Publications
2024 Review in Nature Neuroscience Nat. Neurosci. 27, 2292-2309 (2024)
Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery.
2024 Scientific Article in Glia Glia, DOI: 10.1002/glia.24645 (2024)
Single cell deletion of the transcription factors Trps1 and Sox9 in astrocytes reveals novel functions in the adult cerebral cortex.
2024 Scientific Article in Nature Methods Nat. Methods, 32 (2024)
Probe set selection for targeted spatial transcriptomics.
2024 Scientific Article in Nature Nature 627, 347-357 (2024)
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.
2024 Scientific Article in Nature Communications Nat. Commun. 15:10061 (2024)
Analyzing longitudinal trait trajectories using GWAS identifies genetic variants for kidney function decline.
2024 Scientific Article in Nature Nature 635, 690-698 (2024)
An integrated transcriptomic cell atlas of human neural organoids.
2024 Scientific Article in Journal of Visualized Experiments J. Vis. Exp., DOI: 10.3791/66659:211 (2024)
Application of unsupervised multi-omic factor analysis to uncover patterns of variation and molecular processes linked to cardiovascular disease.
2024 Scientific Article in Cell Research Cell Res., DOI: 10.1038/s41422-024-01045-9 (2024)
A cross-species foundation model for single cells.
2024 Scientific Article in Genome Biology Genome Biol. 25:277 (2024)
Mapping lineage-traced cells across time points with moslin.
2024 Scientific Article in Diabetes, Obesity and Metabolism Diabetes Obes. Metab., DOI: 10.1111/dom.16022 (2024)
Subphenotypes of adult-onset diabetes: Data-driven clustering in the population-based KORA cohort.
2024 Scientific Article in Clinical Epigenetics Clin. Epigenet. 16:149 (2024)
Association analysis between an epigenetic alcohol risk score and blood pressure.
2024 Scientific Article in EMBO Journal, The EMBO J., DOI: 10.1038/s44318-024-00227-w (2024)
Decoupled transcript and protein concentrations ensure histone homeostasis in different nutrients.
2024 Scientific Article in Cells Cells 13:408 (2024)
Comparing viral vectors and fate mapping approaches for astrocyte-to-neuron reprogramming in the injured mouse cerebral cortex.
2024 Scientific Article in Nature medicine Nat. Med., DOI: 10.1038/s41591-024-03214-0 (2024)
An open-source framework for end-to-end analysis of electronic health record data.
2024 Editorial in Epigenomics Epigenomics 16, 1061-1065 (2024)
Breaking the epigenetic code with MARCS: The Modification Atlas of Regulation by Chromatin States.
2024 EMBO Reports EMBO Rep., 3202–3220 (2024)
Publisher Correction: Emerging toolkits for decoding the co-occurrence of modified histones and chromatin proteins.
2024 Scientific Article in Science Advances Sci. Adv. 10:eadl4374 (2024)
Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity.
2024 Scientific Article in BMC Medicine BMC Med. 22:420 (2024)
Association of plasma proteomics with mortality in individuals with and without type 2 diabetes: Results from two population-based KORA cohort studies.
2024 Review in Nature Methods Nat. Methods 21, 1597-1602 (2024)
Small data methods in omics: The power of one.
2024 Scientific Article in Frontiers in bioengineering and biotechnology Front. Bioeng. Biotechnol. 12:1422235 (2024)
A multiparametric analysis including single-cell and subcellular feature assessment reveals differential behavior of spheroid cultures on distinct ultra-low attachment plate types.
Methods in Molecular Biology In: Chromatin Immunoprecipitation. 2024. 1-16 (Methods Mol. Biol. ; 2846)
Native ChIP: Studying the genome-wide distribution of histone modifications in cells and tissue.
Methods in Molecular Biology In: Chromatin Immunoprecipitation. 2024. 63-89 (Methods Mol. Biol. ; 2846)
Differential analysis of protein-DNA binding using ChIP-seq data.
2024 Scientific Article in Nature Communications Nat. Commun. 15:6611 (2024)
scTab: Scaling cross-tissue single-cell annotation models.
2024 Scientific Article in Nature Cell Biology Nat. Cell Biol., DOI: 10.1038/s41556-024-01512-w (2024)
Fasting shapes chromatin architecture through an mTOR/RNA Pol I axis.
2024 Scientific Article in Nature Communications Nat. Commun. 15:7611 (2024)
Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development.
2024 Review in Nature Methods Nat. Methods 21, 1430-1443 (2024)
Transformers in single-cell omics: A review and new perspectives.
2024 Scientific Article in EMBO Journal, The EMBO J., DOI: 10.1038/s44318-024-00183-5 (2024)
Real-time assessment of mitochondrial DNA heteroplasmy dynamics at the single-cell level.
