Behaviour, Brain & Metabolism
About Our Group
The Research Group Behaviour, Brain & Metabolism aims to improve the understanding of genetic contributions to neurodevelopmental, neurodegenerative and rare diseases. To this end we use the mouse as model system and a wide range of established in-vivo behavioural and immunohistochemical brain analysis methods, as well as dietary challenges to unravel metabolic aspects. A particular interest is the application of bioinformatics and machine learning approaches to the large-scale dataset of the International Mouse Phenotyping Consortium (IMPC), focusing on disease-relevant phenotypes. The great advantage of this resource is the comprehensiveness of the phenotyping data from animals of both sexes. This allows for the discovery of unexpected comorbidities and potential sex differences in disease development. We also run the Behavioural Unit of the German Mouse Clinic.
Group Leader, Research Group Behaviour, Brain & Metabolism
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Selected Publications
Safaiyan, S. ; Schmidt, M.V. ; Zimprich, A. ; Steiner, J. ; Schulte, E.C. ; Böhm, C. ; Spanagel, R. ; Dere, E. ; Zlomuzica, A. ; Fischer‐Posovszky, P. ; Tuckermann, J. ; Kolassa, I. ; Hansson, A. ; Nickl-Jockschat, T. ; Remy, S. ; Knappmann, E. ; Starzengruber, R. ; Schmidt, S. ; Koch, P. ; Kumsta, R. ; Hölter, S.M. ; Priller, J.
Model Systems infrastructure of the German Center for Mental Health (DZPG): Toward an integrated, mechanism-based framework for mental health research.Harrer, P. ; Kranz, A. ; Becker, L. ; Garrett, L. ; Hölter, S.M. ; Sanz-Moreno, A. ; Amarie, O.V. ; Rathkolb, B. ; Leuchtenberger, S. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Saparov, A. ; Sieber, C. ; Kittke, V. ; Mirza-Schreiber, N. ; Stewart, A.F. ; Winkelmann, J. ; Oexle, K. ; Pocratsky, A. ; Zech, M.
Motor coordination and behavioural deficits in a mouse model of KMT2B-related dystonia.Acosta, M.T. ; Aibar, J.Á. ; Arango, C. ; Cirauqui, E.A. ; Baeza, C. ; Berry-Kravis, E. ; Bishop, K.I. ; Busner, J. ; Chapman, C. ; Chaumette, B. ; del Cerro, I. ; Diaz, J.C. ; Dorffner, G. ; Edgar, C.J. ; Giorgi, S. ; Hölter, S.M. ; Kittel-Schneider, S. ; Latzman, R.D. ; Moreno, C. ; Pallanti, S. ; Colzi, C. ; Plasencia, C. ; Radtke, F. ; Rockwood, K. ; Santuccione Chadha, A. ; Sevinc, G. ; Singh, M.K. ; Smith, S.H. ; Tandon, P.K. ; Tinoco, D. ; Broggi, E. ; Morgan, S.F. ; Magaraggia, I. ; Zaragoza Domingo, S.
Outcome strategies for clinical trials in Neuropaediatric rare diseases.Selloum, M. ; da Silva Buttkus, P. ; Riet, F. ; Dragano, N.R.V. ; Garrett, L. ; Jacobs, H. ; Hölter, S.M. ; Torquet, N. ; Rathkolb, B. ; Lindner, L. ; Gailus-Durner, V. ; Pavlovic, G. ; Chan, L. ; Beckers, J. ; Demoulière, B.P. ; Fuchs, H. ; Ey, E. ; Sorg, T. ; Hrabě de Angelis, M. ; Herault, Y.
Standardized pipeline for metabolism and cognition in GO-DS21 mouse model: Investigating down syndrome comorbidities.Heinla, I. ; Voikar, V. ; Gates, H. ; Bains, R.S. ; Wells, S. ; Mandillo, S. ; Čater, M. ; Kukk, K. ; Lewejohann, L. ; Hrnčić, D. ; Duarte-Domingues, D. ; Villiger, P. ; Restivo, L. ; Hölter, S.M.
Critical uncertainties in preclinical research: Navigating trust, technology, and ethics.Saad, C. ; Jung-Klawitter, S. ; Dimitrov, B. ; Aguilar-Pimentel, J.A. ; Becker, L. ; da Silva Buttkus, P. ; Dragano, N.R.V. ; Garrett, L. ; Hölter, S.M. ; Rathkolb, B. ; Sanz-Moreno, A. ; Spielmann, N. ; Fuchs, H. ; Gailus-Durner, V. ; Schaaf, C.P. ; la Marca, G. ; Damiano, R. ; Lefeber, D.J. ; Engelke, U. ; Hrabě de Angelis, M. ; Houten, S.M. ; Kölker, S.
Aminoadipate-semialdehyde synthase, a potential target for substrate reduction therapy in glutaric aciduria type 1.Lorenz, S. ; Wahida, A. ; Bostock, M.J. ; Seibt, T. ; Santos Dias Mourão, A. ; Levkina, A. ; Trümbach, D. ; Soudy, M. ; Emler, D. ; Rothammer, N. ; Woo, M.S. ; Sonner, J.K. ; Novikova, M. ; Henkelmann, B. ; Aldrovandi, M. ; Kaemena, D.F. ; Mishima, E. ; Vermonden, P. ; Zong, Z. ; Cheng, D. ; Nakamura, T. ; Ito, J. ; Doll, S. ; Proneth, B. ; Bürkle, E. ; Rizzollo, F. ; Escamilla Ayala, A. ; Napolitano, V. ; Kolonko, M. ; Gaussmann, S. ; Merl-Pham, J. ; Hauck, S.M. ; Pertek, A. ; Orschmann, T. ; Van San, E. ; Vanden Berghe, T. ; Hass, D, ; Maida, A. ; Frenz, J.M. ; Pedrera, L. ; Dolga, A.M. ; Kraiger, M. ; Hrabě de Angelis, M. ; Fuchs, H. ; Ebert, G. ; Lenberg, J. ; Friedman, J. ; Scale, C. ; Agostinis, P. ; Zimprich, A. ; Vogt Weisenhorn, D.M. ; Garrett, L. ; Hölter, S.M. ; Wurst, W. ; Glaab, E. ; Lewerenz, J. ; Popper, B. ; Sieben, C. ; Steinacker, P. ; Zischka, H. ; García-Sáez, A.J. ; Tietze, A. ; Ramesh, S.K. ; Ayton, S. ; Vincendeau, M. ; Friese, M.A. ; Wigby, K. ; Sattler, M. ; Mann, M. ; Ingold, I. ; Jayavelu, A.K. ; Popowicz, G.M. ; Conrad, M.
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis.COST Action TEATIME CA20135 welfare group (Hölter, S.M.)
Advocating for automation in animal research: Using home cage monitoring to advance welfare, reproducibility and scientific openness.Contact