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Feicht, S.
Die Rolle der Raf-Kinasen in der B-Zell-Entwicklung und -Aktivierung.Wachter, F. ; Grunert, M. ; Jeremias, I. ; Ehrhardt, H.
TRAIL targets cell cycle arrested tumor cells.Strehle, M.L.
Aufklärung der Funktion virus-kodierter miRNAs während einer Gammaherpesvirus-Infektion anhand des murinen Gammaherpesvirus 68 (MHV-68) als Modell.Grunert, M.
Die Charakterisierung des rezeptornahen Signalweges der TRAIL-induzierten Aktivierung von NF-κB.Steinbrück, L.
The role of the herpesviral proteins LMP2A, K1, and K15 during oncogenic transformation of primary B cells.Town, J.A.
Functions of the germinal center kinase TNIK in signal transduction of the viral oncoprotein LMP1 and the related CD40 receptor.Hahne, H. ; Neubert, P. ; Kuhn, K. ; Etienne, C. ; Bomgarden, R. ; Rogers, J.C. ; Kuster, B.
Carbonyl-reactive tandem mass tags for the proteome-wide quantification of N-linked glycans.Canis, M. ; Lechner, A. ; Mack, B. ; Zengel, P. ; Laubender, R.P. ; Koehler, U. ; Heissmeyer, V. ; Gires, O.
CD133 is a predictor of poor survival in head and neck squamous cell carcinomas.Martin, L.K. ; Schub, A. ; Dillinger, S. ; Moosmann, A.
Specific CD8+ T cells recognize human herpesvirus 6B.Jochum, S. ; Moosmann, A. ; Lang, S. ; Hammerschmidt, W. ; Zeidler, R.
The EBV immunoevasins vIL-10 and BNLF2a protect newly infected B cells from immune recognition and elimination.Schrader, A. ; Meyer, K. ; von Bonin, F. ; Vockerodt, M. ; Walther, N. ; Hand, E. ; Ulrich, A. ; Matulewicz, K. ; Lenze, D. ; Hummel, M. ; Kieser, A. ; Engelke, M. ; Trümper, L. ; Kube, D.
Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas.Terziyska, N. ; Alves, C.C. ; Groiss, V. ; Schneider, K. ; Farkasova, K. ; Ogris, M. ; Wagner, E. ; Ehrhardt, H. ; Brentjens, R.J. ; Zur Stadt, U. ; Horstmann, M. ; Quintanilla-Martinez, L. ; Jeremias, I.
In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice.Feuerecker, B. ; Pirsig, S. ; Seidl, C. ; Aichler, M. ; Feuchtinger, A. ; Bruchelt, G. ; Senekowitsch-Schmidtke, R.
Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo.Malinowsky, K. ; Wolff, C. ; Berg, D. ; Schuster, T. ; Walch, A.K. ; Bronger, H. ; Mannsperger, H. ; Schmidt, C. ; Korf, U. ; Höfler, H. ; Becker, K.F.
uPA and PAI-1-related signaling pathways differ between primary breast cancers and lymph node metastases.Gündisch, S. ; Boeckeler, E. ; Behrends, U. ; Amtmann, E. ; Ehrhardt, H. ; Jeremias, I.
Glucocorticoids augment survival and proliferation of tumor cells.Grunert, M. ; Gottschalk, K. ; Kapahnke, J. ; Gündisch, S. ; Kieser, A. ; Jeremias, I.
The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-κB by TRAIL.Meding, S. ; Balluff, B. ; Elsner, M. ; Schöne, C. ; Rauser, S. ; Nitsche, U. ; Maak, M. ; Schäfer, A. ; Hauck, S.M. ; Ueffing, M. ; Langer, R. ; Höfler, H. ; Friess, H. ; Rosenberg, R. ; Walch, A.K.
