scientific Article in Cardiovascular Research Cardiovasc. Res. 118:1742–1757 (2021)
Chronically elevated branched chain amino acid levels are pro-arrhythmic.
2021 Scientific Article in Clinical Epigenetics Clin. Epigenet. 13:121 (2021)
DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function.
2021 Scientific Article in Studies in Health Technology and Informatics Stud. Health Technol. Inform. 278, 237-244 (2021)
Needs for an integration of specific data sources and items - first insights of a national survey within the German center for infection research.
2021 Scientific Article in Genetic Epidemiology Genet. Epidemiol. 45, 633-650 (2021)
Comparison of genetic risk prediction models to improve prediction of coronary heart disease in two large cohorts of the MONICA/KORA study.
2021 Scientific Article in Nature Communications Nat. Commun. 12:3505 (2021)
Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes.
2021 Scientific Article in Journal of the American Society of Nephrology J. Am. Soc. Nephrol. 32, 1747-1763 (2021)
Plasma proteomics of renal function: A trans-ethnic metaanalysis and Mendelian randomization study.
2021 Scientific Article in Nature Communications Nat. Commun. 12:3987 (2021)
A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.
2021 Scientific Article in Molecular Psychiatry Mol. Psychiatry 26, 7372–7383 (2021)
A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression.
2021 Scientific Article in Cardiovascular Diabetology Cardiovasc. Diabetol. 20:111 (2021)
Metabolic syndrome and the plasma proteome: From association to causation.
2021 Scientific Article in Molecular Psychiatry Mol. Psychiatry 26, 6293-6304 (2021)
Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.
2021 Scientific Article in British Journal of Dermatology - BJD Br. J. Dermatol. 185, 573-584 (2021)
Host traits, lifestyle and environment are associated with the human skin bacteria.
2021 Scientific Article in Human Genetics and Genomics Advances HGG Advances 2:100013 (2021)
Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits.
2021 Nature Communications Nat. Commun. 12:995 (2021)
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
2021 Scientific Article in Nutrients Nutrients 13:819 (2021)
Association between single nucleotide polymorphisms and weight reduction in behavioural interventions—a pooled analysis.
2021 Scientific Article in Clinical Epigenetics Clin. Epigenet. 13:60 (2021)
Epigenome-wide association study of whole blood gene expression in Framingham Heart Study participants provides molecular insight into the potential role of CHRNA5 in cigarette smoking-related lung diseases.
2021 Scientific Article in European Journal of Epidemiology Eur. J. Epidemiol. 36, 233–241 (2021)
The transplant cohort of the German center for infection research (DZIF Tx-Cohort): Study design and baseline characteristics.
2021 Scientific Article in Journal of human genetics J. Hum. Genet. 66, 625–636 (2021)
Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease.
2021 Scientific Article in Nature Communications Nat. Commun. 12:24 (2021)
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
2021 Scientific Article in FASEB Journal FASEB J. 35:e21302 (2021)
Systemic Jak1 activation provokes hepatic inflammation and imbalanced FGF23 production and cleavage.
2021 Scientific Article in Nature Communications Nat. Commun. 12:1279 (2021)
Revealing the role of the human blood plasma proteome in obesity using genetic drivers.
2021 Scientific Article in Metabolites Metabolites 11:89 (2021)
Validation of candidate phospholipid biomarkers of chronic kidney disease in hyperglycemic individuals and their organ-specific exploration in leptin receptor-deficient db/db mouse.
2021 Scientific Article in Clinical Epigenetics Clin. Epigenet. 13:7 (2021)
DNA methylation and lipid metabolism: An EWAS of 226 metabolic measures.
2021 Scientific Article in Kidney International Kidney Int. 99, 926-939 (2021)
Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline.
2021 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 108, 284-294 (2021)
Genome-wide association study identifies novel susceptibility loci for KIT D816V positive mastocytosis.
2021 Scientific Article in JAMA Pediatrics JAMA Pediatr. 175:E205142 (2021)
Obesity genes and weight loss during lifestyle intervention in children with obesity.
2021 Scientific Article in Movement Disorders Mov. Disord. 36, 449-459 (2021)
Shared genetics of multiple system atrophy and inflammatory bowel disease.
2021 Scientific Article in Nature human behaviour Nat. Hum. Behav. 5, 59–70 (2021)
Genome-wide association study identifies 48 common genetic variants associated with handedness.
2021 Scientific Article in Glycobiology Glycobiology 31, 82-88 (2021)
Replication of fifteen loci involved in human plasma protein N-glycosylation in 4,802 samples from four cohorts.
2020 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 201:A5527 (2020)
Systemic biomarkers of lung function and FEV1 decline across multiple cohorts.
2020 Scientific Article in Clinical Epigenetics Clin. Epigenet. 12:157 (2020)
Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits.
2020 Scientific Article in Antioxidants Antioxidants 9:908 (2020)
The association between serum bilirubin levels and colorectal cancer risk: Results from the prospective cooperative health research in the region of Augsburg (KORA) in Germany.
2020 Scientific Article in Translational Psychiatry Transl. Psychiatry 10:323 (2020)
Subjective mental health, incidence of depressive symptoms in later life, and the role of epigenetics: Results from two longitudinal cohort studies.
2020 Scientific Article in Diabetes Diabetes 69, 2756-2765 (2020)
Machine learning approaches reveal metabolic signatures of incident chronic kidney disease in individuals with prediabetes and type 2 diabetes.
2020 Scientific Article in Diabetes Diabetes 69, 2766-2778 (2020)
Deciphering the plasma proteome of type 2 diabetes.
