Publications of the Group Applied Computational Biology
2025 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 53, D651-D657 (2025)
CORUM in 2024: Protein complexes as drug targets.
2024 Scientific Article in Nature Communications Nat. Commun. 15:10631 (2024)
X-linked deletion of Crossfirre, Firre, and Dxz4 in vivo uncovers diverse phenotypes and combinatorial effects on autosomes.
Lecture Notes in Computer Science In: (Medical Image Understanding and Analysis). Gewerbestrasse 11, Cham, Ch-6330, Switzerland: Springer International Publishing Ag, 2024. 366-381 (Lect. Notes Comput. Sc. ; 14860 LNCS)
EchoVisuAL: Efficient Segmentation of Echocardiograms Using Deep Active Learning.
2023 Scientific Article in Mammalian Genome Mamm. Genome 34, 244-261 (2023)
Knockout mouse models as a resource for the study of rare diseases.
2023 Scientific Article in Mammalian Genome Mamm. Genome 34, 180-199 (2023)
Comprehensive ECG reference intervals in C57BL/6N substrains provide a generalizable guide for cardiac electrophysiology studies in mice.
2023 Scientific Article in Biochimica et Biophysica Acta - Molecular Basis of Disease Biochim. Biophys. Acta-Mol. Basis Dis. 1869:166760 (2023)
AOX delays the onset of the lethal phenotype in a mouse model of Uqcrh (complex III) disease.
2023 Scientific Article in Mammalian Genome Mamm. Genome 34, 200-215 (2023)
Echo2Pheno: A deep-learning application to uncover echocardiographic phenotypes in conscious mice.
2022 Nature Cardiovascular Research Nat. Cardio. Res. 1, 529-531 (2022)
Publisher Correction: Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy (Nature Cardiovascular Research, (2022), 1, 2, (157-173), 10.1038/s44161-022-00018-8).
2022 Scientific Article in BMC Neuroscience BMC Neurosci. 23:81 (2022)
Objective hearing threshold identification from auditory brainstem response measurements using supervised and self-supervised approaches.
2022 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 51, D539-D545 (2022)
CORUM: The comprehensive resource of mammalian protein complexes-2022.
2022 Scientific Article in Nature Communications Nat. Commun. 13:6830 (2022)
Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice.
2022 Scientific Article in Nature Cardiovascular Research Nat. Cardio. Res. 1, 157-173 (2022)
Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy.
2022 Nature Genetics Nat. Genet. 54, 358-360 (2022)
EMPReSS: Standardized phenotype screens for functional annotation of the mouse genome (vol 37, pg 1155, 2005).
2022 Scientific Article in Neuropathology and Applied Neurobiology Neuropathol. Appl. Neurobiol. 48:e12750 (2022)
N471D WASH complex subunit strumpellin knock-in mice display mild motor and cardiac abnormalities and BPTF and KLHL11 dysregulation in brain tissue.
2021 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med.:e14397 (2021)
Characterising a homozygous two-exon deletion in UQCRH: Comparing human and mouse phenotypes.
2021 Scientific Article in PLoS Genetics PLoS Genet. 16:e1009190 (2021)
Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.
2020 Scientific Article in Cancer Research Cancer Res. 80, 5231-5244 (2020)
Phosphorylation control of p53 DNA binding cooperativity balances tumorigensis and aging.
2020 Scientific Article in Mammalian Genome Mamm. Genome 31, 30-48 (2020)
A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes.
2020 Scientific Article in Nature Communications Nat. Commun. 11:655 (2020)
Human and mouse essentiality screens as a resource for disease gene discovery.
2020 Scientific Article in Bioinformatics Bioinformatics 36, 1492-1500 (2020)
Soft windowing application to improve analysis of high-throughput phenotyping data.
2019 Meeting abstract in European Journal of Human Genetics Eur. J. Hum. Genet. 27, 818-819 (2019)
A homozygous two exon deletion in UQCRH: Matching mouse and human phenotype.
2019 Scientific Article in European Journal of Cell Biology Eur. J. Cell Biol. 98:151046 (2019)
CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells.
Handbook of Experimental Pharmacology In:. 2019. 399-423 (Handb. Exp. Pharmacol. ; 257)
Costs of implementing quality in research practice.
2019 Scientific Article in Fluids and barriers of the CNS Fluids barriers CNS 16:30 (2019)
Claudin-12 is not required for blood-brain barrier tight junction function.
2019 Scientific Article in Experimental Eye Research Exp. Eye Res. 188:107632 (2019)
Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia.
2018 Scientific Article in PLoS Biology PLoS Biol. 16:e2005019 (2018)
Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data.
