Jian Cui Lab - The nanoPROBE Lab

The nanoPROBE Lab

Jian Cui Lab

Jian’s team synthesizes novel classes of nanomaterials with unique chemical and optical properties. We aim to apply these materials towards the development of unconventional approaches to biological imaging and sensing.

Jian’s team synthesizes novel classes of nanomaterials with unique chemical and optical properties. We aim to apply these materials towards the development of unconventional approaches to biological imaging and sensing.

About our Research

The most compelling characteristic of nanoscale materials is the emergence of different physical phenomena upon the shrinking of dimensions. We are interested in exploiting these unique properties of the nanoscopic world to develop a new toolkit that will help us understand, and perhaps ultimately control, biological systems.

We are a diverse team of researchers asking interdisciplinary questions, and engaging in multidisciplinary approaches, in the hopes of achieving transdisciplinary outcomes (transcending disciplines).(1)

Creative combinations of engineered nanomaterials and nano-optical detection allow us to develop new platforms for measuring, and potentially controlling, biological processes in previously unexplored ways.

Publications

Nat. Methods, DOI: 10.1038/s41592-025-02694-3 (2025)

Ma, R. ; Santino, L.M. ; Chobola, T. ; Armbrust, N. ; Geilenkeuser, J. ; Sukumaran, S. ; Jing, Z. ; Levkina, A. ; Ridderbeek, K. ; Peng, T. ; Truong, D.J.J. ; Doll, S. ; Westmeyer, G.G. ; Cui, J.

A telescopic microscope equipped with a quanta image sensor for live-cell bioluminescence imaging.
ACS App. Optic. Mat. 3, 676-688 (2025)

Zhou, J. ; Ridderbeek, K. ; Zou, P. ; Naden, A.B. ; Gaussmann, S. ; Song, F. ; Falter-Braun, P. ; Kay, E.R. ; Sattler, M. ; Cui, J.

Modular nanoparticle platform for solution-phase optical sensing of protein-protein interactions.
J. Phys. Chem. Lett. 13, 4145-4151 (2022)

Cocina, A. ; Brechbühler, R. ; Vonk, S.J.W. ; Cui, J. ; Rossinelli, A.A. ; Rojo, H. ; Rabouw, F.T. ; Norris, D.J.

Nanophotonic approach to study excited-state dynamics in semiconductor nanocrystals.
ACS Photonics 9, 630-640 (2022)

Aellen, M. ; Rossinelli, A.A. ; Keitel, R.C. ; Brechbühler, R. ; Antolinez, F.V. ; Rodrigo, S.G. ; Cui, J. ; Norris, D.J.

Role of gain in Fabry-Pérot surface plasmon polariton lasers.
Nano Lett. 21, 8952–8959 (2021)

Keitel, R.C. ; Aellen, M. ; Feber, B.L. ; Rossinelli, A.A. ; Meyer, S.A. ; Cui, J. ; Norris, D.J.

Active mode switching in plasmonic microlasers by spatial control of optical gain.
ACS Nano 13, 9048-9056 (2019)

Antolinez, F.V. ; Winkler, J.M. ; Rohner, P. ; Kress, S.J.P. ; Keitel, R.C. ; Kim, D.K. ; Marques-Gallego, P. ; Cui, J. ; Rabouw, F.T. ; Poulikakos, D. ; Norris, D.J.

Defect-tolerant plasmonic elliptical resonators for long-range energy transfer.
Sci. Adv. 3:e1700688 (2017)

Kress, S.J.P. ; Cui, J. ; Rohner, P. ; Kim, D.K. ; Antolinez, F.V. ; Zaininger, K.A. ; Jayanti, S.V. ; Richner, P. ; McPeak, K.M. ; Poulikakos, D. ; Norris, D.J.

A customizable class of colloidal-quantum-dot spasers and plasmonic amplifiers.
Nano Lett. 17, 1319-1325 (2017)

Prins, F. ; Kim, D.K. ; Cui, J. ; De Leo, E. ; Spiegel, L.L. ; McPeak, K.M. ; Norris, D.J.

Direct patterning of colloidal quantum-dot thin films for enhanced and spectrally selective out-coupling of emission.
Nano Lett. 16, 289-296 (2016)

Cui, J. ; Beyler, A.P. ; Coropceanu, I. ; Cleary, L. ; Avila, T.R. ; Chen, Y. ; Cordero, J.M. ; Heathcote, S.L. ; Harris, D.K. ; Chen, O. ; Cao, J. ; Bawendi, M.G.

