Publications from Dr. Harald Grallert
2022 Scientific Article in Genome Medicine Genome Med. 14:125 (2022)
Network reconstruction for trans acting genetic loci using multi-omics data and prior information.
2022 Scientific Article in Nature Cardiovascular Research Nat. Cardio. Res. 1, 727–731 (2022)
Triggering of myocardial infarction by heat exposure is modified by medication intake.
2022 Scientific Article in Metabolites Metabolites 12:846 (2022)
Fecal bile acids and neutral sterols are associated with latent microbial subgroups in the human gut.
2022 Scientific Article in Stroke Stroke 53, 2331-2339 (2022)
A family and a genome-wide polygenic risk score are independentlyassociated with stroke in a population-based study.
2022 Review in Diabetologie, Die Diabetologie 18, 758–768 (2022)
Molekulargenetische Diagnostik des Diabetes mellitus.
2022 Scientific Article in Pancreatology Pancreatol. 22, 449-456 (2022)
Colocalization analysis of pancreas eQTLs with risk loci from alcoholic and novel non-alcoholic chronic pancreatitis GWAS suggests potential disease causing mechanisms.
2022 Scientific Article in Nature Genetics Nat. Genet. 54, 560-572 (2022)
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.
2022 Scientific Article in Nature Cardiovascular Research Nat. Cardio. Res. 1, 157-173 (2022)
Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy.
2022 Scientific Article in PLoS Computational Biology PLoS Comput. Biol. 18:e1010044 (2022)
A randomization-based causal inference framework for uncovering environmental exposure effects on human gut microbiota.
2022 Scientific Article in Atherosclerosis Atherosclerosis 352, 10-17 (2022)
Association between a polygenic and family risk score on the prevalence and incidence of myocardial infarction in the KORA-F3 study.
2022 Scientific Article in Diabetologia Diabetologia 65, 763-776 (2022)
Epigenome-wide association study of incident type 2 diabetes: A meta-analysis of five prospective European cohorts.
2022 Scientific Article in Nature Genetics Nat. Genet. 54, 18–29 (2022)
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.
2022 Scientific Article in Translational research Transl. Res. 242, 93-104 (2022)
Novel associations between inflammation-related proteins and adiposity: A targeted proteomics approach across four population-based studies.
2021 Scientific Article in Nature Nature 596, 393-397 (2021)
Genetic insights into biological mechanisms governing human ovarian ageing.
2021 Scientific Article in Journal of Hypertension J. Hypertens. 39, 2527-2533 (2021)
N-glycosylation of immunoglobulin G predicts incident hypertension.
2021 Scientific Article in Innate Immunity Innate Immun. 27, 365-376 (2021)
Synergistic effect of genetic polymorphisms in TLR6 and TLR10 genes on the risk of pulmonary tuberculosis in a Moldavian population.
2021 Scientific Article in Diabetes Diabetes 70, 2092-2106 (2021)
Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study.
2021 Scientific Article in Science Advances Sci. Adv. 7:eabg0108 (2021)
Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo.
2021 Scientific Article in Nature Genetics Nat. Genet. 53, 840-860 (2021)
The trans-ancestral genomic architecture of glycemic traits.
2021 Scientific Article in Genetic Epidemiology Genet. Epidemiol. 45, 633-650 (2021)
Comparison of genetic risk prediction models to improve prediction of coronary heart disease in two large cohorts of the MONICA/KORA study.
2021 Scientific Article in Cardiovascular Diabetology Cardiovasc. Diabetol. 20:111 (2021)
Metabolic syndrome and the plasma proteome: From association to causation.
2021 Nature Communications Nat. Commun. 12:995 (2021)
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
2021 Scientific Article in Nutrients Nutrients 13:819 (2021)
Association between single nucleotide polymorphisms and weight reduction in behavioural interventions—a pooled analysis.
2021 Scientific Article in Microbiome Microbiome 9:61 (2021)
Associations between habitual diet, metabolic disease, and the gut microbiota using latent Dirichlet allocation.
2021 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 30, 393-409 (2021)
Genome-wide association study of circulating interleukin 6 levels identifies novel loci.
2021 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 106, 1460-1471 (2021)
A pathophysiology of type 2 diabetes unrelated to metabolic syndrome.
2021 Scientific Article in Nature Communications Nat. Commun. 12:24 (2021)
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
2021 Scientific Article in Nature Communications Nat. Commun. 12:1279 (2021)
Revealing the role of the human blood plasma proteome in obesity using genetic drivers.
2021 Scientific Article in PLoS Genetics PLoS Genet. 17:e1009236 (2021)
Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect.
2021 Scientific Article in Nature Genetics Nat. Genet. 53, 147–155 (2021)
Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome.
2021 Scientific Article in Diabetes Care Diabetes Care 44, 511-518 (2021)
Processes underlying glycemic deterioration in type 2 diabetes: An IMI DIRECT Study.
2021 Scientific Article in PLoS Genetics PLoS Genet. 16:e1009190 (2021)
Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.
2021 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 106, e1647-e1659 (2021)
A panel of six biomarkers significantly improves the prediction of type 2 diabetes in the MONICA/KORA study population.
2021 Scientific Article in JAMA Pediatrics JAMA Pediatr. 175:E205142 (2021)
Obesity genes and weight loss during lifestyle intervention in children with obesity.
2020 Scientific Article in Circulation Genomic and precision medicine Circ. Genom. Precis. Med. 13, 640-648 (2020)
Genetic predisposition to coronary artery disease in type 2 diabetes mellitus.
2020 Scientific Article in Genome Medicine Genome Med. 12:109 (2020)
Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: An IMI-DIRECT study.
2020 Scientific Article in Diabetes Diabetes 69, 2806-2818 (2020)
Genetic studies of leptin concentrations implicate leptin in the regulation of early adiposity.
2020 Scientific Article in Nature Nature 588, 135–140 (2020)
A reference map of potential determinants for the human serum metabolome.
2020 Scientific Article in Clinical Epigenetics Clin. Epigenet. 12:157 (2020)
Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits.
2020 Scientific Article in Diabetes Diabetes 69, 2766-2778 (2020)
Deciphering the plasma proteome of type 2 diabetes.
2020 Scientific Article in Cell Host & Microbe Cell Host Microbe 28, 258-272.e6 (2020)
Arrhythmic gut microbiome signatures predict risk of type 2 diabetes.
2020 Scientific Article in Parkinsonism & Related Disorders Parkinsonism Relat. Disord. 75, 24-26 (2020)
Private variants in PRKN are associated with late-onset Parkinson's disease.
2020 Scientific Article in Microorganisms Microorganisms 8:547 (2020)
Investigation of adiposity measures and operational taxonomic unit (OTU) data transformation procedures in stool samples from a German Cohort Study using machine learning algorithms.
2020 Scientific Article in Movement Disorders Mov. Disord. 35, 1245-1248 (2020)
Rare variants in specific lysosomal genes are associated with Parkinson's disease.
