Publications
Wjst, M. ; Werner, M.
Methods of genotyping.Förster, K. ; Sass, S. ; Dietrich, O. ; Pomschar, A. ; Nährlich, L. ; Schulze, A. ; Flemmer, A.W. ; Ehrhardt, H. ; Hübener, C. ; Eickelberg, O. ; Theis, F.J. ; Ertl-Wagner, B. ; Hilgendorff, A.
LSC Abstract – Early biomarkers indicating the development of neonatal chronic lung disease defined by clinical and imaging parameters.Ge, L. ; Habiel, D.M. ; Hansbro, P.M. ; Kim, R.Y. ; Gharib, S.A. ; Edelman, J.D. ; Königshoff, M. ; Parimon, T. ; Brauer, R. ; Huang, Y. ; Allen, J. ; Jiang, D. ; Kurkciyan, A.A. ; Mizuno, T. ; Stripp, B.R. ; Noble, P.W. ; Hogaboam, C.M. ; Chen, P.
miR-323a-3p regulates lung fibrosis by targeting multiple profibrotic pathways.Kanellakis, N.I. ; Giannou, A.D. ; Pepe, M. ; Agalioti, T. ; Zazara, D.E. ; Vreka, M. ; Lilis, I. ; Giopanou, I. ; Spella, M. ; Marazioti, A. ; Rahman, N. ; Pavord, I.D. ; Psallidas, I. ; Stathopoulos, G.T.
Mouse lung adenocarcinoma cell lines reveal PRL2C2 as a novel lung tumour promoter.Psallidas, I. ; Kanellakis, N.I. ; Vreka, M. ; Giannou, A.D. ; Maniatis, L. ; Moschos, C. ; Giopanou, I. ; Agalioti, T. ; Lilis, I. ; Magkouta, S. ; Kalomenidis, I. ; Rahman, N.M. ; Pavord, I.D. ; Stathopoulos, G.T.
Osteopontin as an airway epithelial tumour promoter.Schnitzler, M.M.Y. ; Storch, U. ; Gudermann, T.
Mechanosensitive G(q/11) protein-coupled receptors mediate myogenic vasoconstriction.Bonella, F. ; Kreuter, M. ; Hagmeyer, L. ; German Nintedanib Compassionate Use Consortium (Neurohr, C. ; Milger, K.) ; Keller, C. ; Kohlhaeufl, M.J. ; Mueller-Quernheim, J. ; Prasse, A.
Insights from the German compassionate use program of nintedanib for the treatment of idiopathic pulmonary fibrosis.Geiger, S. ; Hereth, M. ; Forster, D. ; Hollauer, C. ; Ballester, C.F. ; Hermann, F.G. ; Yildirim, A.Ö. ; Guenther, C.
Amelioration of lung function and pulmonary tissue regeneration after treatment with Alpha-1 antitrypsin (AAT)-expressing mesenchymal stem cells (MSCs) in a murine model of elastase-induced emphysema.Larsson, D.H. ; Vågberg, W. ; Yaroshenko, A. ; Yildirim, A.Ö. ; Hertz, H.M.
High-resolution short-exposure small-animal laboratory x-ray phase-contrast tomography.Dietz, K. ; de los Reyes Jimenez, M. ; Gollwitzer, E.S. ; Chaker, A. ; Zissler, U.M. ; Harris, N.L. ; Königshoff, M. ; Schmidt-Weber, C.B. ; Marsland, B.J. ; Esser-von Bieren, J.
Age-dependent regulation of remodeling factors during allergic airway inflammation.Houssaini, A. ; Abid, S. ; Derumeaux, G. ; Wan, F. ; Parpaleix, A. ; Rideau, D. ; Marcos, E. ; Czibik, G. ; Sawaki, D. ; Dubois-Rande, J.L. ; Zhenlin, L. ; Pende, M. ; Amsellem, V. ; Lipskaia, L. ; Adnot, A.
Selective TSC1 deletion in smooth muscle activates mTOR signaling and induces pulmonary hypertension.Pereira, P.R. ; Oliveira-Junior, M.C. ; MacKenzie, B. ; Chiovatto, J.E.D. ; Matos, Y. ; Greiffo, F.R. ; Rigonato-Oliveira, N.C. ; Brugemman, T.R. ; Delle, H. ; Idzko, M. ; Albertini, R. ; Ligeiro Oliveira, A.P. ; Damaceno-Rodrigues, N.R. ; Caldini, E.G. ; Fernandez, I.E. ; Castro-Faria-Neto, H.C. ; Dolhnikoff, M. ; Eickelberg, O. ; Vieira, R.P.
Exercise reduces lung fibrosis involving serotonin/akt signaling.Hamon, Y. ; Legowska, M. ; Herve, V. ; Dallet-Choisy, S. ; Marchand-Adam, S. ; Vanderlynden, L. ; Demonte, M. ; Williams, R. ; Scott, C.J. ; Si-Tahar, M. ; Heuze-Vourc'h, N. ; Lalmanach, G. ; Jenne, D. ; Lesner, A. ; Gauthier, F. ; Korkmaz, B.
