Publications
Monroy Kuhn, J.M. ; Miok, V. ; Lutter, D.
Correlation-guided Network Integration (CoNI), an R package for integrating numerical omics data that allows multiform graph representations to study molecular interaction networks.Fernandez, A.M. ; Martinez-Rachadell, L. ; Navarrete, M. ; Pose-Utrilla, J. ; Davila, J.C. ; Pignatelli, J. ; Diaz-Pacheco, S. ; Guerra-Cantera, S. ; Viedma-Moreno, E. ; Palenzuela, R. ; Ruiz de Martin Esteban, S. ; Mostany, R. ; García-Cáceres, C. ; Tschöp, M.H. ; Iglesias, T. ; de Ceballos, M.L. ; Gutierrez, A. ; Torres Aleman, I.
Insulin regulates neurovascular coupling through astrocytes.Plaza-Díaz, J. ; Manzano, M. ; Ruiz Ojeda, F.J. ; Giron, M.D. ; Salto, R. ; López-Pedrosa, J.M. ; Santos-Fandila, A. ; Garcia-Corcoles, M.T. ; Rueda, R. ; Gil, A.
Intake of slow-digesting carbohydrates is related to changes in the microbiome and its functional pathways in growing rats with obesity induced by diet.Massacci, G. ; Venafra, V. ; Latini, S. ; Bica, V. ; Pugliese, G.M. ; Graziosi, S. ; Klingelhuber, F. ; Krahmer, N. ; Fischer, T. ; Mougiakakos, D. ; Boettcher, M. ; Perfetto, L. ; Sacco, F.
A key role of the WEE1-CDK1 axis in mediating TKI-therapy resistance in FLT3-ITD positive acute myeloid leukemia patients.Metzner, K.J. ; Darawsha, O. ; Wang, M. ; Gaur, N. ; Cheng, Y. ; Rödiger, A. ; Frahm, C. ; Witte, O.W. ; Perocchi, F. ; Axer, H. ; Grosskreutz, J. ; Brill, M.S.
Age-dependent increase of cytoskeletal components in sensory axons in human skin.Müller, T.D. ; Tschöp, M.H.
Gut-hormone triple agonists: Clinical safety and metabolic benefits.Musiol, S. ; Harris, C. ; Karlina, R. ; Gostner, J.M. ; Rathkolb, B. ; Schnautz, B. ; Schneider, E. ; Mair, L. ; Vergara, E.E. ; Flexeder, C. ; Koletzko, S. ; Bauer, C.P. ; Schikowski, T. ; Berdel, D. ; von Berg, A. ; Herberth, G. ; Rozman, J. ; Hrabě de Angelis, M. ; Standl, M. ; Schmidt-Weber, C.B. ; Ussar, S. ; Alessandrini, F.
Dietary digestible carbohydrates are associated with higher prevalence of asthma in humans and with aggravated lung allergic inflammation in mice.de Angelis, M. ; Maity-Kumar, G. ; Schriever, S.C. ; Kozlova, E.V. ; Müller, T.D. ; Pfluger, P.T. ; Curras-Collazo, M.C. ; Schramm, K.-W.
Development and validation of an LC-MS/MS methodology for the quantification of thyroid hormones in dko MCT8/OATP1C1 mouse brain.Petrus, P. ; Cervantes, M. ; Samad, M. ; Sato, T. ; Chao, A. ; Sato, S. ; Koronowski, K.B. ; Park, G. ; Alam, Y. ; Mejhert, N. ; Seldin, M.M. ; Monroy Kuhn, J.M. ; Dyar, K.A. ; Lutter, D. ; Baldi, P. ; Kaiser, P. ; Jang, C. ; Sassone-Corsi, P.
Tryptophan metabolism is a physiological integrator regulating circadian rhythms.Niemann, B. ; Haufs-Brusberg, S. ; Puetz, L. ; Feickert, M. ; Jaeckstein, M.Y. ; Hoffmann, A. ; Zurkovic, J. ; Heine, M. ; Trautmann, E.-M. ; Müller, C.E. ; Tönjes, A. ; Schlein, C. ; Jafari, A. ; Eltzschig, H.K. ; Gnad, T. ; Blüher, M. ; Krahmer, N. ; Kovacs, P. ; Heeren, J. ; Pfeifer, A.
Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine.Lutomska, L.M. ; Miok, V. ; Krahmer, N. ; Gonzales García, I. ; Gruber, T. ; Le Thuc, O. ; Murat, C. ; Legutko, B. ; Sterr, M. ; Saher, G. ; Lickert, H. ; Müller, T.D. ; Ussar, S. ; Tschöp, M.H. ; Lutter, D. ; García-Cáceres, C.
