Henriette Uhlenhaut

Director of the Institute for Diabetes and Endocriology and W3 Professor, Chair for Metabolic Programming, Technical University of Munich (TUM)

henriette.uhlenhaut@helmholtz-munich.de Website

"Hormones control every second of every day of our lives! Here at IDE, we aim to harness the power of hormones to find novel therapeutic approaches for the treatment of metabolic and inflammatory disorders, and for healthier, longer lives."

Prof. Uhlenhaut's (*1977) research focuses on investigating gene regulatory mechanisms that mediate hormone responses. Latest genome-wide techniques are combined with preclinical models to find new therapeutic approaches for metabolic or inflammatory diseases (e.g. diabetes, asthma).

Prof. Uhlenhaut studied at the Technical University of Braunschweig and at Georgia Tech in Atlanta. She received her doctorate from EMBL in Heidelberg and, after postdoctoral research at the Salk Institute in San Diego and the MDC in Berlin, came to Helmholtz Zentrum München as group leader. She was also professor at the Gene Center of the LMU. In 2019, Prof. Uhlenhaut was appointed professor of 'Metabolic Programming' at the TUM.

Nuclear hormone receptors Transcription Chromatin Genomics Metabolism

Gene Regulation Inflammation Hormones Circadian Clocks Physiology

"Currently, hot topics we are investigating in the lab include fatty liver diseases, fibrosis and cancer; circadian rhythms in health and disease; the effects of the stress hormone cortisol; and life span extension by caloric restriction."

Since 2021

Since 2019

2018 - 2019

2013 - 2018

2023 EJE Award of the European Society of Endocrinology
2023 ERC GRACE
2022 Science Prize from the city of Freising
2019 Heinz-Maier-Leibnitz Prize of the DFG
2015 Friedmund Neumann Prize of the Schering Foundation
2014 ERC Starting Grant SILENCE

Makris K, Fonda V, Ramadhani FF, Fadel L, Davezac M, Payet B, Deligiannis IK, Zhang L, Horn T, Heimerl L, Jouffe C, Heddes M, Martinez-Jimenez CP, Quagliarini F, Uhlenhaut NH

Hepatic metabolic reprogramming in male mice during short-term caloric restriction involves enhanced glucocorticoid rhythms

Trendel J, Trendel S, Sha S, Greulich F, Goll S, Wudy SI, Kleigrewe K, Kubicek S, Uhlenhaut NH, Kuster B

The human proteome with direct physical access to DNA

Höllbacher B, Strickland B, Greulich F, Uhlenhaut NH, Heinig M

Machine learning reveals STAT motifs as predictors for GR-mediated gene repression

Quagliarini F, Makris K, Friano ME, Uhlenhaut NH

EJE Prize 2023: genes on steroids-genomic control of hepatic metabolism by the glucocorticoid receptor

Greulich F, Wierer M, Mechtidou A, Gonzalez-Garcia O, Uhlenhaut NH

The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers

Escoter-Torres L, Greulich F, Quagliarini F, Wierer M, Uhlenhaut NH

Anti-inflammatory functions of the glucocorticoid receptor require DNA binding

Quagliarini F, Mir AA, Balazs K, Wierer M, Dyar KA, Jouffe C, Makris K, Hawe J, Heinig M, Filipp FV, Barish GD, Uhlenhaut NH