Michael Sterr Portrait 2

Group Leader Single-Cell Genomics Unit

Dr. Michael Sterr

Dr. Michael Sterr

Group leader Single-Cell Genomics, Institute of Diabetes and Regeneration Research (IDR)

“By using single-cell genomics, we can increase our understanding of the developmental programs that govern the formation of pancreatic and intestinal endocrine cells to improve diabetes therapy”

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Research focus and Academic Career

Michael studied Bioengineering and Biology in Munich.

In 2013 he joined the Lab of Heiko Lickert for his PhD, where he studied the epigenetics of the endocrine cell fate decision in both pancreas and intestine.

During his postdoc time, he focused on single-cell genomics techniques and data analysis to dissect the dynamics of endocrine differentiation.

Since 2021, he leads the Single-Cell Genomics Group at the Institute of Diabetes and Regeneration Research. 

Single-cell based methods are key technologies to uncover the cellular complexity of biological systems, and allow the characterization different cell types and cellular states, as well as the reconstruction developmental trajectories. Leveraging single-cell transcriptomic and epigenomic analyses, Michael aims to provide insight into the molecular mechanisms guiding the endocrine lineage decision and the specification of different endocrine cell types.

Professional Career

2021

Head of the group Single Cell Analysis

Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Neuherberg, Germany

2019-2021

Postdoc

Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Neuherberg, Germany

2013-2019

PhD Student

Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Prof. Dr. Heiko Lickert. Project: “Transcriptional Regulation of Endocrine Cell Formation and Function in Pancreas and Intestine”

Most important publications

2022 Glia

Lutomska LM, Miok V, Krahmer N, González García I, Gruber T, Le Thuc O, Murat CD, Legutko B, Sterr M, Saher G, Lickert H, Müller TD, Ussar S, Tschöp MH, Lutter D, García-Cáceres C

Diet triggers specific responses of hypothalamic astrocytes in time and region dependent manner
2022 Diabetes

Gottmann P, Speckmann T, Stadion M, Zuljan E, Aga H, Sterr M, Büttner M, Santos PM, Jähnert M, Bornstein SR, Theis FJ, Lickert H, Schürmann A

Heterogeneous Development of β-Cell Populations in Diabetes-Resistant and -Susceptible Mice
2022 Clin Cancer Res

Weber P, Künstner A, Hess J, Unger K, Marschner S, Idel C, Ribbat-Idel J, Baumeister P, Gires O, Walz C, Rietzler S, Valeanu L, Herkommer T, Kreutzer L, Klymenko O, Drexler G, Kirchner T, Maihöfer C, Ganswindt U, Walch A, Sterr M, Lickert H, Canis M, Rades D, Perner S, Berriel Diaz M, Herzig S, Lauber K, Wollenberg B, Busch H, Belka C, Zitzelsberger H

Therapy-Related Transcriptional Subtypes in Matched Primary and Recurrent Head and Neck Cancer
2021 Int J Mol Sci

Tarquis-Medina M, Scheibner K, González-García I, Bastidas-Ponce A, Sterr M, Jaki J, Schirge S, García-Cáceres C, Lickert H, Bakhti M.

Synaptotagmin-13 Is a Neuroendocrine Marker in Brain, Intestine and Pancreas
2021 Nature Metabolism

Aliluev, A; Tritschler, S; Sterr, M; Oppenländer, L; Hinterdobler, J; Greisle, T; Irmler, M; Beckers, J; Sun, N; Walch, A; Stemmer, K; Kindt, A; Krumsiek, J; Tschöp, MH; Luecken, M; Theis, F; Lickert, H* and Böttcher, A*

Diet-induced alteration of intestinal stem cell identity and lineage allocation underlies obesity and pre-diabetes in mice
2021 Nat Biomed Eng

26. Wiedenmann S, Breunig M, Merkle J, von Toerne C, Georgiev T, Moussus M, Schulte L, Seufferlein T, Sterr M, Lickert H, Weissinger SE, Möller P, Hauck SM, Hohwieler M, Kleger A and Meier M

Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip.
2021 Molecular Metabolism

Oppenländer L, Palit S, Stemmer K, Greisle T, Sterr M, Salinno C, Bastidas-Ponce A, Feuchtinger A, Böttcher A, Ansarullah, Theis FJ, Lickert H

Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes
2021 Nature Cell Biology

Scheibner, K; Schirge, S; Burtscher, I; Büttner, M; Sterr, M; Yang, D; Böttcher, A; Ansarullah; Irmler, M; Beckers, J.; Cernilogar, FM; Schotta, G; Theis, FJ* and Lickert H*

Epithelial cell plasticity drives endoderm formation during gastrulation
2021 Nature

Ansarullah; Jain, C; Far, FF; Wißmiller, K; Homberg, S; Gräfin von Hahn, F; Raducanu, A; Schirge, S; Sterr, M; Bilekova, S; Siehler, J; Wiener, J; Oppenländer, L; Morshedi, A; Bastidas-Ponce, A; Collden, G; Irmler, M; Beckers, J; Feuchtinger, A; Grzybek, m; Ahlbrecht, C; Feederle, R; Plettenburg, O; Müller, T; Meier, M; Tschöp, M; Coskun, Ü and Lickert, H

Inceptor counteracts insulin signalling in β -cells to control glycaemia
2021 Nature Cell Biology

Böttcher, A; Büttner, M; Tritschler, S; Sterr, M; Aliluev, A; Oppenländer, L; Burtscher, I; Sass, S; Irmler, M; Beckers, J; Ziegenhain, C; Enard, W; Schamberger, AC; Verhamme, FN; Eickelberg, O; Theis, FJ*; Lickert, H*

Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates

Networks and Affiliations

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German Center for Diabetes Research

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