Neutrophilic cathepsin C is maturated by a multistep proteolytic process and secreted by activated cells during inflammatory lung diseases.Korkmaz, B. ; Lesner, A. ; Guarino, C. ; Wysocka, M. ; Kellenberger, C. ; Watier, H. ; Specks, U. ; Gauthier, F. ; Jenne, D.
Inhibitors and antibody fragments as potential anti-inflammatory therapeutics targeting neutrophil proteinase 3 in human disease.Leppkes, M. ; Maueroeder, C. ; Hirth, S. ; Nowecki, S. ; Günther, C. ; Billmeier, U. ; Paulus, S. ; Biermann, M. ; Munoz, L.E. ; Hoffmann, M. ; Wildner, D. ; Croxford, A.L. ; Waisman, A. ; Mowen, K. ; Jenne, D. ; Krenn, V. ; Mayerle, J. ; Lerch, M.M. ; Schett, G. ; Wirtz, S. ; Neurath, M.F. ; Hermann, M. ; Becker, C.
Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis.White, E.S. ; Borok, Z. ; Brown, K. ; Eickelberg, O. ; Guenther, A. ; Jenkins, R. ; Kolb, M. ; Martinez, F.J. ; Roman, J. ; Sime, P.
An american thoracic society official research statement: Future directions in lung fibrosis research.Strange, C.B. ; Herth, F.J.F. ; Valipour, A. ; Shah, P.L. ; Eberhardt, R. ; Grah, C. ; Egan, J. ; Ficker, J.H. ; Wagner, M. ; Witt, C. ; Liebers, U. ; Hopkins, P.N. ; Gesierich, W. ; Phillips, M.A. ; Stanzel, F. ; McNulty, W. ; Petermann, C. ; Snell, G.I. ; Gompelmann, D.
Step-up randomized controlled trial of segmental vapor ablation in patients with severe emphysema: 6 month results.Oak, P. ; Koschlig, M. ; Windhorst, A. ; Jain, N. ; Reicherzer, T. ; Ehrhardt, H. ; Frankenberger, M. ; Alvira, C.M. ; Schwarz, M.A. ; Eickelberg, O. ; Hilgendorff, A.
Monocyte-centred inflammatory response characterizing early stages of Bpd development in the preterm infant.Jia, J. ; Conlon, T.M. ; Lopez, C.B. ; Eickelberg, O. ; Mall, M.A. ; Yildirim, A.Ö.
Chronic bronchitis enhancement in newborn mice from exposure to environmental tobacco smoke.Bonella, F. ; Kreuter, M. ; Hagmeyer, L. ; Neurohr, C. ; Keller, C. ; Kohlhaeufl, M. ; Mueller-Quernheim, J. ; Milger, K. ; Prasse, A.
Insights from a multi-centre real life experience in Germany with nintedanib for the Tteatment of idiopathic pulmonary fibrosis.Wagner, D.E. ; Mutze, K. ; Schiller, H.B. ; Costa, R. ; Kaminski, N. ; Königshoff, M.
Hippo signaling is deranged in idiopathic pulmonary fibrosis and correlates with disease severity.Knüppel, L. ; Ishikawa, Y. ; Heinzelmann, K. ; Hatz, R. ; Behr, J. ; Bachinger, H. ; Eickelberg, O. ; Staab-Weijnitz, C.A.
Effects of nintedanib and pirfenidone on expression and maturation of collagen - A comprehensive analysis.Behr, J. ; Wirtz, H. ; Prasse, A. ; Pittrow, D. ; Klotsche, J. ; Koschel, D. ; Andreas, S. ; Claussen, M. ; Grohe, C. ; Kreuter, M.
Predictors of mortality in patients with idiopathic pulmonary fibrosis under clinical practice conditions: Insights-Ipf registry.Lehmann, M. ; Mutze, K. ; Schiller, H.B. ; Wagner, D.E. ; Königshoff, M.
Increased alveolar epithelial cell senescence in pulmonary fibrosis.Ciolek, F. ; Königshoff, M. ; Baarsma, H.A.
Regulation of non-canonical Wnt-5a by primary human lung fibroblasts.Skronska-Wasek, W. ; Mutze, K. ; Baarsma, H.A. ; Wagner, D.E. ; Stornaiuolo, M. ; Königshoff, M.
Cigarette smoke-induced downregulation of the epithelial cell enriched WNT receptor Fzd4 contributes to reduced Wnt/beta-catenin signaling and alveolar epithelial cell proliferation in COPD.Keller, I.E. ; Dann, A. ; Lukas, C. ; Brech, D. ; Vosyka, O. ; Nössner, E. ; Eickelberg, O. ; Meiners, S.
Proteasome-dependent Mhc I antigen presentation is altered by cigarette smoke.Conlon, T.M. ; Merthan, L. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Furusawa, T. ; Bustin, M. ; Eickelberg, O. ; Yildirim, A.Ö.
Reduced expression of the epigenetic regulator Hmgn5 enhances susceptibility to emphysema.Baarsma, H.A. ; Skronska-Wasek, W. ; Mutze, K. ; Ciolek, F. ; John-Schuster, G. ; Dagouassat, M. ; Günther, A. ; Boczkowski, J. ; Smits, R. ; Yildirim, A.Ö. ; Königshoff, M.