2020 PLoS ONE PLoS ONE 15:e0229472 (2020)
Correction: Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy.
In: Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease. 2019. 309-347
Omics: Potential role in early phase drug development.
2019 Scientific Article in Science Advances Sci. Adv. 5:eaaw3095 (2019)
GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.
2019 Scientific Article in Journal of Hepatology J. Hepatol. 71, 594-602 (2019)
Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration.
2019 Scientific Article in Diabetes Care Diabetes Care 42, 1027-1033 (2019)
Variation in the plasma membrane monoamine transporter (PMAT, encoded in SLC29A4) and organic cation transporter 1 (OCT1, encoded in SLC22A1) and gastrointestinal intolerance to metformin in type 2 diabetes: An IMI DIRECT study.
2019 Scientific Article in Atherosclerosis Atherosclerosis 288, 1-8 (2019)
Associations between fecal bile acids, neutral sterols, and serum lipids in the KORA FF4 study.
2019 Scientific Article in Scientific Reports Sci. Rep. 9:9439 (2019)
Genome-wide association study of change in fasting glucose over time in 13,807 non-diabetic European Ancestry Individuals.
2019 Scientific Article in Nature Communications Nat. Commun. 10:2581 (2019)
An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis.
2019 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 105, 15-28 (2019)
Exome-derived adiponectin-associated variants implicate obesity and lipid biology.
2019 Scientific Article in British Journal of Nutrition Br. J. Nutr. 122, 309-321 (2019)
Associations between usual food intake and faecal sterols and bile acids: Results from the Cooperative Health Research in the Augsburg Region (KORA FF4) study.
2019 Scientific Article in PLoS ONE PLoS ONE 14:e0216110 (2019)
Dynamic modelling of an ACADS genotype in fatty acid oxidation - Application of cellular models for the analysis of common genetic variants.
2019 Scientific Article in American Journal of Clinical Nutrition Am. J. Clin. Nutr. 109, 276-287 (2019)
Disentangling the genetics of lean mass.
2019 Scientific Article in Nature Genetics Nat. Genet. 51, 452–469 (2019)
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.
2019 Scientific Article in Diabetes Diabetes 68, 188-197 (2019)
Insulin-like growth factor binding protein 2 (IGFBP-2) and the risk of developing type 2 diabetes.
2019 Scientific Article in Infection, Genetics and Evolution Infect. Genet. Evol. 68, 84-90 (2019)
Genetic variation in TLR pathway and the risk of pulmonary tuberculosis in a Moldavian population.
2019 Scientific Article in Addiction Addiction 114, 216-225 (2019)
Association of alcohol consumption with allergic disease and asthma: A multi-centre Mendelian randomization analysis.
2018 Meeting abstract in European Heart Journal Eur. Heart J. 39, 998-998 (2018)
Using the plasma proteome to decipher metabolic syndrome pathophysiology and discover a diagnostic biomarker panel.
2018 Scientific Article in Diabetes Research and Clinical Practice Diabetes Res. Clin. Pract. 146, 251-257 (2018)
Genetic variation in TCF7L2 rs7903146 and history of GDM negatively and independently impact on diabetes-associated metabolic traits.
2018 Scientific Article in Nature Genetics Nat. Genet. 50, 1505-1513 (2018)
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.
2018 Scientific Article in Nature Genetics Nat. Genet. 50, 1514-1523 (2018)
Genetics of blood lipids among similar to 300,000 multi-ethnic participants of the Million Veteran Program.
2018 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 103, 691-706 (2018)
Genome analyses of >200,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders.
2018 Scientific Article in Molecular Metabolism Mol. Metab. 18, 42-50 (2018)
Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesity.
2018 Scientific Article in Metabolomics Metabolomics 14:128 (2018)
Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies.
2018 Scientific Article in Diabetes Diabetes 67, 1414-1427 (2018)
A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes.
2018 Scientific Article in Obesity Facts Obes. Facts 11, 93-108 (2018)
The effect of SH2B1 variants on expression of leptin- and insulin-induced pathways in murine hypothalamus.
2018 Scientific Article in JAMA cardiology JAMA Cardiol. 3, 463-472 (2018)
Association of methylation signals with incident coronary heart disease in an epigenome-wide assessment of circulating tumor necrosis factor.
2018 Scientific Article in PLoS Genetics PLoS Genet. 14:e1007329 (2018)
Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.
2018 Scientific Article in Nature Genetics Nat. Genet. 50, 559-571 (2018)
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
2018 Scientific Article in Frontiers in Immunology Front. Immunol. 9:277 (2018)
Genome-wide association study on immunoglobulin G glycosylation patterns.
2018 Nature Communications Nat. Commun. 9:706 (2018)
Erratum: Publisher Correction: Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway (Nature communications (2017) 8 1 (1483)).
2018 Scientific Article in Nature Communications Nat. Commun. 9:288 (2018)
Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
2018 Scientific Data Sci. Data 5:180002 (2018)
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
2018 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 27, 546-558 (2018)
Genome-wide meta-analysis identifies novel determinants of circulating serum progranulin.
2018 Scientific Article in Biochimica et Biophysica Acta - General Subjects Biochim. Biophys. Acta-Gen. Subj. 1862, 637-648 (2018)
IgG glycosylation and DNA methylation are interconnected with smoking.
2018 Scientific Article in International Journal of Obesity Int. J. Obes. 42, 755-784 (2018)
Maternal and fetal genetic contribution to gestational weight gain.
2018 Scientific Article in Gut (eGut) Gut 67, 1855–186 (2018)
Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.
2018 Scientific Article in The World Journal of Biological Psychiatry World J. Biol. Psychiatry 19, 187-199 (2018)
High-throughput DNA methylation analysis in anorexia nervosa confirms TNXB hypermethylation.
2017 Scientific Article in European Journal of Human Genetics Eur. J. Hum. Genet. 25, 137-146 (2017)
Across-cohort QC analyses of GWAS summary statistics from complex traits.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 1722–1730 (2017)
Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.
2017 Scientific Article in Scientific Data Sci. Data 4:170179 (2017)
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 1758-1766 (2017)
Exome-wide association study of plasma lipids in >300,000 individuals.
2017 Scientific Article in Nature Communications Nat. Commun. 8:1483 (2017)
Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway.
2017 Nature Communications Nat. Commun. 8:1414 (2017)
Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
2017 Scientific Article in BMC Bioinformatics BMC Bioinformatics 18:429 (2017)
pulver: An R package for parallel ultra-rapid p-value computation for linear regression interaction terms.
2017 Scientific Article in Diabetologia Diabetologia 61, 117-129 (2017)
Metabolite ratios as potential biomarkers for type 2 diabetes: A DIRECT study.
2017 Scientific Article in PLoS Medicine PLoS Med. 14:e1002383 (2017)
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.
