What is the aim of the study?

Iodinated contrast-induced acute kidney injury is a serious complication after coronary and peripheral vascular interventions characterized by deterioration of renal function. As an alternative for peripheral interventions, the gas carbon dioxide (CO2) can be used as an excellent negative contrast agent.  As part of a retrospective cohort study, we want to investigate the safety and efficacy of CO2 angiography in all patients who have undergone peripheral vascular surgery and in whom CO2 angiography was performed either with an automatic CO2 injector or by manual injection. The aim is to find out how many patients experience a deterioration in renal function despite maximum contrast medium savings.

Who can be participants in the study?

           Men and women aged 18 years and older who

• have symptomatic peripheral arterial occlusive disease of clinical Rutherford category 2-6 and
• have undergone an interventional peripheral vascular procedure on the leg arteries using CO2 angiography

What happens in the study?

Retrospective cohort analysis of all patients after CO2 angiography. The primary endpoint is the incidence of acute kidney injury after the procedure. Other parameters recorded include the volume of iodinated contrast medium administered, the duration of fluoroscopy, radiation exposure and adverse events such as nausea, vomiting and acute pain in the extremities.