What happens in encapsulins stays in encapsulins | bioorthogonal compartments in mammalian cells
To sequester multi-component enzymatic processes inside living mammalian cells, we introduce heterologously expressed encapsulins as a versatile platform to generate self-assembling ompartments which can serve as nano-reaction chambers.
To sequester multi-component enzymatic processes inside living mammalian cells, we introduce heterologously expressed encapsulins as a versatile platform to generate self-assembling proteinaceous compartments which can be modularly functionalized with enzymes or reporter proteins for auto-conversion into fully genetically encoded nanoparticles for multimodal molecular imaging.
manuscript: https://www.nature.com/articles/s41467-018-04227-3/
related review: https://www.nature.com/articles/s41563-020-00883-3
press release: https://www.tum.de/en/news-and-events/all-news/press-releases/details/34654