Scientific and Technical Head of the German Mouse Clinic (GMC)
Dr. Agr. Helmut Fuchs
“My aim is to contribute to the elucidation how the complex orchestra of our genes functions, and to use this knowledge to find possible curations for genetic diseases, ranging from rare to complex diseases.”
Academic Pathway & Research Area
Dr. Helmut Fuchs is the Scientific and Technical Head of the German Mouse Clinic (GMC) since 2001. He works in mouse genetics for more than 20 years. He has a strong background in mouse phenotyping and mouse genetics including the know-how to handle large-scale research projects.
Helmut Fuchs received his degree in agricultural sciences at the Technical University in Munich, and did his PhD in a combined effort with the institutes of Animal Breeding, Molecular Genetics and Fish Biology to study genetic diversity and evolution of local fish populations.
Helmut joined Helmholtz Munich in 1997. Between 1997 and 2001, he was in charge of the Dysmorphology Screen within the Munich ENU Mouse Mutagenesis Project and established and characterized more than 400 mouse mutant lines, including new model systems for a wide spectrum of diseases such as brittle bone disease, dwarfism, deafness, skin diseases or ALS.
Starting from 2000, he accompanied the construction of the German Mouse Clinic where the GMC-team runs standardized, large-scale mouse phenotyping projects, and established the world-wide first mouse phenotyping pipeline, which served as a template for many other following mouse clinics in the world, and which was the basis for further important developments in this field of research. In 2015 the GMC II was opened up that was designed and constructed based on the GMC’s long standing experiences in this field as a complex phenotyping and laboratory system.
Helmut Fuchs and his colleague Valerie Gailus-Durner developed together with their director Martin Hrabe de Angelis the German Mouse Clinic as the first mouse clinic world-wide, that has become one of the world-leading mouse phenotyping centers. Within the last 20 years, more than 400 mouse mutant lines have been phenotyped, either in the framework of international programs (e.g. EUMODIC, IMPC) or as collaborations with other research institutions. Thereby new mouse models for a variety of diseases have been developed that may serve as potential drug targets.
Dr. Helmut Fuchs has a strong background in genetics and genomics, and more than 20 years expertise in running large-scale mouse phenotyping projects on the national and international level (e.g. as member of Infrafrontier and the International Mouse Phenotyping consortium, IMPC).
As an expert for mouse phenotyping, the GMC’s collaboration partners benefit from his consulting on how to plan and design a phenotyping experiment. The data from the GMC is the basis for Artificial Intelligence projects, and he is engaged to further develop the analysis strategies for large-scale genetics data. These activities also contribute to 3R strategies of the GMC.
Fields of Work and Expertise
Mouse phenotyping Large-scale functional genomics/genetics Pleiotropy and genetic interaction Bone metabolism and morphology Experimental designDevelopment of new strategies for the analysis of large scale phenotyping data
Honors and Awards
- Helmut Fuchs is member of the Infrafrontier Animal Welfare Expert Group (AWEX) and member of several working groups of Infrafrontier and the International Mouse Phenotyping Consortium (IMPC). Some of them he chaired for many years.
- Award Number Two Here comes ehat this awar is about 2019
Selected Publications
Bhattacharya, D. ; da Silva Buttkus, P. ; Nalbach, K. ; Cheng, L. ; Garrett, L. ; Irmler, M. ; Kislinger, G. ; Werner, G. ; Rodde, R. ; Lengger, C. ; Beckers, J. ; Zimprich, A. ; Hölter, S.M. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Wefers, B. ; Wurst, W. ; Brill, M.S. ; Schifferer, M. ; Lichtenthaler, S.F. ; Behrends, C.
Neuropathy-associated Tecpr2 mutation knock-in mice reveal endolysosomal loss of function phenotypes in neurons and microglia.Winkler, R. ; Comas-Armangue, G. ; Corujo, D. ; Sanz-Moreno, A. ; Calzada-Wack, J. ; Bhattacharya, S.A. ; Rathkolb, B. ; Dragano, N.R.V. ; Qiao, C.X. ; Chiodi, V. ; Filipescu, D. ; Park, D.H. ; Domenici, M.R. ; Kirigin Callaú, V. ; Gerlini, R. ; Rozman, J. ; Klein-Rodewald, T. ; Aguilar-Pimentel, J.A. ; Becker, L. ; Seisenberger, C. ; Marschall, S. ; Fuchs, H. ; Gailus-Durner, V. ; Bernstein, E. ; Vinciguerra, M. ; Oberdoerffer, P. ; Hrabě de Angelis, M. ; Teperino, R. ; Buschbeck, M.