2024 Review in EMBO Reports EMBO Rep. 25, 3202-3220 (2024)
Emerging toolkits for decoding the co-occurrence of modified histones and chromatin proteins.
2024 Scientific Article in Lancet, The Lancet 403, 1027-1050 (2024)
Worldwide trends in underweight and obesity from 1990 to 2022: A pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults.
2024 Scientific Article in Kidney international reports Kidney Int. Rep. 9, 1849-1859 (2024)
Prioritization of kidney cell types highlights myofibroblast cells in regulating human blood pressure.
2024 Editorial in Developmental Cell Dev. Cell 59, 1623-1627 (2024)
Understanding how cells and organisms keep time during development.
2024 Scientific Article in Eye Eye, DOI: 10.1038/s41433-024-03264-1 (2024)
Evaluation of OCT biomarker changes in treatment-naive neovascular AMD using a deep semantic segmentation algorithm.
2024 Scientific Article in Nature Computational Science Nat. Comput. Sci. 4, 367–378 (2024)
MISATO: Machine learning dataset of protein-ligand complexes for structure-based drug discovery.
2024 Scientific Article in Cell Cell 187, 4637-4655.e26 (2024)
Innate immune memory after brain injury drives inflammatory cardiac dysfunction.
2024 Nature Communications Nat. Commun. 15:6190 (2024)
Author Correction: IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling.
2024 Scientific Article in Genes Genes 15:806 (2024)
Leveraging integrated RNA sequencing to decipher adrenomedullin's protective mechanisms in experimental bronchopulmonary dysplasia.
2024 Scientific Article in Bioinformatics Bioinformatics 40, i548-i557 (2024)
GraphCompass: Spatial metrics for differential analyses of cell organization across conditions.
2024 Nature Genetics Nat. Genet. 56, 1763-1764 (2024)
Publisher Correction: Understanding the genetic complexity of puberty timing across the allele frequency spectrum.
2024 Scientific Article in Nature Nature 631, 645-653 (2024)
Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis.
2024 Scientific Article in Genome Biology Genome Biol. 25:181 (2024)
Panpipes: A pipeline for multiomic single-cell and spatial transcriptomic data analysis.
2024 Scientific Article in Nature Neuroscience Nat. Neurosci. 27, 1260–1273 (2024)
Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1.
2024 Scientific Article in Nature Genetics Nat. Genet. 56, 1397–1411 (2024)
Understanding the genetic complexity of puberty timing across the allele frequency spectrum.
2024 Scientific Article in Nature Communications Nat. Commun. 15:5577 (2024)
Multi-modal generative modeling for joint analysis of single-cell T cell receptor and gene expression data.
2024 Scientific Article in Genome Biology Genome Biol. 25:109 (2024)
hadge: A comprehensive pipeline for donor deconvolution in single-cell studies.
2024 Scientific Article in Diabetes/Metabolism Research and Reviews Diabetes Metab. Res. Rev. 40:e3834 (2024)
Association of transketolase polymorphisms with diabetic polyneuropathy in the general population: The KORA F4 study.
2024 Scientific Article in Metabolites Metabolites 14:258 (2024)
Prediction of myocardial infarction using a combined generative adversarial network model and feature-enhanced loss function.
2024 Scientific Article in Biomolecules Biomolecules 14:662 (2024)
Smoking-induced DNA hydroxymethylation signature is less pronounced than true DNA methylation: The population-based KORA Fit cohort
In: (Proceedings of Machine Learning Research). 2024. 3664-3672 ( ; 238)
Mixed models with multiple instance learning.
2024 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol., DOI: 10.1038/s41594-024-01341-3 (2024)
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase.
2024 Review in Redox Biology Redox Biol. 75:103211 (2024)
Ferroptosis in health and disease.
2024 Scientific Article in Circulation Genomic and precision medicine Circ. Genom. Precis. Med. 17:e004374 (2024)
Single-cell dissection of the immune response after acute myocardial infarction.
2024 Review in Physiological Reviews Physiol. Rev. 104, 1679-1717 (2024)
Eukaryotic cell size regulation and its implications for cellular function and dysfunction.
2024 Scientific Article in Developmental Cell Dev. Cell 59, 2347-2363.e9 (2024)
An integrated approach identifies the molecular underpinnings of murine anterior visceral endoderm migration.
2024 Scientific Article in Nature Cell Biology Nat. Cell Biol. 26, 962-974 (2024)
Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators.
2024 Scientific Article in Nature Genetics Nat. Genet. 56, 1090-1099 (2024)
Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction.
2024 Scientific Article in Cardiovascular Diabetology Cardiovasc. Diabetol. 23:199 (2024)
Bidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i.
2024 Review in Genome Medicine Genome Med. 16:80 (2024)
Machine learning integrative approaches to advance computational immunology.
