All IDC Publications
Gimm, O. ; Pellegata, N.S.
Multiple endocrine neoplasia type 4 (MEN 4).Gulde, S. ; Pellegata, N.S.
CDKN1B (p27) defects leading to pituitary tumors.Minaskan Karabid, N. ; Pellegata, N.S.
Multiple endocrine neoplasia-type 4 (MEN4) and other MEN1-like syndromes.Kopf, S. ; Kumar, V. ; Kender, Z. ; Han, Z. ; Fleming, T. ; Herzig, S. ; Nawroth, P.P.
Diabetic pneumopathy-a new diabetes-associated complication: Mechanisms, consequences and treatment considerations.Mohr, H. ; Foscarini, A. ; Steiger, K. ; Ballke, S. ; Rischpler, C. ; Schilling, F. ; Pellegata, N.S.
Imaging pheochromocytoma in small animals: Preclinical models to improve diagnosis and treatment.Betz, I.R. ; Qaiyumi, S.J. ; Goeritzer, M. ; Thiele, A. ; Brix, S. ; Beyhoff, N. ; Grune, J. ; Klopfleisch, R. ; Greulich, F. ; Uhlenhaut, N.H. ; Kintscher, U. ; Foryst-Ludwig, A.
Cardioprotective effects of palmitoleic acid (C16:1n7) in a mouse model of catecholamine-induced cardiac damage are mediated by PPAR activation.Erener, S. ; Ellis, C.E. ; Ramzy, A. ; Glavas, M.M. ; O'Dwyer, S. ; Pereira, S. ; Wang, T. ; Pang, J. ; Bruin, J.E. ; Riedel, M.J. ; Baker, R.K. ; Webber, T.D. ; Lesina, M. ; Blüher, M. ; Algül, H. ; Kopp, J.L. ; Herzig, S. ; Kieffer, T.J.
Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice.Della Torre, S. ; Benedusi, V. ; Pepe, G. ; Meda, C. ; Rizzi, N. ; Uhlenhaut, N.H. ; Maggi, A.
Dietary essential amino acids restore liver metabolism in ovariectomized mice via hepatic estrogen receptor α.Sebag, S.C. ; Zhang, Z. ; Qian, Q. ; Li, M. ; Zhu, Z. ; Harata, M. ; Li, W. ; Zingman, L.V. ; Liu, L. ; Lira, V.A. ; Potthoff, M.J. ; Bartelt, A. ; Yang, L.
ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue.Schavinski, A.Z. ; Machado, J. ; Morgan, H.J.N. ; Lautherbach, N. ; Paula-Gomes, S. ; Kettelhut, I.C. ; Navegantes, L.C.C.
Calcitonin gene-related peptide exerts inhibitory effects on autophagy in the heart of mice.Muley, C. ; Kotschi, S. ; Bartelt, A.
Role of ubiquilins for brown adipocyte proteostasis and thermogenesis.Deshpande, S.S. ; Malik, S.C. ; Conforti, P. ; Lin, J.d. ; Chu, Y.H. ; Nath, S. ; Greulich, F. ; Dumbach, M.A. ; Uhlenhaut, N.H. ; Schachtrup, C.
P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke.Han, J. ; Harrison, L. ; Patzelt, L. ; Wu, M. ; Junker, D. ; Herzig, S. ; Berriel Diaz, M. ; Karampinos, D.C.
Imaging modalities for diagnosis and monitoring of cancer cachexia.Giroud, M. ; Jodeleit, H. ; Prentice, K.J. ; Bartelt, A.
Adipocyte function and the development of cardiometabolic disease.Kumar, V. ; Nawroth, P.P.
Is the association between diabetes mellitus and pulmonary fibrosis real?Foesleitner, O. ; Sulaj, A. ; Sturm, V. ; Kronlage, M. ; Godel, T. ; Preisner, F. ; Nawroth, P.P. ; Bendszus, M. ; Heiland, S. ; Schwarz, D.
Diffusion MRI in peripheral nerves: Optimized b values and the role of non-Gaussian diffusion.Herzig, S. ; Schmidt, S.F. ; Loft, A.
