Publications
Publications
2024 Scientific Article in Nature Communications Nat. Commun. 15:6438 (2024)
Phosphorylation of PFKL regulates metabolic reprogramming in macrophages following pattern recognition receptor activation.
2024 Scientific Article in Journal of Neuroinflammation J. Neuroinflamm. 21:174 (2024)
PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation.
2024 Scientific Article in Nature Communications Nat. Commun. 15:5944 (2024)
Rational correction of pathogenic conformational defects in HTRA1.
2024 Scientific Article in Molecular Psychiatry Mol. Psychiatry, DOI: 10.1038/s41380-024-02663-w (2024)
A bipolar disorder-associated missense variant alters adenylyl cyclase 2 activity and promotes mania-like behavior.
2024 Scientific Article in Endocrinology Endocrinology 165:bqae067 (2024)
Comparative phenotyping of mice reveals canonical and noncanonical physiological functions of TRα and TRβ.
2024 Scientific Article in Neuron Neuron, DOI: 10.1016/j.neuron.2024.05.027 (2024)
APP fragment controls both ionotropic and non-ionotropic signaling of NMDA receptors.
2024 Scientific Article in Applied Geochemistry Appl. Geochem. 169:106049 (2024)
Linkage between glyphosate adsorption/desorption and mineralization in Central European agricultural soils.
2024 Letter to the Editor in Cell Discovery Cell Discov. 10:42 (2024)
Engineered, nucleocytoplasmic shuttling Cas13d enables highly efficient cytosolic RNA targeting.
2024 Scientific Article in Acta Physiologica Acta Physiol. 240:e14146 (2024)
The homeostatic effects of the RE-1 silencing transcription factor on cortical networks are altered under ictogenic conditions in the mouse.
2024 Scientific Article in Science Advances Sci. Adv. 10:eadj8769 (2024)
A brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli.
2024 Scientific Article in iScience iScience 27:109507 (2024)
Restoring vision in adult amblyopia by enhancing plasticity through deletion of the transcriptional repressor REST.
2024 Scientific Article in Neurobiology of Disease Neurobiol. Dis. 194:106474 (2024)
Engrailed 1 deficiency induces changes in ciliogenesis during human neuronal differentiation.
2024 Scientific Article in Nature Communications Nat. Commun. 15:2194 (2024)
The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression.
2024 Scientific Article in Nature Methods Nat. Methods 21, 455-464 (2024)
Exonuclease-enhanced prime editors.
2024 Scientific Article in Sleep Sleep 47:zsae015 (2024)
A patient-enriched MEIS1 coding variant causes a restless legs syndrome-like phenotype in mice.
2023 Scientific Article in Neuroscience Applied Neurosci. App. 2:101126 (2023)
GPR101 loss promotes insulin resistance and diet-induced obesity risk.
2023 Scientific Article in Kidney International Kidney Int. 105, 844-864 (2023)
Implication of transcription factor FOXD2 dysfunction in syndromic congenital anomalies of the kidney and urinary tract (CAKUT).
2023 Scientific Article in Frontiers in Cellular Neuroscience Front. Cell. Neurosci. 17:1267609 (2023)
Conditional knockout of REST/NRSF in excitatory neurons reduces seizure susceptibility to chemical kindling.
2023 Scientific Article in Nature Communications Nat. Commun. 14:7674 (2023)
A reversible state of hypometabolism in a human cellular model of sporadic Parkinson's disease.
2023 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 120, 11:e2309205120 (2023)
Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.
2023 Scientific Article in Laser & Photonics Reviews Laser Photon. Rev. 17:2200846 (2023)
Beyond early development: Observing Zebrafish over 6 weeks with hybrid optical and optoacoustic imaging.
2023 Scientific Article in BMC Biology BMC Biol. 21:23 (2023)
A systematic review of the development and application of home cage monitoring in laboratory mice and rats.
2023 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 2631, 207-230 (2023)
Gene editing in mouse zygotes using the CRISPR/Cas9 system.
2023 Cell Death & Disease Cell Death Dis. 14:310 (2023)
Correction: Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF.
2023 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 120:e2301250120 (2023)
Systemic deletion of DMD exon 51 rescues clinically severe Duchenne muscular dystrophy in a pig model lacking DMD exon 52.
2023 Scientific Article in Cell Metabolism Cell Metab. 35, 438-455.e7 (2023)
Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1.
2023 Scientific Article in Life Science Alliance Life Sci. All. 6:e202201730 (2023)
Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain.
2023 Scientific Article in Mammalian Genome Mamm. Genome 34, 244-261 (2023)
Knockout mouse models as a resource for the study of rare diseases.
2023 Scientific Article in Biochimica et Biophysica Acta - Molecular Basis of Disease Biochim. Biophys. Acta-Mol. Basis Dis. 1869:166760 (2023)
AOX delays the onset of the lethal phenotype in a mouse model of Uqcrh (complex III) disease.
2023 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 110, 1394-1413 (2023)
Monoallelic variation in DHX9, the gene encoding the DExH-box helicase DHX9, underlies neurodevelopment disorders and Charcot-Marie-Tooth disease.
2023 Molecular and Cellular Neuroscience Mol. Cell. Neurosci. 125:103837 (2023)
Corrigendum to Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development [Mol. Cell. Neurosci., 2011 Feb;46(2):419-31].
2023 Scientific Article in Journal of Neurochemistry J. Neurochem. 165, 701-721 (2023)
Neuron-restrictive silencer factor/repressor element 1-silencing transcription factor (NRSF/REST) controls spatial K+ buffering in primary cortical astrocytes.
2023 Scientific Article in BMC Medicine BMC Med. 21:14 (2023)
Recommendations for robust and reproducible preclinical research in personalised medicine.
2023 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 110, 146-160 (2023)
Bi-allelic variants in NAE1 cause intellectual disability, ischiopubic hypoplasia, stress-mediated lymphopenia and neurodegeneration.
2023 Scientific Article in Experimental Eye Research Exp. Eye Res. 226:109346 (2023)
Identification of ocular regulatory functions of core histone variant H3.2.
2023 Scientific Article in Laboratory animals Lab. Anim. 57, 79-83 (2023)
Improving biomedical research by automated behaviour monitoring in the animal home cage - action needed for networking.
2022 Nature Cardiovascular Research Nat. Cardio. Res. 1, 529-531 (2022)
Publisher Correction: Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy (Nature Cardiovascular Research, (2022), 1, 2, (157-173), 10.1038/s44161-022-00018-8).
2022 Scientific Article in Scientific Reports Sci. Rep. 12:21951 (2022)
Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein.
2022 Review in Mammalian Genome Mamm. Genome 34, 331-350 (2022)
A rationale for considering heart/brain axis control in neuropsychiatric disease.
2022 Review in Deutsche Apotheker-Zeitung Dtsch. Apoth. Ztg. 162, accepted (2022)
Den „Eisen-Tod“ verhindern Bedeutung der antioxidativen Vitamine und der Vitamin-K-Familie.
2022 Scientific Article in Scientific Reports Sci. Rep. 12:19793 (2022)
New C3H KitN824K/WT cancer mouse model develops late-onset malignant mammary tumors with high penetrance.
2022 Scientific Article in Nature Communications Nat. Commun. 13:6830 (2022)
Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice.
2022 Scientific Article in Nature Nature 609, 590-596 (2022)
Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation.
2022 Review in International Journal of Molecular Sciences Int. J. Mol. Sci. 23:11562 (2022)
A pathophysiological intersection of diabetes and alzheimer's disease.
2022 Scientific Article in Molecular Metabolism Mol. Metab. 66:101616 (2022)
Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome.
2022 Scientific Article in Cell Death Discovery Cell Death Discov. 8:387 (2022)
Mutations within the cGMP-binding domain of CNGA1 causing autosomal recessive retinitis pigmentosa in human and animal model.
2022 Scientific Article in Redox Biology Redox Biol. 57:102490 (2022)
Seizures, ataxia and parvalbumin-expressing interneurons respond to selenium supply in Selenop-deficient mice.
2022 Review in Neuromuscular Disorders Neuromusc. Disord. 32, 543-556 (2022)
Pig models for Duchenne muscular dystrophy - from disease mechanisms to validation of new diagnostic and therapeutic concepts.
2022 Scientific Article in Nature Communications Nat. Commun. 13:4819 (2022)
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease.
2022 Scientific Article in Nature Cardiovascular Research Nat. Cardio. Res. 1, 157-173 (2022)
Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy.
2022 Scientific Article in Nature metabolism Nat. Metab. 4, 589-607 (2022)
PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasis during ageing.
2022 Scientific Article in Cells Cells 11:520 (2022)
Innate immune pathways promote oligodendrocyte progenitor cell recruitment to the injury site in adult Zebrafish brain.
2022 Review in Frontiers in psychiatry Front. Psychiatr. 13:815718 (2022)
Concept of the Munich/Augsburg Consortium Precision in Mental Health for the German Center of Mental Health.
2022 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med.:e14797 (2022)
Parkinson's disease motor symptoms rescue by CRISPRa-reprogramming astrocytes into GABAergic neurons.
2022 Review in Molecular Aspects of Medicine Mol. Aspects Med. 86:101096 (2022)
Chapter 5 – “Parkinson's disease – A role of non-enzymatic posttranslational modifications in disease onset and progression?”.