2024 Scientific Article in Nature Methods Nat. Methods, DOI: 10.1038/s41592-024-02303-9 (2024)
CellRank 2: Unified fate mapping in multiview single-cell data.
2024 Scientific Article in Genome Medicine Genome Med. 16:70 (2024)
Analysis of 3760 hematologic malignancies reveals rare transcriptomic aberrations of driver genes.
2024 Scientific Article in Nature medicine Nat. Med. 30, 1696-1710 (2024)
Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes.
2024 Scientific Article in Cardiovascular Diabetology Cardiovasc. Diabetol. 23:181 (2024)
Plasma proteome association with coronary heart disease and carotid intima media thickness: Results from the KORA F4 study.
2024 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 52, 6129-6144 (2024)
asteRIa enables robust interaction modeling between chromatin modifications and epigenetic readers.
2024 Scientific Article in Nature Genetics Nat. Genet. 56, 778-791 (2024)
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.
2024 Review in Cell Cell 187, 2343-2358 (2024)
The future of rapid and automated single-cell data analysis using reference mapping.
2024 Scientific Article in Bioinformatics Bioinformatics 40:btae267 (2024)
Topological benchmarking of algorithms to infer Gene Regulatory Networks from Single-Cell RNA-seq Data.
2024 Scientific Article in Journal of Cell Biology, The J. Cell Biol. 223:e202309027 (2024)
Determinants of minor satellite RNA function in chromosome segregation in mouse embryonic stem cells.
2024 Nature Genetics Nat. Genet. 56, 1032-1033 (2024)
Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
2024 Nature Nature 628:E6 (2024)
Publisher Correction: Decoding chromatin states by proteomic profiling of nucleosome readers.
2024 Editorial in Cellular Reprogramming Cell. Reprogramm. 26, 37-42 (2024)
Reprogramming Stars #15: Colliding Cellular Reprogramming Paths- An Interview with Dr. Stefan Stricker.
2024 Scientific Article in Nature Communications Nat. Commun. 15:2960 (2024)
Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells.
2024 Scientific Article in Journal of Hepatology J. Hepatol. 81, 289-302 (2024)
Polyploidisation pleiotropically buffers ageing in hepatocytes.
2024 Review in EMBO Reports EMBO Rep. 25, 1721-1733 (2024)
Jump-starting life: balancing transposable element co-option and genome integrity in the developing mammalian embryo.
2024 Scientific Article in Science Advances Sci. Adv. 10:eadn9998 (2024)
Multiple parallel cell lineages in the developing mammalian cerebral cortex.
2024 Scientific Article in Nature Communications Nat. Commun. 15:2866 (2024)
Shared inflammatory glial cell signature after stab wound injury, revealed by spatial, temporal, and cell-type-specific profiling of the murine cerebral cortex.
2024 Scientific Article in Nature Methods Nat. Methods, DOI: 10.1038/s41592-024-02212-x (2024)
SpatialData: An open and universal data framework for spatial omics.
2024 Review in Genes and Development Genes Dev. 38, 98-114 (2024)
Pan-cellular organelles and suborganelles-from common functions to cellular diversity?
2024 Scientific Article in Bioinformatics Bioinformatics 40:btae137 (2024)
Longmixr: A tool for robust clustering of high-dimensional cross-sectional and longitudinal variables of mixed data types.
2024 Scientific Article in Nature Nature 627, 671-679 (2024)
Decoding chromatin states by proteomic profiling of nucleosome readers.
2024 Review in Current Opinion in Genetics & Development Curr. Opin. Genet. Dev. 85:102173 (2024)
The influencers' era: How the environment shapes chromatin in 3D.
2024 Scientific Article in Neuron Neuron 112, 1117-1132.e9 (2024)
Direct neuronal reprogramming of NDUFS4 patient cells identifies the unfolded protein response as a novel general reprogramming hurdle.
2024 Scientific Article in EBioMedicine EBioMedicine 101:105007 (2024)
Phenotypic and genome-wide studies on dicarbonyls: Major associations to glomerular filtration rate and gamma-glutamyltransferase activity.
2024 Scientific Article in Nature Nature 628, 130-138 (2024)
Genome-wide characterization of circulating metabolic biomarkers.
2024 Scientific Article in Biology of Sex Differences Biol. Sex Differ. 15:26 (2024)
Sex and statin-related genetic associations at the PCSK9 gene locus: Results of genome-wide association meta-analysis.
2024 Scientific Article in Clinical Epigenetics Clin. Epigenet. 16:29 (2024)
Epigenome-wide association study of dietary fatty acid intake.
2024 Scientific Article in Liver International Liver Int. 44, 838-847 (2024)
Penetrance, cancer incidence and survival in HFE haemochromatosis-A population-based cohort study.