2020 Scientific Article in BMC Medicine BMC Med. 18:229 (2020)
Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses.
2020 Scientific Article in Annals of Neurology Ann. Neurol. 88, 736-746 (2020)
Circulating metabolites differentiate acute ischemic stroke from stroke mimics.
2020 Scientific Article in Aging Aging 12, 15222-15259 (2020)
Global variability of the human IgG glycome.
2020 Scientific Article in Aging Aging 12, 16539-16554 (2020)
Accelerated epigenetic aging as a risk factor for chronic obstructive pulmonary disease and decreased lung function in two prospective cohort studies.
2020 Scientific Article in Lancet Respiratory Medicine, The Lancet Resp. Med. 8, 696-708 (2020)
Chronic obstructive pulmonary disease and related phenotypes: Polygenic risk scores in population-based and case-control cohorts.
2020 Scientific Article in PLoS ONE PLoS ONE 15:e0232073 (2020)
A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter.
2020 Scientific Article in Biopreservation and Biobanking Biopreserv. Biobank. 18, 155-164 (2020)
Extending the minimum information about bIobank data sharing terminology to describe samples, sample donors, and events.
2020 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 106, 389-404 (2020)
Genome-wide association analysis in humans links nucleotide metabolism to leukocyte telomere length.
2020 Scientific Article in PLoS ONE PLoS ONE 15:e0227648 (2020)
Impact of long-term storage and freeze-thawing on eight circulating microRNAs in plasma samples.
2020 Scientific Article in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 145, 1208-1218 (2020)
Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression.
2020 Scientific Article in Annals of Neurology Ann. Neurol. 87, 184-193 (2020)
Identification of restless legs syndrome genes by mutational load analysis.
2020 Scientific Article in European Journal of Nutrition Eur. J. Nutr. 59, 1357-1369 (2020)
Modifying effect of metabotype on diet-diabetes associations.
2020 Scientific Article in Molecular Psychiatry Mol. Psychiatry 25, 2392-2409 (2020)
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.
2019 Scientific Article in Neurology Neurology 92, e486-e503 (2019)
Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.
In: Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease. 2019. 309-347
Omics: Potential role in early phase drug development.
2019 GigaScience GigaScience 8:giz162 (2019)
A network-based conditional genetic association analysis of the human metabolome (vol 7, gij137, 2018).
2019 Scientific Article in Nature Communications Nat. Commun. 10:5121 (2019)
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.
In: (Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2019, 23-27 June 2019, Munich, Germany). 2019.:8871546
Broadband IR-fingerprinting of human blood as a universal tool for diseases diagnostics.
2019 Scientific Article in Nature Communications Nat. Commun. 10:4957 (2019)
Associations of autozygosity with a broad range of human phenotypes.
2019 Meeting abstract in Multiple Sclerosis Journal Mult. Scler. J. 25, 906-907 (2019)
Identification of functionally relevant genetic variants associated with multiple sclerosis using deep learning.
2019 Scientific Article in Circulation Research Circ. Res. 125, 773-782 (2019)
Circulating monocyte chemoattractant protein-1 and risk of stroke meta-analysis of population-based studies involving 17 180 individuals.
2019 Nature Genetics Nat. Genet. 51, 1423-1424 (2019)
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (Nature Genetics, (2019), 51, 3, (414-430), 10.1038/s41588-019-0358-2).
2019 Nature Communications Nat. Commun. 10:4386 (2019)
Erratum: Publisher Correction: Shared heritability and functional enrichment across six solid cancers (Nature communications (2019) 10 1 (431)).
2019 Scientific Article in Circulation Circulation 140, 645-657 (2019)
Blood leukocyte DNA methylation predicts risk of future myocardial infarction and coronary heart disease: A longitudinal study of 11,461 participants from population-based cohorts.
2019 Scientific Article in JAMA cardiology JAMA Cardiol. 4, 575-579 (2019)
Estimation of the required lipoprotein(a)-lowering therapeutic effect size for reduction in coronary heart disease outcomes a mendelian randomization analysis.
2019 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 28, 2062-2077 (2019)
Defining the genetic control of human blood plasma N-glycome using genome-wide association study.
2019 Scientific Article in American Journal of Epidemiology Am. J. Epidemiol. 188, 991-1012 (2019)
The consortium of metabolomics studies (COMETS): Metabolomics in 47 prospective cohort studies.
2019 Scientific Article in Nature Genetics Nat. Genet. 51, 957-972 (2019)
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
2019 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 28, 2615-2633 (2019)
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.
2019 Scientific Article in Nature Nature 570, 71-76 (2019)
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
2019 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 166, 11370-11379 (2019)
Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-kappa B-driven inflammation and cardiovascular risk.
2019 Scientific Article in Nature Nature 569, 260-264 (2019)
Rising rural body-mass index is the main driver of the global obesity epidemic in adults.
2019 Scientific Article in European Heart Journal Eur. Heart J. 40, 2883-2896 (2019)
Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease.
2019Poster: RECOMB 2019, 4-8 May 2019, Washington D.C.. (2019)
Reconstructing regulatory networks from multi-omics data using prior information.
2019 Scientific Article in American Journal of Epidemiology Am. J. Epidemiol. 188, 1033-1054 (2019)
Multiancestry genome-wide association study of lipid levels incorporating gene-alcohol interactions.
2019 Scientific Article in Nature Genetics Nat. Genet. 51, 636-648 (2019)
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
2019 Scientific Article in Journal of the American College of Cardiology J. Am. Coll. Cardiol. 73, 58-66 (2019)
Association of the PHACTR1/EDN1 genetic locus with spontaneous coronary artery dissection.
