Helmholtz Diabetes Center

Institute of Diabetes Research

The Institute of Diabetes Research (IDF) is dedicated to studying the natural history of type 1 diabetes, identifying mechanisms and predictive markers of the disease, investigating the pathology of the human pancreas, and implementing novel treatment approaches in clinical trials to prevent type 1 diabetes.

Institute Director

Your Contribution

The Institute of Diabetes Research (IDF) is dedicated to studying the natural history of type 1 diabetes, identifying mechanisms and predictive markers of the disease, investigating the pathology of the human pancreas, and implementing novel treatment approaches in clinical trials to prevent type 1 diabetes.

Institute Director

Your Contribution

Doctor diagnose pancreas .
EDENT1FI_Logo_final

Research Platforms

EDENT1FI

EDENT1FI is a global consortium comprised of 28 partners spanning 12 countries. These partners have come together with a shared mission: to identify T1D at its pre-clinical stage in children in the general population. The project is funded through the Horizon Europe program and is set to run over five years.


EDENT1FI website

Press release

Pre-T1D Logo Transparent

European pre-T1D Registry 

European pre-T1D Registry is a network of investigators who register children and adults diagnosed with early-stage type 1 diabetes to inform about monitoring, trials, and treatment to delay or prevent disease progression. European pre-T1D Registry is operated by Helmholtz Munich under the umbrella of GPPAD & INNODIA.

pre-T1D Registry website

pre-T1D Registry dashboard

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Campaigns

K1DS ARE HEROES

The K1DS ARE HEROES campaign spots type 1 diabetes heroes around the world! The campaign aims to raise awareness for type 1 diabetes, early detection and prevention of type 1 diabetes. The campaign is run by GPPAD together with the Institute of Diabetes Research (IDF) at Helmholtz Munich.

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News

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Doctor drawing man's blood sample in clinic, closeup  AdobeStock_1937412501

Diabetes, IDF, Environmental Health, EPI,

Rethinking Early Detection: Type 1 Diabetes in Young Adults

A population-based cohort study provides new data on the prevalence of early-stage type 1 diabetes in young adults, addressing a gap in epidemiological research. Using samples from the LISA and GINIplus cohorts and methodologies established in the…

Blood Screening for Type 1 Diabetes

New Research Findings, Diabetes, IDF,

100,000 Participants Screened for Early-Stage Type 1 Diabetes in the EDENT1FI Project

EDENT1FI (“European action for the Diagnosis of Early Non-clinical Type 1 diabetes For disease Interception”), a research project led by Prof. Anette-Gabriele Ziegler from Helmholtz Munich and Prof. Chantal Mathieu from the KU Leuven, has reached an…

NAKO und BABYDIAB Proben

Awards & Grants, Diabetes, IDF, Environmental Health, EPI,

Helmholtz Munich Secures Funding to Investigate Early-Stage Type 1 Diabetes in Adults

Helmholtz Munich has been awarded a prestigious grant of up to 900 000 US Dollar from Breakthrough T1D, the leading global type 1 diabetes (T1D) research and advocacy organization. The funding will support the research into early-stage T1D in adults,…

Sandra Hummel 1

Awards & Grants, Diabetes, IDF,

Sandra Hummel Awarded the Dr. Heinz Bürger-Büsing Prize

Prof. Sandra Hummel, lead scientist of the research area “Lifestyle, Obesity, and Epigenetic Programming in Type 1 and Gestational Diabetes” at the Institute of Diabetes Research at Helmholtz Munich, has been awarded the Dr. Heinz Bürger-Büsing…

Bild Studie POInT

New Research Findings, Diabetes, IDF,

New Milestone Towards Personalized Prevention of Type 1 Diabetes

First results of the Primary Oral Insulin Trial (POInT) mark an important step towards the prevention of type 1 diabetes, pointing future efforts to personalized strategies. The group led by researchers from Helmholtz Munich and the Technical…

Schwangere Frau mit Ultraschallbildern

New Research Findings, Diabetes, IDF,

Maternal Type 1 Diabetes May Protect Children Through Epigenetic Changes

Children with a family history of type 1 diabetes (T1D) have an increased risk of developing the disease. However, children born to mothers with T1D are less likely to develop the disease than those whose fathers or siblings have T1D. A new study…

Currently Recruiting

Highlight publications

2022 Journal of Clinical Investigation

Warncke, K., Weiss, A., Achenbach, P., von dem Berge, T., Berner, R., Casteels, K., Groele, L., Hatzikotoulas, K., Hommel, A., Kordonouri, O., Elding Larsson, H., Lundgren, M., Marcus, B. A., Snape, M. D., Szypowska, A., Todd, J. A., Bonifacio, E., Ziegler, A. G., & GPPAD and POInT Study Groups

Elevations in blood glucose before and after the appearance of islet autoantibodies in children.
2020 Journal of the American Medical Association

Ziegler, A.-G. ; Kick, K. ; Bonifacio, E. ; Haupt, F. ; Hippich, M. ; Dunstheimer, D. ; Lang, M. ; Laub, O. ; ... ; Assfalg, R. ; Jolink, M. ; Winkler, C. ; Achenbach, P.

Yield of a public health screening of children for islet autoantibodies in Bavaria, Germany.
2019 Diabetes

Hippich, M. ; Beyerlein, A. ; Hagopian, W.A. ; Krischer, J.P. ; Vehik, K. ; Knoop, J. ; Winker, C. ; ... ; Ziegler, A.-G. ; The Teddy Study Group

Genetic contribution to the divergence in type 1 diabetes risk between children from the general population and children from affected families.
2013 Journal of the American Medical Association

Anette G. Ziegler, MD; Marian Rewers, MD, PhD; Olli Simell, MD, PhD; Tuula Simell, MPH, PhD; Johanna Lempainen, MD, PhD; Andrea Steck, MD; Christiane Winkler, PhD; Jorma Ilonen, MD, PhD; Riitta Veijola, MD, PhD; Mikael Knip, MD, PhD; Ezio Bonifacio, PhD; George S. Eisenbarth, MD, PhD

Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children.

Networks & Affiliations

Logo Deutsches Zentrum für Diabetesforschung

DZD

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INNODIA Logo

INNODIA

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Type 1 Diabetes TrialNet Logo

TrialNet

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GPPAD

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Fr1da plex

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Logo Teddy Studie

Teddy consortium

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nPOD

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diabinfo Logo

diabinfo

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Pre-T1D Logo Transparent

pre-T1D registry

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EDENT1FI_Logo_final

EDENT1FI

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Team

Contact

Univ.-Prof. Dr. med. Anette-Gabriele Ziegler

Institute Director, Chair of Diabetes and Gestational Diabetes, Klinikum rechts der Isar and Technical University of Munich, Director of the Global Platform for the Prevention of Autoimmune Diabetes (GPPAD)

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Heidemannstraße 1, 80939 München