2017 Scientific Article in Journal of Steroid Biochemistry and Molecular Biology, The J. Steroid Biochem. Mol. Biol. 174, 114-119 (2017)
Immediate reduction of serum citrulline but no change of steroid profile after initiation of metformin in individuals with type 2 diabetes.
2017 Scientific Article in PLoS ONE PLoS ONE 12:e0181038 (2017)
Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation.
2017 Scientific Article in Diabetes Aktuell Diabetes akt. 15, 104-107 (2017)
Ernährungsgewohnheiten schlagen sich im Erbgut nieder.
2017 Scientific Article in Nature Communications Nat. Commun. 8:80 (2017)
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:6037 (2017)
Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes.
2017 Scientific Article in PLoS Genetics PLoS Genet. 13:e1006812 (2017)
Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions.
2017 Scientific Article in Diabetes Diabetes 66, 2888-2902 (2017)
An expanded genome-wide association study of type 2 diabetes in Europeans.
2017 Scientific Article in PLoS ONE PLoS ONE 12:e0179128 (2017)
Physical fitness and plasma leptin in women with recent gestational diabetes.
2017 Review in Current Opinion in Clinical Nutrition & Metabolic Care Curr. Opin. Clin. Nutr. Metab. Care 20, 266-271 (2017)
Epigenetic regulation of glucose metabolism.
2017 Scientific Article in Hormone and Metabolic Research Horm. Metab. Res. 49, 343-349 (2017)
ANGPTL8 (Betatrophin) is expressed in visceral adipose tissue and relates to human hepatic steatosis in two independent clinical collectives.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 834-841 (2017)
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:2224 (2017)
Investigating the causal effect of smoking on hay fever and asthma: A Mendelian randomization meta-analysis in the CARTA consortium.
2017 Scientific Article in Diabetes Diabetes 66, 2019-2032 (2017)
A low-frequency inactivating Akt2 variant enriched in the Finnish population is associated with fasting insulin levels and type 2 diabetes risk.
2017 Scientific Article in PLoS Genetics PLoS Genet. 13:e1006528 (2017)
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults.
2017 Scientific Article in Nature Communications Nat. Commun. 8:14977 (2017)
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
2017 Scientific Article in PLoS ONE PLoS ONE 12:e0172995 (2017)
Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy.
2017 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 45, 3266-3279 (2017)
Allele-specific quantitative proteomics unravels molecular mechanisms modulated by cis-regulatory PPARG locus variation.
2017 Scientific Article in Nature Communications Nat. Commun. 8:14357 (2017)
Connecting genetic risk to disease end points through the human blood plasma proteome.
2017 Scientific Article in Hepatology research Hepatol. Res. 47, 890-901 (2017)
Increased lipogenesis in spite of upregulated hepatic 5'AMP-activated protein kinase in human non-alcoholic fatty liver.
2017 Scientific Article in Epigenetics & Chromatin Epigenetics Chromatin 10:1 (2017)
Genome-wide methylation data mirror ancestry information.
2017 Scientific Article in Nature Nature 541, 81-86 (2017)
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.
2017 Scientific Article in Age and Ageing Age Ageing 46, 481-486 (2017)
Common eye diseases in older adults of Southern Germany: Results from the KORA-Age Study.
2016 Meeting abstract in Diabetologia Diabetologia 59, S176-S177 (2016)
Genome wide meta-analysis identifies novel regulators of circulating serum progranulin.
2016 Meeting abstract in Diabetologia Diabetologia 59, S142-S143 (2016)
A metabolite ratio associates with measures of insulin secretion and altered risk of type 2 diabetes; a DIRECT study.
2016 Meeting abstract in Diabetologia Diabetologia 59, S127-S127 (2016)
Targeted metabolomics to predict the primary success of metformin monotherapy in type 2 diabetes.
2016 Meeting abstract in Atherosclerosis Atherosclerosis 252, E263-E263 (2016)
Associations between lipoprotein subfractions and genome-wide DNA methylation in KORA F4.
2016 Scientific Article in Genome Biology Genome Biol. 17:255 (2016)
DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases.
2016 Scientific Article in Nature Communications Nat. Commun. 7:13357 (2016)
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0166015 (2016)
Epigenetic signatures at AQP3 and SOCS3 engage in low-grade inflammation across different tissues.
2016 Scientific Article in Diabetologia Diabetologia 59, 1214-1221 (2016)
Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.
2016 Scientific Article in International Journal of Epidemiology Int. J. Epidemiol. 45, 1469-1481 (2016)
Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D: A cross-sectional analysis in population-based data.
2016 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 25, 4094-4106 (2016)
Analysis with the exome array identifies multiple new independent variants in lipid loci.
2016 Scientific Article in Nature Nature 536, 41-47 (2016)
The genetic architecture of type 2 diabetes.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0157733 (2016)
Specific metabolic markers are associated with future waist-gaining phenotype in women.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0153990 (2016)
Effects of genetic loci associated with central obesity on adipocyte lipolysis.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0152314 (2016)
Association between DNA methylation in whole blood and measures of glucose metabolism: Kora F4 study.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0147388 (2016)
Association of forced vital capacity with the developmental gene NCOR2.
2016 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 25, 2082-2092 (2016)
Testing the role of predicted gene knockouts in human anthropometric trait variation.
2016 Scientific Article in Nature Communications Nat. Commun. 7:10494 (2016)
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.
2016 Scientific Article in Nature Communications Nat. Commun. 7:10495 (2016)
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.
2016 Scientific Article in Nature Communications Nat. Commun. 7:10023 (2016)
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
2016 Scientific Article in Diabetes Diabetes 65, 433-437 (2016)
Numerous genes in loci associated with body fat distribution are linked to adipose function.
2016 Scientific Article in BMC Medical Genetics BMC Med. Genet. 17:7 (2016)
Association of common variants identified by recent genome-wide association studies with obesity in Chinese children: A case-control study.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0147904 (2016)
Analysis of genes involved in body weight regulation by targeted re-sequencing.
2016 Scientific Article in Diabetes Diabetes 65, 803-817 (2016)
Genome-wide association studies identify genetic loci associated with albuminuria in diabetes.
2016 Scientific Article in Diabetes Diabetes 65, 574-584 (2016)
A high fat diet during mouse pregnancy and lactation targets GIP-regulated metabolic pathways in adult male offspring.
2016 Scientific Article in American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics Am. J. Med. Genet. B 171, 562-572 (2016)
A genome-wide approach to children's aggressive behavior: The EAGLE consortium.
2016 Scientific Article in Gut (eGut) Gut 65, 184-185 (2016)
Genetic variants of lipase activity in chronic pancreatitis.
2015 Scientific Article in Diabetes Diabetes 64, 4312-4321 (2015)
Genetic predisposition to weight loss and regain with lifestyle intervention: Analyses from the Diabetes Prevention Program and the Look AHEAD randomized controlled trials.