Loss of histone macroH2A1.1 causes kidney abnormalities secondary to a change in nutrient metabolization.Karnebeek, C.D.v. ; Gailus-Durner, V. ; Engelke, U.F.H. ; Seisenberger, C. ; Marschall, S. ; Dragano, N.R.V. ; da Silva Buttkus, P. ; Leuchtenberger, S. ; Fuchs, H. ; Hrabě de Angelis, M. ; Wevers, R.A. ; Coughlin, C.R. ; Lefeber, D.J.
New treatment for PDE-ALDH7A1: First proof-of-principle of upstream enzyme inhibition in the mouse.Gillet, J.P. ; Gerard, L. ; Vieira, W. ; Fourrez, M. ; Gaudray, F. ; Rathkolb, B. ; Rozman, J. ; Klein-Rodewald, T. ; Becker, L. ; Aguilar-Pimentel, J.A. ; Horsch, M. ; Spielmann, N. ; Prehn, C. ; Bihin, B. ; Beckers, J. ; Fuchs, H. ; Gailus-Durner, V. ; Hrabě de Angelis, M. ; Southon, E. ; Tessarollo, L. ; Xia, D. ; Gottesman, M.M.
Abcb5-deficient mice show a subtle, pleiotropic phenotype indicating a role for this transporter in intermediary metabolism.Singh, I. ; Onogi, Y. ; Cardoso Micu Menezes, F.M. ; Khasanova, D. ; Kang, L. ; Wang, C. ; Ruiz-Trave, J. ; Sharma, S. ; Khalil, A. ; Reichenbach, V.K. ; Shi, Y. ; Flatley, A. ; Yan, X. ; Israel, A. ; Dragano, N.R.V. ; Aguilar-Pimentel, J.A. ; Hoffmann, A. ; Ghosh, A. ; Noé, F. ; Wolfrum, C. ; Cucuruz, S. ; König, A.-C. ; Burtscher, I. ; Hauck, S.M. ; Lickert, H. ; Hofmann, S.M. ; Feederle, R. ; Schriever, S.C. ; Hernandez-Bautista, R. ; Sancar, G. ; Cebrian Serrano, A. ; Tetko, I.V. ; Fuchs, H. ; Gailus-Durner, V. ; Blüher, M. ; Hrabě de Angelis, M. ; Ussar, S.
NRAC controls CD36-mediated fatty acid uptake in adipocytes and lipid clearance in vivo.Hang, A. ; Shao, A. ; Shea, M.A. ; Roux, M.J. ; Imai-Leonard, D.M. ; Adams, D.J. ; Amano, T. ; Amarie, O.V. ; Berberovic, Z. ; Bour, R. ; Bower, L. ; Leonard, B.C. ; Brown, S.D. ; Cho, S.Y. ; Clementson-Mobbs, S. ; D'Souza, A.J. ; Dickinson, M. ; Eskandarian, M. ; Flenniken, A.M. ; Fuchs, H. ; Gailus-Durner, V. ; Heaney, J.D. ; Herault, Y. ; Hrabě de Angelis, M. ; Hsu, C.W. ; Jin, S. ; Joynson, R. ; Kang, Y.K. ; Kim, H. ; Masuya, H. ; Nam, K.H. ; Noh, H. ; Nutter, L.M.J. ; Palkova, M. ; Prochazka, J. ; Raishbrook, M.J. ; Riet, F. ; Salazar, J. ; Seavitt, J.R. ; Sedlacek, R. ; Selloum, M. ; Seo, K.Y. ; Seong, J.K. ; Shin, H.S. ; Shiroishi, T. ; Sorg, T. ; Stewart, M. ; Tamura, M. ; Tolentino, H. ; Udensi, U. ; Wells, S. ; Wurst, W. ; Yoshiki, A. ; Meziane, H. ; Yiu, G.C. ; Sieving, P.A. ; Lanoue, L. ; Lloyd, K.C.K. ; McKerlie, C. ; Moshiri, A.