2019 Scientific Article in Metabolites Metabolites 9:61 (2019)
Metabolomics identifies novel blood biomarkers of pulmonary function and COPD in the general population.
2019 Scientific Article in Human Genetics Hum. Genet. 138, 375–388 (2019)
The metabolic network coherence of human transcriptomes is associated with genetic variation at the cadherin 18 locus.
2019 Scientific Article in Metabolites Metabolites 9:44 (2019)
Ageing investigation using two-time-point metabolomics data from KORA and CARLA studies.
2019 Scientific Article in Nature Genetics Nat. Genet. 51, 414-430 (2019)
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
2019 Scientific Article in OncoTarget Oncotarget 10, 1760-1774 (2019)
Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development.
2019 Scientific Article in Nature Genetics Nat. Genet. 51, 481-493 (2019)
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
2019 Scientific Article in Nature Genetics Nat. Genet. 51, 494-505 (2019)
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.
2019 Scientific Article in Nature Communications Nat. Commun. 10:376 (2019)
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.
2019 Scientific Article in Nature Genetics Nat. Genet. 51, 245-257 (2019)
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
2019 Scientific Article in American Journal of Clinical Nutrition Am. J. Clin. Nutr. 109, 276-287 (2019)
Disentangling the genetics of lean mass.
2019 Review in New Biotechnology New Biotech. 49, 98-103 (2019)
Transnational access to large prospective cohorts in Europe: Current trends and unmet needs.
2018 Meeting abstract in European Heart Journal Eur. Heart J. 39, 998-998 (2018)
Using the plasma proteome to decipher metabolic syndrome pathophysiology and discover a diagnostic biomarker panel.
2018 Scientific Article in Clinical Epigenetics Clin. Epigenet. 10:161 (2018)
Analysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction.
2018 Scientific Article in Nature Communications Nat. Commun. 9:5269 (2018)
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies.
2018 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 197 (2018)
Proteomic profiling identifies novel circulating markers associated with lung function.
2018 Scientific Article in Nature Communications Nat. Commun. 9:4919 (2018)
Detecting heritable phenotypes without a model using fast permutation testing for heritability and set-tests.
2018 Scientific Article in GigaScience GigaScience 7, DOI: 10.1093/gigascience/giy137 (2018)
A network-based conditional genetic association analysis of the human metabolome.
2018 Scientific Article in EBioMedicine EBioMedicine 38, 206-216 (2018)
Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults.
2018 Scientific Article in Nature Genetics Nat. Genet. 50, 1505-1513 (2018)
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.
2018 Scientific Article in Nature Genetics Nat. Genet. 50, 1514-1523 (2018)
Genetics of blood lipids among similar to 300,000 multi-ethnic participants of the Million Veteran Program.
2018 Meeting abstract in Genetic Epidemiology Genet. Epidemiol. 42, 719-720 (2018)
Pharmacogenetic effects in population-based metabolic profiles.
2018 Scientific Article in Nature Communications Nat. Commun. 9:4455 (2018)
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.
2018 Scientific Article in Epigenetics Epigenetics 13, 1039-1055 (2018)
Metastable DNA methylation sites associated with longitudinal lung function decline and aging in humans: An epigenome-wide study in the NAS and KORA cohorts.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:15249 (2018)
Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations.
2018 Scientific Article in Nature Genetics Nat. Genet. 50, 1412-1425 (2018)
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
2018 Nature Communications Nat. Commun. 9:3853 (2018)
Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease (vol 9, 3268, 2018).
2018 Scientific Article in American Journal of Clinical Nutrition Am. J. Clin. Nutr. 108, 453-475 (2018)
Body mass index is negatively associated with telomere length: A collaborative cross-sectional meta-analysis of 87 observational studies.
2018 Meeting abstract in Atherosclerosis Atherosclerosis 275, E104-E105 (2018)
Formyl peptide receptors 1-3 and annexin 1 in atherosclerotic plaques - tampere vascular study.
2018 Scientific Article in Nature Communications Nat. Commun. 9:3268 (2018)
Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.
2018 Nature Genetics Nat. Genet. 50:1343 (2018)
Author correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
2018 Scientific Article in Metabolites Metabolites 8:45 (2018)
Night shift work affects urine metabolite profiles of nurses with early chronotype.
2018 Scientific Article in Nature Genetics Nat. Genet. 52, 1112-1121 (2018)
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
2018 Scientific Article in Diabetes Diabetes 67, 1414-1427 (2018)
A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes.
2018 Scientific Article in Nature Genetics Nat. Genet. 50, 1072–1080 (2018)
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
2018 Scientific Article in Wellcome open research Wellcome Open Res. 3:4 (2018)
Meta-analysis of exome array data identifies six novel genetic loci for lung function.
2018 Scientific Article in Nature Genetics Nat. Genet. 50, 834-848 (2018)
Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error.
2018 Scientific Article in Arteriosclerosis, Thrombosis, and Vascular Biology Arterioscler. Thromb. Vasc. Biol. 38, 1230-1241 (2018)
Genetic factors explain a major fraction of the 50% lower lipoprotein(a) concentrations in Finns.
2018 Scientific Article in Frontiers in Immunology Front. Immunol. 9:277 (2018)
Genome-wide association study on immunoglobulin G glycosylation patterns.
2018 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 102, 375-400 (2018)
A large-scale multi-ancestry genome-wide study accounting for smoking behavior identifies multiple significant loci for blood pressure.
2018 Nature Communications Nat. Commun. 9:706 (2018)
Erratum: Publisher Correction: Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway (Nature communications (2017) 8 1 (1483)).
