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Ebinger, S. ; Özdemir, E.Z. ; Ziegenhain, C. ; Tiedt, S. ; Castro Alves, C. ; Grunert, M. ; Dworzak, M. ; Lutz, C. ; Turati, V.A. ; Enver, T. ; Horny, H.-P. ; Sotlar, K. ; Parekh, S. ; Spiekermann, K. ; Hiddemann, W. ; Schepers, A. ; Polzer, B. ; Kirsch, S. ; Hoffmann, M. ; Knapp, B. ; Hasenauer, J. ; Pfeifer, H. ; Panzer-Grümayer, R. ; Enard, W. ; Gires, O. ; Jeremias, I.
Characterization of rare, dormant, and therapy-resistant cells in acute lymphoblastic leukemia.Luber, B. ; Keller, S. ; Zwingenberger, G. ; Ebert, K. ; Maier, D. ; Geier, B. ; Theis, F.J. ; Hasenauer, J. ; Huge, S. ; Meyer-Hermann, M. ; Dehghany, J. ; Walch, A.K. ; Aichler, M. ; Lordick, F. ; Haffner, I.
Identification of predictive response and resistance factors to targeted therapy in gastric cancer using a systems medicine approach.Vergalli, J. ; Carletl, M. ; Hoffmann, T. ; Rothe, M. ; Zuber, J. ; Jeremias, I.
X-Linked inhibitor of apoptosis protein (XIAP) exhibits an essential role of patients' acute lymphoblastic leukemia cells growing in vivo.Jacobsen, C. ; Kopp, N. ; Layer, J. ; Redd, R.A. ; Tschuri, S. ; Haebe, S. ; van Bodegom, D. ; Bird, L. ; Christie, A.L. ; Christodoulou, A.N. ; Saur, A. ; Tivey, T. ; Zapf, S.S. ; Bararia, D. ; Zimber-Strobl, U. ; Rodig, S.J. ; Weigert, O. ; Weinstock, D.M.
HSP90 inhibition overcomes ibrutinib resistance in mantle cell lymphoma.Habringer, S. ; Herhaus, P. ; Schottelius, M. ; Istvanffy, R. ; Goetze, K. ; Oostendorp, R. ; Grigoleit, G.U. ; Lapa, C. ; Jeremias, I. ; Schwaiger, M. ; Peschel, C. ; Wester, H.-J. ; Keller, U.
CXCR4-directed peptide receptor radiotherapy with 177Lu-Pentixather effectively clears leukemia in patient-derived xenografts.Lichtenedger, F.S. ; Deiser, K. ; Rothe, M. ; Krupka, C. ; Schnorfeil, F.M. ; Augsberger, C. ; Koehnke, T. ; Buecklein, V. ; Altmann, T. ; Moosmann, A. ; Brueggemann, M. ; Heemskerk, M.H.M. ; Wagner, B. ; Hiddemann, W.R. ; Bigalke, I. ; Kvalheim, G. ; Subklewe, M.
Induction of antigen-specific T-cell responses through dendritic cell vaccination in AML: results of a phase I/II trial and ex vivo enhancement by checkpoint blockade.Abdelmoula, W.M. ; Balluff, B. ; Englert, S. ; Dijkstra, J. ; Reinders, M.J.T. ; Walch, A.K. ; McDonnell, L.A. ; Lelieveldt, B.P.F.
Data-driven identification of prognostic tumor subpopulations using spatially mapped t-SNE of mass spectrometry imaging data.Schenck, T.L. ; Lin, S. ; Stewart, J.K. ; Koban, K.C. ; Aichler, M. ; Rezaeian, F. ; Giunta, R.E.
Sensory reanimation of the hand by transfer of the superficial branch of the radial nerve to the median and ulnar nerve.Wittmann, A. ; Grimm, M. ; Scherthan, H. ; Horsch, M. ; Beckers, J. ; Fuchs, H. ; Gailus-Durner, V. ; Hrabě de Angelis, M. ; Ford, S.J. ; Burton, N.C. ; Razansky, D. ; Trümbach, D. ; Aichler, M. ; Walch, A.K. ; Calzada-Wack, J. ; Neff, F. ; Wurst, W. ; Hartmann, T. ; Floß, T.