2022 Nature Genetics Nat. Genet. 54, 358-360 (2022)
EMPReSS: Standardized phenotype screens for functional annotation of the mouse genome (vol 37, pg 1155, 2005).
2022 Editorial in Radiation Research Radiat. Res. 197, 1-6 (2022)
Introduction to the special LDLensRad focus issue.
2022 Scientific Article in Disease Models and Mechanisms Dis. Model. Mech. 15:dmm049205 (2022)
Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk.
2022 Scientific Article in American Journal of Physiology - Endocrinology and Metabolism Am. J. Physiol. Endocrinol. Metab. 322, E85-E100 (2022)
Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1.
2022 Scientific Article in Radiation Research Radiat. Res. 197, 67-77 (2022)
Complex long-term effects of radiation on adult mouse behaviour.
2022 Scientific Article in Neuropathology and Applied Neurobiology Neuropathol. Appl. Neurobiol. 48:e12750 (2022)
N471D WASH complex subunit strumpellin knock-in mice display mild motor and cardiac abnormalities and BPTF and KLHL11 dysregulation in brain tissue.
2022 Scientific Article in Radiation Research Radiat. Res. 197, 57-66 (2022)
Radiation-induced lens opacity and cataractogenesis: A lifetime study using mice of varying genetic backgrounds.
2022 Scientific Article in Radiation Research Radiat. Res. 197, 7-21 (2022)
On the nature of murine radiation-induced subcapsular cataracts: Optical coherence tomography-based fine classification, in vivo dynamics and impact on visual acuity.
München, Technische Universität, TUM School of Life Sciences, Diss., 2021, 220 S.
Schädigung des optischen Apparats von Mus musculus nach Exposition gegenüber ionisierender Strahlung moderater Dosis: In-vivo- und post-mortem-Analyse der Linse, Retina und Cornea.
2021 Scientific Article in Nature Immunology Nat. Immunol. 22, 1563-1576 (2021)
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.
2021 Other: Opinion in Brain: A Journal of Neurology Brain 144, 3555-3557 (2021)
c-Abl phosphorylation primes PARIS for neurodegeneration.
2021 Scientific Article in Science immunology Sci. Immunol. 6:eabh2095 (2021)
TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease.
2021 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med.:e14397 (2021)
Characterising a homozygous two-exon deletion in UQCRH: Comparing human and mouse phenotypes.
2021 Scientific Article in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 9:726866 (2021)
iPS cell-based model for MAPT Haplotype as a risk factor for human tauopathies identifies no major differences in TAU expression.
2021 Scientific Article in Neurochemistry International Neurochem. Int. 150:105174 (2021)
Determination of morphine and norlaudanosoline in murine brain regions by dispersive liquid-liquid micro-extraction and liquid chromatograpy-electrochemical detection.
München, Technische Universität, BIO Biowissenschaften; LAN Landbauwissenschaft, Diss., 2021, 160 S.
The long-term effects of low dose ionizing radiation on the adult mouse brain and the consequences for behavior.
2021 Scientific Article in Aging Cell Aging Cell, DOI: 10.1111/acel.13471:e13471 (2021)
REST/NRSF deficiency impairs autophagy and leads to cellular senescence in neurons.
2021 Scientific Article in FASEB Journal FASEB J. 35:e21813 (2021)
Endoglycan (PODXL2) is proteolytically processed by ADAM10 (a disintegrin and metalloprotease 10) and controls neurite branching in primary neurons.
2021 Scientific Article in Nature Cell Biology Nat. Cell Biol. 23, 652-663 (2021)
Non-invasive and high-throughput interrogation of exon-specific isoform expression.
2021 Scientific Article in eLife eLife 10:e63294 (2021)
Introduction to the EQIPD quality system.
2021 Scientific Article in The CRISPR Journal CRISPR J. 4, 178-190 (2021)
Rescue of STAT3 function in hyper-IgE syndrome using adenine base editing.
2021 Scientific Article in Mammalian Genome Mamm. Genome 32, 332-349 (2021)
A comprehensive phenotypic characterization of a whole-body Wdr45 knock-out mouse.
2021 Scientific Article in Annals of Neurology Ann. Neurol. 90, 143-158 (2021)
Mutations in HID1 cause syndromic infantile encephalopathy and hypopituitarism.
2021 Scientific Article in Cell Death & Disease Cell Death Dis. 12:180 (2021)
Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF.
2021 Nature Nature 589, E6 (2021)
Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung (Nature, (2020), 588, 7836, (151-156), 10.1038/s41586-020-2882-8).
2021 Scientific Article in Nature Protocols Nat. Protoc. 16, 1714-1739 (2021)
Simple and reliable detection of CRISPR-induced on-target effects by qgPCR and SNP genotyping.
2021 Scientific Article in Disease Models and Mechanisms Dis. Model. Mech. 14:dmm047803 (2021)
Mutant non-coding RNA resource in mouse embryonic stem cells.
2021 Scientific Article in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 9:561086 (2021)
Comprehensive miRNome-wide profiling in a neuronal cell model of synucleinopathy implies involvement of cell cycle genes.
2021 Review in Nature Genetics Nat. Genet. 53, 416-419 (2021)
A resource of targeted mutant mouse lines for 5,061 genes.
2021 Review in Gene Therapy Gene Ther. 28, 542–548 (2021)
Genome editing for Duchenne muscular dystrophy: A glimpse of the future?
2021 Review in Basic Research in Cardiology Basic Res. Cardiol. 116:2 (2021)
DGK and DZHK position paper on genome editing: Basic science applications and future perspective.
2021 Scientific Article in Molecular Metabolism Mol. Metab. 45:101147 (2021)
Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis.
2021 Scientific Article in Experimental Eye Research Exp. Eye Res. 204:108432 (2021)
Ionising radiation causes vision impairment in neonatal B6C3F1 mice.
2021 Scientific Article in International Journal of Radiation Biology Int. J. Radiat. Biol. 97, 529-540 (2021)
Posterior subcapsular cataracts are a late effect after acute exposure to 0.5 Gy ionizing radiation in mice.
2021 Scientific Article in Blood Blood 137, 1932-1944 (2021)
Mammalian VPS45 orchestrates trafficking through the endosomal system.
2021 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 28, 143–151 (2021)
Imbalances in the eye lens proteome are linked to cataract formation.
2021 Scientific Article in PLoS Genetics PLoS Genet. 16:e1009190 (2021)
Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.
2021 Scientific Article in Environment International Environ. Int. 146:106213 (2021)
Radiation-induced lens opacities: Epidemiological, clinical and experimental evidence, methodological issues, research gaps and strategy.
2021 Scientific Article in International Journal of Radiation Biology Int. J. Radiat. Biol. 97, 156-169 (2021)
Dose-dependent long-term effects of a single radiation event on behaviour and glial cells.
2021 Scientific Article in Cell Stem Cell Cell Stem Cell 28, 524-534.e7 (2021)
CRISPR-mediated induction of neuron-enriched mitochondrial proteins boosts direct glia-to-neuron conversion.
2021 Scientific Article in Brain and behavior Brain Behav. 11:e01928 (2021)
Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans.
2020 Scientific Article in International Journal of Molecular Sciences Int. J. Mol. Sci. 21:9569 (2020)
Application of WES towards molecular investigation of congenital cataracts: Identification of novel alleles and genes in a hospital-based cohort of South India.
2020 Scientific Article in Physical Chemistry, Chemical Physics Phys. Chem. Chem. Phys. 22, 26728-26741 (2020)
Structural perspective on revealing heat dissipation behavior of CoFe2O4-Pd nanohybrids: Great promise for magnetic fluid hyperthermia.
2020 Scientific Article in iScience iScience 23:101797 (2020)
Human dopaminergic neurons lacking PINK1 exhibit disrupted dopamine metabolism related to vitamin B6 co-factors.
2020 Scientific Article in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 8:587778 (2020)
Dose-dependent and subset-specific regulation of midbrain dopaminergic neuron differentiation by LEF1-mediated WNT1/b-catenin signaling.
2020 Scientific Article in Science Translational Medicine Sci. Transl. Med. 12:eaau3960 (2020)
A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease.
2020 Scientific Article in EMBO Journal, The EMBO J. 39:e104472 (2020)
β-catenin signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons.
2020 Scientific Article in Molecular Neurodegeneration Mol. Neurodegener. 15:52 (2020)
The Alzheimer's disease-associated protective Plc gamma 2-P522R variant promotes immune functions.
2020 Scientific Article in EMBO Reports EMBO Rep. 21:e50241 (2020)
Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.
2020 Scientific Article in Cancer Research Cancer Res. 80, 5231-5244 (2020)
Phosphorylation control of p53 DNA binding cooperativity balances tumorigensis and aging.
2020 Scientific Article in Ophthalmic Genetics Ophthalmic Genet. 41, 556-562 (2020)
A novel CRYGC E128* mutation underlying an autosomal dominant nuclear cataract in a south Indian kindred.
2020 Scientific Article in Journal of Clinical Investigation J. Clin. Invest. 130, 6093-6108 (2020)
Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity.
2020 Scientific Article in Neuroscience Letters Neurosci. Lett. 735:135206 (2020)
Physiological relevance of the neuronal isoform of inositol-1,4,5-trisphosphate 3-kinases in mice.
