Optimization of Radiation Applications in Medicine

Our mission is improving the efficiency of medical applications of ionising radiation. The research focus of our working group is to make personalised applications of ionising radiation in medicine in an efficient way with regard to medical diagnostic and therapeutic procedures. Scientific strengths of our working group are the expertise in biokinetic modelling, imaging geometries and tomographic reconstruction methods as well as uncertainty and sensitivity analysis.

Projects of the Working Group

Current projects:

"Radiation protection in the clinics - Exposures of clinical staff during nuclear medicine therapies (ExperT)"
Coordination: Dr. Kerstin Hürkamp
Work Package 1.1: Radionuclides in the breathing air of patients and the room air in nuclear medical facilities. (Dr. Kerstin Hürkamp, Dr. Jochen Tschiersch)
'Work package 3: Biokinetic modelling and internal dose estimation for clinical staff and patients based on experimental measurement data. (Dr. Weibo Li, Dr. Kerstin Hürkamp)

Cooperationwith the Munich Clinics for Nuclear Medicine rechts der Isar, Technische Universität München und Ludwig-Maximilians-Universität München, VKTA Dresden-Rossendorf and Fa. SARAD GmbH

Kompetenzverbund Strahlenforschung
Funding: Federal Ministery of Education and Research, BMBF, 10/2021-09/2024, Funding code: 02NUK065A

 

"Preclinical experiments on nuclide distribution, pharmacokinetic modelling and internal dose estimation in radionuclide therapy with alpha emitters"
Coordination: Dr. Kerstin Hürkamp
Project members: Dr. Weibo Li, Samaa Saleh

The aim of the project is to optimise the use of alpha emitters in radionuclide therapy. In preclinical experiments with 225Ac-PSMA I&T, we

  • determine the nuclide distribution of 225Ac and its progeny bound to the carrier substance PSMA I&T or as low molecular weight compounds in representative organs and tissues, blood, urine and in the tumour at different time points after injection,
  • develop a pharmacokinetic model for 225Ac-PSMA I&T and its downstream products, which also takes into account a possible separation of the radiopharmaceutical from the carrier substance,
  • calculate the internal dose (energy and organ equivalent doses) and compare the results with published data.

Cooperation with the Clinics for Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München (PD Dr. Calogero D'Alessandria, Prof. Dr. Wolfgang Weber).

Funding: Federal Office of Radiation Protection (BfS), funded by Federal Ministry of Environment,
09/2021-01/2024, Funding code: 3621S42440

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Finished projects:

"TransAqua: Transfer of Radionuclides in Aquatic Ecosystems"
Coordination: Dr. Jochen Tschiersch
Work package 1.2: Transport of radionuclides from a snow field to the discharge systems: Radioecologic balance using the example of the Reintal valley, Mt. Zugspitze (Dr. Kerstin Hürkamp)
Work package 3.1: Studies on the biokinetics of incorporated radionuclides from aquatic ecosystems for improved dose assessment (Dr. Uwe Oeh, Dr. Weibo Li, Dr. Vera Höllriegl)

Kompetenzverbund Strahlenforschung
Funding: Federal Ministery of Education and Research, BMBF, 2013-2017

 

"Radiation and Environment II: Radionuclides in the Environment, their Transport in Food Chains to and in Humans"
Coordination: Dr. Jochen Tschiersch
Work package 1.3: Radioecology in the case of snow (Dr. Kerstin Hürkamp, Felix Bernauer, Dr. Jochen Tschiersch)
Work package 3.1: Improved estimation of the internal dose following the incorporation of natural radionuclides from soils by use of model scenarios with healing earth (Dr. Vera Höllriegl, Stefan Träber)
Work package 3.4: Biokinetic modelling and internal dosimetry on the basis of experimental measurement data (Dr. Weibo Li, Dr. Uwe Oeh, Kamil Brudecki)

Kompetenzverbund Strahlenforschung
Funding: Federal Ministery of Education and Research, BMBF, 2010-2014

 

Harmonising Modelling Strategies of European Decision Support Systems for Nuclear Emergencies (HARMONE)
Work Package: Regionalisation of the models for the use in Europe at local and national level. (HMGU, PHE, KIT, IRSN, UCEWP, SCK*CEN): Development of a conceptual snow model (Dr. Kerstin Hürkamp, Dr. Jochen Tschiersch)

Funding: European Commission-OPERRA, 2015-2017

 

Virtual Alpine Observatory (VAO)
Work Package III/03: Influence of climate change on the alpine water budget and the environmental radioactivity (Dr. Kerstin Hürkamp, Dr. Jochen Tschiersch, Anne Reckerth)

Funding: Bavarian State Ministry of the Environment and Consumer Protection, 2014-2017