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Dr. Kenneth Dyar

Group Leader, Metabolic Physiology, Instsitute for Diabetes and Cancer
Email meBuilding/Room: 3620

"We use metabolomics to identify molecular signatures distinguishing health from disease. With this knowledge we seek to develop novel personalized therapeutics to mitigate unhealthy trajectories, and to recover or maintain health status"

"We use metabolomics to identify molecular signatures distinguishing health from disease. With this knowledge we seek to develop novel personalized therapeutics to mitigate unhealthy trajectories, and to recover or maintain health status"

Academic Career and Research Areas

1. Regulation of muscle metabolism by the skeletal muscle circadian clock.

During his doctoral work in the lab of Stefano Schiaffino (Univerity of Padova), Kenneth discovered that circadian clocks in muscles promote insulin sensitivity and glucose utilization during the fasting-feeding transition. His work showed how muscle-specific clock disruption causes insulin resistance, providing an important pathophysiological link between chronic circadian misalignment and type 2 diabetes risk. During his postdoctoral work in the lab of Henriette Uhlenhaut (Helmhotz Munich), Kenneth profiled genomic binding of clock transcription factors in skeletal muscles, and demonstrated mechanistically how muscle clocks also directs diurnal cycles of lipid storage and protein turnover in anticipation of feeding.

 

2. Circadian metabolomics for metabolic phenotyping and biomarker discovery. Kenneth’s collaborative work with the late Paolo Sassone-Corsi (UC Irvine), Dominik Lutter (Helmholtz Munich) and Juleen Zierath (Karolinska Institutet) has highlighted the importance of integrating and comparing both temporal and spatial perspectives in metabolomics experiments. This approach has given unprecedented insight into how dynamic metabolism and tissue cross-talk changes according to time, genotype, and various dietary or therapeutic interventions, including exercise

 

Fields of Work and Expertise

Circadian Physiology Metabolomics  Functional GenomicsSkeletal Muscle

Professional Background

Since Jan 2021

Group leader, Metabolic Physiology, Institute for Diabetes and Cancer (IDC), Helmholtz Munich, Germany

2013 - 2020

Postdoc, lab of Henriette Uhlenhaut, Molecular Endocrinology, Institute for Diabetes and Obesity (IDO), Helmholtz Munich, Germany

2009 - 2013

Postdoc, lab of Stefano Schiaffino, Venetian Institute of Molecular Medicine (VIMM), Padova, Italy

2006 - 2009

Ph.D. Student, lab of Stefano Schiaffino, Department of Biomedical Sciences, University of Padova, Italy

2004 -2005

Research Assistant, lab of Fiona Inglis, Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana, USA

Honors and Awards

  • 2022 - 2025 DFG/TRR333-1 “BATenergy”

  • 2020 - 2021 DZD Grant 2020/21

  • 2019 - 2020 ExNet-0041-Phase2-3 (“SyNergy-HMGU”), Initiative and Network Fund of the Helmholtz Association

  • 2013 Keystone Symposia Future of Science Fund Scholarship

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