The resistome of the human microbiome
Within the framework of a Helmholtz AI-funded project, we investigate in collaboration with colleagues from the UFZ how the resistome - the collective set of antimicrobial resistances within the human gut microbiome - has evolved over the past century as a result of increased antibiotic use in both human and veterinary medicine, with particular focus on how dietary interventions influence the major microbial carriers of these resistances. Preliminary data suggest that a Mediterranean, fish-based diet has the most pronounced effect, leading to a higher diversity of antibiotic-resistant bacteria in the human gut compared to other dietary patterns. This finding raises questions regarding the source of these antibiotic-resistant bacteria and potential mitigation strategies.
This research is closely linked to the broader topic of AMR and its implications for ecosystem health and sustainability.
Within the framework of a Helmholtz AI-funded project, we investigate in collaboration with colleagues from the UFZ how the resistome - the collective set of antimicrobial resistances within the human gut microbiome - has evolved over the past century as a result of increased antibiotic use in both human and veterinary medicine, with particular focus on how dietary interventions influence the major microbial carriers of these resistances. Preliminary data suggest that a Mediterranean, fish-based diet has the most pronounced effect, leading to a higher diversity of antibiotic-resistant bacteria in the human gut compared to other dietary patterns. This finding raises questions regarding the source of these antibiotic-resistant bacteria and potential mitigation strategies.
This research is closely linked to the broader topic of AMR and its implications for ecosystem health and sustainability.
