PI Gerald Burgstaller

Group Leader Immunotherapeutic Technologies

"My vision is to discover and develop innovative therapeutics tackling chronic lung diseases and identify novel molecular targets as well as elucidating the mode-of-action. This only can be achieved by highly multi- and interdisciplinary work and thriving academic, clinical and industrial collaborations."

My vision is to discover and develop innovative therapeutics tackling chronic lung diseases and identify novel molecular targets as well as elucidating the mode-of-action. This only can be achieved by highly multi- and interdisciplinary work and thriving academic, clinical and industrial collaborations.

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Skills

Chronic Lung Diseases Cell Biology Extracellular MatrixDrug Discovery Human Lung Disease Models Advanced Microscopy

Professional Background

Since 2019

Principal Investigator/Research group leader at Helmholtz Munich, Institute of Lung Health and Immunity, Comprehensive Pneumology Center (CPC)

2015 - 2018

Staff Scientist at Helmholtz Munich, Head of Imaging Core Facility, Institute of Lung Biology and Disease, Comprehensive Pneumology Center (CPC)

2010 - 2014

Postdoc at Helmholtz Munich, Head of Imaging Core Facility, Institute of Lung Biology and Disease, Comprehensive Pneumology Center (CPC)

2009 - 2010

Postdoc at Helmholtz Munich, Institute of Clinical Molecular Biology and Tumor Genetics

2005 - 2008

Postdoc at Max Perutz Laboratories Vienna, Austria

2000 - 2004

Doctorial researcher at Austrian Academy of Sciences in Salzburg, Austria

Gerald Burgstaller about his personal vision for the future:

"Our big chance in academic research and drug development is that by setting up innovative drug screening assays, as demonstrated by our phenotypic ECM-deposition assay, that this process leads to “looking at some stuff you didn’t know to look at.”

Publications

2024 Scientific Article in Thorax

Stoleriu, M.-G. ; Ansari, M. ; Strunz, M. ; Schamberger, A.C. ; Heydarian, M. ; Ding, Y. ; Voss, C. ; Schneider, J.J. ; Gerckens, M. ; Burgstaller, G. ; Castelblanco, A. ; Kauke, T. ; Fertmann, J. ; Schneider, C. ; Behr, J. ; ... ; Irmler, M. ; Beckers, J. ; Eickelberg, O. ; Schubert, B. ; Hauck, S.M. ; Schmid, O. ; Stöger, T. ; Schiller, H. ; Hilgendorff, A.

COPD basal cells are primed towards secretory to multiciliated cell imbalance driving increased resilience to environmental stressors.

2024 Scientific Article in European Respiratory Journal

Mayr, C. ; Sengupta, A. ; Asgharpour, S. ; Ansari, M. ; Pestoni, J. ; Ogar, P. ; Angelidis, I. ; Liontos, A. ; Rodriguez-Castillo, J.A. ; Lang, N.J. ; Strunz, M. ; Porras-Gonzalez, D.L. ; Gerckens, M. ; De Sadeleer, L.J. ; Oehrle, B. ; Viteri-Alvarez, V. ; Fernandez, I.E. ; Tallquist, M. ; Irmler, M. ; Beckers, J. ; ... ; Wasnick, R. ; Yildirim, A.Ö. ; Theis, F.J. ; Burgstaller, G. ; Schiller, H.

Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts.

2023 Scientific Article in Science Translational Medicine

Lang, N.J. ; Schniering, J. ; Porras-Gonzalez, D.L. ; Yang, L. ; De Sadeleer, L.J. ; Jentzsch, R.C. ; Shitov, V.A. ; Zhou, S. ; Ansari, M. ; Agami, A. ; Mayr, C. ; Hooshiar Kashani, B. ; Chen, Y. ; Heumos, L. ; Pestoni, J. ; Molnar, E.S. ; Geeraerts, E. ; Anquetil, V. ; Saniere, L. ; Wögrath, M. ; Gerckens, M. ; Lehmann, M. ; Yildirim, A.Ö. ; ... ; Kneidinger, N. ; Behr, J. ; Stoleriu, M.-G. ; Luecken, M. ; Theis, F.J. ; Burgstaller, G. ; Schiller, H.

Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesis.

2023 Scientific Article in OpenNano

Jürgens, D.C. ; Deßloch, L. ; Porras-Gonzalez, D.L. ; Winkeljann, J. ; Zielinski, S. ; ... ; Burgstaller, G. ; Merkel, O.M.

Lab-scale siRNA and mRNA LNP manufacturing by various microfluidic mixing techniques – an evaluation of particle properties and efficiency.

2023 Scientific Article in Frontiers in Immunology

Kastlmeier, M.T. ; Gonzalez-Rodriguez, E. ; Cabanis , P. ; Günther, E. ; König, A.-C. ; Han, L. ; Hauck, S.M. ; See, F. ; Asgharpour, S. ; Bukas, C. ; Burgstaller, G. ; Piraud, M. ; Lehmann, M. ; Hatz, R.A. ; Behr, J. ; Stöger, T. ; Hilgendorff, A. ; Voss, C.

Cytokine signaling converging on IL11 in ILD fibroblasts provokes aberrant epithelial differentiation signatures.

2022 Scientific Article in Journal of Controlled Release

Zimmermann, C.M. ; Baldassi, D. ; Chan, K. ; Adams, N.B.P. ; ... ; Porras-Gonzalez, D.L. ; Wei, X. ; Burgstaller, G. ; Witzigmann, D. ; Luciani, P. ; Merkel, O.M.

Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery.

2022 Scientific Article in Journal of Controlled Release

Baldassi, D. ; Ambike, S. ; Feuerherd, M. ; Cheng, C.-C. ; Peeler, D.J. ; Feldmann, D.P. ; Porras-Gonzalez, D.L. ; Wei, X. ; Keller, L.A. ; Kneidinger, N. ; ... ; Burgstaller, G. ; Michler, T. ; Merkel, O.M.

Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER polyplexes.

2022 Scientific Article in Nature Communications

Günsel, G.G. ; Conlon, T.M. ; Jeridi, A. ; Kim, R. ; Ertüz, Z. ; Lang, N.J. ; Ansari, M. ; Novikova, M. ; Jiang, D. ; Strunz, M. ; Gaianova, M. ; Hollauer, C. ; Gabriel, C. ; Angelidis, I. ; Doll, S. ; Pestoni, J. ; Edelmann, S.L. ; Kohlhepp, M.S. ; Guillot, A. ; Bassler, K. ; ... ; Ballester-Lopez, C. ; Genes Robles, C.M. ; Smirnova, N.F. ; Rehberg, M. ; Agarwal, C. ; Krikki, I. ; Stöger, T. ; Burgstaller, G. ; Heissmeyer, V. ; Rinkevich, Y. ; Schiller, H. B. ; Conrad, M. ; Schneider, R. ; Yildirim, A.Ö.

Dr. rer. nat. Gerald Burgstaller

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Skills

Professional Background

Principal Investigator/Research group leader at Helmholtz Munich, Institute of Lung Health and Immunity, Comprehensive Pneumology Center (CPC)

Staff Scientist at Helmholtz Munich, Head of Imaging Core Facility, Institute of Lung Biology and Disease, Comprehensive Pneumology Center (CPC)

Postdoc at Helmholtz Munich, Head of Imaging Core Facility, Institute of Lung Biology and Disease, Comprehensive Pneumology Center (CPC)

Postdoc at Helmholtz Munich, Institute of Clinical Molecular Biology and Tumor Genetics

Postdoc at Max Perutz Laboratories Vienna, Austria

Doctorial researcher at Austrian Academy of Sciences in Salzburg, Austria

Publications

COPD basal cells are primed towards secretory to multiciliated cell imbalance driving increased resilience to environmental stressors.

Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts.

Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesis.

Lab-scale siRNA and mRNA LNP manufacturing by various microfluidic mixing techniques – an evaluation of particle properties and efficiency.

Cytokine signaling converging on IL11 in ILD fibroblasts provokes aberrant epithelial differentiation signatures.

Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery.

Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER polyplexes.

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.

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