2015 Scientific Article in Genetic Epidemiology Genet. Epidemiol. 39, 624-634 (2015)
A Bayesian approach to the overlap analysis of epidemiologically linked traits.
2015 Scientific Article in Nature Communications Nat. Commun. 6:8658 (2015)
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 1415-1425 (2015)
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
2015 Scientific Article in Genetic Epidemiology Genet. Epidemiol. 39, 499-508 (2015)
Evaluating the calibration and power of three gene-based association tests of rare variants for the X chromosome.
In: Krentz, A.J.* ; Heinemann, L.* ; Hompesch, M.* [Eds.]: Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development. London: Springer, 2015. 189-222
Omics: Potential role in early-phase drug development.
2015 Scientific Article in BMC Medical Genomics BMC Med. Genomics 8:65 (2015)
Extensive alterations of the whole-blood transcriptome are associated with body mass index: Results of an mRNA profiling study involving two large population-based cohorts.
2015 Scientific Article in Epigenetics & Chromatin Epigenetics Chromatin 8:43 (2015)
Characterization of whole-genome autosomal differences of DNA methylation between men and women.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005378 (2015)
The influence of age and sex on genetic associations with adult body size and shape: A large-scale genome-wide interaction study.
2015 Scientific Article in Scientific Reports Sci. Rep. 5:13212 (2015)
The stool microbiota of insulin resistant women with recent gestational diabetes, a high risk group for type 2 diabetes.
2015 Scientific Article in Metabolomics Metabolomics 11, 1815-1833 (2015)
Gender-specific pathway differences in the human serum metabolome.
2015 Scientific Article in International Journal of Epidemiology Int. J. Epidemiol. 44, 662-672 (2015)
Mendelian randomization study of height and risk of colorectal cancer.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005230 (2015)
Discovery and fine-mapping of glycaemic and obesity-related trait loci using high-density imputation.
2015 Scientific Article in Lancet Diabetes and Endocrinology Lancet Diabet. Endocrinol. 3, 526-534 (2015)
Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: A nested case-control study.
2015 Scientific Article in Diabetic Medicine Diabetic Med. 32, 1479-1483 (2015)
Low serum omentin levels in the elderly population with type 2 diabetes and polyneuropathy.
2015 Scientific Article in Cell Cycle Cell Cycle 14, 2293-2300 (2015)
Modulation of insulin degrading enzyme activity and liver cell proliferation.
2015 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 96, 695-708 (2015)
Genome-wide analysis of body proportion classifies height-associated variants by mechanism of action and implicates genes important for skeletal development.
2015 Scientific Article in International Journal of Hygiene and Environmental Health Int. J. Hyg. Environ. Health 218, 535-542 (2015)
Associations between short-term exposure to particulate matter and ultrafine particles and myocardial infarction in Augsburg, Germany.
2015 Scientific Article in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 8, 334-342 (2015)
DNA methylation of lipid-related genes affects blood lipid levels.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 589-597 (2015)
The impact of low-frequency and rare variants on lipid levels.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0125660 (2015)
Fine mapping of a GWAS-derived obesity candidate region on chromosome 16p11.2.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005223 (2015)
Cell specific eQTL analysis without sorting cells.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0126294 (2015)
Mitochondrial GWA analysis of lipid profile identifies genetic variants to be associated with HDL cholesterol and triglyceride levels.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005165 (2015)
The power of gene-based rare variant methods to detect disease-associated variation and test hypotheses about complex disease.
2015 Scientific Article in Experimental Dermatology Exp. Dermatol. 24, 510-515 (2015)
Genome-wide association study identifies new susceptibility loci for cutaneous lupus erythematosus.
2015 Scientific Article in Pain Pain 156, 1845-1851 (2015)
An omics investigation into chronic widespread musculoskeletal pain reveals epiandrosterone sulfate as a potential biomarker.
2015 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 100, E910-E918 (2015)
The diabetes risk phenotype of young women with recent gestational diabetes.
2015 Review in Human Molecular Genetics Hum. Mol. Genet. 24, 3582-3594 (2015)
Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: A systematic review and meta-analysis with evidence from up to 331 175 individuals.
2015 Scientific Article in Nature Communications Nat. Commun. 6:6691 (2015)
Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms.
2015 Scientific Article in Nature Communications Nat. Commun. 6:5890 (2015)
Biological interpretation of genome-wide association studies using predicted gene functions.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005035 (2015)
A meta-analysis of gene expression signatures of blood pressure and hypertension.
2015 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 24, 1185-1199 (2015)
Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci.
2015 Scientific Article in BMC Medicine BMC Med. 13:48 (2015)
Multi-omic signature of body weight change: Results from a population-based cohort study.
2015 Scientific Article in Diabetologia Diabetologia 58, 1118-1128 (2015)
Increased prevalence of cardiac autonomic dysfunction at different degrees of glucose intolerance in the general population: The KORA S4 survey.
2015 Scientific Article in Translational Psychiatry Transl. Psychiatry 5:e524 (2015)
Mitochondrial genetic variants identified to be associated with posttraumatic stress disorder.
2015 Scientific Article in Lancet, The Lancet 385, 351-361 (2015)
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: Evidence from genetic analysis and randomised trials.
2015 Scientific Article in Diabetes Diabetes 64, 1841-1852 (2015)
Age- and sex-specific causal effects of adiposity on cardiovascular risk factors.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1004876 (2015)
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
2015 Scientific Article in Nature Nature 518, 197-206 (2015)
Genetic studies of body mass index yield new insights for obesity biology.
2015 Scientific Article in Nature Nature 518, 187-196 (2015)
New genetic loci link adipose and insulin biology to body fat distribution.
2015 Scientific Article in PLoS Genetics PLoS Genet. 10:e1004854 (2015)
Genome wide meta-analysis highlights the role of genetic variation in RARRES2 in the regulation of circulating serum chemerin.
2015 Scientific Article in Kidney International Kidney Int. 87, 1017–1029 (2015)
Genome-wide association study of kidney function decline in individuals of European descent.
2015 Scientific Article in Psychiatric Genetics Psychiatr. Genet. 25, 41-42 (2015)
No association between the ALDH2 promoter polymorphism rs886205, alcohol dependence, and risky alcohol consumption in a German population.
2015 Scientific Article in American Journal of Hematology Am. J. Hematol. 90, E17-E21 (2015)
Occurrence of the JAK2 V617F mutation in patients with peripheral arterial disease.
2015 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 24, 1155-1168 (2015)
A novel common variant in DCST2 is associated with length in early life and height in adulthood.
2015 Scientific Article in European Journal of Nutrition Eur. J. Nutr. 54, 173-181 (2015)
Changes in the serum metabolite profile in obese children with weight loss.
