Helmholtz Munich

Today we differentiate between two basic forms of asthma, allergic and non-allergic asthma. In allergic asthma, an excessive reaction of the immune system leads to chronic allergic inflammation of the respiratory tract. Patients often suffer from other allergic symptoms, such as allergic rhinitis or conjunctivitis (inflammation of the conjunctiva of the eye). In some cases, the symptoms occur only at certain times of the year, e.g. in the case of an allergy to pollen. House dust mite allergy sufferers often have symptoms all year round. Many patients also suffer from non-allergic asthma which is related to non-allergic airway inflammation. It seems however likely that many more subtypes of asthma exist and which differ between children and adults. Yet, reasons for this heterogeneity are not understood.

In Munich the ALLIANCE study visits are carried out in the Christiane Herzog Outpatient Clinic of the Dr. von Hauner Children's Hospital of the Ludwig-Maximilian University Munich. The ALLIANCE team measures children's lung function, takes blood samples, performs sweat tests and nasal swabs, and measures exhaled air using an electronic nose, the "e-nose". After a first comprehensive basic examination, the patients come again for a further visit every 12 months. Healthy children are also enrolled as a comparison group.

The aim of the ALLIANCE study is to be able to offer asthma patients more individualized treatment in the future. The researchers are focusing on finding biomarkers (measurable indicators) that make the respective subtypes of asthma definable. Pediatricians and physicians should be able to clearly diagnose these subtypes: What prognosis does this child have – a good one or a progressive course of the disease? To which subtype does it belong? In contrast to the current state of diagnosis and therapy, the physicians want to treat children with asthma more specifically, earlier and more individually.

Dr. rer. med. Sabina Illi

Statistician, Deputy Director

Dr. Jimmy Omony

Biostatistician

Dr. med. Nicole Maison

Physician Scientist

DZL Standort ARCN, Airway Research Center North

DZL Standort BREATH, Biomedical Research in Endstage & Obstructive Lung Disease

DZL Standort UGMLC, Universities of Giessen and Marburg Lung Center

2024 Infection

Maison, N. ; Omony, J. ; Rinderknecht, S. ; Kolberg, L. ; Meyer-Bühn, M. ; von Mutius, E. ; Hübner, J. ; von Both, U.

Old foes following news ways?-Pandemic-related changes in the epidemiology of viral respiratory tract infections

2024 Pediatr Allergy Immunol

Omony, J. ; Thölken, C. ; Salimi, A. ; Laubhahn, K. ; Illi, S. ; Weckmann, M. ; Grychtol, R. ; Rabe, KF. ; Thiele, D. ; Foth, S. ; Weber, S. ; Brinkmann, F. ; Kopp, M.V. ; Hansen, G. ; Renz, H. ; von Mutius, E. ; Schaub, B. ; Skevaki, C. ; ALLIANCE Study Group.

Urinary eosinophil-derived neurotoxin is associated with reduced lung function in pediatric asthma

2024 Am J Respir Crit Care Med

Jakwerth, CA. ; Weckmann, M. ; Illi, S. ; Charles, H. ; Zissler, U.M. ; Oelsner, M. ; Guerth, F. ; Omony, J. ; Nemani, S.S.P. ; Grychtol, R. ; Dittrich, A.M. ; Skevaki, C. ; Foth, S. ; Weber, S. ; Alejandre Alcazar, M.A. ; van Koningsbruggen-Rietschel, S. ; Brock, R. ; Blau, S. ; Hansen, G. ; Bahmer, T. ; Rabe, K.F. ; Brinkmann, F. ; Kopp, M.V. ; Chaker, A.M. ; Schaub, B. ; von Mutius, E. ; Schmidt-Weber, C.B. ; ALLIANCE Study Group as part of the German Center for Lung Research.

17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma

2024 Lancet Digit Health

Nahum, U. ; Gorlanova, O. ; Decrue, F. ; Oller, H. ; Delgado-Eckert, E. ; Böck, A. ; Schulzke, S. ; Latzin, P. ; Schaub, B. ; Karvonen, A.M. ; Lauener, R. ; Divaret-Chauveau, A. ; Illi, S. ; Roduit, C. ; von Mutius, E. ; Frey, U. ; BILD study group; PASTURE study group.