Evolution of the single-nanocrystal photoluminescence linewidth with size and shell: Implications for exciton-phonon coupling and the optimization of spectral linewidths.

Han, H.S. ; Niemeyer, E. ; Huang, Y. ; Kamoun, W.S. ; Martin, J.D. ; Bhaumik, J. ; Chen, Y. ; Roberge, S. ; Cui, J. ; Martin, M.R. ; Fukumura, D. ; Jain, R.K. ; Bawendi, M.G. ; Duda, D.G.

Quantum dot/antibody conjugates for in vivo cytometric imaging in mice.
Nano Lett. 14, 6792-6798 (2014)

Beyler, A.P. ; Bischof, T.S. ; Cui, J. ; Coropceanu, I. ; Harris, D.K. ; Bawendi, M.G.

Sample-averaged biexciton quantum yield measured by solution-phase photon correlation.
Chem. Soc. Rev. 43, 1287-310 (2014)

Cui, J. ; Beyler, A.P. ; Bischof, T.S. ; Wilson, M.W.B. ; Bawendi, M.G.

Deconstructing the photon stream from single nanocrystals: From binning to correlation.
Nat. Commun. 5:5093 (2014)

Chen, O. ; Riedemann, L. ; Etoc, F. ; Herrmann, H. ; Coppey, M. ; Barch, M. ; Farrar, C.T. ; Zhao, J. ; Bruns, O.T. ; Wei, H. ; Guo, P. ; Cui, J. ; Jensen, R. ; Chen, Y. ; Harris, D.K. ; Cordero, J.M. ; Wang, Z. ; Jasanoff, A. ; Fukumura, D. ; Reimer, R. ; Dahan, M. ; Jain, R.K. ; Bawendi, M.G.

Magneto-fluorescent core-shell supernanoparticles.
Phys. Rev. Lett. 111:177401 (2013)

Beyler, A.P. ; Marshall, L.F. ; Cui, J. ; Brokmann, X. ; Bawendi, M.G.

Direct observation of rapid discrete spectral dynamics in single colloidal CdSe-CdS core-shell quantum dots.
Nat. Chem. 5, 602-606 (2013)

Cui, J. ; Beyler, A.P. ; Marshall, L.F. ; Chen, O. ; Harris, D.K. ; Wanger, D.D. ; Brokmann, X. ; Bawendi, M.G.

Direct probe of spectral inhomogeneity reveals synthetic tunability of single-nanocrystal spectral linewidths.
Nat. Mater. 12, 445-451 (2013)

Chen, O. ; Zhao, J. ; Chauhan, V.P. ; Cui, J. ; Wong, C. ; Harris, D.K. ; Wei, H. ; Han, H.S. ; Fukumura, D. ; Jain, R.K. ; Bawendi, M.G.

Compact high-quality CdSe-CdS core-shell nanocrystals with narrow emission linewidths and suppressed blinking.
Abstr. Pap. Am. Chem. Soc. 243, 452-PHYS (2012)

Cui, J. ; Marshall, L.F. ; Han, H.S. ; Wanger, D.D. ; Brokmann, X. ; Bawendi, M.G.

Exploring the photoluminescence spectrum of single nanocrystals in solution using photon-correlation Fourier spectroscopy.
Angew. Chem.-Int. Edit. 50, 11417-11420 (2011)

Chauhan, V.P. ; Popović, Z. ; Chen, O. ; Cui, J. ; Fukumura, D. ; Bawendi, M.G. ; Jain, R.K.

Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration.

Wong, C. ; Stylianopoulos, T. ; Cui, J. ; Martin, J. ; Chauhan, V.P. ; Jiang, W. ; Popović, Z. ; Jain, R.K. ; Bawendi, M.G. ; Fukumura, D.

Multistage nanoparticle delivery system for deep penetration into tumor tissue.
Phys. Rev. Lett. 105:053005 (2010)

Marshall, L.F. ; Cui, J. ; Brokmann, X. ; Bawendi, M.G.

Extracting spectral dynamics from single chromophores in solution.
Abstr. Pap. Am. Chem. Soc. 232, 484-PHYS (2006)

Kim, S.Y. ; Cui, J. ; Lu, Z.K. ; Semyonov, A.N. ; Twieg, R.W. ; Moerner, W.E.

PHYS 484-DCDHF dyes can probe environmental changes by protein binding in GroEL.

Photonic Biosystems and Technologies

Jian Cui, Cui Lab, PI
Hintergrund: HDC Foyer
Dr. Jian Cui

Head of Research Unit and Principal Investigator, Photonic Biosystems and Technologies

Building / Room: 25, 909

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