Non-canonical Wnt-5a compromises endogenous lung repair In COPD.Staab-Weijnitz, C.A. ; Schamberger, A.C. ; Fernandez, I.E. ; Schiller, H. B. ; Heinzelmann, K. ; Sterclova, M. ; Vasakova, M. ; Mann, M. ; Eickelberg, O.
Expression and regulation of glutathione peroxidase 3 in interstitial lung disease.Welk, V. ; Semren, N. ; Korfei, M. ; Günther, A. ; Eickelberg, O.
Proteasome activator 200 (pa200) is dysregulated in fibrotic remodeling of the lung.Koschlig, M. ; Tian, X. ; Sudheendra, D. ; Spiekerkoetter, E.F. ; Hilgendorff, A.
Enhanced effects of hyperoxia on Vessel development in newborn mice heterozygote for the bmp receptor 2.Stelzer, D. ; Ihle, F. ; Weber, A. ; Kneidinger, N. ; Zimmermann, G. ; Ceelen, F. ; Schramm, R. ; Winter, H. ; Frey, L. ; Andraschko, M. ; Vogeser, M. ; Behr, J. ; Neurohr, C.
Impact of posaconazol liquid vs. tablet formulation on plasma trough levels in lung transplant recipients.Wrenn, S. ; Coffey, A. ; Uhl, F.E. ; Bianchi, J. ; Dacken, B. ; Petersen, T. ; Wagner, D.E. ; Boyson, J.E. ; Weiss, D.J.
Decellularized wild type and alpha-galactosyltransferase knockout pig lungs stimulate M2 phenotype in human monocyte/macrophages.Mummler, C. ; Vierkotten, S. ; Mutze, K. ; Günther, A. ; Königshoff, M.
Runt-related transcription factor 2 (runx2) regulates mesenchymal cell differentiation and extracellular matrix production in pulmonary fibrosis.Fernandez, I.E. ; Greiffo, F.R. ; Frankenberger, M. ; Heinzelmann, K. ; Neurohr, C. ; Hatz, R. ; Behr, J. ; Eickelberg, O.
Peripheral blood myeloid-derived suppressor cells reflect disease status In Ipf.Klee, S. ; Lehmann, M. ; Wagner, D.E. ; Baarsma, H.A. ; Königshoff, M.
Wisp1 mediates Il6-dependent proliferation in healthy and Ipf-derived primary human lung fibroblasts.Psallidas, I. ; Kanellakis, N.I. ; Vreka, M. ; Giannou, A.D. ; Maniatis, L. ; Magkouta, S. ; Moschos, C. ; Giopanou, I. ; Agalioti, T. ; Lillis, I. ; Kalomenidis, I. ; Rahman, N.M. ; Stathopoulos, G.T.
Osteopontin as an airway epithelial tumor promoter.Houssaini, A. ; Kebe, K. ; Breau, M. ; Marcos, E. ; Huang, J. ; Attwe, A. ; Bizard, E. ; Abid, S. ; Validire, P. ; Maitre, B. ; Meiners, S. ; Amsellem, V. ; Adnot, S.
Targeting the mtor signaling pathway to inhibit lung cell senescence In chronic obstructive pulmonary disease (COPD).Schmid, O. ; Möller, W. ; Stelzl, A. ; Amarie, O.V. ; Eickelberg, O. ; Yildirim, A.Ö.
Towards standardized airway hyperresponsiveness measurements In mice.Dvorkin-Gheva, A. ; Vanderstocken, G. ; Yildirim, A.Ö. ; Brandsma, C.A. ; Obeidat, M. ; Bossé, Y. ; Hassell, J.A. ; Stampfli, M.R.
Total particulate matter concentration skews cigarette smoke’s gene expression profile.Hilgendorff, A. ; Apitz, C. ; Bonnet, D. ; Hansmann, G.
Pulmonary hypertension associated with acute or chronic lung diseases in the preterm and term neonate and infant. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK.Wuttke, S. ; Zimpel, A. ; Bein, T. ; Braig, S. ; Stoiber, K. ; Vollmar, A. ; Müller, D. ; Haastert-Talini, K. ; Schaeske, J. ; Stiesch, M. ; Zahn, G. ; Mohmeyer, A. ; Behrens, P. ; Eickelberg, O. ; Bölükbas, D.A. ; Meiners, S.
Validating metal-organic framework nanoparticles for their nanosafety in diverse biomedical applications.Fuchs, H. ; Sabrautzki, S. ; Przemeck, G.K.H. ; Leuchtenberger, S. ; Lorenz-Depiereux, B. ; Becker, L. ; Rathkolb, B. ; Horsch, M. ; Garrett, L. ; Östereicher, M.A. ; Hans, W. ; Abe, K. ; Sagawa, N. ; Rozman, J. ; Vargas Panesso, I.L. ; Sandholzer, M. ; Lisse, T.S. ; Adler, T. ; Aguilar-Pimentel, J.A. ; Calzada-Wack, J. ; Ehrhard, N. ; Elvert, R. ; Gau, C. ; Hölter, S.M. ; Micklich, K. ; Moreth, K. ; Prehn, C. ; Puk, O. ; Rácz, I. ; Stoeger, C. ; Vernaleken, A. ; Michel, D. ; Diener, S. ; Wieland, T. ; Adamski, J. ; Bekeredjian, R. ; Lengger, C. ; Maier, H. ; Neff, F. ; Ollert, M. ; Stöger, T. ; Yildirim, A.Ö. ; Strom, T.M. ; Zimmer, A. ; Wolf, E. ; Wurst, W. ; Klopstock, T. ; Beckers, J. ; Gailus-Durner, V. ; Hrabě de Angelis, M.
