MA-Foto Anne Hoffmann_neu 2025

Dr. Anne Hoffmann

Dr. Anne Hoffmann

Team leader and scientist at the Helmholtz-Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of Helmholtz Munich at the Leipzig University and the University of Leipzig Medical Center AöR, Germany

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Academic Career

Anne Hoffmann began her academic journey with a Bachelor’s and Master’s degree in Bioinformatics at Martin Luther University Halle-Wittenberg. During her studies, she worked as a student research assistant on projects in molecular genetics, next-generation sequencing data anylsis, and clinical data management. For her Master’s degree, she received the Ferchau Engineering Advancement Award (2016) in recognition of outstanding academic achievement.

She completed her PhD at the University of Leipzig under the supervision of Prof. Peter Stadler, focusing on the development of novel RNA-seq methodologies for short RNAs and transcriptome-wide RNA modification profiling. Her doctoral thesis, “The Marvelous World of tRNAs: From Accurate Mapping to Chemical Modifications,” received the highest academic distinction (summa cum laude).

Research Areas and Expertise

Anne is leading the bioinformatics core, providing bioinformatic support and services to all institute members to ensure successful research execution in clinical obesity research. Her own research project focuses on revealing obesity heterogeneity through machine learning-based patient clustering. By identifying specific risk factors and metabolic traits associated with different obesity subgroups, this project aims to enhance personalized management strategies and improve long-term adherence to treatment plans for individuals affected by obesity.

 

Keys:

Machine Learning, Mulit Omics, Single Cell Transcriptomcis, Database Management, Clinical Obesity Research

Important Career Steps

since 2023

Team Leader and Scientist

at Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of Helmholtz Munich at the Leipzig University and the University of Leipzig Medical Center AöR, Germany

Head of the institute: Prof. Matthias Blüher

2020 - 2023

Postdoctoral Fellow

at Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of Helmholtz Munich at the Leipzig University and the University of Leipzig Medical Center AöR, Germany

Head of the institute: Prof. Matthias Blüher

2019 - 2020

Postdoctoral Fellow

at the University of Leipzig, Medical Research Center

Head of project: Prof. Dr. Matthias Blüher

Honors and Awards

  • 2016 - Ferchau Engineering Advancement Award and Award for outstanding study achievements

Selected Publications

2025 Cell Metab. 2025 Mar 4;37(3):566-569.

Zhong J, Zareifi D, Weinbrenner S, Hansen M, Klingelhuber F, Nono Nankam PA, Frendo-Cumbo S, Bhalla N, Cordeddu L, de Castro Barbosa T, Arner P, Dahlman I, Muniandy M, Heinonen S, Pietiläinen KH, Hoffmann A, Ghosh A, John D, Tönjes A, Ståhl PL, Böttcher Y, Keller M, Kovacs P, Kerr AG, Langin D, Wolfrum C, Blüher M, Krahmer N, Massier L, Mejhert N, Rydén M

adiposetissue.org: A Knowledge Portal Integrating Clinical and Experimental Data from Human Adipose Tissue.
2025 Cell Metab. 2025 Mar 4;37(3):640-655.e4.

Reinisch I, Ghosh A, Noé F, Sun W, Dong H, Leary P, Dietrich A, Hoffmann A, Blüher M, Wolfrum C

Unveiling Adipose Populations Linked to Metabolic Health in Obesity.
2023 Metabolism. 2023 Aug:145:155594.

Hoffmann A, Meir A Y, Hagemann T, Czechowski P, Müller L, Engelmann B, Haange S B, Rolle-Kampczyk U, Tsaban G, Zelicha H, Rinott E, Kaplan A, Shelef I, Stumvoll M, Blüher M, Liang L, Ceglarek U, Isermann B, von Bergen M, Kovacs P, Keller M, Shai I

A Polyphenol-Rich Green Mediterranean Diet Enhances Epigenetic Regulatory Potential: The DIRECT PLUS Randomized Controlled Trial.
2023 Biomedicines. 2023 Oct 17;11(10):2806.

Hagemann T, Czechowski P, Ghosh A, Sun W, Dong H, Noé F, Wolfrum C, Blüher M, Hoffmann A

Laminin α4 Expression in Human Adipose Tissue Depots and Its Association with Obesity and Obesity Related Traits.
2022 Clin Transl Med. 2022 Jun;12(6):e851.

Klemp I, Hoffmann A, Müller L, Hagemann T, Horn K, Rohde-Zimmermann K, Tönjes A, Thiery J, Löffler M, Burkhardt R, Böttcher Y, Stumvoll M, Blüher M, Krohn K, Scholz M, Baber R, Franks PW, Kovacs P, Keller M

DNA Methylation Patterns Reflect Individual's Lifestyle Independent of Obesity.