2024 Scientific Article in Thorax Thorax 79, 524-537 (2024)
COPD basal cells are primed towards secretory to multiciliated cell imbalance driving increased resilience to environmental stressors.
2024 Scientific Article in Nature Communications Nat. Commun. 15:888 (2024)
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications.
2024 Scientific Article in Journal of Neuroinflammation J. Neuroinflamm. 21:33 (2024)
The glucocorticoid receptor as a master regulator of the Müller cell response to diabetic conditions in mice.
2024 Editorial in Molecular Cell Mol. Cell 84, 186-188 (2024)
A quick restart: RNA polymerase jumping onto post-replicative chromatin.
2024 Scientific Article in Respiratory Research Respir. Res. 25:49 (2024)
Assessment of wood smoke induced pulmonary toxicity in normal- and chronic bronchitis-like bronchial and alveolar lung mucosa models at air-liquid interface.
2024 Scientific Article in European Respiratory Journal Eur. Respir. J. 63:2301326 (2024)
Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts.
2024 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 300:105648 (2024)
Ribosome inactivation regulates translation elongation in neurons.
2024 Scientific Article in Cell Cell 187, 149-165.e23 (2024)
Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma.
2024 Scientific Article in Physiological reports Physiol. Rep. 12:e15901 (2024)
LncRNA U90926 is dispensable for the development of obesity-associated phenotypes in vivo.
2024 Scientific Article in Nature Methods Nat. Methods 21, 28–31 (2024)
Modeling fragment counts improves single-cell ATAC-seq analysis.
2024 Scientific Article in Nature Methods Nat. Methods 21, 50-59 (2024)
Deep generative modeling of transcriptional dynamics for RNA velocity analysis in single cells.
2023 Letter to the Editor in Chest Chest 164, 85-89 (2023)
Longitudinal effects of 1-year smoking cessation on human bronchial epithelial transcriptome.
2023 Editorial in Cell Systems Cell Syst. 14, 423-427 (2023)
What do you most hope spatial molecular profiling will help us understand? Part 1.
2023Poster: NeurIPS 2023 AI for Science Workshop (2023)
SpatialSSL: Whole-Brain Spatial Transcriptomics in the Mouse Brain with Self-Supervised Learning.
2023 Meeting abstract in Neuroscience Applied Neurosci. App. 2:101038 (2023)
Effects of glucocorticoid exposure on gene expression and cell fate specification in cerebral organoids.
2023 Scientific Article in Neuroscience Applied Neurosci. App. 2:101126 (2023)
GPR101 loss promotes insulin resistance and diet-induced obesity risk.
2023 Scientific Article in Atherosclerosis Atherosclerosis 386:117384 (2023)
Meta-GWAS on PCSK9 concentrations reveals associations of novel loci outside the PCSK9 locus in White populations.
2023 Scientific Article in Gastroenterology Gastroenterology 165, 946-962.e13 (2023)
HLA-DP on epithelial cells enables tissue damage by NKp44+ natural killer cells in ulcerative colitis.
2023 Scientific Article in Stroke Stroke 54, 810-818 (2023)
Genetic risk Score for intracranial aneurysms: Prediction of subarachnoid hemorrhage and role in clinical heterogeneity.
2023 Scientific Article in The Lancet Public Health Lancet Public Health 8, e453-e462 (2023)
Multiple morbidity across the lifespan in people with Down syndrome or intellectual disabilities: A population-based cohort study using electronic health records.
2023 Scientific Article in Thorax Thorax 78, 496-503 (2023)
Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease.
2023 Scientific Article in Gut (eGut) Gut 72, 2068-2080 (2023)
Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis.
2023 Nature Structural & Molecular Biology Nat. Struct. Mol. Biol., DOI: 10.1038/s41594-023-01179-1 (2023)
Publisher Correction: Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.
2023 Letter to the Editor in Nature medicine Nat. Med. 29, 3018-3019 (2023)
Injury-specific signals elicit plasticity in glial cells from patients with brain injury.
2023 Meeting abstract in European Respiratory Journal Eur. Respir. J. 62:OA2624 (2023)
Spatiotemporal analysis of inflammaging and senescence programs in lung fibrosis using time-resolved single-cell transcriptomics and multiplexed immunofluorescence.
2023 Meeting abstract in European Respiratory Journal Eur. Respir. J. 62:2 (2023)
Evolution of epithelial-mesenchymal cell circuits in the progression of pulmonary fibrosis.
2023 Meeting abstract in European Respiratory Journal Eur. Respir. J. 62:3 (2023)
A spatially resolved extracellular matrix proteome atlas of the distal human lung.
2023 Scientific Article in Nature Nature 625, 401–409 (2023)
Emergence of replication timing during early mammalian development.
2023 Scientific Article in Nature human behaviour Nat. Hum. Behav. 7, 790-801 (2023)
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.
