Multi-Spectral Optoacoustic Tomography (MSOT)

Motivation

MSOT produces an anatomical and functional image at a specific wavelength using photo-absorbers such as oxy- and deoxyhemoglobin, melanin, fat, collagen, water, and various natural or introduced contrast agents. This provides translatable information and valuable insight into organ function in healthy and diseased states. Taking advantage of the real-time, high-resolution and sensitive imaging capability of MSOT, we are studying various diseases using preclinical cells and mouse models by visualising and quantifying optoacoustic signals from the organs at a depth of several centimetres.

Research focus

• In vivo MSOT imaging of cancer, including Glioblastoma, Breast cancer, and Colon cancer
• Gain new insights into diseases such as inflammation,  neurological disorders, ischaemia, fibrosis, etc.
• Investigate the biodistribution of the optoacoustic agents in healthy and diseased mouse models
• Investigate the biological barriers and implications for the delivery of nano-medicines
• Monitor the drug delivery and therapeutic response by volumetric mapping of the tissues