The first Scube3 mutant mouse line with pleiotropic phenotypic alterations.Dau, T. ; Edeleva, E.V. ; Seidel, S.A. ; Stockley, R.A. ; Braun, D. ; Jenne, D.
Quantitative analysis of protease recognition by inhibitors in plasma using microscale thermophoresis.Ota, C. ; Baarsma, H.A. ; Wagner, D.E. ; Hilgendorff, A. ; Königshoff, M.
Linking bronchopulmonary dysplasia to adult chronic lung diseases: Role of WNT signaling.Andrade-Sousa, A.S. ; Rogério Pereira, P. ; MacKenzie, B. ; Oliveira-Junior, M.C. ; Assumpção-Neto, E. ; Brandão-Rangel, M.A. ; Damaceno-Rodrigues, N.R. ; Garcia Caldini, E. ; Velosa, A.P. ; Teodoro, W.R. ; Ligeiro de Oliveira, A.P. ; Dolhnikoff, M. ; Eickelberg, O. ; Vieira, R.P.
Aerobic exercise attenuated bleomycin-induced lung fibrosis in Th2-dominant mice.Liu, X. ; Baarsma, H.A. ; Thiam, C.H. ; Montrone, C. ; Brauner, B. ; Fobo, G. ; Heier, J.S. ; Duscha, S. ; Königshoff, M. ; Angeli, V. ; Ruepp, A. ; Campillos, M.
Systematic identification of pharmacological targets from small-molecule phenotypic screens.Sabrautzki, S. ; Sandholzer, M.A. ; Lorenz-Depiereux, B. ; Brommage, R. ; Przemeck, G.K.H. ; Vargas Panesso, I.L. ; Vernaleken, A. ; Garrett, L. ; Baron, K. ; Yildirim, A.Ö. ; Rozman, J. ; Rathkolb, B. ; Gau, C. ; Hans, W. ; Hölter, S.M. ; Marschall, S. ; Stoeger, C. ; Becker, L. ; Fuchs, H. ; Gailus-Durner, V. ; Klingenspor, M. ; Klopstock, T. ; Lengger, C. ; Stefanie, L. ; Wolf, E. ; Strom, T.M. ; Wurst, W. ; Hrabě de Angelis, M.
Viable EdnraY129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation.Hellbach, K. ; Yaroshenko, A. ; Willer, K. ; Pritzke, T. ; Baumann, A. ; Hesse, N. ; Auweter, S. ; Reiser, M.F. ; Eickelberg, O. ; Pfeiffer, F. ; Hilgendorff, A. ; Meinel, F.G.
Facilitated diagnosis of pneumothoraces in newborn mice using x-ray dark-field radiography.Fernandez, I.E. ; Greiffo, F.R. ; Frankenberger, M. ; Bandres, J. ; Heinzelmann, K. ; Neurohr, C. ; Hatz, R. ; Hartl, D. ; Behr, J. ; Eickelberg, O.
Peripheral blood myeloid-derived suppressor cells reflect disease status in idiopathic pulmonary fibrosis.Lee, Y.C. ; Idell, S. ; Stathopoulos, G.T.
Translational research in pleural infection and beyond.Steer, B. ; Strehle, M. ; Sattler, C. ; Bund, D. ; Flach, B. ; Stöger, T. ; Haas, J.G. ; Adler, H.
The small noncoding RNAs (sncRNAs) of murine gammaherpesvirus 68 (MHV-68) are involved in regulating the latent-to-lytic switch in vivo.Dietz, K. ; de los Reyes Jimenez, M. ; Gollwitzer, E.S. ; Chaker, A. ; Zissler, U.M. ; Rådmark, O.P. ; Baarsma, H.A. ; Königshoff, M. ; Schmidt-Weber, C.B. ; Marsland, B.J. ; Esser-von Bieren, J.
Age dictates a steroid resistant cascade of Wnt5a, transglutaminase-2 and leukotrienes in inflamed airways.Yu, Y. ; He, Z. ; Cao, Y. ; Tang, H. ; Huang, F.
TAGLN2, a novel regulator involved in Hepatitis B virus transcription and replication.Yin, R. ; Liu, X. ; Zhang, P. ; Chen, Y. ; Xie, G. ; Ai, L. ; Xue, C. ; Qian, J. ; Bi, Y. ; Chen, J. ; Sun, Y. ; Stöger, T. ; Ding, Z.
A Raf kinase inhibitor demonstrates antiviral activities both in vitro and in vivo against different genotypes of virulent Newcastle disease virus.Houssaini, A. ; Kebe, K. ; Breau, M. ; Marcos, E. ; Abid, S. ; Bizard, E. ; Huang, J. ; Attwe, A. ; Rideau, D. ; Validire, P. ; Maitre, B. ; Amsellem, V. ; Meiners, S. ; Adnot, S.
