Oxidative cell death: the mitochondrion

1. In vitro studies of mitochondria challenged by chemical induced oxidative stress to identify their most sensitive and decisive molecular target structures. 

2. The consistent further development of the ZE-FFE technology with the aim to study mitochondrial impairment upon damaging impacts.

3. Analysis of mitochondria isolated from animal models for oxidative stress:

  • Cooperation with AG Summer: The influence of persistent oxidative stress on mitochondria, reminiscent of a typical age-related situation, is studied in the Long Evans Cinnamon rat.

  • Cooperation with Prof. A. M. Vollmar, LMU Munich, Department of Pharmacy: The influence of acute oxidative stress on mitochondria is studied in rat tissues subjected to ischemia/reperfusion.