Sphingomyelin synthase 1 is essential for male fertility in mice.Albanese, M. ; Tagawa, T. ; Bouvet, M. ; Maliqi, L. ; Lutter, D. ; Hoser, J.D.S. ; Hastreiter, M. ; Hayes, M. ; Sugden, B. ; Martin, L. ; Moosmann, A. ; Hammerschmidt, W.
Epstein-Barr virus microRNAs reduce immune surveillance by virus-specific CD8+ T cells.Oezdemir, E. ; Ebinger, S. ; Tiedt, S. ; Alves, C.C. ; Ziegenhain, C. ; Enard, W. ; Schepers, A. ; Jeremias, I.
A rare subpopulation of dormant, drug resistant stem cells in all mimics cells of minimal residual disease.Vergalli, J. ; Carlet, M. ; Hoffmann, T. ; Roth, M. ; Zuber, J. ; Jeremias, I.
Novel genetically engineered patient-derived xenograft (GEPDX) models reveal that xiap plays an essential role for patients´all growing in mice.Feuchtinger, A. ; Walch, A.K. ; Dobosz, M.
Deep tissue imaging: A review from a preclinical cancer research perspective.Tagawa, T. ; Albanese, M. ; Bouvet, M. ; Moosmann, A. ; Mautner, J. ; Heissmeyer, V. ; Zielinski, C. ; Lutter, D. ; Hoser, J.D.S. ; Hastreiter, M. ; Hayes, M. ; Sugden, B. ; Hammerschmidt, W.
Epstein-Barr viral miRNAs inhibit antiviral CD4+ T cell responses targeting IL-12 and peptide processing.Vincent-Fabert, C. ; Arnaud, N. ; Zimber-Strobl, U. ; Feuillard, J. ; Faumont, N.
The immune surveillance constraints B Cell lymphomas with continuous CD40 signaling to an indolent phenotype.Huber, M. ; Mall, R. ; Braselmann, H. ; Feuchtinger, A. ; Molatore, S. ; Lindner, K. ; Walch, A.K. ; Gross, E. ; Schmitt, M. ; Falkenberg, N. ; Aubele, M.
uPAR enhances malignant potential of triple-negative breast cancer by directly interacting with uPA and IGF1R.Gamrekelashvili, J. ; Giagnorio, R. ; Jussofie, J. ; Soehnlein, O. ; Duchene, J. ; Briseño, C.G. ; Ramasamy, S.K. ; Krishnasamy, K. ; Limbourg, A. ; Kapanadze, T. ; Ishifune, C. ; Hinkel, R. ; Radtke, F. ; Strobl, L.J. ; Zimber-Strobl, U. ; Napp, L.C. ; Bauersachs, J. ; Haller, H. ; Yasutomo, K. ; Kupatt, C. ; Murphy, K.M. ; Adams, R.H. ; Weber, C. ; Limbourg, F.P.
Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.Stark, K. ; Philippi, V. ; Stockhausen, S. ; Busse, J. ; Antonelli, A. ; Miller, M. ; Schubert, I. ; Hoseinpour, P. ; Chandraratne, S. ; von Brühl, M.L. ; Gärtner, F. ; Lorenz, M. ; Agresti, A. ; Coletti, R. ; Antoine, D.J. ; Heermann, R. ; Jung, K. ; Reese, S. ; Laitinen, I. ; Schwaiger, M. ; Walch, A.K. ; Sperandio, M. ; Nawroth, P.P. ; Reinhardt, C. ; Jäckel, S. ; Bianchi, M.E. ; Massberg, S.
Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice.Chekkoury, A. ; Nunes, A. ; Gateau, J. ; Symvoulidis, P. ; Feuchtinger, A. ; Bézière, N. ; Ovsepian, S.V. ; Walch, A.K. ; Ntziachristos, V.
High-resolution multispectral optoacoustic tomography of the vascularization and constitutive hypoxemia of cancerous tumors.Daschkey, S. ; Bienemann, K. ; Schuster, V. ; Kreth, H.W. ; Linka, R.M. ; Hönscheid, A. ; Fritz, G. ; Johannes, C. ; Fleckenstein, B. ; Kempkes, B. ; Gombert, M. ; Ginzel, S. ; Borkhardt, A.
