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Dr. Siegfried Ussar

Deputy Director (acting), Institute for Diabetes and Obesity and Group Leader Adipocytes & Metaboblism
+49 89 3187 2047Email meBuilding/Room: 3620

“Prevention outweighs treatment. We strive to unravel cellular mechanisms enabling novel therapeutics to dissociate obesity from the metabolic syndrome..”

“Prevention outweighs treatment. We strive to unravel cellular mechanisms enabling novel therapeutics to dissociate obesity from the metabolic syndrome..”

Academic Career and Research Areas

Siegfried Ussar wants to dissociate obesity from its metabolic complications. This is of particular importance as cardiovascular disease, type 2 diabetes and other elements of the metabolic syndrome are major health problems and limit the ability to reduce body weight through lifestyle changes. To this end, the research of Siegfried Ussar investigates how environmental and hormonal signals alter adipose tissue function to impair its ability to store excessive calories in form of fat. The underlying hypothesis is that maintaining fat cell function prevents the development of the metabolic syndrome in context of overweight and obesity. Within this complex area, Siegfried has a particular interest in the role of cell surface proteins as they are prime targets for future therapies and act as central integrators of the various cellular inputs.

Siegfried Ussar studied Genetics at the University of Vienna and obtained his PhD in Biochemistry from the Ludwig-Maximilians University Munich working with Prof. Reinhard Fässler at the Max-Planck Institute for Biochemstry. Supported by a HFSP fellowship Siegfried Ussar then joined Prof. C. Ronald Kahn at the Joslin Diabetes Center/ Harvard Medical School for his PostDoc, where he developed his interest in adipose tissue biology and the systemic effects of insulin action. In 2014 Siegfried was recruited to the Institute for Diabetes and Obesity at the Helmholtz Diabetes Center to setup his independent Junior Research Group working on the metabolic impact of adipose tissues. Since 2016 Siegfried is a TUM Junior Fellow at the Technical University. Siegfried Ussar became a tenured Group Leader and acting Deputy Director at the Institute for Diabetes and Obesity in 2018.

 

 

Fields of Work and Expertise

Adipose Tissue Obesity  Diabetes Tissue Targeting Insulin Resistance  Energy Homeostasis  

Professional Background

2018

Deputy Director (acting)

Institute for Diabetes and Obesity, Helmholtz Center Munich, Munich, Germany

 

2018

Independent Group Leader

Helmholtz Center Munich, Munich, Germany

2016

TUM Junior Fellow (faculty member)

Medical Faculty, Technical University Munich, Germany

2015 - 2018

Independent Junior Research Group Leader (tenure track)

Helmholtz Center Munich, Munich, Germany

2009 - 2014

Postdoctoral Fellow

Joslin Diabetes Center & Harvard Medical School, Boston, USA in the lab of Dr. C. Ronald Kahn

Publications

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2022 Scientific Article in Allergy

Musiol, S. ; Harris, C. ; Karlina, R. ; Gostner, J.M. ; Rathkolb, B. ; Schnautz, B. ; Schneider, E. ; Mair, L. ; Vergara, E.E. ; Flexeder, C. ; Koletzko, S. ; Bauer, C.P. ; Schikowski, T. ; Berdel, D. ; von Berg, A. ; Herberth, G. ; Rozman, J. ; Hrabě de Angelis, M. ; Standl, M. ; Schmidt-Weber, C.B. ; Ussar, S. ; Alessandrini, F.

Dietary digestible carbohydrates are associated with higher prevalence of asthma in humans and with aggravated lung allergic inflammation in mice.

Networks and Affiliations

Deutsches Zentrum für Diabetesforschung

Technical University of Munich (TUM)

Universität Leipzig