2020 Review in Biomolecules Biomolecules 10:966 (2020)
Encapsulins-bacterial protein nanocompartments: Structure, properties, and application.
2020 Scientific Article in Translational Psychiatry Transl. Psychiatry 10:113 (2020)
Polymorphisms in CRYBB2 encoding βB2-crystallin are associated with antisaccade performance and memory function.
2020 Scientific Article in Cell Reports Cell Rep. 30, 3506-3519.e6 (2020)
The FTLD risk factor TMEM106B regulates the transport of lysosomes at the axon initial segment of motoneurons.
2020 Scientific Article in Cell Death & Disease Cell Death Dis. 11:84 (2020)
Alpha-synuclein fragments trigger distinct aggregation pathways.
2020 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 27, 210-220 (2020)
Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics.
2020 Scientific Article in Mammalian Genome Mamm. Genome 31, 30-48 (2020)
A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes.
2020 Scientific Article in Genes and Development Genes Dev. 34, 715-729 (2020)
The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs.
2020 Scientific Article in Nature medicine Nat. Med. 26, 207-214 (2020)
Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy.
2020 Scientific Article in Nature Communications Nat. Commun. 11:655 (2020)
Human and mouse essentiality screens as a resource for disease gene discovery.
2020 Scientific Article in Translational Psychiatry Transl. Psychiatry 10:66 (2020)
A truncating Aspm allele leads to a complex cognitive phenotype and region-specific reductions in parvalbuminergic neurons.
2020 Review in Genome Biology Genome Biol. 21:18 (2020)
The deep genome project.
2020 Scientific Article in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 61:44 (2020)
Mutation in Bmpr1b leads to optic disc coloboma and ventral retinal gliosis in mice.
2020 Nature Structural & Molecular Biology Nat. Struct. Mol. Biol., DOI: 10.1038/s41594-020-0395-7 (2020)
Publisher Correction: Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics (Nature Structural & Molecular Biology, (2020), 27, 2, (210-220), 10.1038/s41594-019-0370-3).
2020 Scientific Article in Scientific Reports Sci. Rep. 10:1984 (2020)
Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis.
2020 Scientific Article in FASEB Journal FASEB J. 34, 2465-2482 (2020)
Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1.
2020 Scientific Article in Applied Microbiology and Biotechnology Appl. Microbiol. Biotechnol. 104, 131-144 (2020)
Factors determining microbial colonization of liquid nitrogen storage tanks used for archiving biological samples.
2020 Scientific Article in Biochimica et Biophysica Acta - Molecular Basis of Disease Biochim. Biophys. Acta-Mol. Basis Dis. 1866:165622 (2020)
In-depth phenotyping reveals common and novel disease symptoms in a hemizygous knock-in mouse model (Mut-ko/ki) of mut-type methylmalonic aciduria.
2020 Scientific Article in Experimental Eye Research Exp. Eye Res. 190:107871 (2020)
Spectral domain - Optical coherence tomography (SD-OCT) as a monitoring tool for alterations in mouse lenses.
2020 Scientific Article in Journal of Proteome Research J. Proteome Res. 19, 337-345 (2020)
Creb signaling mediates dose-dependent radiation response in the murine hippocampus two years after total body exposure.
2020 Scientific Article in Bioinformatics Bioinformatics 36, 1492-1500 (2020)
Soft windowing application to improve analysis of high-throughput phenotyping data.
2020 Scientific Article in Haematologica - The Hematology Journal Haematologica 105, 937-950 (2020)
Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis.
2019 Meeting abstract in Acta Ophthalmologica Acta Ophthalmol. 97 (2019)
Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia.
2019 Meeting abstract in Acta Ophthalmologica Acta Ophthalmol. 97 (2019)
Cataract type in mouse exposed to moderate doses of ionizing radiation depends on mouse age at irradiation.
2019 Scientific Article in Scientific Reports Sci. Rep. 9:19483 (2019)
Dusp8 affects hippocampal size and behavior in mice and humans.
2019 Scientific Article in Nature Nature 575, 693-698 (2019)
FSP1 is a glutathione-independent ferroptosis suppressor.
2019 Review in Nature Chemical Biology Nat. Chem. Biol. 15, 1137-1147 (2019)
The chemical basis of ferroptosis.
2019 Meeting abstract in Acta Physiologica Acta Physiol. 227 (2019)
Constitutive activation of Jak1 leads to increased fibroblast growth factor 23 levels in mice.
2019 Scientific Article in Optics Express Opt. Express. 27, 31644-31666 (2019)
Artifact-free deconvolution in light field microscopy.
2019 Scientific Article in Proceedings of SPIE Proc. SPIE 11077 (2019)
In vivo hybrid microscopy of small model organisms.
2019 Meeting abstract in Transplant international Transpl. Int. 32, 15-15 (2019)
Role of ferroptosis and ischemia reperfusion injury in liver transplantations.
2019 Meeting abstract in Transplant international Transpl. Int. 32, 45-46 (2019)
Activation of innate immune cells by ferroptosis in hepatic ischemia reperfusion injury.
2019 Meeting abstract in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 60 (2019)
Identification of ocular regulatory functions of core histone variant H3.2 in mouse.
2019 Scientific Article in Development / Company of Biologists Development 146:dev181750 (2019)
Muscle-selective RUNX3 dependence of sensorimotor circuit development.
2019 Meeting abstract in European Journal of Human Genetics Eur. J. Hum. Genet. 27, 818-819 (2019)
A homozygous two exon deletion in UQCRH: Matching mouse and human phenotype.
2019 Scientific Article in BioSpektrum BioSpektrum 25, 614-616 (2019)
Ferroptose: Tod durch Eisenabhängige Lipidperoxidation.
2019 Scientific Article in European Journal of Cell Biology Eur. J. Cell Biol. 98:151046 (2019)
CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells.
2019 Scientific Article in Brain Research Brain Res. 1725:146468 (2019)
The alpha- and beta-noradrenergic receptors blockade in the dorsal raphe nucleus impairs the panic-like response elaborated by medial hypothalamus neurons.
2019 Scientific Article in Nature Neuroscience Nat. Neurosci. 22, 1731-1742 (2019)
Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity.
2019 Scientific Article in Fluids and barriers of the CNS Fluids barriers CNS 16:30 (2019)
Claudin-12 is not required for blood-brain barrier tight junction function.
2019Poster: European Radiation Protection Week (ERPW) 2019, 14-18 October 201914-18 October 2019, Stockholm, Sweden. (2019)
Cataract development after gamma irradiation in mice
2019 Scientific Article in ACS Nano ACS Nano 13, 8114-8123 (2019)
Iron-sequestering nanocompartments as multiplexed Electron Microscopy gene reporters.
2019 Scientific Article in Journal of Experimental Medicine J. Exp. Med. 216, 1700-1723 (2019)
Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3.
2019 Scientific Article in Journal of Cell Science J. Cell Sci. 132:jcs225946 (2019)
VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle.
2019 Scientific Article in Journal of Inherited Metabolic Disease J. Inherit. Metab. Dis. 42, 839-849 (2019)
Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase deficiency.
2019 Review in Nature Reviews - Cancer Nat. Rev. Cancer 19, 405-414 (2019)
Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion.
2019Vortrag: EVER-Meeting 2019, 17-19 October 2019, Nizza. (2019)
Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia.
2019 Scientific Article in Experimental Eye Research Exp. Eye Res. 188:107632 (2019)
Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia.
2019 Scientific Article in EMBO Journal, The EMBO J. 38:e100730 (2019)
A protein quality control pathway regulated by linear ubiquitination.
2019 Review in Human Genetics Hum. Genet. 138, 1007-1018 (2019)
Mouse models for microphthalmia, anophthalmia and cataracts.
2019 Scientific Article in Frontiers in Molecular Neuroscience Front. Mol. Neurosci. 12:40 (2019)
Mitochondrial dysfunction in astrocytes impairs the generation of reactive astrocytes and enhances neuronal cell death in the cortex upon photothrombotic lesion.
2019 Scientific Article in Scientific Reports Sci. Rep. 9:4515 (2019)
The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4.
2019 Communications Biology Comm. Biol. 2:97 (2019)
Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts (Communications Biology, (2018), 1, 1, (236), 10.1038/s42003-018-0226-0).
2019 Scientific Article in Environmental Science and Pollution Research Environ. Sci. Pollut. Res. 26, 8779-8788 (2019)
Evidence of non-DDD pathway in the anaerobic degradation of DDT in tropical soil.
2019 Other: Opinion in Cell Research Cell Res. 29, 263-264 (2019)
Broken hearts: Iron overload, ferroptosis and cardiomyopathy.
2019 Scientific Article in ACS sensors ACS sens. 4, 603-612 (2019)
Whole-cell photoacoustic sensor based on pigment relocalization.
2019 Scientific Article in Neuropharmacology Neuropharmacol. 149, 13-26 (2019)
Multiple molecular pathways stimulating macroautophagy protect from alpha-synuclein-induced toxicity in human neurons.
2019 Scientific Article in Journal of Medicinal Chemistry J. Med. Chem. 62, 266-275 (2019)
Novel allosteric activators for ferroptosis regulator glutathione peroxidase 4.