Targeting the mtor signaling pathway to inhibit lung cell senescence in Chronic Obstructive Pulmonary Disease (COPD).Jia, J. ; Conlon, T.M. ; Seimetz, M. ; Bednorz, M. ; Zhou-Suckow, Z. ; Weissmann, N. ; Eickelberg, O. ; Mall, M.A. ; Yildirim, A.Ö.
Cigarette smoke causes acute airways disease and exacerbates chronic obstructive lung disease in neonatal mice.Tufman, A. ; Huber, R.M. ; Voelk, S. ; Aigner, F. ; Edelmann, M. ; Gamarra, F. ; Kiefl, R. ; Kahnert, K. ; Tian, F. ; Boulesteix, A.L. ; Endres, S. ; Kobold, S.
Interleukin-22 is elevated in lavage from patients with lung cancer and other pulmonary diseases.Weber, A. ; Herr, C. ; Hendrowarsito, L. ; Meyer, N. ; Nennstiel-Ratzel, U. ; von Mutius, E. ; Bolte, G. ; Colon, D. ; Kolb, S.
No further increase in the parent reported prevalence of allergies in Bavarian preschool children: Results from three cross-sectional studies.Smirnova, N.F. ; Schamberger, A.C. ; Nayakanti, S. ; Hatz, R. ; Behr, J. ; Eickelberg, O.
Detection and quantification of epithelial progenitor cell populations in human healthy and IPF lungs.Schamberger, A.C. ; Schiller, H. B. ; Fernandez, I.E. ; Sterclova, M. ; Heinzelmann, K. ; Hennen, E. ; Hatz, R.A. ; Behr, J. ; Vasakova, M. ; Mann, M. ; Eickelberg, O. ; Staab-Weijnitz, C.A.
Glutathione peroxidase 3 localizes to the epithelial lining fluid and the extracellular matrix in interstitial lung disease.Richter, M.J. ; Milger, K. ; Tello, K. ; Stille, P. ; Seeger, W. ; Mayer, E. ; Ghofrani, H.A. ; Gall, H.
Heart rate response during 6-minute walking testing predicts outcome in operable chronic thromboembolic pulmonary hypertension.Zvarova, B. ; Uhl, F.E. ; Uriarte, J.J. ; Borg, Z.D. ; Coffey, A.L. ; Bonenfant, N.R. ; Weiss, D.J. ; Wagner, D.E.
Residual detergent detection method for nondestructive cytocompatibility evaluation of decellularized whole lung scaffolds.Meiners, S. ; Hilgendorff, A.
Early injury of the neonatal lung contributes to premature lung aging: A hypothesis.de Jong, S.E. ; Selman, M.H.J. ; Adegnika, A.A. ; Amoah, A.S. ; van Riet, E. ; Kruize, Y.C.M. ; Raynes, J.G. ; Rodriguez, A. ; Boakye, D. ; von Mutius, E. ; Knulst, A.C. ; Genuneit, J. ; Cooper, P.J. ; Hokke, C.H. ; Wuhrer, M. ; Yazdanbakhsh, M.
IgG1 Fc N-glycan galactosylation as a biomarker for immune activation.Hector, A. ; Kirn, T. ; Ralhan, A. ; Graepler-Mainka, U. ; Berenbrinker, S. ; Riethmueller, J. ; Hogardt, M. ; Wagner, M. ; Pfleger, A. ; Autenrieth, I. ; Kappler, M. ; Griese, M. ; Eber, E. ; Martus, P. ; Hartl, D.
Microbial colonization and lung function in adolescents with cystic fibrosis.Kammerl, I.E. ; Meiners, S.
Proteasome function shapes innate and adaptive immune responses.Staab-Weijnitz, C.A. ; Eickelberg, O.
Repositioning compounds from cancer drug discovery to IPF: PI3K inhibition.Platz, J. ; Bonenfant, N.R. ; Uhl, F. ; Coffey, A.J. ; McKnight, T. ; Parsons, C. ; Sokocevic, D. ; Borg, Z.D. ; Lam, Y.W. ; Deng, B. ; Fields, J. ; Desarno, M. ; Loi, R. ; Hoffman, A. ; Bianchi, J. ; Dacken, B. ; Petersen, T. ; Wagner, D.E. ; Weiss, D.J.
Comparative study to the use of decellularized alpha-Gal KO pig lungs for xenogeneic lung transplantation.McLoed, A.G. ; Sherrill, T.P. ; Cheng, D.S. ; Han, W. ; Saxon, J.A. ; Gleaves, L.A. ; Wu, P. ; Polosukhin, V.V. ; Karin, M. ; Yull, F.E. ; Stathopoulos, G.T. ; Georgoulias, V. ; Zaynagetdinov, R. ; Blackwell, T.S.
Neutrophil-derived IL-1β impairs the efficacy of NF-κB inhibitors against lung cancer.Chen, S. ; Yin, R. ; Mutze, K. ; Yu, Y. ; Takenaka, S. ; Königshoff, M. ; Stöger, T.
No involvement of alveolar macrophages in the initiation of carbon nanoparticle induced acute lung inflammation in mice.Psallidas, I. ; Kalomenidis, I. ; Porcel, J.M. ; Robinson, B.W. ; Stathopoulos, G.T.
