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Group Leader

Dr. Soni Deshwal

“Mitochondria thrive on flexibility, but in diseases like neurodegeneration and aging, they lose their ability to adapt. Understanding their metabolic plasticity could be the key to restoring cellular resilience and combating disease.”

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Research we do

The complex role of mitochondria in cell death fascinates me. How can a single organelle both initiate and inhibit cellular death? I am driven to understand the metabolic plasticity of these organelles and how their dynamic flexibility shapes cellular outcomes under stress.

About Soni Deshwal

Soni is passionate about the basic questions in mitochondrial biology. Currently she is leading a group at Helmholtz-Munich, funded by an ERC Starting Grant. Her research focuses on the metabolic plasticity of mitochondria, particularly in relation to stress responses and cell death. Soni gained extensive mitochondrial expertise during her postdoctoral work at the Max-Planck Institute for Biology of Ageing and during her PhD at the University of Padova. She became particularly interested in ferroptosis during her postdoc, where she discovered that mitochondria can inhibit ferroptosis by transporting a lipid molecule, CoQ, to the plasma membrane. Her work aims to understand how mitochondria adapt to cellular stress and how their metabolic flexibility can be leveraged to combat diseases like neurodegeneration and mitochondrial disorders.

Skills & Expertise & Scientific Interests

Cell Biology Ferroptosis Mitochrondia Metabolism Neurodegeneration Lipid Metabolism 

Professional Background

Since 2025

Group Leader at Helmholtz Munich

Institute of Metabolism and Cell Death, Helmholtz Munich

2019 - 2024

Postdoctoral Fellow

Max-Planck Institute for Biology of Ageing, Cologne, Germany

2017 - 2018

Postdoctoral Fellow

University of Cologne, Cologne, Germany
With Prof. Dr. Thomas Langer (Mitochondrial Proteostasis and Aging)

2014 - 2017

Marie Skłodowska-Curie PhD fellow

School of Biochemistry and Biophysics, University of Padova, Italy
Prof. Fabio Di Lisa
Thesis: Role of monoamine oxidases in mitochondrial dysfunction and diabetic cardiomyopathy

June 2016

Lab of Prof. Stefan Janssens

KU Leuven, Belgium

July 2014

Lab of Dr. Thomas Krieg and Prof. Mike Murphy

MRC Unit, University of Cambridge, United Kingdom

2012 - 2013

Masters in Molecular Genetics

Department of Genetics, University of Leicester, United Kingdom
Thesis in the group of Dr. Eamonn Mallon
Topic: Functional role of anti-microbial peptides in the insect (Bombus terrestris) immune response against trypanosome Crithidia (mark: Merit)

2008 - 2012

Bachelors in Biotechnology

Department of Biotechnology, Amity University, Rajasthan, India
Thesis in the group of Prof. Gursaran Prasad Talwar and Dr. Jagdish Gupta (Delhi)
Thesis: Technique development in the expression and development of recombinant anti-human chorionic gonadotropin vaccine for fertility control (mark: Distinction)

Honors and Awards

  • ERC starting of 1.5 million Euros for Mito-FerroQuest (Project 101162697) 2024
  • NK and Irene Cheung Family Scholar Scholarship to attend Keystone meeting on Mitochondrial Biochemistry in Health and Disease, Breckenridge, Colorado, USA 2022
  • Alexander von Humboldt-Research Fellowship for Postdoctoral work in Germany 2019 - 2021
  • Young Investigator Award from the European Section of the International Society for Heart Research, Hamburg, Germany 2017
  • International Centre for Genetic Engineering and Biotechnology (ICGEB) fellowship to attend the annual meeting of the European Section of the International Society for Heart Research in Hamburg, Germany 2017
  • Best Poster award in International Society for Heart Research, Bordeaux, France 2015
  • Marie Skłodowska-Curie fellowship for PhD in Padova, Italy 2014 - 2017
  • Scholarship from University of Leicester, United Kingdom to do Masters in Science 2012 - 2013

Highlight Publications

Deshwal, S, Onishi, M, Tatsuta, T, Bartsch, T, Cors, E, Ried, K, Lemke, K, Nolte, H, Giavalisco, P and Langer, T

Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7. Nature Cell Biology, 1-12, 2023

Garcia B, Prabhu K, Medeiros, Corrado M, Deshwal S, Veronese M, Scorrano M, Pearce E, Zelcer N, Giavilisco P and Pernas L

Glutamine sensing licenses cholesterol synthesis. EMBO, 43: 5837 – 5856, 2024

Grotehans N, McGarry L, Nolte N, Kroker M, Narbona-Perez A, Deshwal S, Giavalisco P, Langer T, MacVicar T

Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression. EMBO, 42: e113256 2023

Di Sante M, Antonucci S, Pontarollo L, Cappellaro I, Segat F, Deshwal S, Greotti E, Grilo LF, Menabò R, Di Lisa F, Kaludercic N.

Monoamine oxidase A-dependent ROS formation modulates human cardiomyocyte differentiation through AKT and WNT activation. Basic Research in Cardiology. 2023 Jan 20;118(1):4

Dr. Soni Deshwal about the ERC Starting Grant for Mito-FerroQuest:

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