2023 Meeting abstract in Leukemia Research Leuk. Res. 128:2 (2023)
Multiomic analysis of chip bone marrow hematopoietic stem/progenitor cells reveals potential early stage of malignancy.
2023 Meeting abstract in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 64:4 (2023)
Single cell atlas of the human retina.
2023 Meeting abstract in Multiple Sclerosis Journal Mult. Scler. J. 29, 1097-1098 (2023)
A genetic association study identifying cis protein quantitative trait loci in patients with MS.
2023 Meeting abstract in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 64:332 (2023)
Predicting OCT-morphological anti-VEGF treatment response in patients with neovascular age-related degeneration using artificial intelligence.
2023 Meeting abstract in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 64:330 (2023)
New OCT based definition of treatment response to anti-VEGF in treatment naive neovascular AMD patients using an Deep Learning Algorithm.
2023 Scientific Article in Aging Aging 15, 14509-14552 (2023)
Mapping of the gene network that regulates glycan clock of ageing.
2023 Scientific Article in Science Translational Medicine Sci. Transl. Med. 15, 19:eadh0908 (2023)
Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesis.
2023 Scientific Article in Klinische Monatsblätter für Augenheilkunde Klin. Monatsbl. Augenheilkd., DOI: 10.1055/a-2227-3742 (2023)
Deep Learning based retinal layer segmentation in optical coherence tomography scans of patients with inherited retinal diseases.
2023 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 109, 1318-1327 (2023)
Skeletal muscle gene expression signatures of obese high- and low- responders to endurance exercise training.
2023 Scientific Article in Nature Nature 615, 874-883 (2023)
Diminishing benefits of urban living for children and adolescents’ growth and development.
2023 Scientific Article in Nature medicine Nat. Med. 29, 3149–3161 (2023)
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain.
2023 Scientific Article in Science Advances Sci. Adv. 9:eadj3793 (2023)
Early life adversity shapes social subordination and cell type-specific transcriptomic patterning in the ventral hippocampus.
2023 Scientific Article in Nature Communications Nat. Commun. 14:7888 (2023)
Explainable machine learning for profiling the immunological synapse and functional characterization of therapeutic antibodies.
2023 Editorial in Nature machine intelligence Nat. Mach. Intell. 5, 1176-1178 (2023)
Reporting electricity consumption is essential for sustainable AI.
2023 Scientific Article in Nature Cell Biology Nat. Cell Biol. 12, 1873-1883 (2023)
Joint epigenome profiling reveals cell-type-specific gene regulatory programmes in human cortical organoids.
2023 Scientific Article in Nature Communications Nat. Commun. 14:7674 (2023)
A reversible state of hypometabolism in a human cellular model of sporadic Parkinson's disease.
2023 Scientific Article in BioSpektrum BioSpektrum 29, 378-380 (2023)
Zugängliche KI-Algorithmen für bessere Zellmikroskopie.
2023 Other: Opinion in Molecular Cell Mol. Cell 83, 3946-3947 (2023)
Too big not to fail: Different paths lead to senescence of enlarged cells.
2023 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 51, 12303-12324 (2023)
Single molecule MATAC-seq reveals key determinants of DNA replication origin efficiency.
2023 Scientific Article in Genes and Development Genes Dev. 37, 901-912 (2023)
Reorganization of lamina-associated domains in early mouse embryos is regulated by RNA polymerase II activity.
2023 Scientific Article in Journal of Visualized Experiments J. Vis. Exp. 2023:16 (2023)
Single-copy gene locus chromatin purification in Saccharomyces cerevisiae.
2023 Scientific Article in American Journal of Physiology - Cell Physiology Am. J. Physiol.-Cell Physiol. 325, C1131-C1143 (2023)
Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes.
2023 Scientific Article in ACS Nano ACS Nano 17, 21056-21072 (2023)
Nanoparticle-exposure-triggered virus reactivation induces lung emphysema in mice.
2023 Scientific Article in Diabetes Diabetes 72, 1870-1880 (2023)
A faecal metabolite signature of impaired fasting glucose: Results from twoindependent population-based cohorts.
2023 Scientific Article in Cardiovascular Research Cardiovasc. Res. 119, 2743-2754 (2023)
Predictive metabolites for incident myocardial infarction: A two-step meta-analysis of individual patient data from six cohorts comprising 7,897 individuals from the the COnsortium of METabolomic Studies.
2023 Scientific Article in Clinical Epigenetics Clin. Epigenet. 15:166 (2023)
Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome.
2023 Scientific Article in Frontiers in Genetics Front. Genet. 14:1235337 (2023)
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.
2023 Scientific Article in Genome Biology Genome Biol. 24:234 (2023)
Single-cell metabolic profiling reveals subgroups of primary human hepatocytes with heterogeneous responses to drug challenge.