Malignant pleural effusion: From bench to bedside.Subramanian, D.R. ; Gupta, S. ; Burggraf, D. ; vom Silberberg, S. ; Heimbeck, I. ; Heiss-Neumann, M.S. ; Haeussinger, K. ; Newby, C. ; Hargadon, B. ; Raj, V. ; Singh, D. ; Kolsum, U. ; Hofer, T.P. ; Al-Shair, K. ; Luetzen, N. ; Prasse, A. ; Müller-Quernheim, J. ; Benea, G. ; Leprotti, S. ; Boschetto, P. ; Gorecka, D. ; Nowinski, A. ; Oniszh, K. ; zu Castell, W. ; Hagen, M. ; Barta, I. ; Döme, B. ; Strausz, J. ; Greulich, T. ; Vogelmeier, C. ; Koczulla, A.R. ; Gut, I. ; Hohlfeld, J. ; Welte, T. ; Lavae-Mokhtari, M. ; Ziegler-Heitbrock, L. ; Brightling, C. ; Parr, D.G.
Emphysema- and airway-dominant COPD phenotypes defined by standardised quantitative computed tomography.Zensen, C. ; Buelvas, I. ; Eickelberg, O. ; Lohmueller, T. ; Feldmann, J.
'Optical shaking' of red blood cells: A strategy to measure cell-fluid coupling with optical tweezers.Hamon, Y. ; Legowska, M. ; Herve, V. ; Dallet-Choisy, S. ; Marchand-Adam, S. ; Vanderlynden, L. ; Demonte, M. ; Williams, R. ; Scott, C.J. ; Si-Tahar, M. ; Heuze-Vourc'h, N. ; Lalmanach, G. ; Jenne, D. ; Lesner, A. ; Gauthier, F. ; Korkmaz, B.
Neutrophilic cathepsin C is maturated by a multistep proteolytic process and secreted by activated cells during inflammatory lung diseases.Schmid, O. ; Stöger, T.
Surface area is the biologically most effective dose metric for acute nanoparticle toxicity in the lung.Lowe, A.J. ; Lodge, C.J. ; Allen, K.J. ; Abramson, M.J. ; Matheson, M.C. ; Thomas, P.S. ; Barton, C.A. ; Bennett, C.M. ; Erbas, B. ; Svanes, C. ; Wjst, M. ; Gómez Real, F. ; Perret, J.L. ; Russell, M.A. ; Southey, M.C. ; Hopper, J.L. ; Gurrin, L.C. ; Axelrad, C.J. ; Hill, D.J. ; Dharmage, S.C.
Cohort profile: Melbourne Atopy Cohort study (MACS).Zhou, H. ; Wang, Q. ; Yuan, D. ; Wang, J. ; Huang, Y. ; Wu, H. ; Jian, J. ; Yang, D. ; Huang, N. ; Haisch, C. ; Jiang, Z. ; Chen, S.
Early apoptosis real-time detection by label-free SERS based on externalized phosphatidylserine.Darquenne, C. ; Fleming, J.S. ; Katz, I. ; Martin, A.R. ; Schroeter, J. ; Usmani, O.S. ; Venegas, J. ; Schmid, O.
Bridging the gap between science and clinical efficacy: Physiology, imaging, and modeling of aerosols in the lung.Bowatte, G. ; Lodge, C.J. ; Lowe, A.J. ; Erbas, B. ; Dennekamp, M. ; Marks, G.B. ; Perret, J. ; Hui, J. ; Wjst, M. ; Gurrin, L.C. ; Allen, K.J. ; Abramson, M.J. ; Matheson, M.C. ; Dharmage, S.C.
Do variants in GSTs modify the association between traffic air pollution and asthma in adolescence?Lipka, J. ; Semmler-Behnke, M. ; Wenk, A. ; Burkhardt, J. ; Aigner, A. ; Kreyling, W.G.
Biokinetic datasets of PEI F25-LMW complexed and non-complexed 32P-siRNA within different lung compartments.Kolahian, S. ; Fernandez, I.E. ; Eickelberg, O. ; Hartl, D.
Immune mechanisms in pulmonary fibrosis.Welk, V. ; Coux, O. ; Kleene, V. ; Abeza, C. ; Trümbach, D. ; Eickelberg, O. ; Meiners, S.
Inhibition of proteasome activity induces formation of alternative proteasome complexes.Yaroshenko, A. ; Pritzke, T. ; Koschlig, M. ; Kamgari, N. ; Willer, K. ; Gromann, L. ; Auweter, S. ; Hellbach, K. ; Reiser, M. ; Eickelberg, O. ; Pfeiffer, F. ; Hilgendorff, A.
Visualization of neonatal lung injury associated with mechanical ventilation using X-ray dark-field radiography.Ehrhardt, H. ; Pritzke, T. ; Oak, P. ; Kossert, M. ; Biebach, L. ; Forster, K. ; Koschlig, M. ; Alvira, C.M. ; Hilgendorff, A.
Absence of TNF-α enhances inflammatory response in the newborn lung undergoing mechanical ventilation.van Rijt, S.H. ; Bölükbas, D.A. ; Argyo, C. ; Wipplinger, K. ; Naureen, M. ; Datz, S. ; Eickelberg, O. ; Meiners, S. ; Bein, T. ; Schmid, O. ; Stöger, T.