2018 Scientific Article in Nature Communications Nat. Commun. 9:288 (2018)
Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
2018 Scientific Article in Journal of Investigative Dermatology, The J. Invest. Dermatol. 138, 179-188 (2018)
The role of Fibroblast growth factor binding protein 1 in skin carcinogenesis and inflammation.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:15453 (2017)
Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema.
2017 Scientific Article in Nature Communications Nat. Commun. 8:886 (2017)
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.
2017 Scientific Article in Behavioural Brain Research Behav. Brain Res. 352, 187-196 (2017)
Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic.
2017 Scientific Article in Current Opinion in Systems Biology Curr. Opin. Syst. Biol. 4, 97-104 (2017)
Big data in large-scale systemic mouse phenotyping.
2017 Scientific Article in Nature Communications Nat. Commun. 8:15475 (2017)
Prevalence of sexual dimorphism in mammalian phenotypic traits.
2017 Scientific Article in Journal of Theoretical Biology J. Theor. Biol. 430, 32-44 (2017)
Modeling coexistence of oscillation and Delta/Notch-mediated lateral inhibition in pancreas development and neurogenesis.
2017 Scientific Article in Journal of Neuroscience Methods J. Neurosci. Methods, DOI: 10.1016/j.jneumeth.2017.05.005 (2017)
Analysis of locomotor behavior in the German Mouse Clinic.
2017 Scientific Article in Disease Models and Mechanisms Dis. Model. Mech. 10, 163-171 (2017)
Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology.
2016 Scientific Article in Genes Genomes Genetics G3 Genes Genomes Genetics G3 6, 4035-4046 (2016)
The first Scube3 mutant mouse line with pleiotropic phenotypic alterations.
2016 Scientific Article in Mammalian Genome Mamm. Genome 27, 587-598 (2016)
Viable EdnraY129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation.
2016 Scientific Article in Journal of the American Association for Laboratory Animal Science J. Amer. Assoc. Lab. Anim. Sci. 55, 375-386 (2016)
Clinical chemistry reference intervals for C57BL/6J, C57BL/6N, and C3HeB/FeJ mice (Mus musculus).
2016 Nature Communications Nat. Commun. 7:11835 (2016)
Erratum: Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.
2016 Scientific Article in Nature Communications Nat. Commun. 7:11317 (2016)
Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005423 (2015)
SLIRP regulates the rate of mitochondrial protein synthesis and protects LRPPRC from degradation.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 969-978 (2015)
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.
2015 Scientific Article in Mammalian Genome Mamm. Genome 26, 467-481 (2015)
Principles and application of LIMS in mouse clinics.
2015 Scientific Article in Circulation Circulation 131, 1191-1201 (2015)
ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling via cleavage of thrombospondin-1.
2015 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 53, D1171-D1175 (2015)
INFRAFRONTIER - providing mutant mouse resources as research tools for the international scientific community.
2014 Scientific Article in PLoS Computational Biology PLoS Comput. Biol. 10:e1003843 (2014)
Fast synchronization of ultradian oscillators controlled by Delta-Notch signaling with Cis-inhibition.
2013 Scientific Article in Systembiologie.de Systembiologie.de 6, 16-19 (2013)
Wer hat an der Uhr gedreht? Regulationsmechanismen der Segmentierung im Wirbeltierembryo.
2012 Scientific Article in Mammalian Genome Mamm. Genome 23, 600-610 (2012)
Mouse large-scale phenotyping initiatives: Overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute mouse genetics project.
2012 Scientific Article in Mammalian Genome Mamm. Genome 23, 611-622 (2012)
Innovations in phenotyping of mouse models in the German Mouse Clinic.
In: Suhre, K.* [Eds.]: Genetics Meets Metabolomics: from Experiment to Systems Biology. Springer, 2012. 85-106
Mouse genetics and metabolic mouse phenotyping.
2012 Scientific Article in PLoS Computational Biology PLoS Comput. Biol. 8:e1002586 (2012)
From dynamic expression patterns to boundary formation in the presomitic mesoderm.
2011 Review in Methods Methods 53, 120-135 (2011)
Mouse phenotyping.
2010 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 38, 1, D577-D585 (2010)
EuroPhenome: A repository for high-throughput mouse phenotyping data.
2009 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 530, 463-509 (2009)
Systemic first-line phenotyping.
2009 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 530, 463-509 (2009)
Systemic first-line phenotyping.
2009 Review in Current Pharmaceutical Biotechnology Curr. Pharm. Biotechnol. 10, 236-243 (2009)
The German Mouse Clinic: A platform for systemic phenotype analysis of mouse models.
2008 Scientific Article in Bioresource Technology Bioresour. Technol. 99, 7183-7191 (2008)