Valérie Gailus-Durner

Scientific Head of the German Mouse Clinic (GMC)

+49 89 3187 3613 valerie.gailusdurner@helmholtz-munich.de Website

Building / Room: 35.14/314

“I want to understand the cause and the pathogenesis of genetic diseases. New scientific knowledge requires to work with the whole organism.”

Valérie is a proud key founding member of the German Mouse Clinic and is leading the GMC as Scientific Head since 2001. She coordinated the setting up of the phenotyping pipelines, project and quality management as well as the assembly of a highly motivated team of scientists, technicians and project managers. Under her guidance the GMC established a reputation for excellence in phenotyping mouse mutants of human diseases.

Valérie has a keen interest to understand gene function by taking a systemic view at the whole organism and to identify new disease genes. Main research interests are metabolic diseases, rare diseases and ageing. She is participating in and coordinating several national and international multi-partner consortia and large-scale projects.

Valérie studied biology and received her PhD in biochemistry in 1994 from the University of Constance, Germany. She spent several years as a postdoctoral fellow at the Waksman Institute, Rutgers University, USA., supported by the German Research Foundation (DFG) as well as US fellowships. Her postdoctoral studies concentrated on genetics and transcriptional regulation of meiosis. In 1998, Valérie accepted a position at the GSF as senior scientist in bioinformatics at the Institute of Mammalian Genetics (Rudi Balling) where she worked on the analysis of complex regulatory transcriptional networks. In 2000 Valérie joined Martin Hrabé de Angelis’ new Institute of Experimental Genetics and together with her colleague Helmut Fuchs she established the first mouse clinic worldwide, the German Mouse Clinic. She served as executive board member of the first European Mouse Clinics (EUMODIC) and is member of the steering committee of the International Mouse Phenotyping Consortium (IMPC), a powerful network of mouse clinics for annotating the whole mammalian genome.

Valérie’s main ambition for the future is to make full use of the great potential of mouse models for human diseases and to make the enormous resource of phenotyping data more accessible for researchers and clinicians. New advanced methods will constantly improve pre-clinical models for studying treatments and genetic diseases, easing the translation to clinics.

mouse phenotyping rare diseases ageing

big data analysis networking quality management

"Working in international networks and collaborations is mandatory and inspiring."

Next to her ambitions in science, supporting women in their careers is an important matter for Valérie. In this respect she is continuously serving as mentor in the Cross-Mentoring München program, which is supposed to foster women leaders and their careers in science and business.

Charles and Johanna Busch Biomedical fellowship 1997-1998
DFG postdoctoral fellowship 1995-1997
EC (EU) junior research fellowship for Genetic Engineering 1990

Bhattacharya, D. ; da Silva Buttkus, P. ; Nalbach, K. ; Cheng, L. ; Garrett, L. ; Irmler, M. ; Kislinger, G. ; Werner, G. ; Rodde, R. ; Lengger, C. ; Beckers, J. ; Zimprich, A. ; Hölter, S.M. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Wefers, B. ; Wurst, W. ; Brill, M.S. ; Schifferer, M. ; Lichtenthaler, S.F. ; Behrends, C.

Neuropathy-associated Tecpr2 mutation knock-in mice reveal endolysosomal loss of function phenotypes in neurons and microglia.

Winkler, R. ; Comas-Armangue, G. ; Corujo, D. ; Sanz-Moreno, A. ; Calzada-Wack, J. ; Bhattacharya, S.A. ; Rathkolb, B. ; Dragano, N.R.V. ; Qiao, C.X. ; Chiodi, V. ; Filipescu, D. ; Park, D.H. ; Domenici, M.R. ; Kirigin Callaú, V. ; Gerlini, R. ; Rozman, J. ; Klein-Rodewald, T. ; Aguilar-Pimentel, J.A. ; Becker, L. ; Seisenberger, C. ; Marschall, S. ; Fuchs, H. ; Gailus-Durner, V. ; Bernstein, E. ; Vinciguerra, M. ; Oberdoerffer, P. ; Hrabě de Angelis, M. ; Teperino, R. ; Buschbeck, M.