2018 Review in Biopreservation and Biobanking Biopreserv. Biobank. 16, 97-105 (2018)
Enhancing reuse of data and biological material in medical research: From FAIR to FAIR-health.
2018 Scientific Article in Nature Communications Nat. Commun. 9:260 (2018)
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
2018 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 27, 546-558 (2018)
Genome-wide meta-analysis identifies novel determinants of circulating serum progranulin.
2018 Scientific Article in Biochimica et Biophysica Acta - General Subjects Biochim. Biophys. Acta-Gen. Subj. 1862, 637-648 (2018)
IgG glycosylation and DNA methylation are interconnected with smoking.
2018 Scientific Article in Molecular Psychiatry Mol. Psychiatry 23, 422-433 (2018)
A DNA methylation biomarker of alcohol consumption.
2017 Scientific Article in European Journal of Human Genetics Eur. J. Hum. Genet. 25, 137-146 (2017)
Across-cohort QC analyses of GWAS summary statistics from complex traits.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 1722–1730 (2017)
Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 1758-1766 (2017)
Exome-wide association study of plasma lipids in >300,000 individuals.
2017 Scientific Article in Biopreservation and Biobanking Biopreserv. Biobank. 15, 512-518 (2017)
Influence of storage and inter- and Intra-assay variability on the measurement of inflammatory biomarkers in population-based biobanking.
2017 Scientific Article in Nature Communications Nat. Commun. 8:1483 (2017)
Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 1752-1757 (2017)
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
2017 Scientific Article in Molecular Psychiatry Mol. Psychiatry 22, 1680-1690 (2017)
An epigenome-wide association study meta-analysis of educational attainment.
2017 Nature Communications Nat. Commun. 8:1414 (2017)
Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
2017 Scientific Article in PLoS ONE PLoS ONE 12:e0182472 (2017)
Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes.
2017 Scientific Article in Neurology Neurology 89, 1829-1839 (2017)
COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls.
2017 Scientific Article in BMC Genomics BMC Genomics 18:805 (2017)
The dynamics of smoking-related disturbed methylation: A two time-point study of methylation change in smokers, non-smokers and former smokers.
2017 Scientific Article in Genetics Genetics 207, 1275-1283 (2017)
RL-SKAT: An exact and efficient score Test for heritability and set tests.
2017 Scientific Article in BMC Bioinformatics BMC Bioinformatics 18:429 (2017)
pulver: An R package for parallel ultra-rapid p-value computation for linear regression interaction terms.
2017 Scientific Article in Lancet Neurology, The Lancet Neurol. 16, 898–907 (2017)
Identification of novel risk loci for restless legs syndrome: A meta-analysis of genome-wide association studies in individuals of European ancestry: A meta-analysis.
2017 Scientific Article in Diabetologia Diabetologia 61, 117-129 (2017)
Metabolite ratios as potential biomarkers for type 2 diabetes: A DIRECT study.
2017 Scientific Article in Journal of the American Society of Nephrology J. Am. Soc. Nephrol. 28, 2311-2321 (2017)
NFAT5 and SLC4A10 loci associate with plasma osmolality.
2017 Scientific Article in Journal of Lipid Research J. Lipid Res. 58, 1834-1844 (2017)
A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms.
2017 Scientific Article in PLoS Medicine PLoS Med. 14:e1002383 (2017)
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.
2017 Scientific Article in PLoS ONE PLoS ONE 12:e0181038 (2017)
Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation.
2017 Scientific Article in Hypertension Hypertension 70, 713-750 (2017)
Transcriptome-wide analysis identifies novel associations with blood pressure.
2017 Scientific Article in Obesity Obesity 25, 1618-1624 (2017)
Metabolomic profiling of long-term weight change: Role of oxidative stress and urate levels in weight gain.
2017 Scientific Article in International Journal of Epidemiology Int. J. Epidemiol. 46, 894-904 (2017)
Evidence for large-scale gene-by-smoking interaction effects on pulmonary function.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:8734 (2017)
Evaluating the causal relation of ApoA-IV with disease-related traits - A bidirectional two-sample mendelian randomization study.
2017 Scientific Article in Nature Communications Nat. Commun. 8:80 (2017)
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
2017 Scientific Article in Hypertension Hypertension 70, e4-e19 (2017)
Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney.
2017 Scientific Article in British Journal of Nutrition Br. J. Nutr. 117, 1631-1644 (2017)
Metabotyping and its application in targeted nutrition: An overview.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:6037 (2017)
Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes.
2017 Scientific Article in PLoS Genetics PLoS Genet. 13:e1006812 (2017)
Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions.
2017 Scientific Article in European Heart Journal Eur. Heart J. 38, 1823-1831 (2017)
A novel but frequent variant in LPA KIV-2 is associated with a pronounced Lp(a) and cardiovascular risk reduction.
2017 Scientific Article in Diabetes Diabetes 66, 2888-2902 (2017)
An expanded genome-wide association study of type 2 diabetes in Europeans.
2017 Scientific Article in PLoS Genetics PLoS Genet. 13:e1006755 (2017)
Identifying systematic heterogeneity patterns in genetic association meta-analysis studies.
2017 Scientific Article in Biological Psychiatry Biol. Psychiatry 81, 325-335 (2017)
Genome-wide association for major depression through age at onset stratification: Major depressive disorder working group of the Psychiatric Genomics Consortium.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 834-841 (2017)
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.
2017 Scientific Article in Nature Communications Nat. Commun. 8:15466 (2017)
Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1.
2017 Scientific Article in Journal of Proteome Research J. Proteome Res. 16, 2547-2559 (2017)
Plasma and serum metabolite association networks: Comparibility within and between studies using NMR and MS profiling.
