Prof. Oliver Plettenburg
Research
Targeted delivery
A systemic exposure of bioactive substances can result in a variety of adverse effects. The specific delivery of drugs into specific cell types is therefore a powerful strategy to enhance biological activity, keeping the required drug amount low and to circumvent adverse effects resulting of uptake into different cells. Therefore, the Plettenburg group focusses on the development of cell specific ligands and the conjugation with drugs thereof.
Inhibitor design
The design of novel inhibitors for enzymes or protein-protein interactions is another core element in the research of the group. Besides classical medicinal chemistry approaches like hit optimization of hits from primary screens based on synthetic or natural product libraries also new fragment based approaches are investigated.
The optimization is done in a multi parametric fashion, taking biological activity as well as physicochemical (e.g. chemical stability, solubility) and eADME properties (e. g. cytotoxicity, plasma stability, plasma protein binding, off-target interactions) into account in order to create new lead structures.
Chemical probes
New dyes and probes as chemical tolls for biological imaging are a specific focus of the Plettenburg group.
Besides molecules for novel detection methods like photoacoustic imaging, also molecules are developed for use as contrast agents, switchable dyes and biosensors for specific metabolites.
Fields of Work and Expertise
Medical Chemistry targeted delivery inhibitor design chemical probes
Academic career
Professor (W3) for Medicinal Chemistry at the Leibniz Universität Hannover; Director, Institute for Medicinal Chemistry, Helmholtz Centre Munich
Head of Biosensing und Chemical Probes, Sanofi, Frankfurt
Head of Chemical Biology, Sanofi, Frankfurt
Senior Research Scientist, TD Cardiovascular Diseases, Sanofi-Aventis, Frankfurt
Research Scientist, TD Cardiovascular Diseases, Sanofi-Aventis, Frankfurt
Research Scientist, Medicinial Chemistry, Aventis, Frankfurt
Postdoctoral stay with Prof. Chi-Huey Wong, Scripps Research
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Ph.D. in Chemistry, University of Wuppertal, Germany
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Studies in Chemistry, University of Wuppertal, Germany
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