Tissue-based proteomics reveals FXYD3, S100A11 and GSTM3 as novel markers for regional lymph node metastasis in colon cancer.Wulfkuhle, J.D. ; Berg, D. ; Wolff, C. ; Langer, R. ; Tran, K. ; Illi, J. ; Espina, V. ; Pierobon, M. ; Deng, J. ; Demichele, A. ; Walch, A.K. ; Bronger, H. ; Becker, I. ; Waldhör, C. ; Höfler, H. ; Esserman, L. ; Liotta, L.A. ; Becker, K.F. ; Petricoin, E.F.
Molecular analysis of HER2 signaling in human breast cancer by functional protein pathway activation mapping.Graf, N. ; Herrmann, K. ; Numberger, B. ; Zwisler, D. ; Aichler, M. ; Feuchtinger, A. ; Schuster, T. ; Wester, H.-J. ; Senekowitsch-Schmidtke, R. ; Peschel, C. ; Schwaiger, M. ; Keller, U. ; Dechow, T. ; Buck, A.K.
[18F]FLT is superior to [18F]FDG for predicting early response to antiproliferative treatment in high-grade lymphoma in a dose-dependent manner.Haneklaus, M. ; Gerlic, M. ; Kurowska-Stolarska, M. ; Rainey, A.A. ; Pich, D. ; McInnes, I.B. ; Hammerschmidt, W. ; O'Neill, L.A.J. ; Masters, S.L.
Cutting edge: MiR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1β production.Wöllmer, A. ; Arteaga-Salas, J.M. ; Hammerschmidt, W.
BZLF1 governs CpG-methylated chromatin of Epstein-Barr virus reversing epigenetic repression.Mayer, C.E. ; Geerlof, A. ; Schepers, A.
Efficient expression and purification of tag-free Epstein-Barr virus EBNA1 protein in Escherichia coli by auto-induction.Ruiss, R. ; Ohno, S. ; Steer, B. ; Zeidler, R. ; Adler, H.
Murine gammaherpesvirus 68 glycoprotein 150 does not contribute to latency amplification in vivo.Stross, L. ; Günther, J. ; Gasteiger, G. ; Asen, T. ; Graf, S. ; Aichler, M. ; Esposito, I. ; Busch, D.H. ; Knolle, P. ; Sparwasser, T. ; Protzer, U.
Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice.Papior, P. ; Arteaga-Salas, J.M. ; Günther, T. ; Grundhoff, A. ; Schepers, A.
Open chromatin structures regulate the efficiencies of pre-RC formation and replication initiation in Epstein-Barr virus.Lehmann, F.M. ; Feicht, S. ; Helm, F. ; Maurberger, A. ; Ladinig, C. ; Zimber-Strobl, U. ; Kühn, R. ; Mautner, J. ; Gerbitz, A. ; Bornkamm, G.W.
Humanized c-Myc mouse.Slotta-Huspenina, J. ; Berg, D. ; Bauer, K. ; Wolff, C. ; Malinowsky, K. ; Bauer, L. ; Drecoll, E. ; Bettstetter, M. ; Feith, M. ; Walch, A.K. ; Höfler, H. ; Becker, K.F. ; Langer, R.
Evidence of prognostic relevant expression profiles of heat-shock proteins and glucose-regulated proteins in oesophageal adenocarcinomas.Vallon, M. ; Seidl, C. ; Blechert, B. ; Li, Z. ; Gilbertz, K.P. ; Baumgart, A. ; Aichler, M. ; Feuchtinger, A. ; Gaertner, F.C. ; Bruchertseifer, F. ; Morgenstern, A. ; Walch, A.K. ; Senekowitsch-Schmidtke, R. ; Essler, M.
Enhanced efficacy of combined 213Bi-DTPA-F3 and paclitaxel therapy of peritoneal carcinomatosis is mediated by enhanced induction of apoptosis and G2/M phase arrest.Li, Z. ; Graf, N.A. ; Herrmann, K. ; Jünger, A. ; Aichler, M. ; Feuchtinger, A. ; Baumgart, A. ; Walch, A.K. ; Peschel, C. ; Schwaiger, M. ; Buck, A. ; Keller, U. ; Dechow, T.