Purification of GFP-tagged nuclei from frozen livers of INTACT mice for RNA- and ATAC-sequencing.Heidenreich, E. ; Pfeffer, T. ; Kracke, T. ; Mechtel, N. ; Nawroth, P.P. ; Hoffmann, G.F. ; Schmitt, C.P. ; Hell, R. ; Poschet, G. ; Peters, V.
A novel uplc-ms/ms method identifies organ-specific dipeptide profiles.Scheiber, D. ; Zweck, E. ; Albermann, S. ; Jelenik, T. ; Spieker, M. ; Bönner, F. ; Horn, P. ; Schultheiss, H.P. ; Aleshcheva, G. ; Escher, F. ; Boeken, U. ; Akhyari, P. ; Roden, M. ; Kelm, M. ; Szendroedi, J. ; Westenfeld, R.
Human myocardial mitochondrial oxidative capacity is impaired in mild acute heart transplant rejection.Patzelt, L. ; Junker, D. ; Syväri, J. ; Burian, E. ; Wu, M. ; Prokopchuk, O. ; Nitsche, U. ; Makowski, M.R. ; Braren, R.F. ; Herzig, S. ; Diaz, M.B. ; Karampinos, D.C.
Mri‐determined psoas muscle fat infiltration correlates with severity of weight loss during cancer cachexia.Morgenstern, J. ; Groener, J.B. ; Jende, J.M.E. ; Kurz, F.T. ; Strom, A. ; Göpfert, J. ; Kender, Z. ; Le Marois, M. ; Brune, M. ; Kuner, R. ; Herzig, S. ; Roden, M. ; Ziegler, D. ; Bendszus, M. ; Szendroedi, J. ; Nawroth, P.P. ; Kopf, S. ; Fleming, T.
Neuron-specific biomarkers predict hypo- and hyperalgesia in individuals with diabetic peripheral neuropathy.Ruppert, P.M. ; Deng, L. ; Hooiveld, G.J. ; Hangelbroek, R.W. ; Zeigerer, A. ; Kersten, S.
RNA sequencing reveals niche gene expression effects of beta-hydroxybutyrate in primary myotubes.Madhavan, B.K. ; Han, Z. ; Sickmann, A. ; Pepperkok, R. ; Nawroth, P.P. ; Kumar, V.
A laser-mediated photo-manipulative toolbox for generation and real-time monitoring of DNA lesions.Morigny, P. ; Kaltenecker, D. ; Zuber, J. ; Machado, J. ; Mehr, L. ; Tsokanos, F.-F. ; Kuzi, H. ; Hermann, C.D. ; Voelkl, M. ; Monogarov, G. ; Springfeld, C. ; Laurent, V. ; Engelmann, B. ; Friess, H. ; Zörnig, I. ; Krüger, A. ; Krijgsveld, J. ; Prokopchuk, O. ; Schmidt, S.F. ; Rohm, M. ; Herzig, S. ; Berriel Diaz, M.
Association of circulating PLA2G7 levels with cancer cachexia and assessment of darapladib as a therapy.Gonzalez-Rellan, M.J. ; Fondevila, M.F. ; Fernandez, U. ; Rodriguez, A. ; Varela-Rey, M. ; Veyrat-Durebex, C. ; Seoane, S. ; Bernardo, G. ; Lopitz-Otsoa, F. ; Fernández-Ramos, D. ; Bilbao, J. ; Iglesias, C. ; Novoa, E. ; Ameneiro, C. ; Senra, A. ; Beiroa, D. ; Cuñarro, J. ; DP Chantada-Vazquez, M. ; Garcia-Vence, M. ; Bravo, S.B. ; Da Silva Lima, N. ; Porteiro, B. ; Carneiro, C. ; Vidal, A. ; Tovar, S. ; Müller, T.D. ; Ferno, J. ; Guallar, D. ; Fidalgo, M. ; Sabio, G. ; Herzig, S. ; Yang, W.H. ; Cho, J.W. ; Martínez-Chantar, M.L. ; Perez-Fernandez, R. ; López, M. ; Dieguez, C. ; Mato, J.M. ; Millet, O. ; Coppari, R. ; Woodhoo, A. ; Fruhbeck, G. ; Nogueiras, R.
