Research Group Cell Signaling and Chemical Biology (AG Hadian)

 

Research topics:

1. Ferroptosis Research: Unraveling mechanisms and cellular regulators that induce or block ferroptosis, a regulated non-apoptotic cell-death pathway.

2. Ubiquitin Signaling: Identification and characterization of protein interactions and regulators of ubiquitin signaling pathways mainly implicated in immune response, cancer development and DNA repair.

3. Chemical Biology: Interrogate biological systems with small molecules to understand underlying mechanistic details.

 

Drug Discovery:

We collaborate with researchers at the center as well as national and international cooperation partners to custom-design assays to screen and identify novel bioactive molecules. Here, a major focus is devoted to the development of phenotypic assays for High-Content Screening (HCS) in order to better reflect the biology of the underlying disease state. We use machine learning techniques to analyze high-content images. We provide state-of-the-art equipment and screening techniques as well as oversees the in-house diversity and focussed compound libraries.

 Research Group Cell Signaling and Chemical Biology