FLT-PET is superior to FDG-PET for very early response prediction in NPM-ALK-positive lymphoma treated with targeted therapy.Shkoda, A. ; Town, J.A. ; Griese, J. ; Romio, M. ; Sarioglu, H. ; Knöfel, T. ; Giehler, F. ; Kieser, A.
The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor.Gehrmann, M. ; Stangl, S. ; Kirschner, A. ; Foulds, G.A. ; Sievert, W. ; Doß, B.T. ; Walch, A.K. ; Pockley, A.G. ; Multhoff, G.
Immunotherapeutic targeting of membrane Hsp70-expressing tumors using recombinant human granzyme B.Balluff, B. ; Rauser, S. ; Ebert, M.P. ; Siveke, J.T. ; Höfler, H. ; Walch, A.K.
Direct molecular tissue analysis by MALDI imaging mass spectrometry in the field of gastrointestinal disease.Saraste, A. ; Laitinen, I. ; Weidl, E. ; Wildgruber, M. ; Weber, A.W. ; Nekolla, S.G. ; Hölzlwimmer, G. ; Esposito, I. ; Walch, A.K. ; Leppänen, P. ; Lisinen, I. ; Luppa, P.B. ; Yla-Herttuala, S. ; Wester, H.J. ; Knuuti, J. ; Schwaiger, M.
Diet intervention reduces uptake of αvβ3 integrin-targeted PET tracer 18F-galacto-RGD in mouse atherosclerotic plaques.Ehrhardt, H. ; Höfig, I. ; Wachter, F. ; Obexer, P. ; Fulda, S. ; Terziyska, N. ; Jeremias, I.
NOXA as critical mediator for drug combinations in polychemotherapy.Trede, D. ; Schiffler, S. ; Becker, M. ; Wirtz, S. ; Steinhorst, K. ; Strehlow, J. ; Aichler, M. ; Kobarg, J.H. ; Oetjen, J. ; Dyatlov, A. ; Heldmann, S. ; Walch, A.K. ; Thiele, H. ; Maass, P. ; Alexandrov, T.
Exploring three-dimensional matrix-assisted laser desorption/ionization imaging mass spectrometry data: Three-dimensional spatial segmentation of mouse kidney.Baumhoer, D. ; Smida, J. ; Zillmer, S. ; Rosemann, M. ; Atkinson, M.J. ; Nelson, P.J. ; Jundt, G. ; von Luettichau, I. ; Nathrath, M.
Strong expression of CXCL12 is associated with a favorable outcome in osteosarcoma.Spranger, S. ; Jeremias, I. ; Wilde, S. ; Leisegang, M. ; Stärck, L. ; Mosetter, B. ; Uckert, W. ; Heemskerk, M.H. ; Schendel, D.J. ; Frankenberger, B.
TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.Prade, E. ; Tobiasch, M. ; Hitkova, I. ; Schaffer, I. ; Lian, F. ; Xing, X.B. ; Tänzer, M. ; Rauser, S. ; Walch, A.K. ; Feith, M. ; Post, S. ; Röcken, C. ; Schmid, R.M. ; Ebert, M.P.A. ; Burgermeister, E.
Bile acids down-regulate caveolin-1 in esophageal epithelial cells through sterol responsive element-binding protein.Höfig, I. ; Ehrhardt, H. ; Jeremias, I.
Efficient RNA interference in patients' acute lymphoblastic leukemia cells amplified as xenografts in mice.Jochum, S. ; Ruiss, R. ; Moosmann, A. ; Hammerschmidt, W. ; Zeidler, R.
RNAs in Epstein-Barr virions control early steps of infection.Kalla, M. ; Göbel, C. ; Hammerschmidt, W.