O-GlcNAcylated p53 in the liver modulates hepatic glucose production.Fritsche, A. ; Wagner, R. ; Heni, M. ; Kantartzis, K. ; Machann, J. ; Schick, F. ; Lehmann, R. ; Peter, A. ; Dannecker, C. ; Fritsche, L. ; Valenta, V. ; Nawroth, P.P. ; Kopf, S. ; Pfeiffer, A.F. ; Kabisch, S. ; Dambeck, U. ; Stumvoll, M. ; Blüher, M. ; Birkenfeld, A.L. ; Schwarz, P. ; Hauner, H. ; Clavel, J. ; Seißler, J. ; Lechner, A. ; Müssig, K. ; Weber, K. ; Laxy, M. ; Bornstein, S. ; Schürmann, A. ; Roden, M. ; Hrabě de Angelis, M. ; Stefan, N. ; Häring, H.-U.
Different effects of lifestyle intervention in high- and low-risk prediabetes.Volta, F. ; Scerbo, M.J. ; Seelig, A. ; Wagner, R. ; O'Brien, N. ; Gerst, F. ; Fritsche, A. ; Häring, H.-U. ; Zeigerer, A. ; Ullrich, S. ; Gerdes, J.M.
Author Correction: Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing.Chondronikola, M. ; Bartelt, A. ; Vidal-Puig, A. ; Virtanen, K.A.
Editorial: Brown adipose tissue: From heat production in rodents to metabolic health in humans.Muley, C. ; Bartelt, A.
Fuse your mitochondria, lose appetite: An anorexic, anti-obesity sphingolipid.Tokarz, J. ; Möller, G. ; Artati, A. ; Huber, S. ; Zeigerer, A. ; Blaauw, B. ; Adamski, J. ; Dyar, K.A.
Common muscle metabolic signatures highlight arginine and lysine metabolism as potential therapeutic targets to combat unhealthy aging.Demir, S. ; Nawroth, P.P. ; Herzig, S. ; Ekim Üstünel, B.
Emerging targets in type 2 diabetes and diabetic complications.Loft, A. ; Alfaro, A.J. ; Schmidt, S.F. ; Pedersen, F.B. ; Terkelsen, M.K. ; Puglia, M. ; Chow, K.K. ; Feuchtinger, A. ; Troullinaki, M. ; Maida, A. ; Wolff, G. ; Sakurai, M. ; Berutti, R. ; Ekim Üstünel, B. ; Nawroth, P.P. ; Ravnskjaer, K. ; Diaz, M.B. ; Blagoev, B. ; Herzig, S.
Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication.Maida, A. ; Zota, A. ; Vegiopoulos, A. ; Appak-Baskoy, S. ; Augustin, H.G. ; Heikenwalder, M. ; Herzig, S. ; Rose, A.J.
Corrigendum to "Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance" [The Journal of Nutritional Biochemistry 57 (2018) 189-196].Qi, H. ; Schmöhl, F. ; Li, X. ; Qian, X. ; Tabler, C.T. ; Bennewitz, K. ; Sticht, C. ; Morgenstern, J. ; Fleming, T. ; Volk, N. ; Hausser, I. ; Heidenreich, E. ; Hell, R. ; Nawroth, P.P. ; Kroll, J.
Reduced acrolein detoxification in akr1a1a zebrafish mutants causes impaired insulin receptor signaling and microvascular alterations.Di Franco, S. ; Pellegata, N.S. ; Luconi, M. ; Stassi, G.
Editorial: Stem cells in endocrine tumors.Gulde, S. ; Wiedemann, T. ; Schillmaier, M. ; Valença, I. ; Lupp, A. ; Steiger, K. ; Yen, H.Y. ; Bäuerle, S. ; Notni, J. ; Luque, R. ; Schmid, H. ; Schulz, S. ; Ankerst, D.P. ; Schilling, F. ; Pellegata, N.S.