2017 Scientific Article in PLoS Genetics PLoS Genet. 13:e1006528 (2017)
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:45040 (2017)
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
2017 Scientific Article in PLoS ONE PLoS ONE 12:e0176372 (2017)
Validation of standard operating procedures in a multicenter retrospective study to identify -omics biomarkers for chronic low back pain.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:1855 (2017)
Determination of nasal and oropharyngeal microbiomes in a multicenter population-based study - findings from Pretest 1 of the German National Cohort.
2017 Scientific Article in Arthritis & Rheumatology Arthritis Rheum. 69, 1090-1099 (2017)
Immune-array analysis in sporadic inclusion body myositis reveals HLA-DRB1 amino acid heterogeneity across the myositis spectrum.
2017 Scientific Article in Biochimica et Biophysica Acta - General Subjects Biochim. Biophys. Acta-Gen. Subj. 1861, 1152-1158 (2017)
Effects of statins on the immunoglobulin G glycome.
2017 Scientific Article in Nature Communications Nat. Commun. 8:14357 (2017)
Connecting genetic risk to disease end points through the human blood plasma proteome.
2017 Scientific Article in Clinical & Experimental Allergy Clin. Exp. Allergy 47, 395-400 (2017)
Early life travelling does not increase risk of atopic outcomes until 15 years: Results from GINIplus and LISAplus.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 416-425 (2017)
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 403-415 (2017)
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
2017 Scientific Article in Journal of Investigative Dermatology, The J. Invest. Dermatol. 137, 1074-1081 (2017)
Association of atopic dermatitis with cardiovascular risk factors and diseases.
2017 Scientific Article in Epigenetics & Chromatin Epigenetics Chromatin 10:1 (2017)
Genome-wide methylation data mirror ancestry information.
2017 Scientific Article in Nature Nature 541, 81-86 (2017)
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.
2017 Scientific Article in Pain practice Pain Pract. 17, 8-15 (2017)
Past, present, and future of informed consent in pain and genomics research: Challenges facing global medical community.
2017 Scientific Article in LabAnimal Lab. Animal. 51, 301-310 (2017)
Murine norovirus detection in the exhaust air of IVCs is more sensitive than serological analysis of soiled bedding sentinels.
2017 Scientific Article in Molecular Psychiatry Mol. Psychiatry 22, 192-201 (2017)
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index.
2016 Meeting abstract in Diabetologia Diabetologia 59, S176-S177 (2016)
Genome wide meta-analysis identifies novel regulators of circulating serum progranulin.
2016 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 113, 14372-14377 (2016)
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.
2016 Meeting abstract in Atherosclerosis Atherosclerosis 252, E263-E263 (2016)
Associations between lipoprotein subfractions and genome-wide DNA methylation in KORA F4.
2016 Meeting abstract in Allergy Allergy 71, 431-431 (2016)
Genome-wide association study unravels genetic determinants of the atopic march.
2016 Scientific Article in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 9, 250-258 (2016)
Common and rare genetic variation in CCR2, CCR5, or CX3CR1 and risk of atherosclerotic coronary heart disease and glucometabolic traits.
2016 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 113, 13366-13371 (2016)
Genetic variants linked to education predict longevity.
2016 Scientific Article in Clinical Epigenetics Clin. Epigenet. 8:124 (2016)
Mendelian inheritance of trimodal CpG methylation sites suggests distal cis-acting genetic effects.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0165548 (2016)
Are epigenetic factors implicated in chronic widespread pain?
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0166015 (2016)
Epigenetic signatures at AQP3 and SOCS3 engage in low-grade inflammation across different tissues.
2016 Scientific Article in BMJ Open BMJ Open 6:e012070 (2016)
'Omics' biomarkers associated with chronic low back pain: Protocol of a retrospective longitudinal study.
2016 Scientific Article in PLoS Genetics PLoS Genet. 12:e1006379 (2016)
Effect of insulin resistance on monounsaturated fatty acid levels: A multi-cohort non-targeted metabolomics and mendelian randomization study.
2016 Scientific Article in Nature Genetics Nat. Genet. 48, 1462-1472 (2016)
Genome-wide analysis identifies 12 loci influencing human reproductive behavior.
2016 Scientific Article in BMC Medical Informatics and Decision Making BMC Med. Inform. Decis. Mak. 16:137 (2016)
Open data models for smart health interconnected applications: The example of openEHR.
2016 Scientific Article in OncoTarget Oncotarget 7, 74510-74525 (2016)
Long-term exposure to air pollution is associated with biological aging.
2016 Scientific Article in Nature Genetics Nat. Genet. 48, 1151-1161 (2016)
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.
2016 Scientific Article in Aging Aging 8, 1844-1865 (2016)
DNA methylation-based measures of biological age: Meta-analysis predicting time to death.
2016 Scientific Article in Metabolomics Metabolomics 12:178 (2016)
Identification of putative biomarkers for type 2 diabetes using metabolomics in the Korea Association REsource (KARE) cohort.
2016 Scientific Article in Journal of the American College of Cardiology J. Am. Coll. Cardiol. 68, 1435-1448 (2016)
52 Genetic loci influencing myocardial mass.
2016 Scientific Article in Diabetes Diabetes 65, 3776-3785 (2016)
Metformin effect on non-targeted metabolite profiles in patients with type 2 diabetes and multiple murine tissues.
2016 Scientific Article in Scientific Reports Sci. Rep. 6:25853 (2016)
Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium.
2016 Scientific Article in Diabetologia Diabetologia 59, 1214-1221 (2016)
Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.