2019 Scientific Article in Molecular Neurobiology Mol. Neurobiol. 56, 4215-4230 (2019)
Crybb2 mutations consistently affect Schizophrenia endophenotypes in mice.
2019 Scientific Article in European Journal of Immunology Eur. J. Immunol. 49, 121-132 (2019)
miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1.
2019 Review in Free Radical Biology and Medicine Free Radical Biol. Med. 133, 144-152 (2019)
Role of GPX4 in ferroptosis and its pharmacological implication.
2019 Review in Cell Death and Differentiation Cell Death Differ. 26, 14-24 (2019)
Ferroptosis and necroinflammation, a yet poorly explored link.
2018 Meeting abstract in Acta Ophthalmologica Acta Ophthalmol. 96, 4-4 (2018)
Animal case.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2018, 124 S.
Direct conversion of somatic cells utilizing CRISPR/Cas9.
2018 Scientific Article in Journal of Visualized Experiments J. Vis. Exp. 142:e58556 (2018)
A customizable protocol for string assembly gRNA cloning (STAgR).
2018 Scientific Article in Journal of the American Chemical Society J. Am. Chem. Soc. 140, 17835-17839 (2018)
Empowerment of 15-lipoxygenase catalytic competence in selective oxidation of membrane ETE-PE to ferroptotic death signals, HpETE-PE.
2018 Scientific Article in Communications Biology Comm. Biol. 1:236 (2018)
Identification of genes required for eye development by high-throughput screening of mouse knockouts.
2018 Scientific Article in Biochimica et Biophysica Acta - Molecular Basis of Disease Biochim. Biophys. Acta-Mol. Basis Dis. 1865, 2083-2093 (2018)
A mouse model for intellectual disability caused by mutations in the X-linked 2 '-O-methyltransferase Ftsj1 gene.
2018 Scientific Article in Cell Reports Cell Rep. 25, 3241-3251.e5 (2018)
The aryl hydrocarbon receptor pathway defines the time frame for restorative neurogenesis.
2018 Meeting abstract in Transplant international Transpl. Int. 31, 10-10 (2018)
Innate immune cells are activated by regulated cell death events in early hepatic ischemia reperfusion injury.
2018 Meeting abstract in Swiss Medical Weekly Swiss Med. Wkly. 148, 8S-8S (2018)
The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell but not B-cell metabolic reprogramming and proliferation.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:16196 (2018)
Phosphorylation of the neurogenic transcription factor SOX11 on serine 133 modulates neuronal morphogenesis.
2018 Meeting abstract in Transplantation Transplantation 102, S713-S713 (2018)
Targeting innate immune cells and regulated cell death in early hepatic ischemia reperfusion injury.
2018 Scientific Article in Molecular Neurodegeneration Mol. Neurodegener. 13:49 (2018)
The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.
2018 Scientific Article in Neuron Neuron 99, 1188-1203.e6 (2018)
FoxO function is essential for maintenance of autophagic flux and neuronal morphogenesis in adult neurogenesis.
2018 Scientific Article in Nature microbiology Nat. Microbiol. 3, 1161–1174 (2018)
Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood.
2018 Scientific Article in Biochemical and Biophysical Research Communications Biochem. Biophys. Res. Commun. 503, 2770-2777 (2018)
The heterozygous R155C VCP mutation: Toxic in humans! Harmless in mice?
2018 Scientific Article in Nature Communications Nat. Commun. 9:2929 (2018)
Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:11335 (2018)
Streptozotocin-induced beta-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain.
2018 Scientific Article in Current Protocols of Mouse Biology Curr. Protoc. Mouse Biol. 8, 79-128 (2018)
Analysis of neuropsychiatric disease-related functional neuroanatomical markers in mice.
2018 Scientific Article in Cell Death & Disease Cell Death Dis. 9:757 (2018)
Exosomal secretion of alpha-synuclein as protective mechanism after upstream blockage of macroautophagy.
2018 Nature Communications Nat. Commun. 9:2859 (2018)
Author Correction: Zebrafish and medaka offer insights into the neurobehavioral correlates of vertebrate magnetoreception (Nature Communications DOI: 10.1038/s41467-018-03090-6).
2018 Meeting abstract in Science Science 120, S7-S7 (2018)
Molecular underpinnings controlling ferroptotic cell death.
2018 Scientific Article in Journal of Clinical Investigation J. Clin. Invest. 128, 3341-3355 (2018)
Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma.
2018 Editorial in OncoTarget Oncotarget 9, 22241-22242 (2018)
Selenium and iron, two elemental rivals in the ferroptotic death process.
2018 Review in Genes and Development Genes Dev. 32, 602-619 (2018)
Regulation of lipid peroxidation and ferroptosis in diverse species.
2018 Scientific Article in PLoS Pathogens PLoS Pathog. 14:e1007026 (2018)
Peroxidasin contributes to lung host defense by direct binding and killing of gram-negative bacteria.
2018 Review in Frontiers in Neuroscience Front. Neurosci. 12:214 (2018)
Oxytosis/ferroptosis-(Re-) emerging roles for oxidative stress-dependent non-apoptotic cell death in diseases of the central nervous system. .
2018 Scientific Article in Nature Neuroscience Nat. Neurosci. 21, 803-807 (2018)
Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety.
2018 Review in Free Radical Biology and Medicine Free Radical Biol. Med. 127, 153-159 (2018)
Selenium and GPX4, a vital symbiosis.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:8097 (2018)
TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons.
2018 Editorial in ACS central science ACS Cent. Sci. 4, 312-314 (2018)
Lipoxygenases-killers against their will?
2018 Scientific Article in Nature Communications Nat. Commun. 9:1851 (2018)
The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation.
2018 Scientific Article in Biochemical and Biophysical Research Communications Biochem. Biophys. Res. Commun. 503, 123-130 (2018)
Crybb2 associates with Tmsb4X and is crucial for dendrite morphogenesis.
2018 Scientific Article in Chemical Communications Chem. Commun. 54, 5426-5429 (2018)
hIAPP forms toxic oligomers in plasma.
2018 Scientific Article in Nature Communications Nat. Commun. 9:1990 (2018)
Bacterial encapsulins as orthogonal compartments for mammalian cell engineering.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2018, 160 S.
Identification of Sox2 as a key regulator of cell-matrix adhesion in Schwann cells.
2018 Scientific Article in Journal of the American Chemical Society J. Am. Chem. Soc. 140, 4712-4720 (2018)
Quantitative profiling of protein carbonylations in ferroptosis by an aniline-derived probe.
2018 Scientific Article in PLoS Biology PLoS Biol. 16:e2005019 (2018)
Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data.
2018 Scientific Article in Frontiers in Immunology Front. Immunol. 9:587 (2018)
RNase H2 loss in murine astrocytes results in cellular defects reminiscent of nucleic acid-mediated autoinflammation.
2018Poster: Federation of European Neuroscience Societies Forum, 7-11 July 2018, Berlin. (2018)
Identifying underlying mechanisms of voluntary activity by mining large data sets of genetically modified mouse lines.
2018 Scientific Article in BMC Developmental Biology BMC Dev. Biol. 18:3 (2018)
Expression and function of microRNA-9 in the mid-hindbrain area of embryonic chick.
2018 Review in Cell Death and Differentiation Cell Death Differ. 25, 486-541 (2018)
Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018.
2018 Scientific Article in Advanced functional materials Adv. Func. Mat. 28:1706793 (2018)
Genetically controlled lysosomal entrapment of superparamagnetic ferritin for multimodal and multiscale imaging and actuation with low tissue attenuation.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:968 (2018)
The ferroptosis inducer erastin irreversibly inhibits system xc- and synergizes with cisplatin to increase cisplatin's cytotoxicity in cancer cells.
2018 Scientific Article in Nature Communications Nat. Commun. 9:288 (2018)
Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
2018 Scientific Article in Nature Communications Nat. Commun. 9:802 (2018)
Zebrafish and medaka offer insights into the neurobehavioral correlates of vertebrate magnetoreception.
2018 Scientific Article in Radiation and Environmental Biophysics Radiat. Environ. Biophys. 57, 99-113 (2018)
Lifetime study in mice after acute low-dose ionizing radiation: A multifactorial study with special focus on cataract risk.
2018 Scientific Article in Journal of Chromatography A J. Chromatogr. A 1534, 85-92 (2018)
Determination of thyroid hormones in placenta using isotope-dilution liquid chromatography quadrupole time-of-flight mass spectrometry.
2018 Scientific Article in Cell Cell 172, 409–422.e21 (2018)
Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis.
2018 Scientific Article in Glia Glia 66, 413-427 (2018)
Synthetic AAV/CRISPR vectors for blocking HIV-1 expression in persistently infected astrocytes.
2018 Redox Biology Redox Biol. 14, 694-696 (2018)
European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) (vol 13, pg 94, 2017).
2018 Scientific Article in Journal of the American Chemical Society J. Am. Chem. Soc. 140, 2718-2721 (2018)
Calcium sensor for photoacoustic imaging.
2018 Scientific Article in Molecular Psychiatry Mol. Psychiatry 23, 533-543 (2018)
Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood.
2017 Meeting abstract in Toxicology Letters Toxicol. Lett. 280, S305-S305 (2017)
On importance of pathophysiology for an integrative toxicology.
