Epigenetics and neural cell death

Cerebral cortex. Immunostained for Uhrf1 (neural stem cells, red). Picture: Vidya Ramesh

Researchers at Helmholtz Zentrum München and LMU Munich have demonstrated how deregulation of an epigenetic mechanism that is active only in the early phases of neurogenesis triggers the subsequent death of neural cells. The work is published in Genes and Development.  

For more information see the original publication Ramesh V et al., Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration. Genes and Development, (2016) doi:10.1101/gad.284992.11                                                                                                                                           or the press release by Helmholtz Zentrum München.

To find out more about the work of groups in the ISF, visit the institute webpage here.