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Helmholtz Munich | ©Stefanie Winkler

PD Dr. Kristian Unger

Deputy Head Research Unit Radiation Cytogenetics
+49 89 3187 3515Email meBuilding/Room: 57/029

“My vision is to better understand and target oncological diseases by analyzing the molecular landscape of tumors and their microenvironment at multiple molecular levels.”

“My vision is to better understand and target oncological diseases by analyzing the molecular landscape of tumors and their microenvironment at multiple molecular levels.”

Academic Career and Research Areas

Kristian Unger is a computational biologist working in translational oncology. He combines biological knowledge with the data science methodology for the design, analysis and interpretation of multi-omics translational oncology studies. He leads the competence field “translational bioinformatics” in the research unit Radiation Cytogenetics (ZYTO) with a focus on regression-based machine learning and deep learning for the generation of prognostic models predicting clinical outcome. Kristian Unger completed his habilitation at the Medical Faculty of the LMU and has a broad and active cooperation network consisting of partners at Munich universities, national and international scientists.

Fields, skills and expertises

translational oncology computational biology head and neck cancer and glioblastoma/brain cancer machine learning cancer biology multi-omics high-performance computing single-cell, spatial and bulk omics

Publications

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2022 Clin Cancer Res. doi:10.1158/1078-0432.CCR-21-2244

Weber P, Kunstner A, Hess J, Unger K, Marschner S, Idel C, Ribbat-Idel J, Baumeister P, Gires O, Walz C, Rietzler S, Valeanu L, Herkommer T, Kreutzer L, Klymenko O, Drexler G, Kirchner T, Maihofer C, Ganswindt U, Walch A, Sterr M, Lickert H, Canis M, Rades D, Perner S, Berriel Diaz M, Herzig S, Lauber K, Wollenberg B, Busch H, Belka C, Zitzelsberger H

Therapy-Related Transcriptional Subtypes in Matched Primary and Recurrent Head and Neck Cancer

2022 Int J Cancer doi: 10.1002/ijc.33842

Tawk B, Wirkner U, Schwager C, Rein K, Zaoui K, Federspil PA, Adeberg S, Linge A, Ganswindt U, Hess J, Unger K, Tinhofer I, Budach V, Lohaus F, Krause M, Guberina M, Stuschke M, Balermpas P, Rödel C, Grosu AL, Schäfer H, Zips D, Combs SE, Pigorsch S, Zitzelsberger H, Baumeister P, Kirchner T, Bewerunge-Hudler M, Weichert W, Hess J, Herpel E, Belka C, Baumann M, Debus J, Abdollahi A

Tumor DNA-methylome derived epigenetic fingerprint identifies HPV-negative head and neck patients at risk for locoregional recurrence after postoperative radiochemotherapy