2017 Nature Nature 551, 398 (2017)
Corrigendum: High-throughput discovery of novel developmental phenotypes.
2017 Neuron Neuron 93, 1518 (2017)
Role of mitochondrial metabolism in the control of early lineage progression and aging phenotypes in adult hippocampal neurogenesis.
2017 Scientific Article in Current Protocols of Mouse Biology Curr. Protoc. Mouse Biol. 7, 287-305 (2017)
Assessing sociability, social memory, and pup retrieval in mice.
2017 Scientific Article in Journal of Neuroscience J. Neurosci. 37, 11688-11700 (2017)
Heterozygosity for the mood disorder-associated variant Gln460Arg alters P2X7 receptor function and sleep quality.
2017 Meeting abstract 112, 9-9 (2017)
In vivo relevance of ferroptotic cell death.
2017 Meeting abstract in Free Radical Biology and Medicine Free Radical Biol. Med. 112, 24-24 (2017)
Selenium utilization by GPX4 was an evolutionary requirement to prevent hydroperoxide-induced ferroptosis.
2017 Scientific Article in BMC Genomics BMC Genomics 18:905 (2017)
ENCoRE: An efficient software for CRISPR screens identifies new players in extrinsic apoptosis.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:15453 (2017)
Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema.
2017 Meeting abstract in Transplant international Transpl. Int. 30, 365-365 (2017)
Interaction of innate immune cells and regulated cell death in early hepatic ischemia reperfusion injury.
2017 Scientific Article in Nature Communications Nat. Commun. 8:886 (2017)
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.
2017 Scientific Article in Cell Cell 171, 273-285 (2017)
Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease.
2017 Scientific Article in Nature Methods Nat. Methods 14, 1079-1082 (2017)
NeuBtracker-imaging neurobehavioral dynamics in freely behaving fish.
2017 Scientific Article in Behavioural Brain Research Behav. Brain Res. 352, 187-196 (2017)
Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic.
2017 Scientific Article in Drug discovery today Drug Discov. Today, DOI: 10.1016/j.ddmod.2017.08.002 (2017)
Genome wide conditional mouse knockout resources.
2017 Scientific Article in Oxidative medicine and cellular longevity Oxid. Med. Cell. Longev. 2017:8325754 (2017)
Modulation of glutathione hemostasis by inhibition of 12/15-lipoxygenase prevents ROS-mediated cell death after hepatic ischemia and reperfusion.
2017 Scientific Article in Journal of Biomedical Science J. Biomed. Sci. 24:57 (2017)
Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1I27N mutant mice.
2017 Scientific Article in Mammalian Genome Mamm. Genome 28, 262-274 (2017)
Control of gene editing by manipulation of DNA repair mechanisms.
2017 Meeting abstract in FASEB Journal FASEB J. 31, 1:946.3 (2017)
Tocopherols and tocotrienols prevent lipoxygenase-driven phospholipid oxidation in ferroptosis.
2017 Scientific Article in Nature Communications Nat. Commun. 8:155 (2017)
Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2017, 162 S.
The role of Glypican 4 during mouse brain development.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 1231-1238 (2017)
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.
2017 Scientific Article in Disease Models and Mechanisms Dis. Model. Mech. 10, 981-991 (2017)
Meis1 effects on motor phenotypes and the sensorimotor system in mice.
2017 Scientific Article in Methods Methods 121-122, 55-67 (2017)
Gene editing in mouse zygotes using the CRISPR/Cas9 system.
2017 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 45, 3102-3115 (2017)
Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts.
2017 Meeting abstract in Haematologica - The Hematology Journal Haematologica 102, 333-333 (2017)
Lack of the ferroptosis inhibitor GPX4 in erythroid cells causes a block in reticulocyte maturation and a hypoxic signature with impaired hepcidin regulation.
2017 Meeting abstract in Glia Poster: (2017)
Mitochondrial function in Pink1 deficient astrocytes.
2017 Scientific Article in Molecular Neurobiology Mol. Neurobiol. 55, 4580–4595 (2017)
Fgf9Y162C mutation alters information processing and social memory in mice.
2017 Scientific Article in Biochimica et Biophysica Acta Biochim. Biophys. Acta 1863, 2220-2228 (2017)
Elevated glutaric acid levels in Dhtkd1-/Gcdh- double knockout mice challenge our current understanding of lysine metabolism.
2017 Review in Redox Biology Redox Biol. 13, 94-162 (2017)
European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).
2017 Scientific Article in Neurobiology of Disease Neurobiol. Dis. 105, 179-193 (2017)
The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson's disease in the mouse.
2017 Scientific Article in EMBO Reports EMBO Rep. 18, 1186-1198 (2017)
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.
2017 Scientific Article in Methods Methods 121-122, 29-44 (2017)
Gene editing and clonal isolation of human induced pluripotent stem cells using CRISPR/Cas9.
2017 Scientific Article in Antioxidants & Redox Signaling Antioxid. Redox Signal. 29, 61-74 (2017)
GPx4, lipid peroxidation, and cell death: Discoveries, rediscoveries, and open issues.
2017 Scientific Article in ACS central science ACS Cent. Sci. 3, 232-243 (2017)
On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death.
2017 Scientific Article in EMBO Journal, The EMBO J., DOI: 10.15252/embj.201796516 (2017)
The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.
2017 Review in Trends in Pharmacological Sciences Trends Pharmacol. Sci. 38, 489-498 (2017)
Ferroptosis inhibition: Mechanisms and opportunities.
2017 Scientific Article in Neuroscience Neuroscience 357, 241-254 (2017)
Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency.
2017 Review in IUBMB Life IUBMB Life 69, 423-434 (2017)
Iron and ferroptosis: A still ill-defined liaison.
2017 Scientific Article in Acta Neuropathologica Acta Neuropathol. 134, 241–254 (2017)
Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss.
2017 Scientific Article in Journal of Neuroscience Methods J. Neurosci. Methods, DOI: 10.1016/j.jneumeth.2017.05.005 (2017)
Analysis of locomotor behavior in the German Mouse Clinic.
2017 Scientific Article in Molecular Psychiatry Mol. Psychiatry 23, 1345-1355 (2017)
A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice.
2017 Scientific Article in OncoTarget Oncotarget 8, 17428-17442 (2017)
Cytosolic Hsp90a and its mitochondrial isoform Trap1 are differentially required in a breast cancer model.
2017 Scientific Article in BioSpektrum BioSpektrum 23, 138-141 (2017)
Verhaltensphänotypisierung von Mäusen.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:44041 (2017)
The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.
2017 Scientific Article in Neuron Neuron 93, 560-573.e6 (2017)
Role of mitochondrial metabolism in the control of early lineage progression and aging phenotypes in adult hippocampal neurogenesis.
2017 Scientific Article in Disease Models and Mechanisms Dis. Model. Mech. 10, 163-171 (2017)
Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology.
2017 Scientific Article in Nature Chemical Biology Nat. Chem. Biol. 13, 81-90 (2017)
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.
2017 Scientific Article in Molecular and Cellular Biology Mol. Cell. Biol. 37:e00522-16 (2017)
The chromatin associated Phf12 protein maintains nucleolar integrity and prevents premature cellular senescence.
2017 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 45, 3031-3045 (2017)
Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation.
2017 Scientific Article in Purinergic Signalling Purinergic Signal. 13, 153–170 (2017)
Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice.
2017 Scientific Article in Age and Ageing Age Ageing 46, 481-486 (2017)
Common eye diseases in older adults of Southern Germany: Results from the KORA-Age Study.
2017 Scientific Article in Nature Chemical Biology Nat. Chem. Biol. 13, 91-98 (2017)
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition.
2017 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 1493, 443-466 (2017)
Characterizing semaphorin-mediated effects on sensory and motor axon pathfinding and connectivity during embryonic development.
2017 Scientific Article in Plant, Cell and Environment Plant Cell Environ. 40, 36-50 (2017)
Nitric oxide-fixation by non-symbiotic hemoglobin proteins in Arabidopsis thaliana under N-limited conditions.
2017 Scientific Article in Experimental Eye Research Exp. Eye Res. 156, 5-9 (2017)
From eyeless to neurological diseases.
2016 Editorial in Methods in Molecular Biology Methods Mol. Biol. 1338, v (2016)
Preface.
In: Selenium: Its Molecular Biology and Role in Human Health. 2016. 567-578 ( ; 5)
Mouse models that target individual selenoproteins.
In: Selenium: Its Molecular Biology and Role in Human Health. 2016. 511-521 ( ; 4)
Glutathione peroxidase 4 and ferroptosis.
2016 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 1338, 229-243 (2016)
Genome editing in mice using TALE nucleases.
2016 Scientific Article in Molecular Neurobiology Mol. Neurobiol. 54, 8242–8262 (2016)
Serum response factor (SRF) ablation interferes with acute stress-associated immediate and long-term coping mechanisms.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0167181 (2016)
Features of age-related macular degeneration in the general adults and their dependency on age, sex, and smoking: Results from the German KORA study.
2016 Scientific Article in Mutation Research / Reviews in Mutation Research Mutat. Res.- Rev. Mutat. Res. 770, 238-261 (2016)
Ionizing radiation induced cataracts: Recent biological and mechanistic developments and perspectives for future research.
