DNA strands on Scientific background. 3d illustration, modified

Teperino Lab

Environmental Epigenetics

About our Group

Diabetes and Obesity affect almost 400 million people worldwide and forecasts anticipate an increase of at least 20% by 2030.

Epidemiological studies have shown a high degree of genetic predisposition and familial aggregation in both diabetes and obesity. Nevertheless, lifestyle interventions have proven valuable in disease prevention and management.

Our group of Environmental Epigenetics focuses on the interface between metabolism, genetics and disease. We study physiological and pathological aspects of gene-environment interaction and epigenetic control of inheritance and aim to find novel targets and/or mechanisms towards effective strategies for disease prevention.

Group Members

Raffaele Teperino
Dr. Raffaele Teperino

Group Leader, Research Group 'Evironmental Epigenetics'

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Dr. Archana Tomar

Post Doctoral Researcher

Dr. David Skerrett-Byrne

Postdoctoral Researcher

Shruta Pai

PhD Student

Shefa Aljabali

PhD Student

Publications

Sci. Rep. 10:18334 (2020)

Aguilar-Pimentel, J.A. ; Cho, Y.-L. ; Gerlini, R. ; Calzada-Wack, J. ; Wimmer, M. ; Mayer-Kuckuk, P. ; Adler, T. ; Schmidt-Weber, C.B. ; Busch, D.H. ; Fuchs, H. ; Gailus-Durner, V. ; Ollert, M. ; Hrabě de Angelis, M. ; Ohlsson, C. ; Poutanen, M. ; Teperino, R. ; Strauss, L.

Increased estrogen to androgen ratio enhances immunoglobulin levels and impairs B cell function in male mice.

Chhabra, N.F. ; Amarie, O.V. ; Wu, M. ; Amend, A.-L. ; Rubey, M. ; Gradinger, D. ; Irmler, M. ; Beckers, J. ; Rathkolb, B. ; Wolf, E. ; Feuchtinger, A. ; Huypens, P. ; Teperino, R. ; Rozman, J. ; Przemeck, G.K.H. ; Hrabě de Angelis, M.

PAX6 mutation alters circadian rhythm and beta cell function in mice without affecting glucose tolerance.
Genome Med. 12:87 (2020)

Binyamin, D. ; Werbner, N. ; Nuriel-Ohayon, M. ; Uzan, A. ; Mor, H. ; Abbas, A. ; Ziv, O. ; Teperino, R. ; Gutmann, R. ; Koren, O.

The aging mouse microbiome has obesogenic characteristics.
Mamm. Genome, DOI: 10.1007/s00335-020-09843-3 (2020)

Beckers, J. ; Teperino, R. ; Hérault, Y. ; Hrabě de Angelis, M.

Introduction to mammalian genome special issue: Epigenetics.
2020 in
In: Beyond Our Genes. 2020. 159-173

Lassi, M. ; Teperino, R.

Introduction to epigenetic inheritance: Definition, mechanisms, implications and relevance.
2020 in
Springer International Publishing, 2020.:doi.org/10.1007/978-3-030-35213-

Teperino, R.

Pathophyiology of gene and environment interaction and epigenetic inheritance.
Cell Rep. 30, 3183-3194.e4 (2020)

Darr, J. ; Tomar, A. ; Lassi, M. ; Gerlini, R. ; Berti, L. ; Hering, A. ; Scheid, F. ; Hrabě de Angelis, M. ; Witting, M. ; Teperino, R.

iTAG-RNA isolates cell-specific transcriptional responses to environmental stimuli and identifies an RNA-based endocrine axis.

Contact

Raffaele Teperino
Dr. Raffaele Teperino

Group Leader, Research Group 'Evironmental Epigenetics'

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