DNA strands on Scientific background. 3d illustration, modified

Teperino Lab

Environmental Epigenetics

About our Group

Diabetes and Obesity affect almost 400 million people worldwide and forecasts anticipate an increase of at least 20% by 2030.

Epidemiological studies have shown a high degree of genetic predisposition and familial aggregation in both diabetes and obesity. Nevertheless, lifestyle interventions have proven valuable in disease prevention and management.

Our group of Environmental Epigenetics focuses on the interface between metabolism, genetics and disease. We study physiological and pathological aspects of gene-environment interaction and epigenetic control of inheritance and aim to find novel targets and/or mechanisms towards effective strategies for disease prevention.

Group Members

Raffaele Teperino
Dr. Raffaele Teperino

Group Leader, Research Group 'Evironmental Epigenetics'

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Dr. Archana Tomar

Post Doctoral Researcher

Dr. David Skerrett-Byrne

Postdoctoral Researcher

Shruta Pai

PhD Student

Shefa Aljabali

PhD Student

Publications

Front. Endocrin. 16:1680893 (2025)

Harten, A. ; Schmidtke, M. ; Giesert, F. ; Skerrett-Byrne, D.A. ; Teperino, R. ; Przemeck, G.K.H. ; Hrabě de Angelis, M.

MODY PDX1P33T: A mouse model reveals phenotypic divergence from human disease.
Sci. Adv. 11:eadz1242 (2025)

Winkler, R. ; Comas-Armangue, G. ; Corujo, D. ; Sanz-Moreno, A. ; Calzada-Wack, J. ; Bhattacharya, S.A. ; Rathkolb, B. ; Dragano, N.R.V. ; Qiao, C.X. ; Chiodi, V. ; Filipescu, D. ; Park, D.H. ; Domenici, M.R. ; Kirigin Callaú, V. ; Gerlini, R. ; Rozman, J. ; Klein-Rodewald, T. ; Aguilar-Pimentel, J.A. ; Becker, L. ; Seisenberger, C. ; Marschall, S. ; Fuchs, H. ; Gailus-Durner, V. ; Bernstein, E. ; Vinciguerra, M. ; Oberdoerffer, P. ; Hrabě de Angelis, M. ; Teperino, R. ; Buschbeck, M.

Loss of histone macroH2A1.1 causes kidney abnormalities secondary to a change in nutrient metabolization.
Mol. Nutr. Food Res. 69:e70261 (2025)

Skerrett-Byrne, D.A. ; Pepin, A.-S. ; Laurent, K. ; Beckers, J. ; Schneider, R. ; Hrabě de Angelis, M. ; Teperino, R.

Dad's diet shapes the future: How paternal nutrition impacts placental development and childhood metabolic health.
Reproduction 169:e250105 (2025)

Pini, T. ; Nixon, B. ; Timothy L, K. ; Teperino, R. ; Sanz-Moreno, A. ; da Silva Buttkus, P. ; Tüttelmann, F. ; Kliesch, S. ; Gailus-Durner, V. ; Fuchs, H. ; Marschall, S. ; Hrabě de Angelis, M. ; Skerrett-Byrne, D.A.

Towards a kingdom of reproductive life - the core sperm proteome.
Nat. Metab., DOI: 10.1038/s42255-025-01222-z (2025)

Teperino, R.

Intergenerational metabolic effects of cold exposure.

Contact

Raffaele Teperino
Dr. Raffaele Teperino

Group Leader, Research Group 'Evironmental Epigenetics'

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