Loss of histone macroH2A1.1 causes kidney abnormalities secondary to a change in nutrient metabolization.

Karnebeek, C.D.v. ; Gailus-Durner, V. ; Engelke, U.F.H. ; Seisenberger, C. ; Marschall, S. ; Dragano, N.R.V. ; da Silva Buttkus, P. ; Leuchtenberger, S. ; Fuchs, H. ; Hrabě de Angelis, M. ; Wevers, R.A. ; Coughlin, C.R. ; Lefeber, D.J.

New treatment for PDE-ALDH7A1: First proof-of-principle of upstream enzyme inhibition in the mouse.

Gillet, J.P. ; Gerard, L. ; Vieira, W. ; Fourrez, M. ; Gaudray, F. ; Rathkolb, B. ; Rozman, J. ; Klein-Rodewald, T. ; Becker, L. ; Aguilar-Pimentel, J.A. ; Horsch, M. ; Spielmann, N. ; Prehn, C. ; Bihin, B. ; Beckers, J. ; Fuchs, H. ; Gailus-Durner, V. ; Hrabě de Angelis, M. ; Southon, E. ; Tessarollo, L. ; Xia, D. ; Gottesman, M.M.

Abcb5-deficient mice show a subtle, pleiotropic phenotype indicating a role for this transporter in intermediary metabolism.

Singh, I. ; Onogi, Y. ; Cardoso Micu Menezes, F.M. ; Khasanova, D. ; Kang, L. ; Wang, C. ; Ruiz-Trave, J. ; Sharma, S. ; Khalil, A. ; Reichenbach, V.K. ; Shi, Y. ; Flatley, A. ; Yan, X. ; Israel, A. ; Dragano, N.R.V. ; Aguilar-Pimentel, J.A. ; Hoffmann, A. ; Ghosh, A. ; Noé, F. ; Wolfrum, C. ; Cucuruz, S. ; König, A.-C. ; Burtscher, I. ; Hauck, S.M. ; Lickert, H. ; Hofmann, S.M. ; Feederle, R. ; Schriever, S.C. ; Hernandez-Bautista, R. ; Sancar, G. ; Cebrian Serrano, A. ; Tetko, I.V. ; Fuchs, H. ; Gailus-Durner, V. ; Blüher, M. ; Hrabě de Angelis, M. ; Ussar, S.

NRAC controls CD36-mediated fatty acid uptake in adipocytes and lipid clearance in vivo.

Segur-Bailach, E. ; Mateu-Bosch, A. ; Bofill-De Ros, X. ; Parés, M. ; da Silva Buttkus, P. ; Rathkolb, B. ; Gailus-Durner, V. ; Hrabě de Angelis, M. ; Moeini, P. ; Gonzalez-Aseguinolaza, G. ; Tort, F. ; Ribes, A. ; van Karnebeek, C.D.M. ; García-Villoria, J. ; Fillat, C.

Therapeutic AASS inhibition by AAV-miRNA rescues glutaric aciduria type I severe phenotype in mice.