2023 Scientific Article in Hemasphere Hemasphere 7:e958 (2023)
CSF3R T618I collaborates With RUNX1-RUNX1T1 to expand hematopoietic progenitors and sensitizes to GLI inhibition.
2023 Scientific Article in Nature Communications Nat. Commun. 14:7206 (2023)
Speos: An ensemble graph representation learning framework to predict core gene candidates for complex diseases.
2023 Review in Genes and Development Genes Dev. 37, 779-780 (2023)
Folding makes an imprint.
2023 Scientific Article in Nature Methods Nat. Methods 20, 1683-1692 (2023)
Population-level integration of single-cell datasets enables multi-scale analysis across samples.
2023 Scientific Article in Nature Communications Nat. Commun. 14:6840 (2023)
Reconstructing disease dynamics for mechanistic insights and clinical benefit.
2023 Scientific Article in iScience iScience 26:108205 (2023)
Human pluripotent stem cell fate trajectories toward lung and hepatocyte progenitors.
Lecture Notes in Computer Science In: (26th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI), Vancouver, CANADA, 8-12 October 2023). Gewerbestrasse 11, Cham, Ch-6330, Switzerland: Springer International Publishing Ag, 2023. 514-524 (Lect. Notes Comput. Sc. ; 14227 LNCS)
B-Cos Aligned Transformers Learn Human-Interpretable Features.
2023 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 30, 1628-1639 (2023)
Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.
2023 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 30, 1549-1560 (2023)
Regulation with cell size ensures mitochondrial DNA homeostasis during cell growth.
2023 Scientific Article in Nature Methods Nat. Methods 20, 1037-1047 (2023)
Multiplex-GAM: genome-wide identification of chromatin contacts yields insights overlooked by Hi-C.
Methods in Cell Biology In:. 525 B Street, Suite 1900, San Diego, Ca 92101-4495 Usa: Elsevier Academic Press Inc, 2023. 199-219 (Methods Cell Biol. ; 182)
An automated image analysis pipeline to quantify the coordination and overlap of transcription and replication activity in mammalian genomes.
2023 Review in AoB Plants AoB Plants 15:plad032 (2023)
Plant environmental memory: Implications, mechanisms and opportunities for plant scientists and beyond.
2023 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 32, 2717-2734 (2023)
Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria.
2023 Scientific Article in Annals of the American Thoracic Society Ann. Am. Thorac. Soc. 20, 1124-1135 (2023)
Systemic markers of lung function and forced expiratory volume in 1 second decline across diverse cohorts.
2023 Nature Immunology Nat. Immunol. 24:1960 (2023)
Author Correction: Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets (Nature Immunology, (2023), 24, 9, (1540-1551), 10.1038/s41590-023-01588-w).
2023 Scientific Article in Nature Genetics Nat. Genet. 55, 1448-1461 (2023)
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.
2023 Nature Genetics Nat. Genet. 55, 1778-1779 (2023)
Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk (Nature Genetics, (2023), 55, 3, (410-422), 10.1038/s41588-023-01314-0).
2023 Scientific Article in Nature Communications Nat. Commun. 14:5846 (2023)
epiAneufinder identifies copy number alterations from single-cell ATAC-seq data.
2023 Microbiome Microbiome 11:206 (2023)
Correction: Darier’s disease exhibits a unique cutaneous microbial dysbiosis associated with inflammation and body malodour (Microbiome, (2023), 11, 1, (162), 10.1186/s40168-023-01587-x).
2023 Scientific Article in Nature Communications Nat. Commun. 14:5391 (2023)
The Oncology Biomarker Discovery framework reveals cetuximab and bevacizumab response patterns in metastatic colorectal cancer.
2023 Scientific Article in Frontiers in Plant Science Front. Plant Sci. 14:1124899 (2023)
Arabidopsis histone deacetylase HD2A and HD2B regulate seed dormancy by repressing DELAY OF GERMINATION 1.
2023 Scientific Article in Genes Genes 14:27 (2023)
Histone deacetylases HD2A and HD2B undergo feedback regulation by ABA and modulate drought tolerance via mediating ABA-induced transcriptional repression.
2023 Scientific Article in Nature metabolism Nat. Metab. 5, 1615-1637 (2023)
Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas.
2023 Scientific Article in Briefings in Bioinformatics Brief. Bioinform. 24:13 (2023)
Multi-omics regulatory network inference in the presence of missing data.
2023 Scientific Article in Stem Cell Reports Stem Cell Rep. 18, 1972-1986 (2023)
Single-cell characterization of neovascularization using hiPSC-derived endothelial cells in a 3D microenvironment.
2023 Editorial in Molecular Systems Biology Mol. Syst. Biol. 19:e11799 (2023)
Single-cell biology: What does the future hold?
