New IDC Paper in Advanced Science
New IDC publication by Marcos Rios Garcia, Stephan Herzig and Mauricio Berriel Diaz et al.:
Trip13 depletion in liver cancer induces a lipogenic response contributing to Plin2-dependent mitotic cell death.
They discovered a novel mechanism by which depletion of the ATPase Trip13 results in mitotic cell death of tumor cells, including enhanced lipogenesis and a role of lipid droplet accumulation in aberrant mitotic spindle polarity. Specifically, Plin2 confers susceptibility to Trip13 KD- and anti-mitotic drug-induced cell death, allowing for stratification for Paclitaxel treatment-responsive tumor cells.