2014 Meeting abstract in Experimental and Clinical Endocrinology & Diabetes Exp. Clin. Endocrinol. Diabet. 122:P012 (2014)
A high-fat diet during pregnancy and lactation targets GIP-regulated metabolic pathways in male offspring in mice.
2014 Meeting abstract in Diabetologia Diabetologia 57, S50-S51 (2014)
Fine-mapping type 2 diabetes susceptibility loci with high-density imputation.
2014 Meeting abstract in Diabetologia Diabetologia 57, S66 (2014)
FOXA2 bound sites are enriched for type 2 diabetes risk variants.
2014 Meeting abstract in Diabetologia Diabetologia 57, S41 (2014)
A high fat diet during pregnancy and lactation affects the metabolic fate of Gipr-/- mice via hypothalamic insulin signalling and DNA-methylation of lipid metabolism genes.
2014 Meeting abstract in Diabetologia Diabetologia 57, S67-S68 (2014)
Genome wide meta-analysis highlights the role of genetic variation in RARRES2 in regulation of circulating serum chemerin.
2014 Scientific Article in Nature Genetics Nat. Genet. 46, 357-363 (2014)
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.
2014 Scientific Article in Clinical Endocrinology Clin. Endocrinol. 81, 702-710 (2014)
Associations of genetic variants in/near body mass index-associated genes with type 2 diabetes: A systematic meta-analysis.
2014 Scientific Article in European Journal of Human Genetics Eur. J. Hum. Genet. 22, 1217-1224 (2014)
Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R.
2014 Scientific Article in PLoS Genetics PLoS Genet. 10:e100451 (2014)
Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.
2014 Scientific Article in Lancet Neurology, The Lancet Neurol. 13, 893-903 (2014)
Genetic determinants of common epilepsies: A meta-analysis of genome-wide association studies.
2014 Scientific Article in Nature Genetics Nat. Genet. 46, 1173-1186 (2014)
Defining the role of common variation in the genomic and biological architecture of adult human height.
2014 Scientific Article in Molecular Genetics and Metabolism Mol. Genet. Metab. 112, 317-338 (2014)
Pleiotropic genes for metabolic syndrome and inflammation.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e105116 (2014)
Mitochondrial genetic variants identified to be associated with BMI in adults.
2014 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 23, 4738-4744 (2014)
Multi-ethnic fine-mapping of 14 central adiposity loci.
2014 Scientific Article in Nature Protocols Nat. Protoc. 9, 1192-1212 (2014)
Quality control and conduct of genome-wide association meta-analyses.
2014 Scientific Article in PLoS Genetics PLoS Genet. 10, 1-12:e1004508 (2014)
Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on Body Mass Index.
2014 Scientific Article in BMC Bioinformatics BMC Bioinformatics 15:232 (2014)
On the potential of models for location and scale for genome-wide DNA methylation data.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e102113 (2014)
A systematic evaluation of short tandem repeats in lipid candidate genes: Riding on the SNP-wave.
2014 Scientific Article in American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics Am. J. Med. Genet. B 165, 283-293 (2014)
Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity.
2014 Scientific Article in Genetic Epidemiology Genet. Epidemiol. 38, 381-388 (2014)
Harmonization of study and reference data by PhaseLift: Saving time when imputing study data.
2014 Scientific Article in Diabetes Diabetes 63, 4343-4359 (2014)
Genetic determinants of circulating interleukin-1 receptor antagonist levels and their association with glycemic traits.
2014 Scientific Article in Nature Genetics Nat. Genet. 46, 669-677 (2014)
Genome-wide association analysis identifies six new loci associated with forced vital capacity.
2014 Scientific Article in Cardiovascular Diabetology Cardiovasc. Diabetol. 13:90 (2014)
PLA1A2 platelet polymorphism predicts mortality in prediabetic subjects of the population based KORA S4-cohort.
2014 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 94, 710-720 (2014)
Simulation of finnish population history, guided by empirical genetic data, to assess power of rare-variant tests in Finland.
2014 Scientific Article in Journal of Clinical Periodontology J. Clin. Periodontol. 41, 531-540 (2014)
SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e94882 (2014)
Mitochondrial DNA variants in obesity.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e93844 (2014)
Mapping the genetic architecture of gene regulation in whole blood.
2014 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 94, 437-452 (2014)
An excess of risk-increasing low-frequency variants can be a signal of polygenic inheritance in complex diseases.
2014 Scientific Article in Lancet, The Lancet 383, 1990-1998 (2014)
DNA methylation and body-mass index: A genome-wide analysis.
2014 Scientific Article in Nature Genetics Nat. Genet. 46, 234-244 (2014)
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e89728 (2014)
Targeted metabolomics identifies reliable and stable metabolites in human serum and plasma samples.
2014 Review in Cell Cell 156, 343-358 (2014)
Leveraging cross-species transcription factor binding site patterns: From diabetes risk loci to disease mechanisms.
2014 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 23, 2498-2510 (2014)
Gene-centric meta-analyses for central adiposity traits in up to 57412 individuals of European descent confirm known loci and reveal several novel associations.
2014 Scientific Article in Diabetes Diabetes 63, 1154-1165 (2014)
Expression of phosphofructokinase in skeletal muscle is influenced by genetic variation and associated with insulin sensitivity.
2014 Scientific Article in American Journal of Hematology Am. J. Hematol. 89, 295-301 (2014)
Evaluation of the prevalence and prospective clinical impact of the JAK2 V617F mutation in coronary patients.
2014 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 23, 239-246 (2014)
Genome-wide association study identifies three novel loci for type 2 diabetes.
2014 Scientific Article in Catalysis Letters Catal. Lett. 10, 386-401 (2014)
Comparative analysis of plasma metabolomics response to metabolic challenge tests in healthy subjects and influence of the FTO obesity risk allele.
2014 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 23, 534-545 (2014)
Epigenetics meets metabolomics: An epigenome-wide association study with blood serum metabolic traits.
2014 Scientific Article in Clinical Oral Investigations Clin. Oral Investig. 18, 677-682 (2014)
Genome-Wide Association Study (GWAS) for Molar-Incisor Hypomineralization (MIH).
2013 Scientific Article in Nature Genetics Nat. Genet. 45, 1418-1427 (2013)
Evaluating empirical bounds on complex disease genetic architecture.
2013 Scientific Article in Bioinformatics Bioinformatics 29, 2419-2426 (2013)
Assessing association between protein truncating variants and quantitative traits.
2013 Scientific Article in Genetic Epidemiology Genet. Epidemiol. 37, 539-550 (2013)
Recommended joint and meta-analysis strategies for case-control association testing of single low-count variants.
2013 Scientific Article in PLoS ONE PLoS ONE 8:e81431 (2013)
Development and application of genomic control methods for genome-wide association studies using non-additive models.
2013 Scientific Article in PLoS Genetics PLoS Genet. 9:e1003919 (2013)
Mining the human phenome using allelic scores that index biological intermediates.