Symptom trajectories in infancy for the prediction of subsequent wheeze and asthma in the BILD and PASTURE cohorts: a dynamic network analysis

2024 Allergy

Risha, M.A. ; Reddy, K.D. ; Nemani, S.S.P. ; Jakwerth, C. ; Schmidt-Weber, C. ; Bahmer, T. ; Hansen, G. ; von Mutius, E. ; Rabe, K.F. ; Dittrich, A.M. ; Grychtol, R. ; Maison, N. ; Schaub, B. ; Kopp, M.V. ; Brinkmann, F. ; Meiners, S. ; Jappe, U. ; Weckmann, M. ; ALLIANCE Study Group as part of the German Centre for Lung Research (DZL).

Epigenetic training of human bronchial epithelium cells by repeated rhinovirus infections

2023 J Allergy Clin Immunol

Grychtol, R. ; Riemann, L. ; Gaedcke, S. ; Liu, B. ; DeLuca, D. ; Förster, R. ; Maison, N. ; Thiele, D. ; Jakobs, N. ; Bahmer, T. ; Meyer, M. ; Foth, S. ; Weber, S. ; Rietschel, E. ; Rabe, K.F. ; Kopp, M.V. ; von Mutius, E. ; Dittrich, A.M. ; Hansen, G. ; ALLIANCE Study Group as part of the German Center for Lung Research (DZL).

Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE Cohort

2023 J Breath Res

Shahrokny, P. ; Maison, N. ; Riemann, L. ; Ehrmann, M. ; DeLuca, D. ; Schuchardt, S. ; Thiele, D. ; Weckmann, M. ; Dittrich, A.M. ; Schaub, B. ; Brinkmann, F. ; Hansen, G. ; Kopp, M.V. ; von Mutius, E. ; Rabe, K.F. ; Bahmer, T. ; Hohlfeld, J.M. ; Grychtol, R. ; Holz, O.

Increased breath naphthalene in children with asthma and wheeze of the All Age Asthma Cohort (ALLIANCE)

2022 Eur Respir J

Maison, N. ; Omony, J. ; Illi, S. ; Thiele, D. ; Skevaki, C. ; Dittrich, A.M. ; Bahmer, T. ; Rabe, K.F. ; Weckmann, M. ; Happle, C. ; Schaub, B. ; Meyer, M. ; Foth, S. ; Rietschel, E. ; Renz, H. ; Hansen, G. ; Kopp, M.V. ; von Mutius, E. ; Grychtol, R. ; ALLIANCE Study Group.

T2-high asthma phenotypes across lifespan

2022 Infection

Maison, N. ; Peck, A. ; Illi, S. ; Meyer-Buehn, M. ; von Mutius, E. ; Hübner, J. ; von Both U.

The rising of old foes: impact of lockdown periods on "non-SARS-CoV-2" viral respiratory and gastrointestinal infections

2022 Am J Respir Crit Care Med

Illi, S. ; Depner, M. ; Pfefferle, PI. ; Renz, H. ; Roduit, C. ; Taft, D.H. ; Kalanetra, K.M. ; Mills, D.A. ; Farquharson, F.M. ; Louis, P. ; Schmausser-Hechfellner, E. ; Divaret-Chauveau, A. ; Lauener, R. ; Karvonen, A.M. ; Pekkanen, J. ; Kirjavainen, P.V. ; Roponen, M. ; Riedler, J. ; Kabesch, M. ; Schaub, B. ; von Mutius, E. ; PASTURE Study Group.

Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers

2021 Allergy Asthma Clin Immunol

Maison, N. ; Herbrüggen, H. ; Schaub, B. ; Schauberger, C. ; Foth, S. ; Grychtol, R. ; Abdo, M. ; Watz, H. ; Nikolaizik, W. ; Rabe, KF. ; Kopp, M.V. ; Hansen, G. ; von Mutius, E. ; Bahmer, T. ; Omony, J. ; ALLIANCE Study Group.

Impact of imposed social isolation and use of face masks on asthma course and mental health in pediatric and adult patients with recurrent wheeze and asthma

ALLIANCE – Study on asthma subtypes

On This Page

Scientists

Dr. rer. med. Sabina Illi

Dr. Jimmy Omony

Dr. med. Nicole Maison

Networks and Partners

DZL Standort ARCN, Airway Research Center North

DZL Standort BREATH, Biomedical Research in Endstage & Obstructive Lung Disease

DZL Standort UGMLC, Universities of Giessen and Marburg Lung Center

Selected Publications

Contact

Dr. rer. med. Sabina Illi

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