2023 Scientific Article in Life Science Alliance Life Sci. All. 6:19 (2023)
A SAM-key domain required for enzymatic activity of the Fun30 nucleosome remodeler.
2023 Scientific Article in Genes and Development Genes Dev. 37, 336-350 (2023)
A change in biophysical properties accompanies heterochromatin formation in mouse embryos.
2023 Scientific Article in Molecular Metabolism Mol. Metab. 74:101748 (2023)
Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis.
2023 Editorial in Nucleic Acids Research Nucleic Acids Res. 51, 7709-7713 (2023)
Editorial: Colyn Crane-Robinson (1935-2023).
2023 Scientific Article in Development / Company of Biologists Development 150:12 (2023)
CIARA: A cluster-independent algorithm for identifying markers of rare cell types from single-cell sequencing data.
2023 Scientific Article in Physical Review E Phys. Rev. E 107:044403 (2023)
Emergent statistical laws in single-cell transcriptomic data.
2023 Editorial in Nature Reviews - Molecular Cell Biology Nat. Rev. Mol. Cell Biol. 24, 691-694 (2023)
Heterochromatin definition and function.
2023 Other: Opinion in Genes and Development Genes Dev. 37, 56-57 (2023)
Totipotency, development, and chromatin.
2023 Review in Developmental Cell Dev. Cell 58, 435-449 (2023)
Dynamics of nuclear architecture during early embryonic development and lessons from liveimaging.
2023 Scientific Article in Cell Reports Cell Rep. 42:112380 (2023)
Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures.
2023 Scientific Article in EMBO Reports EMBO Rep. 24:e56194 (2023)
Hyperosmotic stress induces 2-cell-like cells through ROS and ATR signaling.
2023 Review in Current Opinion in Genetics & Development Curr. Opin. Genet. Dev. 81:102083 (2023)
Regulation of mammalian totipotency: A molecular perspective from in vivo and in vitro studies.
2023 Scientific Article in Blood Blood 142, 90-105 (2023)
A noncanonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML.
2023 Review in Nucleus Nucleus 14:2229642 (2023)
Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes.
2023 Scientific Article in Molecular Metabolism Mol. Metab. 75:101774 (2023)
Differences in DNA methylation of HAMP in blood cells predicts the development of type 2 diabetes.
2023 Scientific Article in Scientific Reports Sci. Rep. 13:4805 (2023)
A polygenic and family risk score are both independently associated with risk of type 2 diabetes in a population-based study.
2023 Scientific Article in Nature Genetics Nat. Genet. 55, 410-422 (2023)
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.
2023 Scientific Article in Nature Aging Nature Aging 3, 450-458 (2023)
Development and validation of DNA methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes.
2023 Scientific Article in Nature Genetics Nat. Genet. 55, 973-983 (2023)
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake.
2023 Scientific Article in BMC Genomic Data BMC Genom Data 24:28 (2023)
Polygenic scores for estimated glomerular filtration rate in a population of general adults and elderly - comparative results from the KORA and AugUR study.
2023 Scientific Article in Movement Disorders Mov. Disord. 38, 1410-1418 (2023)
Epigenetic association analyses and risk prediction of RLS.
2023 Scientific Article in Nature Immunology Nat. Immunol. 24, 1540-1551 (2023)
Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.
2023 Scientific Article in Molecular Psychiatry Mol. Psychiatry 28, 3874-3887 (2023)
Circulating metabolites modulated by diet are associated with depression.
2023 Scientific Article in eLife eLife 12:29 (2023)
Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals.
2023 Scientific Article in Genome Biology Genome Biol. 24:80 (2023)
Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data.
2023 Scientific Article in Journal of Translational Medicine J. Transl. Med. 21:566 (2023)
An arrhythmogenic metabolite in atrial fibrillation.
2023 Scientific Article in Microbiome Microbiome 11:162 (2023)
Darier's disease exhibits a unique cutaneous microbial dysbiosis associated with inflammation and body malodour.
2023 Scientific Article in Antioxidants Antioxidants 12:16 (2023)
L-aminoguanidine induces imbalance of ROS/RNS homeostasis and polyamine catabolism of tomato roots after short-term salt exposure.
2023 Scientific Article in PLOS Digit Health PLOS Digit Health 2:e0000187 (2023)
Explainable AI identifies diagnostic cells of genetic AML subtypes.
2023 Scientific Article in iScience iScience 26:107328 (2023)
Progressive disruption of hematopoietic architecture from clonal hematopoiesis to MDS.
2023 Review in Nature Biotechnology Nat. Biotechnol. 41, 604-606 (2023)
The scverse project provides a computational ecosystem for single-cell omics data analysis.
