Teperino Lab
Environmental Epigenetics
About our Group
Diabetes and Obesity affect almost 400 million people worldwide and forecasts anticipate an increase of at least 20% by 2030.
Epidemiological studies have shown a high degree of genetic predisposition and familial aggregation in both diabetes and obesity. Nevertheless, lifestyle interventions have proven valuable in disease prevention and management.
Our group of Environmental Epigenetics focuses on the interface between metabolism, genetics and disease. We study physiological and pathological aspects of gene-environment interaction and epigenetic control of inheritance and aim to find novel targets and/or mechanisms towards effective strategies for disease prevention.
Publications
Aguilar-Pimentel, J.A. ; Cho, Y.-L. ; Gerlini, R. ; Calzada-Wack, J. ; Wimmer, M. ; Mayer-Kuckuk, P. ; Adler, T. ; Schmidt-Weber, C.B. ; Busch, D.H. ; Fuchs, H. ; Gailus-Durner, V. ; Ollert, M. ; Hrabě de Angelis, M. ; Ohlsson, C. ; Poutanen, M. ; Teperino, R. ; Strauss, L.
Increased estrogen to androgen ratio enhances immunoglobulin levels and impairs B cell function in male mice.Chhabra, N.F. ; Amarie, O.V. ; Wu, M. ; Amend, A.-L. ; Rubey, M. ; Gradinger, D. ; Irmler, M. ; Beckers, J. ; Rathkolb, B. ; Wolf, E. ; Feuchtinger, A. ; Huypens, P. ; Teperino, R. ; Rozman, J. ; Przemeck, G.K.H. ; Hrabě de Angelis, M.
PAX6 mutation alters circadian rhythm and beta cell function in mice without affecting glucose tolerance.Binyamin, D. ; Werbner, N. ; Nuriel-Ohayon, M. ; Uzan, A. ; Mor, H. ; Abbas, A. ; Ziv, O. ; Teperino, R. ; Gutmann, R. ; Koren, O.
The aging mouse microbiome has obesogenic characteristics.Beckers, J. ; Teperino, R. ; Hérault, Y. ; Hrabě de Angelis, M.
Introduction to mammalian genome special issue: Epigenetics.Tomar, A. ; Teperino, R.
Genetic control of non-genetic inheritance in mammals: state-of-the-art and perspectives.Lassi, M. ; Teperino, R.
Introduction to epigenetic inheritance: Definition, mechanisms, implications and relevance.Teperino, R.
Pathophyiology of gene and environment interaction and epigenetic inheritance.Darr, J. ; Tomar, A. ; Lassi, M. ; Gerlini, R. ; Berti, L. ; Hering, A. ; Scheid, F. ; Hrabě de Angelis, M. ; Witting, M. ; Teperino, R.
iTAG-RNA isolates cell-specific transcriptional responses to environmental stimuli and identifies an RNA-based endocrine axis.