
Bioinformatics
Hansen LabLorem ipsum dolor sit amet, consetetursadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet.
Lorem ipsum dolor sit amet, consetetursadipscing elitr, sed diam.
Research Group/Lab: About our … | Option A
The management and analysis of increasingly large amounts of research data is of enormous importance for the understanding of fundamental metabolic processes, their regulation and the subsequent development of innovative approaches to disease therapy.
The Bioinformatics team at the MCD develops informatics infrastructures for the management of data and performs gene function analysis, the analysis of high-throughput and omics data, the modeling of genetic and protein interaction networks, and of statistical data. We develop databases and software tools for data storage, data exchange and data visualization, and software to assist in the design of genome-wide gene editing experiments and the evaluation of RNA guide sequences for the CRISPR/Cas9 system. In addition, we work on the modeling of genetic interactions and extend regulatory networks by predicting genetic interactions using high-throughput gene expression data and in-silico promoter analysis based on sophisticated statistical analysis.
Research Group/Lab: Publications | Option A
Read more2022 Scientific Article in Nature Communications
Spatial transcriptomics landscape of lesions from non-communicable inflammatory skin diseases.
2022 Scientific Article in Nature Neuroscience
TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury.
2022 Scientific Article in Nature Biotechnology
Modeling intercellular communication in tissues using spatial graphs of cells.
Lecture Notes in Computer Science
Noise transfer for unsupervised domain adaptation of retinal OCT images.
2022 Letter to the Editor in Clinical and Translational Allergy
Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response.
2022 Scientific Article in Molecular Systems Biology
Probing cell identity hierarchies by fate titration and collision during direct reprogramming.
2022 Scientific Article in Nature Genetics
Origin and function of activated fibroblast states during zebrafish heart regeneration.
2022 Scientific Article in Diabetes
Heterogeneous development of β-cell populations In diabetes-resistant and -susceptible mice.
2022 Scientific Article in Science
Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.
2022 Scientific Article in Molecular Metabolism
A transcriptional cross species map of pancreatic islet cells.
2022 Scientific Article in Cell Reports Medicine
Mature neutrophils and a NF-κB-to-IFN transition determine the unifying disease recovery dynamics in COVID-19.
2022 Scientific Article in Respiratory Research
Early transcriptional responses of bronchial epithelial cells to whole cigarette smoke mirror those of in-vivo exposed human bronchial mucosa.
2022 Scientific Article in Nature Communications
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease.
2022 Scientific Article in Brain: A Journal of Neurology
Interpretable surface-based detection of focal cortical dysplasias: A Multi-centre Epilepsy Lesion Detection study.
2022 Scientific Article in Frontiers in Immunology