The lytic phase of Epstein-Barr virus requires a viral genome with 5-methylcytosine residues in CpG sites.Grüner, B.M. ; Hahne, H. ; Mazur, P.K. ; Trajkovic-Arsic, M. ; Maier, S.K. ; Esposito, I. ; Kalideris, E. ; Michalski, C.W. ; Kleeff, J. ; Rauser, S. ; Schmid, R.M. ; Kuster, B. ; Walch, A.K. ; Siveke, J.T.
MALDI imaging mass spectrometry for in situ proteomic analysis of preneoplastic lesions in pancreatic cancer.Alves, C.C. ; Terziyska, N. ; Grunert, M. ; Gündisch, S. ; Graubner, U. ; Quintanilla-Martinez, L. ; Jeremias, I.
Leukemia-initiating cells of patient-derived acute lymphoblastic leukemia xenografts are sensitive toward TRAIL.Ohno, S. ; Steer, B. ; Sattler, C. ; Adler, H.
ORF23 of murine gammaherpesvirus 68 is non-essential for in vitro and in vivo infection.Heindl, S. ; Eggenstein, E. ; Keller, S. ; Kneissl, J. ; Keller, G. ; Mutze, K. ; Rauser, S. ; Gasteiger, G. ; Drexler, I. ; Hapfelmeier, A. ; Höfler, H. ; Luber, B.
Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines.Seiz, L. ; Dorn, J. ; Kotzsch, M. ; Walch, A.K. ; Grebenchtchikov, N.I. ; Gkazepis, A. ; Schmalfeldt, B. ; Kiechle, M. ; Bayani, J. ; Diamandis, E.P. ; Langer, R. ; Sweep, F.C. ; Schmitt, M. ; Magdolen, V.
Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients.von Brühl, M.L. ; Stark, K. ; Steinhart, A. ; Chandraratne, S. ; Konrad, I. ; Lorenz, M. ; Khandoga, A. ; Tirniceriu, A. ; Coletti, R. ; Köllnberger, M. ; Byrne, R.A. ; Laitinen, I. ; Walch, A.K. ; Brill, A. ; Pfeiler, S. ; Manukyan, D. ; Braun, S. ; Lange, P. ; Riegger, J. ; Ware, J. ; Eckart, A. ; Haidari, S. ; Rudelius, M. ; Schulz, C. ; Echtler, K. ; Brinkmann, V. ; Schwaiger, M. ; Preissner, K.T. ; Wagner, D.D. ; Mackman, N. ; Engelmann, B. ; Massberg, S.
Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo.Manook, A. ; Yousefi, B.H. ; Willuweit, A. ; Platzer, S. ; Reder, S. ; Voss, A. ; Huisman, M. ; Settles, M. ; Neff, F. ; Velden, J. ; Schoor, M. ; von der Kammer, H. ; Wester, H.J. ; Schwaiger, M. ; Henriksen, G. ; Drzezga, A..
Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's disease.Grunewald, T.G. ; Ranft, A. ; Esposito, I. ; Da Silva-Buttkus, P. ; Aichler, M. ; Baumhoer, D. ; Schaefer, K.L. ; Ottaviano, L. ; Poremba, C. ; Jundt, G. ; Jürgens, H. ; Dirksen, U. ; Richter, G.H. ; Burdach, S.
High STEAP1 expression is associated with improved outcome of Ewing's sarcoma patients.Elsner, M. ; Rauser, S. ; Maier, S.K. ; Schöne, C. ; Balluff, B. ; Meding, S. ; Jung, G. ; Nipp, M. ; Sarioglu, H. ; Maccarrone, G. ; Aichler, M. ; Feuchtinger, A. ; Langer, R. ; Jütting, U. ; Feith, M. ; Kuster, B. ; Ueffing, M. ; Zitzelsberger, H. ; Höfler, H. ; Walch, A.K.
MALDI imaging mass spectrometry reveals COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in Barrett's adenocarcinoma.Meding, S. ; Nitsche, U. ; Balluff, B. ; Elsner, M. ; Rauser, S. ; Schöne, C. ; Nipp, M. ; Maak, M. ; Feith, M. ; Ebert, M.P. ; Friess, H. ; Langer, R. ; Höfler, H. ; Zitzelsberger, H. ; Rosenberg, R. ; Walch, A.K.