Diet triggers specific responses of hypothalamic astrocytes in time and region dependent manner.Maity-Kumar, G. ; Ständer, L. ; de Angelis, M. ; Lee, S. ; Molenaar, A. ; Becker, L. ; Garrett, L. ; Amarie, O.V. ; Hölter, S.M. ; Wurst, W. ; Fuchs, H. ; Feuchtinger, A. ; Gailus-Durner, V. ; García-Cáceres, C. ; Othman, A.E. ; Brockmann, C. ; Schöffling, V.I. ; Beiser, K. ; Krude, H. ; Mroz, P.A. ; Hofmann, S.M. ; Tuckermann, J. ; DiMarchi, R.D. ; Hrabě de Angelis, M. ; Tschöp, M.H. ; Pfluger, P.T. ; Müller, T.D.
Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome.Haile, A. ; Watts, M. ; Aichner, S. ; Stahlberg, F. ; Hoffmann, V. ; Tschöp, M.H. ; Meissner, K.
Central correlates of placebo effects in nausea differ between men and women.Achenbach, P. ; Hippich, M. ; Zapardiel-Gonzalo, J. ; Karges, B. ; Holl, R.W. ; Petrera, A. ; Bonifacio, E. ; Ziegler, A.-G.
A classification and regression tree analysis identifies subgroups of childhood type 1 diabetes.Sekar, R. ; Motzler, K. ; Kwon, Y. ; Novikoff, A. ; Jülg, J. ; Najafi, B. ; Wang, S. ; Seitz, S. ; Hass, D, ; Gancheva, S. ; Kahl, S. ; Yang, B. ; Finan, B. ; Schwarz, K. ; Okun, J.G. ; Roden, M. ; Blüher, M. ; Müller, T.D. ; Krahmer, N. ; Behrends, C. ; Plettenburg, O. ; Miaczynska, M. ; Herzig, S. ; Zeigerer, A.
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.Quarta, C. ; Stemmer, K. ; Novikoff, A. ; Yang, B. ; Klingelhuber, F. ; Harger, A. ; Bakhti, M. ; Bastidas-Ponce, A. ; Baugé, E. ; Campbell, J.E. ; Capozzi, M.E. ; Clemmensen, C. ; Collden, G. ; Cota, P. ; Douros, J. ; Drucker, D.J. ; Dubois, B. ; Feuchtinger, A. ; García-Cáceres, C. ; Grandl, G. ; Hennuyer, N. ; Herzig, S. ; Hofmann, S.M. ; Knerr, P.J. ; Kulaj, K. ; Lalloyer, F. ; Lickert, H. ; Liskiewicz, A. ; Liskiewicz, D. ; Maity-Kumar, G. ; Perez-Tilve, D. ; Prakash, S. ; Sanchez-Garrido, M.A. ; Zhang, Q. ; Staels, B. ; Krahmer, N. ; DiMarchi, R.D. ; Tschöp, M.H. ; Finan, B. ; Müller, T.D.
GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice.Herrera Moro Chao, D. ; Kirchner, M.K. ; Pham, C. ; Foppen, E. ; Denis, R.G.P. ; Castel, J. ; Morel, C. ; Montalban, E. ; Hassouna, R. ; Bui, L.C. ; Renault, J. ; Mouffle, C. ; García-Cáceres, C. ; Tschöp, M.H. ; Li, D. ; Martin, C. ; Stern, J.E. ; Luquet, S.H.
Hypothalamic astrocytes control systemic glucose metabolism and energy balance.Galle, E. ; Wong, C.W. ; Ghosh, A. ; Desgeorges, T. ; Melrose, K. ; Hinte, L.C. ; Castellano-Castillo, D. ; Engl, M. ; de Sousa, J.A. ; Ruiz Ojeda, F.J. ; de Bock, K. ; Ruiz, J.R. ; von Meyenn, F.
H3K18 lactylation marks tissue-specific active enhancers.Parikh, S. ; Parikh, R. ; Michael, K. ; Bikovski, L. ; Barnabas, G. ; Mardamshina, M. ; Hemi, R. ; Manich, P. ; Goldstein, N. ; Malcov-Brog, H. ; Ben-Dov, T. ; Glaich, O. ; Liber, D. ; Bornstein, Y. ; Goltseker, K. ; Ben-Bezalel, R. ; Pavlovsky, M. ; Golan, T. ; Spitzer, L. ; Matz, H. ; Gonen, P. ; Percik, R. ; Leibou, L. ; Perluk, T. ; Ast, G. ; Frand, J. ; Brenner, R. ; Ziv, T. ; Khaled, M. ; Ben-Eliyahu, S. ; Barak, S. ; Karnieli-Miller, O. ; Levin, E. ; Gepner, Y. ; Weiss, R. ; Pfluger, P.T. ; Weller, A. ; Levy, C.