2016 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 291, 24036-24040 (2016)
Selenoprotein gene nomenclature.
2016 Scientific Article in Genes Genomes Genetics G3 Genes Genomes Genetics G3 6, 4035-4046 (2016)
The first Scube3 mutant mouse line with pleiotropic phenotypic alterations.
2016 Scientific Article in Stem Cells Stem Cells, DOI: 10.1002/stem.2536 (2016)
p27kip1 is required for functionally relevant adult hippocampal neurogenesis in mice.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0164298 (2016)
Sphingomyelin synthase 1 is essential for male fertility in mice.
2016 Scientific Article in Development / Company of Biologists Development 143, 4279-4287 (2016)
Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons.
2016 Scientific Article in Nature Nanotechnology Nat. Nanotechnol. 11, 977-985 (2016)
Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth.
2016 Scientific Article in Journal of Chromatography J. Chromatogr. B 1033-1034, 413-420 (2016)
Determination of thyroid hormones in mouse tissues by isotope-dilution microflow liquid chromatography-mass spectrometry method.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2016, 133 S.
Genome engineering in mice using TALEN or CRISPR/Cas9 nucleases.
2016 Scientific Article in Mammalian Genome Mamm. Genome 27, 587-598 (2016)
Viable EdnraY129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation.
2016 Scientific Article in Nature Nature 537, 508-514 (2016)
High-throughput discovery of novel developmental phenotypes.
2016 Scientific Article in Diabetes Diabetes 65, 3776-3785 (2016)
Metformin effect on non-targeted metabolite profiles in patients with type 2 diabetes and multiple murine tissues.
2016 Scientific Article in Neuron Neuron 91, 1276-1291 (2016)
Dual function of NRP1 in axon guidance and subcellular target recognition in cerebellum.
2016 Scientific Article in Scientific Reports Sci. Rep. 6:32326 (2016)
CRISPR-Cas9 enables conditional mutagenesis of challenging loci.
2016 Scientific Article in Journal of Cell Science J. Cell Sci. 129, 3295-3308 (2016)
The role of Sema3-Npn-1 signaling during diaphragm innervation and muscle development.
2016 Scientific Article in Arteriosclerosis, Thrombosis, and Vascular Biology Arterioscler. Thromb. Vasc. Biol. 36, 1891-1899 (2016)
Endothelial dysfunction, and a prothrombotic, proinflammatory phenotype is caused by loss of mitochondrial thioredoxin reductase in endothelium.
2016 Scientific Article in Nature Nature 535, 299-302 (2016)
Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios.
2016 Scientific Article in Blood Blood 128, 1181-1192 (2016)
Identification of factors promoting ex vivo maintenance of mouse hematopoietic stem cells by long-term single-cell quantification.
2016 Scientific Article in Scientific Reports Sci. Rep. 6:28080 (2016)
Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness.
2016 Scientific Article in Proceedings of SPIE Proc. SPIE 9708:970825 (2016)
Imaging the distribution of photoswitchable probes with temporally-unmixed multispectral optoacoustic tomography.
2016 Review in Journal of Neurochemistry J. Neurochem. 139, 8-26 (2016)
Diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson's disease.
2016 Scientific Article in PLoS Genetics PLoS Genet. 12:e1006013 (2016)
Animal models are valid to uncover disease mechanisms.
2016 Nature Communications Nat. Commun. 7:11835 (2016)
Erratum: Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.
2016 Scientific Article in Redox Biology Redox Biol. 9, 22-31 (2016)
Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration.
2016 Scientific Article in Cell Metabolism Cell Metab. 23, 1185-1199 (2016)
CRFR1 in AgRP neurons modulates sympathetic nervous system activity to adapt to cold stress and fasting.
2016 Scientific Article in BioSpektrum BioSpektrum 22, 19-21 (2016)
Pax6: Funktionen entlang der rostro-kaudalen Achse des Neuralrohrs.
2016 Scientific Article in Hippocampus Hippocampus 26, 1250-1264 (2016)
Beware of your Cre-Ation: lacZ expression impairs neuronal integrity and hippocampus-dependent memory.
2016 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 291, 13147-13159 (2016)
Inhibition of proteasome activity induces formation of alternative proteasome complexes.
2016 Scientific Article in Nature Communications Nat. Commun. 7:11317 (2016)
Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.
2016 Meeting abstract in Acta Physiologica Acta Physiol. 216:P02-03 (2016)
Early and localized expression of ion channels and ion channel subunits in the developing mesodiencephalic dopaminergic domain of the mouse embryo.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0150472 (2016)
Generation and standardized, systemic phenotypic analysis of Pou3f3L423P mutant mice.
2016 Meeting abstract in American Journal of Hematology Am. J. Hematol. 91, E119 (2016)
Genetically controlled uptake of ferritin as an MRI contrast agent.
2016 Scientific Article in Journal of Breath Research J. Breath Res. 10:016009 (2016)
Diet-induced and mono-genetic obesity alter volatile organic compound signature in mice.
2016 Scientific Article in Neurobiology of Disease Neurobiol. Dis. 89, 112-125 (2016)
Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism.
2016 Review in Nature Reviews - Drug Discovery Nat. Rev. Drug Discov. 15, 348-366 (2016)
Regulated necrosis: Disease relevance and therapeutic opportunities.
2016 Scientific Article in PLoS Genetics PLoS Genet. 12:e1005800 (2016)
A glutathione-Nrf2-thioredoxin cross-talk ensures keratinocyte survival and efficient wound repair.
2016 Scientific Article in Development / Company of Biologists Development 143, 691-702 (2016)
Differences in the spatiotemporal expression and epistatic gene regulation of the mesodiencephalic dopaminergic precursor marker PITX3 during chicken and mouse development.
2016 Scientific Article in eLife eLife 5:e09584 (2016)
The REST remodeling complex protects genomic integrity during embryonic neurogenesis.
2016 Scientific Article in Cell Stem Cell Cell Stem Cell 18, 396-409 (2016)
Identification and successful negotiation of a metabolic checkpoint in direct neuronal repogramming.
2016 Scientific Article in Brain: A Journal of Neurology Brain 139, 346-354 (2016)
Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration.
2016 Scientific Article in Developmental Biology Dev. Biol. 413, 86-103 (2016)
Functional dissection of the Pax6 paired domain: Roles in neural tube patterning and peripheral nervous system development.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2015, 230 S.
Generation and analysis of FUS and TMEM106B mouse models.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2015, 347 S.
Genetic dissection of CRH-controlled neurocircuitries of stress.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2015, 184 S.
Translational Strategies to address Parkinson's disease.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2015, 90 S.
Examining the role of SoxC transcription factors in adult hippocampal neuronal differentiation.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2015, 193 S.
Genetically dissecting the role of CRHR2 and UCN2 in the control of emotional behavior.
2015 Scientific Article in Frontiers in Behavioral Neuroscience Front. Behav. Neurosci. 9:302 (2015)
Conditional reduction of adult born doublecortin-positive neurons reversibly impairs selective behaviors.
2015 Scientific Article in Current Protocols of Mouse Biology Curr. Protoc. Mouse Biol. 5, 291-301:doi: 10.1002/9780470942390.mo160 (2015)
Tests for anxiety-related behavior in mice.
2015 Scientific Article in Current Protocols of Mouse Biology Curr. Protoc. Mouse Biol. 5, 331-358:doi: 10.1002/9780470942390.mo160 (2015)
Assessing cognition in mice.
2015 Scientific Article in Frontiers in Behavioral Neuroscience Front. Behav. Neurosci. 9:302 (2015)
Conditional reduction of adult born doublecortin-positive neurons reversibly impairs selective behaviors.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2015, 188 S.
Establishment and cell biological analysis of neurodegeneration models in zebrafish based on Parkinson’s disease-linked genes LRRK2 and PINK1.
München, Ludwig-Maximilians-Universität, Medizinische Fakultät, Diss., 2015, 89 S.
Relevanz posttranslationaler Modifikation der Glutathionperoxidase 4 (Gpx4) in der Signaltransduktion sowie Identifizierung genetischer Polymorphismen der humanen GPX4 zur präferenziellen Ausbildung einer Delayed Graft Function (DGF).
2015, 155 S. (Zugl. München, Technische Universität, Diss., 2015)
Analysis of LRRK2 function in Parkinsons's disease etiology with focus on mitochondrial dysfunction.
2015 Scientific Article in Optics Letters Opt. Lett. 40, 4691-4694 (2015)
Light fluence normalization in turbid tissues via temporally unmixed multispectral optoacoustic tomography.
2015 Scientific Article in Mechanisms of Development Mech. Dev. 138, 300-304 (2015)
Volumetric tracking of migratory melanophores during zebrafish development by optoacoustic microscopy.
2015 Scientific Article in Journal of Neuroscience J. Neurosci. 35, 13385-13401 (2015)
Dickkopf3 promotes the differentiation of a rostrolateral midbrain dopaminergic neuronal subset in vivo and from pluripotent stem cells in vitro in the mouse.
2015 Scientific Article in BMC Neuroscience BMC Neurosci. 16:60 (2015)
RNA interference machinery-mediated gene regulation in mouse adult neural stem cells.
München, Ludwig-Maximilians-Universität, Medizinische Fakultät, Diss., 2015, 105 S.