2016 Scientific Article in Cancer Epidemiology, Biomarkers & Prevention Cancer Epidemiol. Biomarkers Prev. 25, 1043-1049 (2016)
Genetic variation associated with longer telomere length increases risk of chronic lymphocytic leukemia.
2016 Scientific Article in International Journal of Epidemiology Int. J. Epidemiol. 45, 1469-1481 (2016)
Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D: A cross-sectional analysis in population-based data.
2016 Scientific Article in Parkinsonism & Related Disorders Parkinsonism Relat. Disord. 31, 119-123 (2016)
Systematic TOR1A non-c.907_909delGAG variant analysis in isolated dystonia and controls.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0158101 (2016)
Meta-analysis of genome-wide association studies and network analysis-based integration with gene expression data identify new suggestive loci and unravel a Wnt-centric network associated with Dupuytren's disease.
2016 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 25, 4094-4106 (2016)
Analysis with the exome array identifies multiple new independent variants in lipid loci.
2016 Scientific Article in European Journal of Nutrition Eur. J. Nutr. 56, 2379-2391 (2016)
Metabolites of milk intake: A metabolomic approach in UK twins with findings replicated in two European cohorts.
2016 Scientific Article in Arthritis Research & Therapy Arthritis Res. Ther. 18:156 (2016)
Systematic protein-protein interaction and pathway analyses in the idiopathic inflammatory myopathies.
2016 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 25, 3635-3646 (2016)
A genome-wide association meta-analysis on apolipoprotein A-IV concentrations.
2016 Scientific Article in PLoS Medicine PLoS Med. 13:e1001976 (2016)
Investigating the causal relationship of c-reactive protein with 32 complex somatic and psychiatric outcomes: A large-scale cross-consortium mendelian randomization study.
2016 Scientific Article in Nature Nature 536, 41-47 (2016)
The genetic architecture of type 2 diabetes.
2016 Scientific Article in Diabetologia Diabetologia 59, 2114-2124 (2016)
Non-targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes.
2016 Scientific Article in Carcinogenesis Carcinogenesis 37, 576-582 (2016)
Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers.
2016 Scientific Article in Science Advances Sci. Adv. 2:e1501678 (2016)
Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.
2016 Scientific Article in Nature Nature 533, 539-542 (2016)
Genome-wide association study identifies 74 loci associated with educational attainment.
2016 Scientific Article in PLoS Genetics PLoS Genet. 12:e1006034 (2016)
Discovery of genetic variation on chromosome 5q22 associated with mortality in heart failure.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0154872 (2016)
Compare and Contrast Meta Analysis (CCMA): A method for identification of pleiotropic loci in genome-wide association studies.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0153163 (2016)
The pharmacogenetic footprint of ACE inhibition: A population-based metabolomics study.
2016 Meeting abstract in Experimental Dermatology Exp. Dermatol. 25, E16 (2016)
Epidemiologic and genetic association between atopic dermatitis, rheumatoid arthritis, inflammatory bowel disease, and type-1 diabetes.
2016 Scientific Article in Nature Communications Nat. Commun. 7:11122 (2016)
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.
2016 Scientific Article in Nature Genetics Nat. Genet. 48, 624-633 (2016)
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0152314 (2016)
Association between DNA methylation in whole blood and measures of glucose metabolism: Kora F4 study.
2016 Scientific Article in Nature Communications Nat. Commun. 7:11008 (2016)
Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.
2016 Scientific Article in Biopreservation and Biobanking Biopreserv. Biobank. 14, 298-306 (2016)
Toward global biobank integration by implementation of the Minimum Information About BIobank Data Sharing (MIABIS 2.0 Core).
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0147388 (2016)
Association of forced vital capacity with the developmental gene NCOR2.
2016 Scientific Article in Science Science 351, 1166-1671 (2016)
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.
2016 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 25, 2082-2092 (2016)
Testing the role of predicted gene knockouts in human anthropometric trait variation.
2016 Scientific Article in Lancet Neurology, The Lancet Neurol. 15, 174-184 (2016)
Loci associated with ischaemic stroke and its subtypes (SiGN): A genome-wide association study.
2016 Scientific Article in Nature Communications Nat. Commun. 7:10494 (2016)
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.
2016 Scientific Article in Nature Communications Nat. Commun. 7:10495 (2016)
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.
2016 Scientific Article in Nature Communications Nat. Commun. 7:10023 (2016)
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
2016 Scientific Article in Aging Aging 8, 77-94 (2016)
Metabolomics profiling reveals novel markers for leukocyte telomere length.
2016 Scientific Article in Journal of the American College of Cardiology J. Am. Coll. Cardiol. 67, 407-416 (2016)
Causal assessment of serum urate levels in cardiometabolic diseases through a mendelian randomization study.
2016 Scientific Article in Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz Bundesgesundheitsbl.-Gesund. 59, 385-389 (2016)
Vernetzung von Biobanken großer europäischer Kohorten (EU-Projekt BBMRI-LPC).
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0147129 (2016)
Alterations in lipid and inositol metabolisms in two dopaminergic disorders.
2016 Scientific Article in Stroke Stroke 47, 307-316 (2016)
Genome-wide association analysis of young onset stroke identifies a locus on chromosome 10q25 near HABP2.
2016 Scientific Article in Journal of Proteome Research J. Proteome Res. 15, 554-562 (2016)
Diagnostic and prognostic metabolites identified for joint symptoms in the KORA population.
2016 Scientific Article in Diabetes Diabetes 65, 803-817 (2016)
Genome-wide association studies identify genetic loci associated with albuminuria in diabetes.
2016 Scientific Article in Journal of the American Society of Nephrology J. Am. Soc. Nephrol. 27, 1175-1188 (2016)
A metabolome-wide association study of kidney function and disease in the general population.
