Marion Jasnin Lab
The Cryoskeleton LabMarion’s team explores the diversity of actin structures involved in cell invasion and contractility using cryo-electron tomography. Her group aims to elucidate the structural principles governing actin functions across scales, and to provide an integrated view of the mechanisms of force generation by actin networks in cells.
Marion’s team explores the diversity of actin structures involved in cell invasion and contractility using cryo-electron tomography. Her group aims to elucidate the structural principles governing actin functions across scales, and to provide an integrated view of the mechanisms of force generation by actin networks in cells.
Helmholtz Munich | ©Marion JasninAbout our research
Our group uses in situ cryo-electron tomography methodologies, including correlative cryo-focused ion beam milling sample preparation and image processing to reveal actin architectures directly inside the native cellular environment. We explore the diversity of actin structures involved in invasion, including podosomes (Jasnin et al. Nat Commun 2022), invadopodia, and other actin-propelled membrane protrusions, as well as in cell contractility (Burbaum, Schneider et al. Nat Commun 2021). We develop computational tools for in-cell structural analysis of actin organization. For all these exciting projects, we collaborate with international teams of biologists, biophysicists and biochemists to combine structural, molecular, cellular and theoretical approaches.
To understand how actin, a small globular protein, and its associated cytoskeletal proteins can build a spectacular variety of complex filamentous structures inside cells, in order to advance our understanding of cell biology and disease mechanisms.
To understand how actin, a small globular protein, and its associated cytoskeletal proteins can build a spectacular variety of complex filamentous structures inside cells, in order to advance our understanding of cell biology and disease mechanisms.
ANR-DFG NLE 2024 - Individual Research Grant (ACTIS)
CZI Cryo-CLEM labels grant - CryoEMcapsulins
ANR-DFG NLE 2024 - Individual Research Grant (ACTIS)
CZI Cryo-CLEM labels grant - CryoEMcapsulins
- Immune synapse - In collaboration with Loïc Dupré / INFINITy and Alphée Michelot / IBDM
- Macrophage podosomes – In collaboration with Renaud Poincloux / IPBS and Mira Krendel / SUNY Upstate Medical University
- Multiscale modeling of invadosome force sensing – In collaboration with Matthieu Chavent and Renaud Poincloux / IPBS, Serge Dmitrieff and Antoine Jégou / Institut Jacques Monod, and Jean-Philip Piquemal / Sorbonne University
- Tumor cell invadopodia – In collaboration with Philippe Chavrier / Institut Curie
- Deep learning-based segmentation tools – In collaboration with Tingying Peng / Helmholtz AI
- Synthetic cell division – In collaboration with Petra Schwille / Max Planck Institute of Biochemistry
- Immune synapse - In collaboration with Loïc Dupré / INFINITy and Alphée Michelot / IBDM
- Macrophage podosomes – In collaboration with Renaud Poincloux / IPBS and Mira Krendel / SUNY Upstate Medical University
- Multiscale modeling of invadosome force sensing – In collaboration with Matthieu Chavent and Renaud Poincloux / IPBS, Serge Dmitrieff and Antoine Jégou / Institut Jacques Monod, and Jean-Philip Piquemal / Sorbonne University
- Tumor cell invadopodia – In collaboration with Philippe Chavrier / Institut Curie
- Deep learning-based segmentation tools – In collaboration with Tingying Peng / Helmholtz AI
- Synthetic cell division – In collaboration with Petra Schwille / Max Planck Institute of Biochemistry
Publications
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