Fatal lymphoproliferative disease in two siblings lacking functional FAAP24.Ly, A. ; Buck, A. ; Balluff, B. ; Sun, N. ; Gorzolka, K. ; Feuchtinger, A. ; Janssen, K.P. ; Kuppen, P.J. ; van de Velde, C.J. ; Weirich, G. ; Erlmeier, F. ; Langer, R. ; Aubele, M. ; Zitzelsberger, H. ; McDonnell, L.A. ; Aichler, M. ; Walch, A.K.
High-mass-resolution MALDI mass spectrometry imaging of metabolites from formalin-fixed paraffin-embedded tissue.Mendler, C.T. ; Feuchtinger, A. ; Heid, I. ; Aichler, M. ; D'Alessandria, C. ; Pirsig, S. ; Blechert, B. ; Wester, H.J. ; Braren, R. ; Walch, A.K. ; Skerra, A. ; Schwaiger, M.
Tumor uptake of anti-CD20 Fabs depends on tumor perfusion.Hubmann, M. ; Fritsch, S. ; Zoellner, A.K. ; Prevalsek, D. ; Engel, N. ; Bücklein, V.L. ; Mumm, F. ; Schulz, C. ; Stemmler, H.J. ; Jäger, G. ; Ledderose, G. ; Kolb, H.J. ; Hausmann, A. ; Hiddemann, W. ; Moosmann, A. ; Tischer, J.
Occurrence, risk factors and outcome of adenovirus infection in adult recipients of allogeneic hematopoietic stem cell transplantation.Bader, E. ; Migliorini, A. ; Gegg, M. ; Moruzzi, N. ; Gerdes, J.M. ; Roscioni, S. ; Bakhti, M. ; Brandl, E. ; Irmler, M. ; Beckers, J. ; Aichler, M. ; Feuchtinger, A. ; Leitzinger, C. ; Zischka, H. ; Wang-Sattler, R. ; Jastroch, M. ; Tschöp, M.H. ; Machicao, F. ; Staiger, H. ; Häring, H.-U. ; Chmelova, H. ; Chouinard, J.A. ; Oskolkov, N. ; Korsgren, O. ; Speier, S. ; Lickert, H.
Identification of proliferative and mature β-cells in the islets of Langerhans.Mall, S. ; Yusufi, N. ; Wagner, R. ; Klar, R. ; Bianchi, H. ; Steiger, K. ; Straub, M. ; Audehm, S. ; Laitinen, I. ; Aichler, M. ; Peschel, C. ; Ziegler, S. ; Mustafa, M. ; Schwaiger, M. ; D'Alessandria, C. ; Krackhardt, A.M.
Immuno-PET imaging of engineered human T cells in tumors.Huber, M. ; Falkenberg, N. ; Hauck, S.M. ; Priller, M. ; Braselmann, H. ; Feuchtinger, A. ; Walch, A.K. ; Schmitt, M. ; Aubele, M.
Cyr61 and YB-1 are novel interacting partners of uPAR and elevate the malignancy of triple-negative breast cancer.Frankó, A. ; Huypens, P. ; Neschen, S. ; Irmler, M. ; Rozman, J. ; Rathkolb, B. ; Neff, F. ; Prehn, C. ; Dubois, G. ; Baumann, M. ; Massinger, R. ; Gradinger, D. ; Przemeck, G.K.H. ; Repp, B. ; Aichler, M. ; Feuchtinger, A. ; Schommers, P. ; Stöhr, O. ; Sanchez-Lasheras, C. ; Adamski, J. ; Peter, A. ; Prokisch, H. ; Beckers, J. ; Walch, A.K. ; Fuchs, H. ; Wolf, E. ; Schubert, M. ; Wiesner, R.J. ; Hrabě de Angelis, M.
Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice.Vitenshtein, A. ; Weisblum, Y. ; Hauka, S. ; Halenius, A. ; Oiknine-Djian, E. ; Tsukerman, P. ; Bauman, Y. ; Bar-On, Y. ; Stern-Ginossar, N. ; Enk, J. ; Ortenberg, R. ; Tai, J. ; Markel, G. ; Blumberg, R.S. ; Hengel, H. ; Jonjic, S. ; Wolf, D.G. ; Adler, H. ; Kammerer, R. ; Mandelboim, O.