Tumor classification of six common cancer types based on proteomic profiling by MALDI imaging.Takenaka, S. ; Möller, W. ; Semmler-Behnke, M. ; Karg, E.W. ; Wenk, A. ; Schmid, O. ; Stöger, T. ; Jennen, L. ; Aichler, M. ; Walch, A.K. ; Pokhrel, S. ; Mädler, L. ; Eickelberg, O. ; Kreyling, W.G.
Efficient internalization and intracellular translocation of inhaled gold nanoparticles in rat alveolar macrophages.Berg, D. ; Wolff, C. ; Malinowsky, K. ; Tran, K. ; Walch, A.K. ; Bronger, H. ; Schuster, T. ; Höfler, H. ; Becker, K.-F.
Profiling signalling pathways in formalin-fixed and paraffin-embedded breast cancer tissues reveals cross-talk between EGFR, HER2, HER3 and uPAR.Bonilla, W.V. ; Fröhlich, A. ; Senn, K. ; Kallert, S. ; Fernandez, M. ; Johnson, S. ; Kreutzfeldt, M. ; Hegazy, A.N. ; Schrick, C. ; Fallon, P.G. ; Klemenz, R. ; Nakae, S. ; Adler, H. ; Merkler, D. ; Löhning, M. ; Pinschewer, D.D.
The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses.Ebert, M.P. ; Tänzer, M. ; Balluff, B. ; Burgermeister, E. ; Kretzschmar, A.K. ; Hughes, D.J. ; Tetzner, R. ; Lofton-Day, C. ; Rosenberg, R. ; Reinacher-Schick, A.C. ; Schulmann, K. ; Tannapfel, A. ; Hofheinz, R. ; Röcken, C. ; Keller, G. ; Langer, R. ; Specht, K. ; Porschen, R. ; Stöhlmacher-Williams, J. ; Schuster, T. ; Ströbel, P. ; Schmid, R.M.
TFAP2E-DKK4 and chemoresistance in colorectal cancer.Loder, S. ; Fakler, M. ; Schoeneberger, H. ; Cristofanon, S. ; Leibacher, J. ; Vanlangenakker, N. ; Bertrand, M.J. ; Vandenabeele, P. ; Jeremias, I. ; Debatin, K.M. ; Fulda, S.
RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis.Aichler, M. ; Seiler, C. ; Tost, M. ; Siveke, J. ; Mazur, P.K. ; Da Silva-Buttkus, P. ; Bartsch, D.K. ; Langer, P. ; Chiblak, S. ; Dürr, A. ; Höfler, H. ; Klöppel, G. ; Müller-Decker, K. ; Brielmeier, M. ; Esposito, I.
Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: A comparative study in transgenic mice and human tissues.Kernt, M. ; Walch, A.K. ; Neubauer, A.S. ; Hirneiss, C. ; Haritoglou, C. ; Ulbig, M.W. ; Kampik, A.
Filtering blue light reduces light-induced oxidative stress, senescence, and accumulation of extracellular matrix proteins in human retinal pigment epithelium cells.Moosmann, A. ; Hammerschmidt, W. ; Kolb, H.-J.
Virus-specific T cells for therapy - approaches, problems, solutions.Kalla, M. ; Hammerschmidt, W.
Human B cells on their route to latent infection - early but transient expression of lytic genes of Epstein-Barr virus.Nipp, M. ; Elsner, M. ; Balluff, B. ; Meding, S. ; Sarioglu, H. ; Ueffing, M. ; Rauser, S. ; Unger, K. ; Höfler, H. ; Walch, A.K. ; Zitzelsberger, H.
S100-A10, thioredoxin, and S100-A6 as biomarkers of papillary thyroid carcinoma with lymph node metastasis identified by MALDI Imaging.