2013 Scientific Article in Diabetes Diabetes 63, 2158-2171 (2013)
Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity.
2013 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 93, 236-248 (2013)
Meta-analysis of gene-level associations for rare variants based on single-variant statistics.
2013 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 22, 3597-3607 (2013)
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.
2013 Scientific Article in Diabetologia Diabetologia 56, 1306-1316 (2013)
Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels.
2013 Scientific Article in Journal of Pediatric Endocrinology and Metabolism J. Pediatr. Endocrinol. Metab. 26, 1209-1213 (2013)
No impact of obesity susceptibility loci on weight regain after a lifestyle intervention in overweight children.
2013 Scientific Article in PLoS ONE PLoS ONE 8:e62378 (2013)
Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations.
2013 Scientific Article in Diabetologia Diabetologia 56, 1291-1305 (2013)
Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4.
2013 Scientific Article in Diabetes Diabetes 62, 2141-2150 (2013)
Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.
2013 Scientific Article in Nature Genetics Nat. Genet. 45, 1274-1283 (2013)
Discovery and refinement of loci associated with lipid levels.
2013 Scientific Article in Nutrition, Metabolism and Cardiovascular Diseases Nutr. Metab. Cardiovasc. Dis. 23, 1043-1049 (2013)
The SH2B1 obesity locus and abnormal glucose homeostasis: Lack of evidence for association from a meta-analysis in individuals of European ancestry.
2013 Scientific Article in Diabetes Diabetes 62, 1746-1755 (2013)
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
2013 Scientific Article in PLoS ONE PLoS ONE 8:e78430 (2013)
Plasma metabolomics reveal alterations of sphingo- and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146.
2013 Scientific Article in Nature Genetics Nat. Genet. 45, 1345-1352 (2013)
Common variants associated with plasma triglycerides and risk for coronary artery disease.
2013 Scientific Article in Nature Genetics Nat. Genet. 45, 1238-1243 (2013)
Systematic identification of trans eQTLs as putative drivers of known disease associations.
2013 Scientific Article in American Journal of Epidemiology Am. J. Epidemiol. 178, 451-460 (2013)
Association of adiposity genetic variants with menarche timing in 92,105 women of European descent.
2013 Scientific Article in Catalysis Letters Catal. Lett. 9, 1157-1167 (2013)
Metabolomics reveals determinants of weight loss during lifestyle intervention in obese children.
2013 Scientific Article in PLoS Genetics PLoS Genet. 9:e1003500 (2013)
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
2013 Scientific Article in International Journal of Obesity Int. J. Obes. 37, 861-866 (2013)
Genetic variation in the vaspin gene affects circulating serum vaspin concentrations.
2013 Scientific Article in Diabetes Care Diabetes Care 36, 1321-1326 (2013)
Acute-phase serum amyloid A protein and its implication in the development of type 2 diabetes in the KORA S4/F4 study.
2013 Scientific Article in Diabetologie, Die Diabetologie 9, 243-250 (2013)
Epigenetische Prozesse beim Typ-2-Diabetes. Beitrag zum Verständnis der genetischen Prädisposition.
2013 Scientific Article in Nature Genetics Nat. Genet. 45, 501-512 (2013)
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
2013 Scientific Article in PLoS Medicine PLoS Med. 10:e1001383 (2013)
Causal relationship between obesity and vitamin D status: Bi-directional Mendelian randomization analysis of multiple cohorts.
2013 Scientific Article in Diabetologia Diabetologia 56, 298-310 (2013)
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.
2013 Scientific Article in Diabetes Diabetes 62, 977-986 (2013)
Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.
2013 Scientific Article in PLoS ONE PLoS ONE 8:e55884 (2013)
Gene set of nuclear-encoded mitochondrial regulators is enriched for common inherited variation in obesity.
2013 Scientific Article in Diabetes Diabetes 62, 291-298 (2013)
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
2013 Scientific Article in Nature Genetics Nat. Genet. 45, 76-82 (2013)
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
2013 Scientific Article in Nature Genetics Nat. Genet. 45, 145-154 (2013)
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
2012 Meeting abstract in Annals of Human Genetics Ann. Hum. Genet. 76, 429-430 (2012)
Search for novel type 2 diabetes susceptibility loci using genome-wide association studies imputed from a 1000 Genomes references panel.
2012 Scientific Article in PLoS Genetics PLoS Genet. 8:e1002505 (2012)
Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes.
2012 Scientific Article in Nature Genetics Nat. Genet. 44, 302-306 (2012)
Common variants at CDKAL1 and KLF9 are associated with body mass index in East Asian populations.
2012 Scientific Article in Nature Genetics Nat. Genet. 44, 307-311 (2012)
Meta-analysis identifies common variants associated with body mass index in east Asians.
2012 Scientific Article in Nature Genetics Nat. Genet. 44, 1015-1019 (2012)
Evidence of widespread selection on standing variation in Europe at height-associated SNPs.
2012 Scientific Article in Nature Genetics Nat. Genet. 44, 297-301 (2012)
Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes.
2012 Scientific Article in BMC Medical Genomics BMC Med. Genomics 5:65 (2012)
Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants.
2012 Scientific Article in Blood Blood 120, 4873-4881 (2012)
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
2012 Scientific Article in PLoS ONE PLoS ONE 7:e50938 (2012)
Analyzing illumina gene expression microarray data from different tissues: Methodological aspects of data analysis in the MetaXpress consortium.
2012 Scientific Article in PLoS Genetics PLoS Genet. 8:e1003046 (2012)
Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems.
2012 Scientific Article in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 5, 676-685 (2012)
Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
2012 Scientific Article in BioSpektrum BioSpektrum 18, 508-510 (2012)
Genomweite Assoziationsstudien (GWAS) - Möglichkeiten und Grenzen.
2012 Scientific Article in PLoS ONE PLoS ONE 7:e47647 (2012)
Association of common genetic variants in the MAP4K4 locus with prediabetic traits in humans.
2012 Scientific Article in Diabetes Aktuell Diabetes akt. 10, 123-128 (2012)
Genetik und Epigenetik des Typ-2-Diabetes. Die verschiedenen Ebenen der Genregulation.
2012 Scientific Article in Lancet, The Lancet 380, 1674-1682 (2012)
Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: An exome sequencing study.
2012 Scientific Article in PLoS ONE PLoS ONE 7:e32670 (2012)
Circadian gene variants and susceptibility to type 2 diabetes: A pilot study.
2012 Scientific Article in International Journal of Epidemiology Int. J. Epidemiol. 41, 1376-1382 (2012)
Sex-specific differences in effect size estimates at established complex trait loci.
2012 Scientific Article in Obesity Facts Obes. Facts 5, 660-670 (2012)
Childhood obesity is associated with changes in the serum metabolite profile.
2012 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 21, 3042-3049 (2012)
A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.
2012 Scientific Article in Genes and Immunity Genes Immun. 13, 549-555 (2012)
A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes.
