Principal Investigator Helmholtz Pioneer Campus
Dr. Boyan Bonev
Research Area
Our long-term objective is to decipher the genetic and epigenetic blueprints of cortical development and evolution. To accomplish this, we study the interplay between transcription factors, 3D nuclear organization and gene expression in vivo and using cerebral organoids. Our research is highly interdisciplinary and combines developmental neurobiology, single cell –omics, mouse genetics, CRISPR-based techniques and computational biology.
Professional Background
Principal Investigator Helmholtz Pioneer Campus, Helmholtz Zentrum München
Postdoctoral Fellow Institute of Human Genetics – CNRS (France) Mentor: Giacomo Cavalli
Postdoctoral Fellow Harvard University (United States) Mentor: Paola Arlotta & John Rinn
Honors and Awards
- EMBO Young Investigator Award 2022
- ERC Consolidator Award 2022
- ERA-NET Neuron Grant 2022
- Great Advances in Biology Award, French Academy of Sciences 2018
- Best Poster Award, EMBO Gene regulation in neural fate decisions 2017
- Sir Henry Wellcome Postdoctoral Fellowship 2013 - 2017
- Beddington Medal for best PhD thesis in Developmental Biology, British Society for Developmental Biology 2012
- Wellcome Trust PhD Fellowship 2007 - 2011
- Best Poster Award, Faculty Research Symposium Manchester 2011
- Best Presentation Award, Faculty Showcase Symposium, Manchester 2010
- Gold Medal, Bulgarian National Olympiad in Biology 2001 & 2002
Publications
Matthews, R.E. ; Danac, J.M.C. ; Naden, E.L. ; Farleigh Smith, L.E. ; Lestari, S. ; Gungi, A. ; Appert, A. ; Buttress, T. ; Verma, A. ; Sinclair, O. ; Chong, F. ; Suberu, J. ; Antrobus, R. ; Bonev, B. ; Dawson, M.A. ; Reid, A.J. ; Timms, R.T. ; Ahringer, J. ; Tchasovnikarova, I.A.
CRAMP1 drives linker histone expression to enable Polycomb repression.Bonev, B. ; Castelo-Branco, G. ; Chen, F. ; Codeluppi, S. ; Corces, M.R. ; Fan, J. ; Heiman, M. ; Harris, K. ; Inoue, F. ; Kellis, M. ; Levine, A.P. ; Lotfollahi, M. ; Luo, C. ; Maynard, K.R. ; Nitzan, M. ; Ramani, V. ; Satijia, R. ; Schirmer, L. ; Shen, Y. ; Sun, N. ; Green, G.S. ; Theis, F. ; Wang, X. ; Welch, J.D. ; Gokce, O. ; Konopka, G. ; Liddelow, S.A. ; Macosko, E. ; Ali Bayraktar, O. ; Habib, N. ; Nowakowski, T.J.
Author Correction: Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery.Bonev, B. ; Gonçalo, C.B. ; Chen, F. ; Codeluppi, S. ; Corces, M.R. ; Fan, J. ; Heiman, M. ; Harris, K. ; Inoue, F. ; Kellis, M. ; Levine, A.P. ; Lotfollahi, M. ; Luo, C. ; Maynard, K.R. ; Nitzan, M. ; Ramani, V. ; Satijia, R. ; Schirmer, L. ; Shen, Y. ; Sun, N. ; Green, G.S. ; Theis, F. ; Wang, X. ; Welch, J.D. ; Gokce, O. ; Konopka, G. ; Liddelow, S.A. ; Macosko, E. ; Bayraktar, O. ; Habib, N. ; Nowakowski, T.J.
Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery.Simats, A. ; Zhang, S. ; Messerer, D. ; Chong, F. ; Beşkardeş, S. ; Chivukula, A.S. ; Cao, J. ; Besson-Girard, S. ; Montellano, F.A. ; Morbach, C. ; Carofiglio, O. ; Ricci, A. ; Roth, S. ; Llovera, G. ; Singh, R. ; Chen, Y. ; Filser, S. ; Plesnila, N. ; Braun, C. ; Spitzer, H. ; Gokce, O. ; Dichgans, M. ; Heuschmann, P.U. ; Hatakeyama, K. ; Beltrán, E. ; Clauss, S. ; Bonev, B. ; Schulz, C. ; Liesz, A.
Innate immune memory after brain injury drives inflammatory cardiac dysfunction.Pereira, A. ; Diwakar, S.J. ; Masserdotti, G. ; Beşkardeş, S. ; Simon, T. ; So, Y. ; Martín-Loarte, L. ; Bergemann, F. ; Vasan, L. ; Schauer, T. ; Danese, A. ; Bocchi, R. ; Colomé-Tatché, M. ; Schuurmans, C. ; Philpott, A. ; Straub, T. ; Bonev, B. ; Götz, M.
Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1.Pfaller, A.M. ; Kaplan, L. ; Moreira Carido Pereira, M. ; Grassmann, F. ; Díaz-Lezama, N. ; Ghaseminejad, F. ; Wunderlich, K.A. ; Glänzer, S. ; Bludau, O. ; Pannicke, T. ; Weber, B.H.F. ; Koch, S.F. ; Bonev, B. ; Hauck, S.M. ; Grosche, A.
The glucocorticoid receptor as a master regulator of the Müller cell response to diabetic conditions in mice.Noack, F. ; Vangelisti, S. ; Ditzer, N. ; Chong, F. ; Albert, M. ; Bonev, B.
Joint epigenome profiling reveals cell-type-specific gene regulatory programmes in human cortical organoids.Noack, F. ; Vangelisti, S. ; Raffl, G. ; Moreira Carido Pereira, M. ; Diwakar, S.J. ; Chong, F. ; Bonev, B.
Multimodal profiling of the transcriptional regulatory landscape of the developing mouse cortex identifies Neurog2 as a key epigenome remodeler.Aboelnour, E. ; Bonev, B.
Evolutionary conservation and cell type specificity of nuclear compartments in the brain.Aboelnour, E. ; Bonev, B.
Decoding the organization, dynamics, and function of the 4D genome.