Food-seeking behavior is triggered by skin ultraviolet exposure in males.Kullmann, S. ; Goj, T. ; Veit, R. ; Fritsche, L. ; Wagner, L. ; Schneeweiss, P. ; Hoene, M. ; Hoffmann, C. ; Machann, J. ; Niess, A. ; Preissl, H. ; Birkenfeld, A.L. ; Peter, A. ; Häring, H.-U. ; Fritsche, A. ; Moller, A. ; Weigert, C. ; Heni, M.
Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese.Abuhattum, S. ; Kotzbeck, P. ; Schlüßler, R. ; Harger, A. ; Ariza de Schellenberger, A. ; Kim, K. ; Escolano, J.C. ; Müller, T. ; Braun, J. ; Wabitsch, M. ; Tschöp, M.H. ; Sack, I. ; Brankatschk, M. ; Guck, J. ; Stemmer, K. ; Taubenberger, A.V.
Adipose cells and tissues soften with lipid accumulation while in diabetes adipose tissue stiffens.Welman, S. ; Jastroch, M. ; Mzilikazi, N.
Obligatory homeothermy of mesic adapted African striped mice, Rhabdomys pumilio, is governed by seasonal basal metabolism and year-round "thermogenic readiness" of brown adipose tissue.Caliskan, Ö.S. ; Massacci, G. ; Krahmer, N. ; Sacco, F.
Phosphoproteomics and organelle proteomics in pancreatic islets.Artati, A. ; Prehn, C. ; Lutter, D. ; Dyar, K.A.
Untargeted and targeted circadian metabolomics using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and flow injection-electrospray ionization-tandem mass spectrometry (FIA-ESI-MS/MS).Agrawal, S. ; Pathak, E. ; Mishra, R. ; Parveen, A. ; Mishra, S.K. ; Byadgi, P.S. ; Dubey, S.K. ; Chaudhary, A.K. ; Singh, V. ; Chaurasia, R.N. ; Atri, N.
Computational exploration of the dual role of the phytochemical fortunellin: Antiviral activities against SARS-CoV-2 and immunomodulatory abilities against the host.Smith, J.G. ; Sato, T. ; Shimaji, K. ; Koronowski, K.B. ; Petrus, P. ; Cervantes, M. ; Kinouchi, K. ; Lutter, D. ; Dyar, K.A. ; Sassone-Corsi, P.
Antibiotic-induced microbiome depletion remodels daily metabolic cycles in the brain.Wang, J. ; Onogi, Y. ; Krueger, M. ; Oeckl, J. ; Karlina, R. ; Singh, I. ; Hauck, S.M. ; Feederle, R. ; Li, Y. ; Ussar, S.
PAT2 regulates vATPase assembly and lysosomal acidification in brown adipocytes.Lopez Gonzales, E. ; Lehmann, L. ; Ruiz Ojeda, F.J. ; Hernandez-Bautista, R. ; Altun, I. ; Onogi, Y. ; Khalil, A. ; Liu, X. ; Israel, A. ; Ussar, S.
L-serine supplementation blunts fasting-induced weight regain by increasing brown fat thermogenesis.Sundaram, S.M. ; Pereira, A.A. ; Mueller-Fielitz, H. ; Koepke, H. ; de Angelis, M. ; Müller, T.D. ; Heuer, H. ; Koerbelin, J. ; Krohn, M. ; Mittag, J. ; Nogueiras, R. ; Prévot, V. ; Schwaninger, M.
Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency.Raineri, S. ; Sherriff, J.A. ; Thompson, K.S.J. ; Jones, H. ; Pfluger, P.T. ; Ilott, N.E. ; Mellor, J.
Pharmacologically induced weight loss is associated with distinct gut microbiome changes in obese rats.Altun, I. ; Yan, X. ; Ussar, S.
Immune cell regulation of white adipose progenitor cell fate.Müller, G. ; Müller, T.D.
Biological role of the intercellular transfer of glycosylphosphatidylinositol-anchored proteins: Stimulation of lipid and glycogen synthesis.Tan, Q. ; Akindehin, S.E. ; Orsso, C.E. ; Waldner, R.C. ; DiMarchi, R.D. ; Müller, T.D. ; Haqq, A.M.
Recent advances in incretin-based pharmacotherapies for the treatment of obesity and diabetes.Plaza-Díaz, J. ; Izquierdo, D. ; Torres-Martos, Á. ; Baig, A.T. ; Aguilera, C.M. ; Ruiz Ojeda, F.J.