2012 Scientific Article in Hormone Research in Paediatrics Horm. Res. Paediatr. 77, 358-368 (2012)
Do common variants separate between obese melanocortin-4 receptor gene mutation carriers and non-carriers? The impact of cryptic relatedness.
2012 Scientific Article in Nature Genetics Nat. Genet. 44, 991-1005 (2012)
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
2012 Scientific Article in Nature Genetics Nat. Genet. 44, 981-990 (2012)
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
2012 Scientific Article in Molecular Systems Biology Mol. Syst. Biol. 8:615 (2012)
Novel biomarkers for pre-diabetes identified by metabolomics.
2012 Scientific Article in Diabetes Diabetes 61, 2176-2186 (2012)
Impact of common variation in bone-related genes on type 2 diabetes and related traits.
2012 Scientific Article in Nature Genetics Nat. Genet. 44, 659-669 (2012)
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
2012 Scientific Article in Obesity Facts Obes. Facts 5, 408-419 (2012)
Fat mass and obesity-associated gene (FTO) in eating disorders: Evidence for association of the rs9939609 obesity risk allele with bulimia nervosa and anorexia nervosa.
2012 Scientific Article in PLoS Genetics PLoS Genet. 8:e1002695 (2012)
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
2012 Scientific Article in Nature Genetics Nat. Genet. 44, 369-375 (2012)
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits.
2012 Scientific Article in Diabetologie, Die Diabetologie 8, 26-34 (2012)
Typ-2-Diabetes-assoziierte Gene.
2012 Scientific Article in PLoS Genetics PLoS Genet. 8:e1002741 (2012)
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
2012 Scientific Article in Nature Genetics Nat. Genet. 44, 483-489 (2012)
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis.
2012 Scientific Article in PLoS Genetics PLoS Genet. 8:e1002607 (2012)
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: A multi-ethnic meta-analysis of 45,891 individuals.
2012 Scientific Article in PLoS ONE PLoS ONE 7:e35410 (2012)
Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes.
2012 Scientific Article in Diabetes Diabetes 61, 524-530 (2012)
Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk.
2012 Scientific Article in PLoS ONE PLoS ONE 7:e29202 (2012)
A genome-wide association search for type 2 diabetes genes in African Americans.
2012 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 90, 410-425 (2012)
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.
2012 Scientific Article in Obesity Obesity 20, 466-470 (2012)
SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents.
2012 Scientific Article in Nature Genetics Nat. Genet. 44, 67-72 (2012)
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
2012 Scientific Article in European Heart Journal Eur. Heart J. 33, 238-251 (2012)
Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: Meta-analysis of genome-wide association studies from five community-based studies.
2011 Nature Genetics Nat. Genet. 43, 1164 (2011)
Corrigendum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
2011 Scientific Article in Nature Genetics Nat. Genet. 43, 117-120 (2011)
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.
2011 Scientific Article in Diabetologia Diabetologia 54, 1052-1056 (2011)
Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release.
2011 Scientific Article in Diabetes Diabetes 60, 685-690 (2011)
An interferon-induced helicase (IFIH1) gene polymorphism associates with different rates of progression from autoimmunity to type 1 diabetes.
2011 Scientific Article in Diabetes Diabetes 60, 2407-2416 (2011)
Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: A 14-cohort meta-analysis.
2011 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 89, 619-627 (2011)
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1.
2011 Scientific Article in Diabetologia Diabetologia 54, 2038-2046 (2011)
Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas.
2011 Scientific Article in Diabetes Diabetes 60, 345-354 (2011)
Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study.
2011 Scientific Article in Nature Genetics Nat. Genet. 43, 1131-1138 (2011)
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
2011 Scientific Article in PLoS ONE PLoS ONE 6:e15813 (2011)
Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a combined analysis of 55,521 Europeans.
2011 Scientific Article in Nature Genetics Nat. Genet. 43, 561-564 (2011)
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes.
2011 Scientific Article in Diabetes Diabetes 60, 2624-2634 (2011)
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
2011 Scientific Article in Cell Cell 147, 81-94 (2011)
The Lin28/let-7 axis regulates glucose metabolism.
2011 Scientific Article in Nature Genetics Nat. Genet. 43, 1082-1090 (2011)
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
2011 Scientific Article in PLoS Genetics PLoS Genet. 7:e1001324 (2011)
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
2011 Scientific Article in European Journal of Endocrinology Eur. J. Endocrinol. 164, 205-212 (2011)
Association of a MTNR1B gene variant with fasting glucose and HOMA-B in children and adolescents with high BMI-SDS.
2011 Scientific Article in Diabetes Diabetes 60, 1340-1348 (2011)
Updated genetic score based on 34 confirmed type 2 diabetes loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program.
2011 Scientific Article in Diabetologia Diabetologia 54, 111-119 (2011)
A role for coding functional variants in HNF4A in type 2 diabetes susceptibility.
2011 Scientific Article in Diabetes Care Diabetes Care 34, 121-125 (2011)
Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.
2011 Scientific Article in American Journal of Clinical Nutrition Am. J. Clin. Nutr. 93, 382-391 (2011)
Genetic variants in the FADS gene cluster are associated with arachidonic acid concentrations of human breast milk at 1.5 and 6 mo postpartum and influence the course of milk dodecanoic, tetracosenoic, and trans-9-octadecenoic acid concentrations over the duration of lactation.
2011 Scientific Article in Journal of Epidemiology and Community Health J. Epidemiol. Community Health 65, 174-176 (2011)
First investigation of two obesity-related loci (TMEM18, FTO) concerning their association with educational level as well as income: The MONICA/KORA study.
2010 Scientific Article in PLoS Genetics PLoS Genet. 6:e1001058 (2010)
Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits.
2010 Scientific Article in Diabetes Diabetes 59, 3229-3239 (2010)
Common variants at 10 genomic loci influence hemoglobin A₁C levels via glycemic and nonglycemic pathways.
2010 Scientific Article in PLoS Genetics PLoS Genet. 6:e1001213 (2010)
Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A.
2010 Scientific Article in Nature Genetics Nat. Genet. 42, 937-948 (2010)
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
2010 Scientific Article in Nature Genetics Nat. Genet. 42, 949-960 (2010)
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
2010 Scientific Article in International Journal of Obesity Int. J. Obes. 34, 1538-1545 (2010)
Genes and lifestyle factors in obesity: Results from 12 462 subjects from MONICA/KORA.
2010 Scientific Article in European Journal of Endocrinology Eur. J. Endocrinol. 163, 259-264 (2010)
Association of variants in gastric inhibitory polypeptide receptor gene with impaired glucose homeostasis in obese children and adolescents from Berlin.
2010 Scientific Article in Lancet, The Lancet 375, 1634-1639 (2010)
Triglyceride-mediated pathways and coronary disease: Collaborative analysis of 101 studies.