CEACAM1-mediated inhibition of virus production.Krupka, C. ; Kufer, P. ; Kischel, R. ; Zugmaier, G. ; Koehnke, T. ; Lichtenegger, F.S. ; Altmann, T. ; Spiekermann, K. ; Vick, B. ; Jeremias, I. ; Hiddemann, W. ; Riethmueller, G. ; Subklewe, M.
Characterization of covariables modulating CD33/CD3 BITE antibody construct mediated cytotoxicity against primary AML cells.Lichtenegger, F.S. ; Schnorfeil, F.M. ; Koehnke, T. ; Altmann, T. ; Buecklein, V. ; Moosmann, A. ; Brueggemann, M. ; Wagner, B. ; Hiddemann, W. ; Bigalke, I. ; Kvalheim, G. ; Subklewe, M.
Next-generation dendritic cell vaccination in postremission therapy of AML: Results of a clinical phase I trial.Cassese, A. ; Ellis, S. ; Ogrinc Potočnik, N. ; Burgermeister, E. ; Ebert, M. ; Walch, A.K. ; van den Maagdenberg, A.M. ; McDonnell, L.A. ; Heeren, R.M. ; Balluff, B.
Spatial autocorrelation in mass spectrometry imaging.Dietzel, S. ; Hermann, S. ; Kugel, Y. ; Sellner, S. ; Uhl, B. ; Hirn, S. ; Krombach, F. ; Rehberg, M.
Multiphoton microscopy of nonfluorescent nanoparticles in vitro and in vivo.Buck, A. ; Balluff, B. ; Voss, A. ; Langer, R. ; Zitzelsberger, H. ; Aichler, M. ; Walch, A.K.
How suitable is MALDI-TOF for metabolite imaging from clinical formalin-fixed and paraffin-embedded tissue samples in comparison to MALDI-FT-ICR mass spectrometry?Dorn, J. ; Yassouridis, A. ; Walch, A.K. ; Diamandis, E.P. ; Schmitt, M. ; Kiechle, M. ; Wang, P. ; Drecoll, E. ; Schmalfeldt, B. ; Loessner, D. ; Kotzsch, M. ; Magdolen, V.
Assessment of kallikrein-related peptidase 5 (KLK5) protein expression in tumor tissue of advanced ovarian cancer patients by immunohistochemistry and ELISA: Correlation with clinical outcome.Townsend, E.C. ; Murakami, M.A. ; Christodoulou, A.N. ; Christie, A.L. ; Koster, J. ; DeSouza, T.A. ; Morgan, E.A. ; Kallgren, S.P. ; Liu, H. ; Wu, S.C. ; Plana, O. ; Montero, J. ; Stevenson, K.E. ; Rao, P. ; Vadhi, R. ; Andreeff, M. ; Armand, P. ; Ballen, K.K. ; Barzaghi-Rinaudo, P. ; Cahill, S. ; Clark, R.A. ; Cooke, V.G. ; Davids, M.S. ; DeAngelo, D.J. ; Dorfman, D.M. ; Eaton, H. ; Ebert, B.L. ; Etchin, J. ; Firestone, B. ; Fisher, D.C. ; Freedman, A.S. ; Galinsky, I.A. ; Gao, H. ; Garcia, J.S. ; Garnache-Ottou, F. ; Graubert, T.A. ; Gutierrez, A. ; Halilovic, E. ; Harris, M.H. ; Herbert, Z.T. ; Horwitz, S.M. ; Inghirami, G. ; Intlekoffer, A.M. ; Ito, M. ; Izraeli, S. ; Jacobsen, E.D. ; Jacobson, C.A. ; Jeay, S. ; Jeremias, I. ; Kelliher, M.A. ; Koch, R. ; Konopleva, M. ; Kopp, N. ; Kornblau, S.M. ; Kung, A.L. ; Kupper, T.S. ; LaBoeuf, N. ; LaCasce, A.S. ; Lees, E. ; Li, L.S. ; Look, A.T. ; Murakami, M. ; Muschen, M. ; Neuberg, D. ; Ng, S.Y. ; Odejide, O.O. ; Orkin, S.H. ; Paquette, R.R. ; Place, A.E. ; Roderick, J.E. ; Ryan, J.A. ; Sallan, S.E. ; Shoji, B. ; Silverman, L.B. ; Soiffer, R.J. ; Steensma, D.P. ; Stegmaier, K. ; Stone, R.M. ; Tamburini, J. ; Thorner, A.R. ; van Hummelen, P. ; Wadleigh, M. ; Wiesmann, M. ; Weng, A.P. ; Wuerthner, J.U. ; Williams, D.A. ; Wollison, B.M. ; Lane, A.A. ; Letai, A.G. ; Bertagnolli, M.M. ; Ritz, J. ; Brown, M. ; Long, H. ; Aster, J.C. ; Shipp, M.A. ; Griffin, J.D. ; Weinstock, D.M.