2016 Scientific Article in Annals of the Rheumatic Diseases : ARD online Ann. Rheum. Dis. 75, 1558-1566 (2016)
Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups.
2016 Scientific Article in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 137, 130–136 (2016)
Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes.
2015 Scientific Article in Molecular Psychiatry Mol. Psychiatry 20, 1588-1595 (2015)
Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus.
2015 Scientific Article in Diabetes Diabetes 64, 4312-4321 (2015)
Genetic predisposition to weight loss and regain with lifestyle intervention: Analyses from the Diabetes Prevention Program and the Look AHEAD randomized controlled trials.
2015 Scientific Article in Neurology Genetics Neurol. Genet. 1:e9 (2015)
Loss-of-function mutations in RAB39B are associated with typical early-onset Parkinson disease.
2015 Scientific Article in Genetic Epidemiology Genet. Epidemiol. 39, 624-634 (2015)
A Bayesian approach to the overlap analysis of epidemiologically linked traits.
2015 Nature Communications Nat. Commun. 6:10257 (2015)
Corrigendum: Rare coding variants and X-linked loci associated with age at menarche.
2015 Other: Opinion in Obstetrics & Gynecology Obstet. Gynecol. 70, 758-762 (2015)
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility, and BRCA1-mediated DNA repair.
2015 Scientific Article in Nature Communications Nat. Commun. 6:8658 (2015)
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 1415-1425 (2015)
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
2015 Scientific Article in Genetic Epidemiology Genet. Epidemiol. 39, 499-508 (2015)
Evaluating the calibration and power of three gene-based association tests of rare variants for the X chromosome.
2015 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 97, 816-836 (2015)
Genome-wide association analysis of psoriatic arthritis and cutaneous psoriasis reveals differences in their genetic architecture.
In: Krentz, A.J.* ; Heinemann, L.* ; Hompesch, M.* [Eds.]: Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development. London: Springer, 2015. 189-222
Omics: Potential role in early-phase drug development.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 1449-1456 (2015)
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.
2015 Scientific Article in Nature Communications Nat. Commun. 6:8804 (2015)
Meta-analysis identifies seven susceptibility loci involved in the atopic march.
2015 Scientific Article in BMC Medical Genomics BMC Med. Genomics 8:65 (2015)
Extensive alterations of the whole-blood transcriptome are associated with body mass index: Results of an mRNA profiling study involving two large population-based cohorts.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 1294-1303 (2015)
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
2015 Scientific Article in Epigenetics & Chromatin Epigenetics Chromatin 8:43 (2015)
Characterization of whole-genome autosomal differences of DNA methylation between men and women.
2015 Scientific Article in Lancet Respiratory Medicine, The Lancet Resp. Med. 3, 769-781 (2015)
Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): A genetic association study in UK Biobank.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005378 (2015)
The influence of age and sex on genetic associations with adult body size and shape: A large-scale genome-wide interaction study.
2015 Scientific Article in Lancet Respiratory Medicine, The Lancet Resp. Med. 3, 782-795 (2015)
Molecular mechanisms underlying variations in lung function: A systems genetics analysis.
2015 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 24, 6836-6848 (2015)
Integrative pathway genomics of lung function and airflow obstruction.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 1121-1130 (2015)
A comprehensive 1000 genomes–based genome-wide association meta-analysis of coronary artery disease.
2015 Scientific Article in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 8, 618-627 (2015)
Effect of bile acid sequestrants on the risk of cardiovascular events: A mendelian randomization analysis.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 1282-1293 (2015)
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005487 (2015)
Genome-wide association study with targeted and non-targeted NMR metabolomics identifies 15 novel loci of urinary human metabolic individuality.
2015 Scientific Article in European Journal of Neurology Eur. J. Neurol. 22, 1488-1491 (2015)
Heritability of young- and old-onset ischaemic stroke.
2015 Meeting abstract in Journal of Investigative Dermatology, The J. Invest. Dermatol. 135, S63 (2015)
Epidemiologic and genetic association between atopic dermatitis, rheumatoid arthritis, inflammatory bowel disease, and type-1 diabetes.
2015 Meeting abstract in International Journal of Stroke Int. J. Stroke 10, 250 (2015)
Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease.
2015 Scientific Article in Parkinsonism & Related Disorders Parkinsonism Relat. Disord. 21, 1278-1281 (2015)
Large-scale TUBB4A mutational screening in isolated dystonia and controls.
2015 Scientific Article in European Journal of Human Genetics Eur. J. Hum. Genet. 24, 521-528 (2015)
Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research.
2015 Scientific Article in Metabolomics Metabolomics 11, 1815-1833 (2015)
Gender-specific pathway differences in the human serum metabolome.
2015 Scientific Article in International Journal of Genomics Int. J. Genomics 2015:693193 (2015)
Genetic geostatistical framework for spatial analysis of fine-scale genetic heterogeneity in modern populations: Results from the KORA study.
2015 Scientific Article in Nature Communications Nat. Commun. 6:7756 (2015)
Rare coding variants and X-linked loci associated with age at menarche.
2015 Scientific Article in Diabetes Care Diabetes Care 38, 1858-1867 (2015)
Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes.
2015 Scientific Article in International Journal of Epidemiology Int. J. Epidemiol. 44, 662-672 (2015)
Mendelian randomization study of height and risk of colorectal cancer.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 172-179 (2015)
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.
2015 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 24, R93-R101 (2015)
Genetics of human metabolism: An update.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005230 (2015)
Discovery and fine-mapping of glycaemic and obesity-related trait loci using high-density imputation.