2010 Meeting abstract Obes. Facts 3, 59 (2010)
(MEMORI) - Associations between BMI and the FTO gene are age dependent: Results from the GINI and LISA Birth Cohort Studies up to age 6 years.
2010 Scientific Article in Nature Genetics Nat. Genet. 42, 579-589 (2010)
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
2010 Scientific Article in BMC Medical Genetics BMC Med. Genet. 11:2 (2010)
Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity.
2010 Scientific Article in Blood Blood 115, 4517-4523 (2010)
The JAK2 46/1 haplotype predisposes to MPL-mutated myeloproliferative neoplasms.
2010 Scientific Article in Obesity Facts Obes. Facts 3, 173-180 (2010)
Associations between BMI and the FTO gene are age dependent: Results from the GINI and LISA birth cohort studies up to age 6 years.
2010 Scientific Article in PLoS Genetics PLoS Genet. 6:e1000916 (2010)
Two new loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and German study groups.
2010 Scientific Article in BMC Medical Genetics BMC Med. Genet. 11:12 (2010)
Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).
2010 Scientific Article in Hormone and Metabolic Research Horm. Metab. Res. 42, 149-151 (2010)
Association of genetic variation in KCNQ1 with type 2 diabetes in the KORA surveys.
2010 Scientific Article in Diabetes Diabetes 59, 2063-2067 (2010)
BMI at age 8 years is influenced by the type 2 diabetes susceptibility genes HHEX-IDE and CDKAL1.
2010 Scientific Article in Nature Genetics Nat. Genet. 42, 105-116 (2010)
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
2010 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 19, 535-544 (2010)
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes.
2010 Scientific Article in Nature Genetics Nat. Genet. 42, 142-148 (2010)
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
2010 Scientific Article in Nature Genetics Nat. Genet. 42, 36-44 (2010)
Genome-wide association study identifies five loci associated with lung function.
2009 Scientific Article in Nature Nature 462, 868-874 (2009)
Parental origin of sequence variants associated with complex diseases.
2009 Scientific Article in Molecular Genetics and Metabolism Mol. Genet. Metab. 98, 400-405 (2009)
Evidence for the Thr79Met polymorphism of the ileal fatty acid binding protein (FABP6) to be associated with type 2 diabetes in obese individuals.
2009 Scientific Article in Obesity Facts Obes. Facts 2, 235-242 (2009)
Gene-gene interaction between APOA5 and USF1: Two candidate genes for the metabolic syndrome.
2009 Scientific Article in Molecular Nutrition and Food Research Mol. Nutr. Food Res. 53, 681-685 (2009)
Association between functional FABP2 promoter haplotypes and body mass index: Analyses of 8072 participants of the KORA cohort study.
2009 Scientific Article in American Journal of Epidemiology Am. J. Epidemiol. 170, 537-545 (2009)
Underlying genetic models of inheritance in established type 2 diabetes associations.
2009 Scientific Article in Diabetologia Diabetologia 52, 1881-1888 (2009)
Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk.
2009 Scientific Article in PLoS Genetics PLoS Genet. 5:e1000508 (2009)
Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution.
2009 Scientific Article in Annals of Medicine Ann. Med. 41, 128-138 (2009)
Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.
2009 Scientific Article in Genetic Testing and Molecular Biomarkers Genet. Test. Mol. Biomark. 13, 223-226 (2009)
Association analysis between the prostaglandin E synthase 2 R298H polymorphism and body mass index in 8079 participants of the KORA study cohort.
2009 Scientific Article in BMC Medical Genetics BMC Med. Genet. 10:19 (2009)
Gastric inhibitory polypeptide receptor: Association analyses for obesity of several polymorphisms in large study groups.
2009 Scientific Article in Thrombosis and Haemostasis Thromb. Haemost. 101, 317-324 (2009)
Association study between variants in the fibrinogen gene cluster, fibrinogen levels and hypertension: Results from the MONICA/KORA study.
2009 Scientific Article in BMC Medical Genetics BMC Med. Genet. 10:14 (2009)
Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry.
2008 Scientific Article in Hormone and Metabolic Research Horm. Metab. Res. 40, 722-26 (2008)
Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies.
2008 Scientific Article in Molecular Genetics and Metabolism Mol. Genet. Metab. 95, 229-232 (2008)
MTTP variants and body mass index, waist circumference and serum cholesterol level: Association analyses in 7582 participants of the KORA study cohort.
2008 Scientific Article in European Journal of Endocrinology Eur. J. Endocrinol. 159, 407-416 (2008)
Genetic variants in the USF1 gene are associated with lowdensity lipoprotein cholesterol levels and incident type 2 diabetes mellitus in women: Results from the MONICA/KORA Augsburg case-cohort study, 1984-2002.
München, Technsche Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2008, 133 S.
Genetic analysis of candidate genes for the metabolic syndrome and type 2 diabetes.
2008 Scientific Article in American Journal of Epidemiology Am. J. Epidemiol. 168, 878-889 (2008)
Estimating the Single Nucleotide Polymorphism Genotype Misclassification From Routine Double Measurements in a Large Epidemiologic Sample.
2008 Scientific Article in Nature Genetics Nat. Genet. 40, 638-645 (2008)
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
2007 Scientific Article in Molecular Nutrition and Food Research Mol. Nutr. Food Res. 51, 178-184 (2007)
Association of acyl-CoA-binding protein (ACBP) single nucleotide polymorphisms and type 2 diabetes in two German study populations.
2007 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 92, 3183-3188 (2007)
Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations.
2007 Scientific Article in PLoS ONE PLoS ONE 2:e1361 (2007)
Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants.
2007 Scientific Article in Journal of Lipid Research J. Lipid Res. 48, 2614-2621 (2007)
APOA5 variants and metabolic syndrome in Caucasians.
2007 Scientific Article in European Journal of Endocrinology Eur. J. Endocrinol. 157, R1-R5 (2007)
Genetic variants in the leukemia-associated Rho guanine nucleotide exchange factor (ARHGEF12) gene are not associated with T2DM and related parameters in Caucasians (KORA study).
2007 Scientific Article in European Journal of Endocrinology Eur. J. Endocrinol. 156, 377-385 (2007)
Gene variants of monocyte chemoattractant protein 1 and components of metabolic syndrome in KORA S4, Augsburg.
2007 Scientific Article in Hormone and Metabolic Research Horm. Metab. Res. 39, 46-52 (2007)
Variants of the transcription factor 7-like 2 gene (TCF7L2) are strongly associated with type 2 diabetes but not with the metabolic syndrome in the MONICA/KORA surveys.
2006 Scientific Article in Diabetes Diabetes 55, 2915-2921 (2006)
IL6 gene promoter polymorphisms and type 2 diabetes: Joint analysis of individual participants' data from 21 studies.
2006 Scientific Article in Experimental Gerontology Exp. Gerontol. 41, 737-745 (2006)