The public repository of xenografts enables discovery and randomized phase II-like trials in mice.Brenke, J.K. ; Salmina, E.S. ; Ringelstetter, L. ; Dornauer, S. ; Kuzikov, M. ; Rothenaigner, I. ; Schorpp, K.K. ; Giehler, F. ; Gopalakrishnan, J. ; Kieser, A. ; Gul, S. ; Tetko, I.V. ; Hadian, K.
Identification of small-molecule frequent hitters of glutathione S-transferase-glutathione interaction.Hachmöller, O. ; Aichler, M. ; Schwamborn, K. ; Lutz, L. ; Werner, M. ; Sperling, M. ; Walch, A.K. ; Karst, U.
Element bioimaging of liver needle biopsy specimens from patients with Wilson's disease by laser ablation-inductively coupled plasma-mass spectrometry.Sattler, C. ; Steer, B. ; Adler, H.
Multiple lytic origins of replication are required for optimal gammaherpesvirus fitness in vitro and in vivo.Trajkovic-Arsic, M. ; Kalideris, E. ; Sun, N. ; Feuchtinger, A. ; Gupta, A. ; Aichler, M. ; Schmid, R.M. ; Walch, A.K. ; Siveke, J.T.
Identification of metabolic changes in pancreatic ductal adenocarcinoma.Haffner, I. ; Luber, B. ; Maier, D. ; Geier, B. ; Theis, F.J. ; Meyer-Hermann, M. ; Walch, A.K. ; Kretzschmar, A.K. ; von Weikersthal, L.F. ; Knorrenschild, J.R. ; Schierle, K. ; Wittekind, C. ; Lordick, F.
Clinical validation of response and resistance factor candidates to targeted therapy in Gastric Cancer (GC).Hachmöller, O. ; Buzanich, A.G. ; Aichler, M. ; Radtke, M. ; Dietrich, D. ; Schwamborn, K. ; Lutz, L. ; Werner, M. ; Sperling, M. ; Walch, A.K. ; Karst, U.
Elemental bioimaging and speciation analysis for the investigation of Wilson's disease using μXRF and XANES.Dislich, B. ; Stein, A. ; Seiler, C.A. ; Walch, A.K. ; Berezowska, S. ; Zlobec, I. ; Galvan, J.A. ; Langer, R.
Low frequency of epithelial PD-L1 staining in esophageal and other gastrointestinal adenocarcinomas.Li, J. ; Dawidek, T. ; Liegsalz, V. ; Tzalis, V. ; Feuchtinger, A. ; Avril, S.
Intratumoral heterogeneity of common protein biomarkers assessed by immunohistochemistry in breast cancer tissues.Ly, A. ; Merl-Pham, J. ; Priller, M. ; Gruhn, F. ; Senninger, N. ; Ueffing, M. ; Hauck, S.M.
Proteomic profiling suggests central role of STAT signaling during retinal degeneration in the rd10 mouse model.Dislich, B. ; Stein, A. ; Seiler, C.A. ; Walch, A.K. ; Berezowska, S. ; Zlobec, I. ; Galvan, J.A. ; Langer, R.
Low frequency of epithelial PD-L1 staining in esophageal and other gastrointestinal adenocarcinomas.Li, J. ; Dawidek, T. ; Liegsalz, V. ; Tzalis, V. ; Feuchtinger, A. ; Avril, S.