Applicability of avidin protein coated mesoporous silica nanoparticles as drug carriers in the lung.Sui, T. ; Lunt, A.J.G. ; Baimpas, N. ; Sandholzer, M. ; Li, T. ; Zeng, K. ; Landini, G. ; Korsunsky, A.M.
Understanding nature's residual strain engineering at the human dentine-enamel junction interface.Horowitz, J.C. ; Osterholzer, J.J. ; Marazioti, A. ; Stathopoulos, G.T.
"Scar-cinoma": Viewing the fibrotic lung mesenchymal cell in the context of cancer biology.Kermanizadeh, A. ; Gosens, I. ; MacCalman, L. ; Johnston, H. ; Danielsen, P.H. ; Jacobsen, N.R. ; Lenz, A.-G. ; Fernandes, T.F. ; Schins, R.P. ; Cassee, F.R. ; Wallin, H. ; Kreyling, W.G. ; Stöger, T. ; Loft, S. ; Møller, P. ; Tran, L. ; Stone, V.
A multilaboratory toxicological assessment of a panel of 10 engineered nanomaterials to human health - ENPRA project - the highlights, limitations, and current and future challenges.Fernandez, I.E. ; Amarie, O.V. ; Mutze, K. ; Königshoff, M. ; Yildirim, A.Ö. ; Eickelberg, O.
Systematic phenotyping and correlation of biomarkers with lung function and histology in lung fibrosis.Leppkes, M. ; Maueroeder, C. ; Hirth, S. ; Nowecki, S. ; Guenther, C. ; Billmeier, U. ; Paulus, S. ; Biermann, M. ; Munoz, L.E. ; Hoffmann, M. ; Wildner, D. ; Croxford, A.L. ; Waisman, A. ; Mowen, K. ; Jenne, D. ; Krenn, V. ; Mayerle, J. ; Lerch, M.M. ; Schett, G. ; Wirtz, S. ; Neurath, M.F. ; Hermann, M. ; Becker, C.
Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis.Chen, S. ; Kammerl, I.E. ; Vosyka, O. ; Baumann, T. ; Yu, Y. ; Wu, Y. ; Irmler, M. ; Overkleeft, H.S. ; Beckers, J. ; Eickelberg, O. ; Meiners, S. ; Stöger, T.
Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages.Minelli, C. ; Dean, C.H. ; Hind, M. ; Alves, A.C. ; Amaral, A.F.S. ; Siroux, V. ; Huikari, V. ; Artigas, M.S. ; Evans, D.M ; Loth, D.W. ; Bossé, Y. ; Postma, D.S. ; Sin, D. ; Thompson, J. ; Demenais, F. ; Henderson, J. ; SpiroMeta Consortium () ; CHARGE Consortium (Albrecht, E. ; Flexeder, C. ; Gieger, C. ; Grallert, H. ; Hampel, R. ; Heinrich, J. ; Karrasch, S. ; Schulz, H. ; Wjst, M.) ; Bouzigon, E. ; Jarvis, D. ; Jarvelin, M.R. ; Burney, P.
Association of forced vital capacity with the developmental gene NCOR2.Wysocka, M. ; Gruba, N. ; Grzywa, R. ; Giełdoń, A. ; Bąchor, R. ; Brzozowski, K. ; Sienczyk, M. ; Jenne, D. ; Szewczuk, Z. ; Rolka, K. ; Lesner, A.
PEGylated substrates of NSP4 protease: A tool to study protease specificity.Putman, R.K. ; Hatabu, H. ; Araki, T. ; Gudmundsson, G. ; Gao, W. ; Nishino, M. ; Okajima, Y. ; Dupuis, J. ; Latourelle, J.C. ; Cho, M.H. ; El-Chemaly, S. ; Coxson, H.O. ; Celli, B.R. ; Fernandez, I.E. ; Zazueta, O.E. ; Ross, J.C. ; Harmouche, R. ; Estépar, R.S. ; Diaz, A.A. ; Sigurdsson, S. ; Gudmundsson, E.F. ; Eiriksdottir, G. ; Aspelund, T. ; Budoff, M.J. ; Kinney, G.L. ; Hokanson, J.E. ; Williams, M.C. ; Murchison, J.T. ; MacNee, W. ; Hoffmann, U. ; O'Donnell, C.J. ; Launer, L.J. ; Harrris, T.B. ; Gudnason, V. ; Silverman, E.K. ; O'Connor, G.T. ; Washko, G.R. ; Rosas, I.O. ; Hunninghake, G.M.
Association between interstitial lung abnormalities and all-cause mortality.Klee, S. ; Lehmann, M. ; Wagner, D.E. ; Baarsma, H.A. ; Königshoff, M.
WISP1 mediates IL-6-dependent proliferation in primary human lung fibroblasts.Bartmann, J. ; Frankenberger, M. ; Neurohr, C. ; Eickelberg, O. ; Nößner, E. ; von Wulffen, W.
A novel role of MMP-13 for murine DC function: Its inhibition dampens T cell activation.Heinzelmann, K. ; Noskovicova, N. ; Merl-Pham, J. ; Preissler, G. ; Winter, H. ; Lindner, M. ; Hatz, R.A. ; Hauck, S.M. ; Behr, J. ; Eickelberg, O.
