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©Barth-Jan van Rossum

Calcium Sensor for Photoacoustics (CaSPA)


We have synthesized a calcium sensor for photoacoustics, which changes its absorbance and thus photoacoustic spectrum upon selective binding to Ca2+ for future use in organoids or in vivo models.

In its esterified form, CaSPA is cell-permeable such that we could use it to image intracellular calcium changes in cells, organoids and in vivo in zebrafish larvae with photoacoustic tomography. 



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