Intratumoral heterogeneity of common protein biomarkers assessed by immunohistochemistry in breast cancer tissues.Gunnell, A. ; Webb, H.M. ; Wood, C.D. ; McClellan, M.J. ; Wichaidit, B. ; Kempkes, B. ; Jenner, R.G. ; Osborne, C. ; Farrell, P.J. ; West, M.J.
RUNX super-enhancer control through the Notch pathway by Epstein-Barr virus transcription factors regulates B cell growth.Grüner, B.M. ; Winkelmann, I. ; Feuchtinger, A. ; Sun, N. ; Balluff, B. ; Teichmann, N. ; Herner, A. ; Kalideris, E. ; Steiger, K. ; Braren, R. ; Aichler, M. ; Esposito, I. ; Schmid, R.M. ; Walch, A.K. ; Siveke, J.T.
Modeling therapy response and spatial tissue distribution of erlotinib in pancreatic cancer.Lahiri, S. ; Sun, N. ; Buck, A. ; Imhof, A. ; Walch, A.K.
MALDI imaging mass spectrometry as a novel tool for detecting histone modifications in clinical tissue samples.Hammoud, A.A. ; Kirstein, N. ; Mournetas, V. ; Darracq, A. ; Broc, S. ; Blanchard, C. ; Zeineddine, D. ; Mortada, M. ; Boeuf, H.
Murine embryonic stem cell plasticity is regulated through klf5 and maintained by metalloproteinase mmp1 and hypoxia.Kalchschmidt, J.S. ; Gillman, A.C. ; Paschos, K. ; Bazot, Q. ; Kempkes, B. ; Allday, M.J.
EBNA3C directs recruitment of RBPJ (CBF1) to chromatin during the process of gene repression in EBV infected B cells.Girst, S. ; Greubel, C. ; Reindl, J. ; Siebenwirth, C. ; Zlobinskaya, O. ; Walsh, D.W. ; Ilicic, K. ; Aichler, M. ; Walch, A.K. ; Wilkens, J.J. ; Multhoff, G. ; Dollinger, G. ; Schmid, T.E.
Proton minibeam radiation therapy reduces side effects in an in vivo mouse ear model.Sun, N. ; Fernandez, I.E. ; Wei, M. ; Wu, Y. ; Aichler, M. ; Eickelberg, O. ; Walch, A.K.
Pharmacokinetic and pharmacometabolomic study of pirfenidone in normal mouse tissues using high mass resolution MALDI-FTICR-mass spectrometry imaging.Dutta, S. ; Krause, A. ; Vosberg, S. ; Herold, T. ; Ksienzyk, B. ; Quintanilla-Martinez, L. ; Tizazu, B. ; Chopra, M. ; Graf, A. ; Krebs, S. ; Blum, H. ; Greif, P.A. ; Vetter, A. ; Metzeler, K.H. ; Rothenberg-Thurley, M. ; Schneider, M.R. ; Dahlhoff, M. ; Spiekermann, K. ; Zimber-Strobl, U. ; Wolf, E. ; Bohlander, S.K.
The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models.Lahiri, S. ; Sun, N. ; Solis-Mezarino, V. ; Fedisch, A. ; Ninkovic, J. ; Feuchtinger, A. ; Götz, M. ; Walch, A.K. ; Imhof, A.
In situ detection of histone variants and modifications in mouse brain using imaging mass spectrometry.Krupka, C. ; Kufer, P. ; Kischel, R. ; Zugmaier, G. ; Lichtenegger, F.S. ; Köhnke, T. ; Vick, B. ; Jeremias, I. ; Metzeler, K.H. ; Altmann, T. ; Schneider, S. ; Fiegl, M. ; Spiekermann, K. ; Baeuerle, P.A. ; Hiddemann, W. ; Riethmüller, G. ; Subklewe, M.
Blockade of the PD-1/PD-L1 axis augments lysis of AML cells by the CD33/CD3-BiTE antibody construct AMG 330: Reversing a T-cell induced immune escape mechanism.van Nierop, G.P. ; Mautner, J. ; Mitterreiter, J.G. ; Hintzen, R.Q. ; Verjans, G.M.
Intrathecal CD8 T-cells of multiple sclerosis patients recognize lytic Epstein-Barr virus proteins.