DNA strands on Scientific background. 3d illustration, modified

Teperino Lab

Environmental Epigenetics

About our Group

Diabetes and Obesity affect almost 400 million people worldwide and forecasts anticipate an increase of at least 20% by 2030.

Epidemiological studies have shown a high degree of genetic predisposition and familial aggregation in both diabetes and obesity. Nevertheless, lifestyle interventions have proven valuable in disease prevention and management.

Our group of Environmental Epigenetics focuses on the interface between metabolism, genetics and disease. We study physiological and pathological aspects of gene-environment interaction and epigenetic control of inheritance and aim to find novel targets and/or mechanisms towards effective strategies for disease prevention.

Group Members

Raffaele Teperino
Dr. Raffaele Teperino

Group Leader, Research Group 'Evironmental Epigenetics'

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Dr. Archana Tomar

Post Doctoral Researcher

Dr. David Skerrett-Byrne

Postdoctoral Researcher

Shruta Pai

PhD Student

Shefa Aljabali

PhD Student

Publications

Front. Cell Dev. Biol. 12:1520783 (2024)

Aljabali, S. M. ; Pai, S. ; Teperino, R.

Paternal impact on the developmental programming of sexual dimorphism.

Trigg, N. ; Schjenken, J.E. ; Martin, J.H. ; Skerrett-Byrne, D.A. ; Smyth, S.P. ; Bernstein, I.R. ; Anderson, A.L. ; Stanger, S.J. ; Simpson, E.N.A. ; Tomar, A. ; Teperino, R. ; Conine, C.C. ; De Iuliis, G.N. ; Roman, S.D. ; Bromfield, E.G. ; Dun, M.D. ; Eamens, A.L. ; Nixon, B.

Subchronic elevation in ambient temperature drives alterations to the sperm epigenome and accelerates early embryonic development in mice.
Reprod. Fertil. Dev. 36:RD24079 (2024)

Skerrett-Byrne, D.A. ; Teperino, R. ; Nixon, B.

ShinySperm: Navigating the sperm proteome landscape.
Mol. Cell. Proteomics 23:100811 (2024)

Schäfer, F. ; Tomar, A. ; Sato, S. ; Teperino, R. ; Imhof, A. ; Lahiri, S.

Enhanced in situ spatial proteomics by effective combination of MALDI imaging and LC-MS/MS.
Nature 638, 720-727 (2024)

Tomar, A. ; Gómez Velázquez, M. ; Gerlini, R. ; Comas-Armangue, G. ; Makharadze, L. ; Kolbe, T. ; Boersma, A. ; Dahlhoff, M. ; Burgstaller, J.P. ; Lassi, M. ; Darr, J. ; Toppari, J. ; Virtanen, H. ; Kühnapfel, A. ; Scholz, M. ; Landgraf, K. ; Kiess, W. ; Vogel, M. ; Gailus-Durner, V. ; Fuchs, H. ; Marschall, S. ; Hrabě de Angelis, M. ; Kotaja, N. ; Körner, A. ; Teperino, R.

Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs.

Contact

Raffaele Teperino
Dr. Raffaele Teperino

Group Leader, Research Group 'Evironmental Epigenetics'

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