Untersuchungen zur Rolle der Glutathion-Peroxidase 4 als möglicher Redox-Sensor in Säugetierzellen.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2015, 111 S.
Axonal wiring defects and critical period plasticity in the postnatal motor system.
2015 Scientific Article in Sleep Sleep 38, 1371-1380 (2015)
CACNA1C (Cav1.2) modulates electroencephalographic rhythm and rapid eye movement sleep recovery.
2015 Scientific Article in Chemical Communications Chem. Commun. 51, 15149-15152 (2015)
Wavelength-dependent optoacoustic imaging probes for NMDA receptor visualisation.
2015 Scientific Article in Mammalian Genome Mamm. Genome 26, 456-466 (2015)
Beyond knockouts: The International Knockout Mouse Consortium delivers modular and evolving tools for investigating mammalian genes.
2015 Scientific Article in Journal of Biomedical Optics J. Biomed. Opt. 20:96009 (2015)
Calcium neuroimaging in behaving zebrafish larvae using a turn-key light field camera.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0136768 (2015)
Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) clustering with MAGUKs is mediated via its C-terminal PDZ binding motif.
2015 Scientific Article in Brain Structure & Function Brain Struct. Funct. 221, 3095-3109 (2015)
Fgf15 regulates thalamic development by controlling the expression of proneural genes.
2015 Meeting abstract in European Neuropsychopharmacology : ENP Eur. Neuropsychopharmacol. 25, S8-S9 (2015)
Clustering of corticotropin-releasing hormone receptor type 1 with membrane-associated guanylate kinases.
2015 Scientific Article in Development / Company of Biologists Development 142, 3009-3020 (2015)
Meis1 coordinates a network of genes implicated in eye development and microphthalmia.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005423 (2015)
SLIRP regulates the rate of mitochondrial protein synthesis and protects LRPPRC from degradation.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 969-978 (2015)
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.
2015 Meeting abstract in Glia Glia 63, E297-E298 (2015)
Mitochondrial dysfunction mimics the impact of ageing on hippocampal neurogenesis.
2015 Scientific Article in Genome Research Genome Res. 25, 1295-1308 (2015)
Functional compensation among HMGN variants modulates the DNase I hypersensitive sites at enhancers.
2015 Scientific Article in Human Gene Therapy : Methods Hum. Gene Ther. Methods 26, 107-122 (2015)
Limitations of in vivo reprogramming to dopaminergic neurons via a tricistronic strategy.
2015 Scientific Article in Scientific Reports Sci. Rep. 5:11048 (2015)
Violacein as a genetically-controlled, enzymatically amplified and photobleaching-resistant chromophore for optoacoustic bacterial imaging.
2015 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 43, 6450-6458 (2015)
Development of an intein-mediated split-Cas9 system for gene therapy.
2015 Scientific Article in Neuron Neuron 86, 1189-1202 (2015)
Genetic differences in the immediate transcriptome response to stress predict risk-related brain function and psychiatric disorders.
2015 Scientific Article in Developmental Cell Dev. Cell 33, 644-659 (2015)
MIM-induced membrane bending promotes dendritic spine initiation.
2015 Scientific Article in Neurobiology of Disease Neurobiol. Dis. 82, 32-45 (2015)
A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1+/- mice.
Hamburg: Kovac Verlag, 2015, 234 S. (Zugl. München, Technische Universität, Diss., 2015) (HIPPOKRATES ; 94)
Pharmacological and dietary interventions for the treatment of diabetes in mouse models.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0127681 (2015)
Hairy/enhancer-of-split MEGANE and proneural MASH1 factors cooperate synergistically in midbrain GABAergic neurogenesis.
2015 Scientific Article in Molecular & Cellular Oncology Mol. Cell. Oncol. 2:e995047 (2015)
Glutathione peroxidase 4 (Gpx4) and ferroptosis: What's so special about it?
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0125304 (2015)
New mutation in the mouse Xpd/Ercc2 gene leads to recessive cataracts.
2015 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 290, 14668-14678 (2015)
Expression of a catalytically inactive mutant form of Glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0123643 (2015)
A critical period for postnatal adaptive plasticity in a model of motor axon miswiring.
2015 Scientific Article in Free Radical Biology and Medicine Free Radical Biol. Med. 84, 246-253 (2015)
The antioxidant requirement for plasma membrane repair in skeletal muscle.
2015 Scientific Article in Acta Ophthalmologica Acta Ophthalmol. 93, e499–e506 (2015)
Morphological and proliferative studies on ex vivo cultured human anterior lens epithelial cells - relevance to capsular opacification.
2015 Review in Biological Chemistry Biol. Chem. 396, 465-482 (2015)
Thiol switches in mitochondria: Operation and physiological relevance.
2015 Scientific Article in Antioxidants & Redox Signaling Antioxid. Redox Signal. 22, 938-950 (2015)
Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis.
2015 Scientific Article in Journal of Experimental Medicine J. Exp. Med. 212, 555-568 (2015)
T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.
2015 Scientific Article in Nature Communications Nat. Commun. 6:6669 (2015)
Orphan receptor IL-17RD regulates toll-like receptor signalling via SEFIR/TIR interactions.
2015 Scientific Article in Nature Biotechnology Nat. Biotechnol. 33, 543-548 (2015)
Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.
2015 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 290, 8778-8788 (2015)
Cystathionine is a novel substrate of cystine/glutamate transporter: Implications for immune function.
2015 Scientific Article in Circulation Circulation 131, 1191-1201 (2015)
ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling via cleavage of thrombospondin-1.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0118505 (2015)
Engrailed 1 mediates correct formation of limb innervation through two distinct mechanisms.
2015 Scientific Article in Optics Letters Opt. Lett. 40, 367-370 (2015)
High-contrast imaging of reversibly switchable fluorescent proteins via temporally unmixed multispectral optoacoustic tomography.
2015 Scientific Article in Antioxidants & Redox Signaling Antioxid. Redox Signal. 22, 1667-1680 (2015)
Cardiolipin signaling mechanisms: Collapse of asymmetry and oxidation.
2015 Scientific Article in Nature Neuroscience Nat. Neurosci. 18, 239-251 (2015)
Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition.
2015 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 24, 2247-2266 (2015)
MTO1 mediates tissue-specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention.
2015 Scientific Article in Development / Company of Biologists Development 142, 31-40 (2015)
Mga is essential for the survival of pluripotent cells during peri-implantation development.
2015 Scientific Article in FEBS Open Bio FEBS Open Bio 5, 26-35 (2015)
Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos.
2015 Scientific Article in Developmental Biology Dev. Biol. 398, 280-291 (2015)
Ascl1 and Helt act combinatorially to specify thalamic neuronal identity by repressing Dlxs activation.
2015 Scientific Article in Developmental Biology Dev. Biol. 399, 2-14 (2015)
Loss of Npn1 from motor neurons causes postnatal deficits independent from Sema3A signaling.
2015 Scientific Article in Neuroscience Neuroscience 285, 11-23 (2015)
Neurotransmitter receptor density changes in Pitx3AK mice - a model relevant to Parkinson's disease.
2015 Review in Biochimica et Biophysica Acta - General Subjects Biochim. Biophys. Acta-Gen. Subj. 1850, 1566-1574 (2015)
ROS, thiols and thiol-regulating systems in male gametogenesis.
2015 Scientific Article in Journal of Nutritional Biochemistry, The J. Nutr. Biochem. 26, 75-81 (2015)
The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice.
2015 Scientific Article in Mammalian Genome Mamm. Genome 26, 33-42 (2015)
Generation of mice lacking DUF1220 protein domains: Effects on fecundity and hyperactivity.
2015 Scientific Article in Journal of Autoimmunity J. Autoimmun. 56, 34-44 (2015)
Neutralizing IL-17 protects the optic nerve from autoimmune pathology and prevents retinal nerve fiber layer atrophy during experimental autoimmune encephalomyelitis.
2015 Scientific Article in Diabetes Diabetes 64, 284-290 (2015)
Metformin supports the antidiabetic effect of a sodium glucose cotransporter 2 inhibitor by suppressing endogenous glucose production in diabetic mice.
2015 Review in Cell and Tissue Research Cell Tissue Res. 359, 161-177 (2015)
The conserved miR-8/miR-200 microRNA family and their role in invertebrate and vertebrate neurogenesis.
2015 Scientific Article in Oncogene Oncogene 34, 1363-1374 (2015)
The Parkinson's gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes.
2014 Meeting abstract in Free Radical Biology and Medicine Free Radical Biol. Med. 76, S77-S78 (2014)
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in a therapeutically relevant mechanism.
München, Technische Universität, Diss., 2014, 188 S.
Die Rolle des Wnt/ß-Catenin-Signalweges bei der Entwicklung meso-diencephalisch dopaminerger Neuronen.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2014, 109 S.
Role of Sp transcription factors in adult neurogenesis.
2014 Meeting abstract in Purinergic Signalling Purinergic Signal. 10, 718 (2014)
P2RX7-a susceptibility gene for mood disorders?
2014 Scientific Article in Communicative & Integrative Biology Commun. Integr. Biol. 7:e994383 (2014)
Identification of the zebrafish red nucleus using wheat germ agglutinin transneuronal tracing.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2014, 158 S.
Establishment of mouse disease models by using sequence specific nucleases.