Gender-specific efficacy revealed by head-to-head comparison of pasireotide and octreotide in a representative in vivo model of nonfunctioning pituitary tumors.Madhavan, B.K. ; Han, Z. ; Singh, B. ; Bordt, N. ; Kaymak, S. ; Bandapalli, O.R. ; Kihm, L. ; Shahzad, K. ; Isermann, B. ; Herzig, S. ; Nawroth, P.P. ; Kumar, V.
Elevated expression of the rage variant-v in sclc mitigates the effect of chemotherapeutic drugs.Egea, V. ; Kessenbrock, K. ; Lawson, D. ; Bartelt, A. ; Weber, C. ; Ries, C.
Let-7f miRNA regulates SDF-1α- and hypoxia-promoted migration of mesenchymal stem cells and attenuates mammary tumor growth upon exosomal release.Greulich, F. ; Mechtidou, A. ; Horn, T. ; Uhlenhaut, N.H.
Protocol for using heterologous spike-ins to normalize for technical variation in chromatin immunoprecipitation.Herzig, S. ; Thorand, B. ; Peters, A. ; Ziegler, D.
Folgeerkrankungen des Diabetes mellitus.Georgiadi, A. ; Lopez Salazar, V. ; El-Merahbi, R. ; Karikari, R.A. ; Ma, X. ; Mourao, A. ; Klepac, K. ; Bühler, L. ; Alfaro, A.J. ; Kaczmarek, I. ; Linford, A. ; Bosma, M. ; Shilkova, O. ; Ritvos, O. ; Nakamura, N. ; Hirose, S. ; Lassi, M. ; Teperino, R. ; Machado, J. ; Scheideler, M. ; Dietrich, A. ; Geerlof, A. ; Feuchtinger, A. ; Blutke, A. ; Fischer, K. ; Müller, T.D. ; Kessler, K. ; Schöneberg, T. ; Thor, D. ; Hornemann, S. ; Kruse, M. ; Nawroth, P.P. ; Pivovarova-Ramich, O. ; Pfeiffer, A.F.H. ; Sattler, M. ; Blüher, M. ; Herzig, S.
Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.Giroud, M. ; Tsokanos, F.-F. ; Caratti, G. ; Kotschi, S. ; Khani, S. ; Jouffe, C. ; Vogl, E.S. ; Irmler, M. ; Glantschnig, C. ; Gil Lozano, M. ; Haß, D. ; Khan, A.A. ; Rios Garcia, M. ; Mattijssen, F. ; Maida, A. ; Tews, D. ; Fischer-Posovszky, P. ; Feuchtinger, A. ; Virtanen, K.A. ; Beckers, J. ; Wabitsch, M. ; Uhlenhaut, N.H. ; Blüher, M. ; Tuckermann, J. ; Scheideler, M. ; Bartelt, A. ; Herzig, S.
HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling.Gruber, T. ; Pan, C. ; Contreras, R. ; Wiedemann, T. ; Morgan, D.A. ; Skowronski, A.A. ; Lefort, S. ; De Bernardis Murat, C. ; Le Thuc, O. ; Legutko, B. ; Ruiz Ojeda, F.J. ; Fuente-Fernández, M. ; García-Villalón, A.L. ; González-Hedström, D. ; Huber, M. ; Szigeti-Buck, K. ; Müller, T.D. ; Ussar, S. ; Pfluger, P.T. ; Woods, S.C. ; Ertürk, A. ; LeDuc, C.A. ; Rahmouni, K. ; Granado, M. ; Horvath, T.L. ; Tschöp, M.H. ; García-Cáceres, C.
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension.Altamura, S. ; Müdder, K. ; Schlotterer, A. ; Fleming, T. ; Poschet, G. ; Qiu, R. ; Hammes, H.P. ; Nawroth, P.P. ; Muckenthaler, M.U.
Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload.Zeigerer, A. ; Sekar, R. ; Kleinert, M. ; Nason, S. ; Habegger, K.M. ; Müller, T.D.
Glucagon's metabolic action in health and disease.Tsokanos, F.-F. ; Muley, C. ; Khani, S. ; Haß, D. ; Fleming, T. ; Wolff, G. ; Bartelt, A. ; Nawroth, P.P. ; Herzig, S.
Methylglyoxal drives a distinct, nonclassical macrophage activation status.Jende, J.M.E. ; Kender, Z. ; Mooshage, C. ; Groener, J.B. ; Alvarez-Ramos, L. ; Kollmer, J. ; Juerchott, A. ; Hahn, A. ; Heiland, S. ; Nawroth, P.P. ; Bendszus, M. ; Kopf, S. ; Kurz, F.T.
Diffusion tensor imaging of the sciatic nerve as a surrogate marker for nerve functionality of the upper and lower limb in patients with diabetes and prediabetes.Suwandhi, L. ; Altun, I. ; Karlina, R. ; Miok, V. ; Wiedemann, T. ; Fischer, D.S. ; Walzthoeni, T. ; Lindner, C. ; Böttcher, A. ; Heinzmann, S.S. ; Israel, A. ; Khalil, A. ; Braun, A. ; Pramme-Steinwachs, I. ; Burtscher, I. ; Schmitt-Kopplin, P. ; Heinig, M. ; Elsner, M. ; Lickert, H. ; Theis, F.J. ; Ussar, S.
Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population.Morigny, P. ; Boucher, J. ; Langin, D.
Lipid and glucose metabolism in white adipocytes: Pathways, dysfunction and therapeutics.Deshpande, D. ; Agarwal, N. ; Fleming, T. ; Klose, C.S.N. ; Tappe-Theodor, A. ; Kuner, R. ; Nawroth, P.P.
Publisher Correction: Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.Greulich, F. ; Wierer, M. ; Mechtidou, A. ; Gonzalez-Garcia, O. ; Uhlenhaut, N.H.
The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers.Novikoff, A. ; O'Brien, S.L. ; Bernecker, M. ; Grandl, G. ; Kleinert, M. ; Knerr, P.J. ; Stemmer, K. ; Klingenspor, M. ; Zeigerer, A. ; DiMarchi, R. ; Tschöp, M.H. ; Finan, B. ; Calebiro, D. ; Müller, T.D.
Spatiotemporal GLP-1 and GIPR receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists.Lemmer, I.L. ; Willemsen, N. ; Hilal, N. ; Bartelt, A.
A guide to understanding endoplasmic reticulum stress in metabolic disorders.Schlein, C. ; Fischer, A.W. ; Sass, F. ; Worthmann, A. ; Tödter, K. ; Jaeckstein, M.Y. ; Behrens, J. ; Lynes, M.D. ; Kiebish, M.A. ; Narain, N.R. ; Bussberg, V. ; Darkwah, A. ; Jespersen, N.Z. ; Nielsen, S. ; Scheele, C. ; Schweizer, M. ; Braren, I. ; Bartelt, A. ; Tseng, Y.H. ; Heeren, J. ; Scheja, L.
Endogenous fatty acid synthesis drives brown adipose tissue involution.Mohr, H. ; Ballke, S. ; Bechmann, N. ; Gulde, S. ; Malekzadeh Najafabadi, J. ; Peitzsch, M. ; Ntziachristos, V. ; Steiger, K. ; Wiedemann, T. ; Pellegata, N.S.
Mutation of the cell cycle regulator p27kip1 drives pseudohypoxic pheochromocytoma development.Okun, J.G. ; Rusu, P.M. ; Chan, A.Y. ; Yap, Y.W. ; Sharkie, T. ; Schumacher, J. ; Schmidt, K.V. ; Zota, A. ; Hille, S. ; Jungmann, A. ; Maggi. L. ; Lee, Y. ; Blüher, M. ; Herzig, S. ; Heikenwalder, M. ; Müller, O. ; Rose, A.J.
Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes.Mastrototaro, G. ; Zaghi, M. ; Massimino, L. ; Moneta, M. ; Mohammadi, N. ; Banfi, F. ; Bellini, E. ; Indrigo, M. ; Fagnocchi, G. ; Bagliani, A. ; Taverna, S. ; Rohm, M. ; Herzig, S. ; Sessa, A.
TBL1XR1 ensures balanced neural development through NCOR complex-mediated regulation of the MAPK pathway.Bühler, L. ; Maida, A. ; Vogl, E.S. ; Georgiadi, A. ; Takacs, A. ; Kluth, O. ; Schürmann, A. ; Feuchtinger, A. ; von Toerne, C. ; Tsokanos, F.-F. ; Klepac, K. ; Wolff, G. ; Sakurai, M. ; Ekim Üstünel, B. ; Nawroth, P.P. ; Herzig, S.
Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic control.Zhang, Q. ; Delessa, C.T. ; Augustin, R. ; Bakhti, M. ; Collden, G. ; Drucker, D.J. ; Feuchtinger, A. ; García-Cáceres, C. ; Grandl, G. ; Harger, A. ; Herzig, S. ; Hofmann, S.M. ; Holleman, C.L. ; Jastroch, M. ; Keipert, S. ; Kleinert, M. ; Knerr, P.J. ; Kulaj, K. ; Legutko, B. ; Lickert, H. ; Liu, X. ; Luippold, G. ; Lutter, D. ; Malogajski, E. ; Tarquis Medina, M. ; Mowery, S.A. ; Blutke, A. ; Perez-Tilve, D. ; Salinno, C. ; Sehrer, L. ; DiMarchi, R.D. ; Tschöp, M.H. ; Stemmer, K. ; Finan, B. ; Wolfrum, C. ; Müller, T.D.
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling.Hartleben, G. ; Schorpp, K.K. ; Kwon, Y. ; Betz, B. ; Tsokanos, F.-F. ; Dantes, Z. ; Schäfer, A. ; Rothenaigner, I. ; Monroy Kuhn, J.M. ; Morigny, P. ; Mehr, L. ; Lin, S. ; Seitz, S. ; Tokarz, J. ; Artati, A. ; Adamski, J. ; Plettenburg, O. ; Lutter, D. ; Irmler, M. ; Beckers, J. ; Reichert, M. ; Hadian, K. ; Zeigerer, A. ; Herzig, S. ; Berriel Diaz, M.
Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism.Deshpande, D. ; Agarwal, N. ; Fleming, T. ; Klose, C.S.N. ; Tappe-Theodor, A. ; Kuner, R. ; Nawroth, P.P.
Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.Sager, C.P. ; Weber, S. ; Negri, M. ; Banachowicz, P. ; Möller, G. ; Adamski, J. ; Hartmann, R.W. ; Marchais-Oberwinkler, S.
Homology modeling meets site-directed mutagenesis: An ideal combination to elucidate the topology of 17β-HSD2.Chen, J. ; Fleming, T. ; Katz, S. ; Dewenter, M. ; Hofmann, K. ; Saadatmand, A. ; Kronlage, M. ; Werner, M.P. ; Pokrandt, B. ; Schreiter, F. ; Lin, J. ; Katz, D. ; Morgenstern, J. ; Elwakiel, A. ; Sinn, P. ; Gröne, H.J. ; Hammes, H.P. ; Nawroth, P.P. ; Isermann, B. ; Sticht, C. ; Brügger, B. ; Katus, H.A. ; Hagenmueller, M. ; Backs, J.
CaM kinase II-δ is required for diabetic hyperglycemia and retinopathy but not nephropathy.Camacho Londoño, J.E. ; Kuryshev, V. ; Zorn, M. ; Saar, K. ; Tian, Q. ; Hübner, N. ; Nawroth, P.P. ; Dietrich, A. ; Birnbaumer, L. ; Lipp, P. ; Dieterich, C. ; Freichel, M.
Transcriptional signatures regulated by TRPC1/C4-mediated Background Ca2+ entry after pressure-overload induced cardiac remodelling.