Impact of physical activity and exercise on the epigenome in skeletal muscle and effects on systemic metabolism.Onogi, Y. ; Ussar, S.
Regulatory networks determining substrate utilization in brown adipocytes.Liu, X. ; Jin, Z. ; Summers, S. ; Derous, D. ; Li, M. ; Li, B. ; Li, L. ; Speakman, J.R.
Calorie restriction and calorie dilution have different impacts on body fat, metabolism, behavior, and hypothalamic gene expression.Kraus, G. ; Weigelt, M. ; Reinhardt, S. ; Petzold, A. ; Dahl, A. ; Bonifacio, E.
Reproducibility of 10x Genomics single cell RNA sequencing method in the immune cell environment.Fritsche, L. ; Hummel, J. ; Wagner, R. ; Löffler, D. ; Hartkopf, J. ; Machann, J. ; Hilberath, J. ; Kantartzis, K. ; Jakubowski, P. ; Pauluschke-Fröhlich, J. ; Brucker, S. ; Hörber, S. ; Häring, H.-U. ; Roden, M. ; Schürmann, A. ; Solimena, M. ; Hrabě de Angelis, M. ; Peter, A. ; Birkenfeld, A.L. ; Preissl, H. ; Fritsche, A. ; Heni, M.
The German Gestational Diabetes Study (PREG), a prospective multicentre cohort study: Rationale, methodology and design.Gruber, T. ; García-Cáceres, C.
Astroglial clean-up of satiety synapses.Giehrl-Schwab, J. ; Giesert, F. ; Rauser, B. ; Lao, C.L. ; Hembach, S. ; Lefort, S. ; Ibarra Del Rio, I.A. ; Koupourtidou, C. ; Luecken, M. ; Truong, D.J.J. ; Fischer-Sternjak, J. ; Masserdotti, G. ; Prakash, N. ; Ninkovic, J. ; Hölter, S.M. ; Vogt Weisenhorn, D.M. ; Theis, F.J. ; Götz, M. ; Wurst, W.
Parkinson's disease motor symptoms rescue by CRISPRa-reprogramming astrocytes into GABAergic neurons.Harbauer, A.B. ; Hees, J.T. ; Wanderoy, S. ; Segura, I. ; Gibbs, W. ; Cheng, Y. ; Ordonez, M. ; Cai, Z. ; Cartoni, R. ; Ashrafi, G. ; Wang, C. ; Perocchi, F. ; He, Z. ; Schwarz, T.L.
Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy.Gonzales García, I. ; Urisarri, A. ; Nogueiras, R. ; Dieguez, C. ; Couce, M.L. ; López, M.
An updated view on human neonatal thermogenesis.Karlina, R. ; Flexeder, C. ; Musiol, S. ; Bhattacharyya, M. ; Schneider, E. ; Altun, I. ; Gschwendtner, S. ; Neumann, A.U. ; Nano, J. ; Schloter, M. ; Peters, A. ; Schulz, H. ; Schmidt-Weber, C.B. ; Standl, M. ; Traidl-Hoffmann, C. ; Alessandrini, F. ; Ussar, S.
Differential effects of lung inflammation on insulin resistance in humans and mice.Sato, S. ; Dyar, K.A. ; Treebak, J.T. ; Jepsen, S.L. ; Ehrlich, A.M. ; Ashcroft, S.P. ; Trost, K. ; Kunzke, T. ; Prade, V.M. ; Small, L. ; Basse, A.L. ; Schönke, M. ; Chen, S. ; Samad, M. ; Baldi, P. ; Barrès, R. ; Walch, A.K. ; Moritz, T. ; Holst, J.J. ; Lutter, D. ; Zierath, J.R. ; Sassone-Corsi, P.
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis.Evers, S.S. ; Shao, Y. ; Ramakrishnan, S.K. ; Shin, J.H. ; Bozadjieva-Kramer, N. ; Irmler, M. ; Stemmer, K. ; Sandoval, D.A. ; Shah, Y.M. ; Seeley, R.J.
Gut HIF2α signaling is increased after VSG, and gut activation of HIF2α decreases weight, improves glucose, and increases GLP-1 secretion.Mejhert, N. ; Gabriel, K.R. ; Frendo-Cumbo, S. ; Krahmer, N. ; Song, J. ; Kuruvilla, L. ; Chitraju, C. ; Boland, S. ; Jang, D.K. ; von Grotthuss, M. ; Costanzo, M.C. ; Rydén, M. ; Olzmann, J.A. ; Flannick, J. ; Burtt, N.P. ; Farese, R.V.
The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology.Müller, T.D. ; Blüher, M. ; Tschöp, M.H. ; DiMarchi, R.D.
Anti-obesity drug discovery: Advances and challenges.