2023 Scientific Article in Nature Biotechnology Nat. Biotechnol. 41, 1787-1800 (2023)
Epicardioid single-cell genomics uncovers principles of human epicardium biology in heart development and disease.
2023 Scientific Article in Nature Reviews - Genetics Nat. Rev. Genet. 24, 550-572 (2023)
Best practices for single-cell analysis across modalities.
2023 Review in Nature Cancer Nat. Cancer 4, 454-467 (2023)
Single-cell profiling to explore pancreatic cancer heterogeneity, plasticity and response to therapy.
2023 Scientific Article in Science Advances Sci. Adv. 9:eadd8564 (2023)
Synthetic enforcement of STING signaling in cancer cells appropriates the immune microenvironment for checkpoint inhibitor therapy.
2023 Scientific Article in Journal of Investigative Dermatology, The J. Invest. Dermatol. 143, 1461-1469.e5 (2023)
Gene expression-based molecular test as diagnostic aid for the differential diagnosis of psoriasis and eczema in formalin-fixed and paraffin-embedded tissue, microbiopsies, and tape strips.
2023 Scientific Article in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 152, 408-419 (2023)
The neglected twin: Nummular eczema is a variant of atopic dermatitis with codominant TH2/TH17 immune response.
2023 Scientific Article in Nature medicine Nat. Med. 29, 1563-1577 (2023)
An integrated cell atlas of the lung in health and disease.
2023 Scientific Article in Nature Methods Nat. Methods 20, 1058-1069 (2023)
Learning consistent subcellular landmarks to quantify changes in multiplexed protein maps.
2023 Scientific Article in Cell Reports Cell Rep. 42:112525 (2023)
Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease.
2023 Scientific Article in Molecular Systems Biology Mol. Syst. Biol. 19:e11503 (2023)
Robust dimethyl-based multiplex-DIA doubles single-cell proteome depth via a reference channel.
2023 Scientific Article in Cell Cell 186, 3706-3725.e29 (2023)
Distinct molecular profiles of skull bone marrow in health and neurological disorders.
2023 Scientific Article in NAR: Genomics and Bioinformatics NAR Gen. Bioinfo. 5:lqad070 (2023)
Single-cell reference mapping to construct and extend cell-type hierarchies.
2023 Scientific Article in Cell Death & Disease Cell Death Dis. 14:414 (2023)
Tolerance of repeated toxic injuries of murine livers is associated with steatosis and inflammation.
2023 Scientific Article in Histochemistry and Cell Biology Histochem. Cell Biol. 160, 223-251 (2023)
OME-Zarr: A cloud-optimized bioimaging file format with international community support.
2023 Scientific Article in Molecular Systems Biology Mol. Syst. Biol. 19:e11517 (2023)
Predicting cellular responses to complex perturbations in high-throughput screens.
2023 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 51, 4252-4265 (2023)
Linker histone H1 modulates defense priming and immunity in plants.
2023 Scientific Article in Metabolites Metabolites 13:227 (2023)
Metabolic signatures elucidate the effect of body mass index on type 2 diabetes.
2023 Scientific Article in Plants Plants 12:17 (2023)
ROP2 GTPase participates in nitric oxide (NO)-induced root shortening in arabidopsis.
2023 Scientific Article in Computational and Structural Biotechnology Journal Comp. Struc. Biotech. J. 21, 1697-1710 (2023)
Machine learning reveals STAT motifs as predictors for GR-mediated gene repression.
2023 Scientific Article in Neuron Neuron 111, 1241-1263.e16 (2023)
Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain.
2023 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 51, 1608-1624 (2023)
Predictive model of transcriptional elongation control identifies trans regulatory factors from chromatin signatures.
2023 Scientific Article in International Journal of Obesity Int. J. Obes. 47, 313-324 (2023)
Acute and long-term exercise adaptation of adipose tissue and skeletal muscle in humans: A matched transcriptomics approach after 8-week training-intervention.
2023 Scientific Article in Nature Cell Biology Nat. Cell Biol. 25, 337-350 (2023)
Biologically informed deep learning to query gene programs in single-cell atlases.
2023 Scientific Article in Cell Reports Cell Rep. 42:112045 (2023)
Single-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control.
2023 Scientific Article in Thyroid Thyroid 33, 301-311 (2023)
Epigenome-wide association study reveals CpG sites associated with thyroid function and regulatory effects on KLF9.
2023 Scientific Article in Bioinformatics Bioinformatics 39:9 (2023)
DeepSom: A CNN-based approach to somatic variant calling in WGS samples without a matched normal.
2023 Scientific Article in JCI insight JCI insight 8:e155968 (2023)
A20 and the non-canonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogeny.
2023 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 32, 907–916 (2023)
Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.
2023 Scientific Article in Nature Biotechnology Nat. Biotechnol. 41, 140–149 (2023)