Assay Development and Screening Platform



The Assay Development and Screening Platform (ADSP) has been established in 2010 as a Research Group within the Institute of Molecular Toxicology and Pharmacology.

Research topics:

1.    Unraveling mechanisms and cellular regulators that induce or block ferroptosis, a regulated non-apoptotic cell-death pathway.

2.    Identification and characterization of protein interactions and regulators of Ubiquitin Signaling pathways mainly implicated in immune response, cancer development and DNA repair.

Chemical Biology / Drug Discovery efforts:

We collaborate with researchers at the center as well as national and international cooperation partners to custom-designed assays to screen and identify novel bioactive molecules. Here, a major focus is devoted to the development of phenotypic assays for High-Content Screening (HCS) approaches in order to better reflect the biology of the underlying disease state. ADSP provides state-of-the-art equipment and screening techniques as well as oversees the in-house diversity compound library. In order to evaluate and manage the screening data, ADSP uses IDBS ActivityBase together with PerkinElmer Columbus/Harmony.

 Assay Development and Screening Platform Hompage