Molecular Targets and Therapeutics Center Institute of Molecular Toxicology and Pharmacology
At the Institute of Molecular Toxicology and Pharmacology (TOXI), we explore how the human body responds to bioactive chemicals at the molecular level. Our mission is to uncover the complex molecular mechanism, our body’s molecular machines, that determine whether a chemical compound leads to therapeutic benefits or harmful effects.
A central goal of our research is to generate cutting-edge knowledge that drives the development of innovative, effective, and safe pharmaceuticals. Through our work, we contribute to advancing precision medicine and improving drug safety for the future.
At the Institute of Molecular Toxicology and Pharmacology (TOXI), we explore how the human body responds to bioactive chemicals at the molecular level. Our mission is to uncover the complex molecular mechanism, our body’s molecular machines, that determine whether a chemical compound leads to therapeutic benefits or harmful effects.
A central goal of our research is to generate cutting-edge knowledge that drives the development of innovative, effective, and safe pharmaceuticals. Through our work, we contribute to advancing precision medicine and improving drug safety for the future.
About our Research
Our research targets the interface between biomedicine and chemistry from complementary perspectives. Specific projects may start from:
elicited by a small chemical in mice or man
pathways
for novel chemical matter that could address a promising pharmacologic target
screens to unravel the mechanism behind a physiological response to a chemical challenge
Latest Publications of Our Institute
Read more2025 Scientific Article in Nature Communications
Prion protein promotes copper toxicity in Wilson disease.
2024 Scientific Article in Chemosphere
Revealing mercury species-specific transfer and toxicity mechanisms in placental trophoblasts.
2024 Scientific Article in Muscle & Nerve
Amyotrophic Lateral Sclerosis and swim training affect copper metabolism in skeletal muscle in a mouse model of disease.
2024 Review in International Journal of Molecular Sciences
Metabolic derangement of essential transition metals and potential antioxidant therapies.
2024 Scientific Article in Analytical and Bioanalytical Chemistry
Subzero project: Comparing trace element profiles of enriched mitochondria fractions from frozen and fresh liver tissue.
2024 Scientific Article in Metabolism: clinical and experimental
Copper impairs the intestinal barrier integrity in Wilson disease.
2024 Scientific Article in ChemBioChem