Surface proteome analysis identifies platelet derived growth factor receptor-alpha as a critical mediator of transforming growth factor-beta-induced collagen secretion.Kammerl, I.E. ; Dann, A. ; Mossina, A. ; Brech, D. ; Lukas, C. ; Vosyka, O. ; Nathan, P. ; Conlon, T.M. ; Wagner, D.E. ; Overkleeft, H.S. ; Prasse, A. ; Rosas, I.O. ; Straub, T. ; Krauss-Etschmann, S. ; Königshoff, M. ; Preissler, G. ; Winter, H. ; Lindner, M. ; Hatz, R.A. ; Behr, J. ; Heinzelmann, K. ; Yildirim, A.Ö. ; Nößner, E. ; Eickelberg, O. ; Meiners, S.
Impairment of immunoproteasome function by cigarette smoke and in COPD.Mori, Y. ; Takahashi, N. ; Ogawa, N. ; Gudermann, T.
Oxygen physiology: Sensors and ion channels.Spanjer, A.I. ; Baarsma, H.A. ; Oostenbrink, L.M. ; Jansen, S.R. ; Kuipers, C.C. ; Lindner, M. ; Postma, D.S. ; Meurs, H. ; Heijink, I.H. ; Gosens, R. ; Königshoff, M.
TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8.Lipka, J. ; Semmler-Behnke, M. ; Wenk, A. ; Burkhardt, J. ; Aigner, A. ; Kreyling, W.G.
Biokinetic studies of non-complexed siRNA versus nano-sized PEI F25-LMW/siRNA polyplexes following intratracheal instillation into mice.Zhang, P. ; Xie, G. ; Liu, X. ; Ai, L. ; Chen, Y. ; Meng, X. ; Bi, Y. ; Chen, J. ; Sun, Y. ; Stöger, T. ; Ding, Z. ; Yin, R.
High genetic diversity of Newcastle disease virus in wild and domestic birds in Northeastern China from 2013 to 2015 reveals potential epidemic trends.Sun, N. ; Fernandez, I.E. ; Wei, M. ; Wu, Y. ; Aichler, M. ; Eickelberg, O. ; Walch, A.K.
Pharmacokinetic and pharmacometabolomic study of pirfenidone in normal mouse tissues using high mass resolution MALDI-FTICR-mass spectrometry imaging.Bardou, O. ; Menou, A. ; François, C. ; Duitman, J.W. ; von der Thüsen, J.H. ; Borie, R. ; Sales, K.U. ; Mutze, K. ; Castier, Y. ; Sage, E.H. ; Liu, L. ; Bugge, T.H. ; Fairlie, D.P. ; Königshoff, M. ; Crestani, B. ; Borensztajn, K.S.
Membrane-anchored serine protease matriptase is a trigger of pulmonary fibrogenesis.Hamon, Y. ; Legowska, M. ; Fergelot, P. ; Dallet-Choisy, S. ; Newell, L. ; Vanderlynden, L. ; Kord Valeshabad, A. ; Acrich, K. ; Kord, H. ; Charalampos, T. ; Morice-Picard, F. ; Surplice, I. ; Zoidakis, J. ; David, K. ; Vlahou, A. ; Ragunatha, S. ; Nagy, N. ; Farkas, K. ; Széll, M. ; Goizet, C. ; Schacher, B. ; Battino, M. ; Al Farraj Aldosari, A. ; Wang, X. ; Liu, Y. ; Marchand-Adam, S. ; Lesner, A. ; Kara, E. ; Korkmaz-Icöz, S. ; Moss, C. ; Eickholz, P. ; Taïeb, A. ; Kavukcu, S. ; Jenne, D. ; Gauthier, F. ; Korkmaz, B.
Analysis of urinary cathepsin C for diagnosing Papillon-Lefèvre syndrome.Conlon, T.M. ; Bartel, J. ; Ballweg, K. ; Günter, S. ; Prehn, C. ; Krumsiek, J. ; Meiners, S. ; Theis, F.J. ; Adamski, J. ; Eickelberg, O. ; Yildirim, A.Ö.
Metabolomics screening identifies reduced L-carnitine to be associated with progressive emphysema.Chillappagari, S. ; Müller, C. ; Mahavadi, P. ; Guenther, A. ; Nahrlich, L. ; Rosenblum, J. ; Rubin, B.K. ; Henke, M.O.
A small molecule neutrophil elastase inhibitor, KRP-109, inhibits cystic fibrosis mucin degradation.Karo-Atar, D. ; Bordowitz, A. ; Wand, O. ; Pasmanik-Chor, M. ; Fernandez, I.E. ; Itan, M. ; Frenkel, R. ; Herbert, D.R. ; Finkelman, F.D. ; Eickelberg, O. ; Munitz, A.
A protective role for IL-13 receptor α 1 in bleomycin-induced pulmonary injury and repair.John-Schuster, G. ; Günter, S. ; Hager, K. ; Conlon, T.M. ; Eickelberg, O. ; Yildirim, A.Ö.
Inflammaging increases susceptibility to cigarette smoke-induced COPD.