Hang, A. ; Shao, A. ; Shea, M.A. ; Roux, M.J. ; Imai-Leonard, D.M. ; Adams, D.J. ; Amano, T. ; Amarie, O.V. ; Berberovic, Z. ; Bour, R. ; Bower, L. ; Leonard, B.C. ; Brown, S.D. ; Cho, S.Y. ; Clementson-Mobbs, S. ; D'Souza, A.J. ; Dickinson, M. ; Eskandarian, M. ; Flenniken, A.M. ; Fuchs, H. ; Gailus-Durner, V. ; Heaney, J.D. ; Herault, Y. ; Hrabě de Angelis, M. ; Hsu, C.W. ; Jin, S. ; Joynson, R. ; Kang, Y.K. ; Kim, H. ; Masuya, H. ; Nam, K.H. ; Noh, H. ; Nutter, L.M.J. ; Palkova, M. ; Prochazka, J. ; Raishbrook, M.J. ; Riet, F. ; Salazar, J. ; Seavitt, J.R. ; Sedlacek, R. ; Selloum, M. ; Seo, K.Y. ; Seong, J.K. ; Shin, H.S. ; Shiroishi, T. ; Sorg, T. ; Stewart, M. ; Tamura, M. ; Tolentino, H. ; Udensi, U. ; Wells, S. ; Wurst, W. ; Yoshiki, A. ; Meziane, H. ; Yiu, G.C. ; Sieving, P.A. ; Lanoue, L. ; Lloyd, K.C.K. ; McKerlie, C. ; Moshiri, A.

Ocular phenotyping of knockout mice identifies genes associated with late adult retinal phenotypes.

Schuurman, J.L. ; van Tetering, L. ; Houthuijs, K.J. ; Kooijman, P. ; Gailus-Durner, V. ; Leuchtenberger, S. ; Fuchs, H. ; Hrabě de Angelis, M. ; Engelke, U.F.H. ; Lefeber, D.J. ; van Karnebeek, C.D.M. ; Wevers, R.A. ; Grgic, A. ; Balluf, B. ; Vandenbosch, M. ; Vreeken, R. ; Heeren, R.M.A. ; Berden, G. ; Oomens, J. ; Martens, J.W.M.

Structure elucidation for MALDI mass spectrometry imaging using infrared ion spectroscopy.

Lechner, S. ; Sha, S. ; Sethiya, J.P. ; Szczupak, P. ; Dolot, R. ; Lomada, S. ; Sakhteman, A. ; Tüshaus, J. ; Prokofeva, P. ; Krauss, M. ; Breu, F. ; Voegerl, K. ; Morgenstern, M. ; German Mouse Clinic Consortium (Hrabě de Angelis, M. ; Amarie, O.V. ; Becker, L. ; Calzada-Wack, J. ; Dámek, F. ; Dragano, N.R.V. ; Garrett, L. ; Hölter, S. ; Kraiger, M. ; Leuchtenberger, S. ; Marschall, S. ; Östereicher, M.A. ; Rathkolb, B. ; Sanz-Moreno, A. ; Seisenberger, C. ; Spielmann, N. ; Stoeger, C. ; Wurst, W. ; Zimprich, A. ; Fuchs, H. ; Gailus-Durner, V.) ; Haucke, V. ; Wieland, T. ; Wagner, C. ; Médard, G. ; Bracher, F. ; Kuster, B. ; German Mouse Clinic Consortium (da Silva Buttkus, P.)

Serendipitous and systematic chemoproteomic discovery of MBLAC2, HINT1, and NME1-4 inhibitors from histone deacetylase-targeting pharmacophores.

Luo, S. ; Gailus-Durner, V. ; McGivern, B. ; Li, Q. ; Kottmeier, J. ; Ho, M.L. ; Mor-Shaked, H. ; Elpeleg, O. ; Aref-Eshghi, E. ; Brodeur, A.C. ; Schmitz-Abe, K. ; Genetti, C.A. ; Picker, J. ; Shi, J. ; Bux, R.I. ; Ben-Omran, T. ; Fuchs, H. ; Harel, T. ; Hrabě de Angelis, M. ; German Mouse Clinic Consortium (Garrett, L. ; Amarie, O.V. ; Spielmann, N. ; Sanz-Moreno, A. ; da Silva Buttkus, P. ; Becker, L. ; Hölter, S. ; Seisenberger, C. ; Marschall, S.) ; German Mouse Clinic Consortium (Dragano, N.R.V.) ; German Mouse Clinic Consortium (Aguilar-Pimentel, J.A.)

Recessive variants in WSB2 encoding a substrate receptor of E3 ubiquitin ligase underlie a neurodevelopmental syndrome.