2014 Scientific Article in Oncoscience Oncoscience 1, 283-286 (2014)
Knock-down of BCL6 / STAT6 sensitizes primary B cell lymphoma cells for treatment with current therapeutic agents.
2014 Scientific Article in BMC Ophthalmology BMC Ophthalmol. 14:165 (2014)
Characterization of ex vivo cultured neuronal- and glial- like cells from human idiopathic epiretinal membranes.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e114918 (2014)
MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2014, 150 S.
Fox transcription factors in adult neurogenesis.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2014, 218 S.
Nedd8 in the brain - Its impact on synaptic function and the role of PSD-95.
In: IEEE 11th International Symposium on Biomedical Imaging. Bejing, China: 2014. 890-893
Serial sectioning and mulstispectral imaging system for versatile biomedical applications.
2014 Scientific Article in Cell Reports Cell Rep. 9, 1292-1305 (2014)
Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation.
2014 Scientific Article in eLife eLife 3:e02755 (2014)
MicroRNA-9 controls dendritic development by targeting REST.
2014 Scientific Article in Nature Cell Biology Nat. Cell Biol. 16, 1180-1191 (2014)
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.
2014 Scientific Article in Biopreservation and Biobanking Biopreserv. Biobank. 12, 343-350 (2014)
Stability of cryopreserved samples of mutant mice.
2014 Scientific Article in International Journal of Cancer Int. J. Cancer 136, 2293-2303 (2014)
MiR-34a deficiency accelerates medulloblastoma formation in vivo.
2014 Scientific Article in Methods Methods 69, 94-101 (2014)
Generation of targeted mouse mutants by embryo microinjection of TALENs.
2014 Scientific Article in European Journal of Neuroscience Eur. J. Neurosci. 40, 2691-2700 (2014)
Enriched environment impacts trimethylthiazoline-induced anxiety-related behavior and immediate early gene expression: Critical role of Crhr1.
2014 Editorial in Methods Methods 69:1 (2014)
Editing and investigating genomes with TALE and CRISPR/Cas systems: Genome engineering across species using TALENs.
2014 Meeting abstract in Transgenic Research Transgenic Res. 23, 870 (2014)
Generation of targeted deletions in mouse zygotes by pairs of TALENs or SGRNAS/Cas9.
2014 Scientific Article in PLoS Computational Biology PLoS Comput. Biol. 10:e1003843 (2014)
Fast synchronization of ultradian oscillators controlled by Delta-Notch signaling with Cis-inhibition.
2014 Scientific Article in Journal of Cellular and Molecular Medicine J. Cell. Mol. Med. 18, 1444-1459 (2014)
TGF-beta signalling in the adult neurogenic niche promotes stem cell quiescence as well as generation of new neurons.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e107069 (2014)
Usefulness of a darwinian system in a biotechnological application: Evolution of optical window fluorescent protein variants under selective pressure.
2014 Scientific Article in Database: The Journal of Biological Databases and Curation Database 2014:bau083 (2014)
Mouse IDGenes: A reference database for genetic interactions in the developing mouse brain.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e105478 (2014)
HIV-1 replication in human immune cells is independent of TAR DNA binding Protein 43 (TDP-43) expression.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e104568 (2014)
Pleiotropic functions for transcription factor Zscan10.
2014 Scientific Article in Journal of Biomedical Science J. Biomed. Sci. 21:68 (2014)
Standardized, systemic phenotypic analysis of Slc12a1 I299F mutant mice.
2014 Letter to the Editor in Journal of Biological Chemistry, The J. Biol. Chem. 289, 18594 (2014)
Reply to Jawaid et al.: Mitochondrial dysfunction and decrease in body weight of transgenic knock-in mouse model for TDP-43: The question of glucose?.
2014 Scientific Article in EMBO Journal, The EMBO J. 33, 2020-2039 (2014)
Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.
2014 Scientific Article in Biology Open Biol. Open 3, 777-784 (2014)
Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival.
2014 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 111, 11846-11851 (2014)
Functional regionalization of the teleost cerebellum analyzed in vivo.
2014 Scientific Article in Psychoneuroendocrinology Psychoneuroendocrinology 48, 41-51 (2014)
Blunted HPA axis reactivity reveals glucocorticoid system dysbalance in a mouse model of high anxiety-related behavior.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e101124 (2014)
FGF/FGFR2 signaling regulates the generation and correct positioning of Bergmann glia cells in the developing mouse cerebellum.
2014 Scientific Article in Antioxidants & Redox Signaling Antioxid. Redox Signal. 20, 2907-2922 (2014)
Phosphoinositide 3-kinases upregulate system xc - via eukaryotic initiation factor 2α and activating transcription factor 4-A pathway active in glioblastomas and epilepsy.
2014 Scientific Article in International Journal of Nanomedicine Int. J. Nanomed. 9, 2815-2832 (2014)
Surface modifications of silica nanoparticles are crucial for their inert versus proinflammatory and immunomodulatory properties.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e98072 (2014)
Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments.
2014 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 23, 5597-5614 (2014)
Peroxidasin is essential for eye development in the mouse.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e98092 (2014)
Blood cis-eQTL analysis fails to identify novel association signals among sub-threshold candidates from genome-wide association studies in restless legs syndrome.
2014 Scientific Article in Atherosclerosis Atherosclerosis 235, 213-222 (2014)
Induction of inducible Nitric Oxide Synthase (iNOS) expression by oxLDL inhibits macrophage derived foam cell migration.
2014 Scientific Article in Cell Death & Disease Cell Death Dis. 5:e1235 (2014)
Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2.
2014 Scientific Article in Biological Trace Element Research Biol. Trace Elem. Res. 158, 203-210 (2014)
Cerebellar hypoplasia in mice lacking selenoprotein biosynthesis in neurons.
2014 Scientific Article in Journal of Neuroscience J. Neurosci. 34, 6624-6633 (2014)
Mitochondria modify exercise-induced development of stem cell-derived neurons in the adult brain.
2014 Scientific Article in Neuromethods Neuromethods 87, 145-162 (2014)
Quantitative analysis of axonal outgrowth in mice.
2014 Scientific Article in Frontiers in Behavioral Neuroscience Front. Behav. Neurosci. 8:125 (2014)
A robust and reliable non-invasive test for stress responsivity in mice.
2014 Scientific Article in Journal of Comparative Physiology B J. Comp. Physiol. B 184, 763-775 (2014)
High-throughput phenotypic assessment of cardiac physiology in four commonly used inbred mouse strains.
2014 Scientific Article in Circulation Research Circ. Res. 115, 23-31 (2014)
HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region.
2014 Scientific Article in Molecular and Cellular Biology Mol. Cell. Biol. 34, 2147-2161 (2014)
Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain.
2014 Scientific Article in Molecular Biotechnology : MB Online Mol. Biotechnol. 56, 697-713 (2014)
Simple derivation of transgene-free iPS cells by a dual recombinase approach.
2014 Scientific Article in Drug Discovery Today: Disease Models Drug Discov. Today Dis. Models 10, e189-e194 (2014)
Genetic models for cataracts.
2014 Scientific Article in Journal of Proteome Research J. Proteome Res. 13, 2339-2351 (2014)
High fat diet induced isoform changes of the Parkinson’s disease protein DJ-1.
2014 Scientific Article in Chemistry and Biology Chem. Biol. 21, 422-429 (2014)
MRI-based detection of alkaline phosphatase gene reporter activity using a porphyrin solubility switch.
2014 Scientific Article in Genome Research Genome Res. 24, 592-603 (2014)
Restless Legs Syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon.
2014 Scientific Article in Molecular and Cellular Proteomics Mol. Cell. Proteomics 13, 733-748 (2014)
A cell surface biotinylation assay to reveal membrane-associated neuronal cues: Negr1 regulates dendritic arborization.
2014 Scientific Article in Stem Cell Reports Stem Cell Rep. 2, 153-162 (2014)
In vivo targeting of adult neural stem cells in the dentate gyrus by a split-cre approach.
2014 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 289, 10769-10784 (2014)
Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.
2014 Scientific Article in Tissue Engineering / Part C: Methods Tissue Eng. Part C Meth. 20, 11-18 (2014)
Comparison of different strategies for in vivo seeding of prevascularized scaffolds.
2014 Scientific Article in Neuroscience Neuroscience 261, 173-183 (2014)
Increased dopaminergic innervation in the brain of conditional mutant mice overexpressing Otx2: Effects on locomotor behaviour and seizure susceptibility.
2014 Scientific Article in Development / Company of Biologists Development 141, 377-388 (2014)
Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity.
2014 Scientific Article in Developmental Biology Dev. Biol. 386, 358-370 (2014)
MicroRNA-9 promotes the switch from early-born to late-born motor neuron populations by regulating Onecut transcription factor expression.
2014 Scientific Article in Journal of Molecular Cell Biology J. Mol. Cell Biol. 6, 34-41 (2014)
Wnt1-regulated genetic networks in midbrain dopaminergic neuron development.
2014 Scientific Article in Science of the Total Environment, The Sci. Total Environ. 470-471, 895-906 (2014)
Nitrogen deposition along differently exposed slopes in the Bavarian Alps.
München, Ludwig-Maximilians-Universität, Medizinische Fakultät, Diss., 2014