Ocular phenotyping of knockout mice identifies genes associated with late adult retinal phenotypes.Schuurman, J.L. ; van Tetering, L. ; Houthuijs, K.J. ; Kooijman, P. ; Gailus-Durner, V. ; Leuchtenberger, S. ; Fuchs, H. ; Hrabě de Angelis, M. ; Engelke, U.F.H. ; Lefeber, D.J. ; van Karnebeek, C.D.M. ; Wevers, R.A. ; Grgic, A. ; Balluf, B. ; Vandenbosch, M. ; Vreeken, R. ; Heeren, R.M.A. ; Berden, G. ; Oomens, J. ; Martens, J.W.M.
Structure elucidation for MALDI mass spectrometry imaging using infrared ion spectroscopy.Lechner, S. ; Sha, S. ; Sethiya, J.P. ; Szczupak, P. ; Dolot, R. ; Lomada, S. ; Sakhteman, A. ; Tüshaus, J. ; Prokofeva, P. ; Krauss, M. ; Breu, F. ; Voegerl, K. ; Morgenstern, M. ; German Mouse Clinic Consortium (Hrabě de Angelis, M. ; Amarie, O.V. ; Becker, L. ; Calzada-Wack, J. ; Dámek, F. ; Dragano, N.R.V. ; Garrett, L. ; Hölter, S. ; Kraiger, M. ; Leuchtenberger, S. ; Marschall, S. ; Östereicher, M.A. ; Rathkolb, B. ; Sanz-Moreno, A. ; Seisenberger, C. ; Spielmann, N. ; Stoeger, C. ; Wurst, W. ; Zimprich, A. ; Fuchs, H. ; Gailus-Durner, V.) ; Haucke, V. ; Wieland, T. ; Wagner, C. ; Médard, G. ; Bracher, F. ; Kuster, B. ; German Mouse Clinic Consortium (da Silva Buttkus, P.)
Serendipitous and systematic chemoproteomic discovery of MBLAC2, HINT1, and NME1-4 inhibitors from histone deacetylase-targeting pharmacophores.Luo, S. ; Gailus-Durner, V. ; McGivern, B. ; Li, Q. ; Kottmeier, J. ; Ho, M.L. ; Mor-Shaked, H. ; Elpeleg, O. ; Aref-Eshghi, E. ; Brodeur, A.C. ; Schmitz-Abe, K. ; Genetti, C.A. ; Picker, J. ; Shi, J. ; Bux, R.I. ; Ben-Omran, T. ; Fuchs, H. ; Harel, T. ; Hrabě de Angelis, M. ; German Mouse Clinic Consortium (Garrett, L. ; Amarie, O.V. ; Spielmann, N. ; Sanz-Moreno, A. ; da Silva Buttkus, P. ; Becker, L. ; Hölter, S. ; Seisenberger, C. ; Marschall, S.) ; German Mouse Clinic Consortium (Dragano, N.R.V.) ; German Mouse Clinic Consortium (Aguilar-Pimentel, J.A.)
Recessive variants in WSB2 encoding a substrate receptor of E3 ubiquitin ligase underlie a neurodevelopmental syndrome.Briere, A. ; Vo, P. ; Yang, B. ; Adams, D. ; Amano, T. ; Amarie, O.V. ; Berberovic, Z. ; Bower, L. ; Brown, S.D.M. ; Burrill, S. ; Cho, S.Y. ; Clementson-Mobbs, S. ; D'Souza, A.R. ; Eskandarian, M. ; Flenniken, A.M. ; Fuchs, H. ; Gailus-Durner, V. ; Hérault, Y. ; Hrabě de Angelis, M. ; Jin, S. ; Joynson, R. ; Kang, Y.K. ; Kim, H. ; Masuya, H. ; Meziane, H. ; Nam, K.H. ; Noh, H. ; Nutter, L.M.J. ; Palkova, M. ; Prochazka, J. ; Raishbrook, M.J. ; Riet, F. ; Salazar, J. ; Sedlacek, R. ; Selloum, M. ; Seo, K.Y. ; Seong, J.K. ; Shin, H.S. ; Shiroishi, T. ; Stewart, M. ; Svenson, K.L. ; Tamura, M. ; Tolentino, H. ; Wells, S. ; Wurst, W. ; Yoshiki, A. ; Lanoue, L. ; Lloyd, K.C.K. ; Leonard, B.C. ; Roux, M.J. ; McKerlie, C. ; Moshiri, A.
Systematic ocular phenotyping of knockout mouse lines identifies genes associated with age-related corneal dystrophies.
