YIG Adipose Tissue Microarchitecture and Metabolism

White adipose tissue plays a pivotal role in energy storage, metabolic regulation, and endocrine signaling. In obesity, white adipose tissue undergoes significant alterations in its cellular composition, which contributes to the development of various pathophysiological conditions, including chronic inflammation, impaired angiogenesis, and insulin resistance.

Understanding the specific cellular components and their interactions within white adipose tissue is crucial for elucidating the mechanisms underlying these dysfunctions. The overall aim of our group is to better define the cellular composition of human white adipose tissue at high resolution and to validate the presence of previously uncharacterized cell types, as well as to study their relevance and functions through both in vitro and in vivo approaches. This will help us to comprehend their contributions to the pathophysiology of white adipose tissue in conditions such as inflammation, reduced angiogenesis, and insulin resistance.

White adipose tissue plays a pivotal role in energy storage, metabolic regulation, and endocrine signaling. In obesity, white adipose tissue undergoes significant alterations in its cellular composition, which contributes to the development of various pathophysiological conditions, including chronic inflammation, impaired angiogenesis, and insulin resistance.

Understanding the specific cellular components and their interactions within white adipose tissue is crucial for elucidating the mechanisms underlying these dysfunctions. The overall aim of our group is to better define the cellular composition of human white adipose tissue at high resolution and to validate the presence of previously uncharacterized cell types, as well as to study their relevance and functions through both in vitro and in vivo approaches. This will help us to comprehend their contributions to the pathophysiology of white adipose tissue in conditions such as inflammation, reduced angiogenesis, and insulin resistance.

We developed and actively maintain the Adipose Tissue Knowledge Portal, an open web-based resource for researchers and clinicians interested in human adipose tissue biology and metabolic disease.

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Long non-coding RNAs (lncRNAs) constitute a large and still poorly understood fraction of the human transcriptome. This research line aims to define the landscape and biological relevance of lncRNAs in metabolically active organs.

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DNA patterns, DNA sequencing gel, genomics, science and genetic analysis, data, DNA testing. 3D illustration

White adipose tissue harbours a highly diverse population of adipose stromal and progenitor cells (ASPCs). This project aims to systematically dissect ASPC heterogeneity and function by combining spatially resolved human tissue data with advanced experimental models.

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Matrigel-based tube formation of HUVECs with ASPC-conditioned media

MA-Foto Lucas Massier 01.2025 - freigestellt

Dr. Lucas Massier

Group Leader "Adipose Tissue Microarchitecture and Metabolism"

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Maxi Albert

PhD Candidate, Massier Lab

Claudia Ruffert

Technician, Massier Lab

Jalkanen J, Zhong J, Nono Nankam PA, Bhalla N, Elmastas M, Luo J, Weinbrenner S, Frendo-Cumbo S, Pesti B, Gourash W, Courcoulas A, Yang Loureiro Z, Dietrich A, Bäckdahl J, Thorell A, Buggert M, Kalucka J, Emont MP, Rosen ED, Blüher M, Kovacs P, Ståhl PL, Massier L, Rydén M, Mejhert N

Cytoarchitectural multi-depot profiling reveals immune-metabolic crosstalk in human colon-associated adipose tissue

Zhong J, Zareifi D, Weinbrenner S, Hansen M, Klingelhuber F, Nono Nankam PA, Frendo-Cumbo S, Bhalla N, Cordeddu L, de Castro Barbosa T, Arner P, Dahlman I, Muniandy M, Heinonen S, Pietiläinen KH, Hoffmann A, Ghosh A, John D, Tönjes A, Ståhl PL, Böttcher Y, Keller M, Kovacs P, Kerr AG, Langin D, Wolfrum C, Blüher M, Krahmer N, Massier L, Mejhert N, Rydén M

adiposetissue.org: A knowledge portal integrating clinical and experimental data from human adipose tissue

Loft A, Emont MP, Weinstock A, Divoux A, Ghosh A, Wagner A, Hertzel AV, Maniyadath B, Deplancke B, Liu B, Scheele C, Lumeng C, Ding C, Ma C, Wolfrum C, Strieder-Barboza C, Li C, Truong DD, Bernlohr DA, Stener-Victorin E, Kershaw EE, Yeger-Lotem E, Shamsi F, Hui HX, Camara H, Zhong J, Kalucka J, Ludwig JA, Semon JA, Jalkanen J, Whytock KL, Dumont KD, Sparks LM, Muir LA, Fang L, Massier L, Saraiva LR, Beyer MD, Jeschke MG, Mori MA, Boroni M, Walsh MJ, Patti ME, Lynes MD, Blüher M, Rydén M, Hamda N, Solimini NL, Mejhert N, Gao P, Gupta RK, Murphy R, Pirouzpanah S, Corvera S, Tang S, Das SK, Schmidt SF, Zhang T, Nelson TM, O'Sullivan TE, Efthymiou V, Wang W, Tong Y, Tseng YH, Mandrup S, Rosen ED

Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution

Massier L, Andersson DP, Viguerie N, Zhong J, Zareifi D, Kerr AG, Langin D, Arner P

The nature of sex differences in catecholamine-induced lipolysis in subcutaneous fat cells

Adipose Tissue Microarchitecture and Metabolism / Massier-Lab

Projects

The Adipose Tissue Knowledge Portal

Understanding the Role of lncRNAs in Metabolic Disease

Resolving the Heterogeneity of Adipose Stromal and Progenitor Cells (ASPCs)

Lab Members

Selected Publications