2015 Scientific Article in Nature Nature 523, 459-462 (2015)
Directional dominance on stature and cognition in diverse human populations.
2015 Scientific Article in Lancet Diabetes and Endocrinology Lancet Diabet. Endocrinol. 3, 526-534 (2015)
Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: A nested case-control study.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005274 (2015)
The human blood metabolome-transcriptome interface.
2015 Scientific Article in Molecular Psychiatry Mol. Psychiatry 20, 735-743 (2015)
The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects.
2015 Scientific Article in Atherosclerosis Atherosclerosis 241, 419-426 (2015)
Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk.
2015 Scientific Article in Nature Communications Nat. Commun. 6:7208 (2015)
Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.
2015 Scientific Article in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 192, 727-736 (2015)
Identification of immune-relevant factors conferring sarcoidosis genetic risk.
2015 Scientific Article in Hypertension Hypertension 66, 422-429 (2015)
Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate.
2015 Scientific Article in International Journal of Epidemiology Int. J. Epidemiol. 44, 578-586 (2015)
Adiposity as a cause of cardiovascular disease: A Mendelian randomization study.
2015 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 96, 695-708 (2015)
Genome-wide analysis of body proportion classifies height-associated variants by mechanism of action and implicates genes important for skeletal development.
2015 Scientific Article in International Journal of Hygiene and Environmental Health Int. J. Hyg. Environ. Health 218, 535-542 (2015)
Associations between short-term exposure to particulate matter and ultrafine particles and myocardial infarction in Augsburg, Germany.
2015 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 96, 883-893 (2015)
Recessive mutations in the α3 (VI) collagen gene COL6A3 cause early-onset isolated dystonia.
2015 Scientific Article in Genetics Genetics 200, 707-718 (2015)
Non-additive effects of genes in human metabolomics.
2015 Scientific Article in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 8, 334-342 (2015)
DNA methylation of lipid-related genes affects blood lipid levels.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 589-597 (2015)
The impact of low-frequency and rare variants on lipid levels.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005226 (2015)
Burden analysis of rare microdeletions suggests a strong impact of neurodevelopmental genes in genetic generalised epilepsies.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005165 (2015)
The power of gene-based rare variant methods to detect disease-associated variation and test hypotheses about complex disease.
2015 Meeting abstract in Experimental Dermatology Exp. Dermatol. 24, E15 (2015)
Psoriasis and cardiometabolic risk: independent association but distinct genetic architectures.
2015 Scientific Article in Pain Pain 156, 1845-1851 (2015)
An omics investigation into chronic widespread musculoskeletal pain reveals epiandrosterone sulfate as a potential biomarker.
2015 Scientific Article in Human Genome Variation Hum. Genome Var. 2:14028 (2015)
Excess of rare coding variants in PLD3 in late- but not early-onset Alzheimer’s disease.
2015 Scientific Article in Nature Communications Nat. Commun. 6:6804 (2015)
Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells.
2015 Scientific Article in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 136, 802-806 (2015)
A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis.ϖ
2015 Scientific Article in European Journal of Epidemiology Eur. J. Epidemiol. 30, 305-315 (2015)
Prevalence of refractive error in Europe: The European Eye Epidemiology (E3) consortium.
2015 Nature Communications Nat. Commun. 6:6542 (2015)
Corrigendum: Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.
2015 Review in Human Molecular Genetics Hum. Mol. Genet. 24, 3582-3594 (2015)
Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: A systematic review and meta-analysis with evidence from up to 331 175 individuals.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0119752 (2015)
Modulation of genetic associations with serum urate levels by body-mass-index in humans.
2015 Scientific Article in Nature Communications Nat. Commun. 6:5890 (2015)
Biological interpretation of genome-wide association studies using predicted gene functions.
2015 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 24, 1185-1199 (2015)
Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci.
2015 Scientific Article in BMC Medicine BMC Med. 13:48 (2015)
Multi-omic signature of body weight change: Results from a population-based cohort study.
2015 Scientific Article in Diabetes Diabetes 64, 1841-1852 (2015)
Age- and sex-specific causal effects of adiposity on cardiovascular risk factors.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1004876 (2015)
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
2015 Scientific Article in Nature Nature 518, 197-206 (2015)
Genetic studies of body mass index yield new insights for obesity biology.
2015 Scientific Article in Nature Nature 518, 187-196 (2015)
New genetic loci link adipose and insulin biology to body fat distribution.
2015 Scientific Article in European Journal of Human Genetics Eur. J. Hum. Genet. 23, 1328-1333 (2015)
Rare variants in β-Amyloid Precursor Protein (APP) and Parkinson's disease.
2015 Scientific Article in Journal of Investigative Dermatology, The J. Invest. Dermatol. 135, 1283-1293 (2015)
Psoriasis and cardiometabolic traits: Modest association but distinct genetic architectures.
2015 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 96, 104-120 (2015)
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.
2015 Scientific Article in PLoS Genetics PLoS Genet. 10:e1004854 (2015)
Genome wide meta-analysis highlights the role of genetic variation in RARRES2 in the regulation of circulating serum chemerin.
2015 Scientific Article in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 8, 159-167 (2015)
Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 78-83 (2015)
Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection.
2015 Scientific Article in Human Genetics Hum. Genet. 134, 131-146 (2015)
Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: The CREAM consortium.
2015 Scientific Article in Arteriosclerosis, Thrombosis, and Vascular Biology Arterioscler. Thromb. Vasc. Biol. 35, 229-236 (2015)
Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease.
2015 Scientific Article in Molecular Psychiatry Mol. Psychiatry 20, 647-656 (2015)