In the Future, novel embryo models that form out of self-organizing stem cells "in the dish" can be used to understand how cell complexity arises in an embryo during development. Recently, the journal Development published a perspective article by Antiono Scialdone (Helmholtz Munich) and Nicolas Rivron (Vienna Biocenter). The two authors summarize and discuss the two preprints by Anand et al. and Wehmeyer et al. that advance the use of embryo models for pioneering discoveries.
Anand et al. present their new method that augments the efficiency and reproducibility of embryo models. In their preprint, the team around Alexandra shed light into previously unknown functions of classical developmental genes using chimeric gastruloids.
Further Information
Antonio Scialdone and Nicolas Rivron. (2022). In preprints: improving and interrogating embryo models. Development