How Stem Cells form the Placenta

Source: Helmholtz Zentrum München

Researchers from the Drukker lab have investigated how pluripotent stem cells develop into cells of the placenta, identifying four transcription factors playing a key role.  They examined the transcriptome and epigenome (CpG methylation, H3K4me3 and H3K27me3) of progenitor and placental cells derived from human pluripotent stem cells and the study was recently published in the journal “Proceedings of the National Academy of Sciences”.

For further information see the original publication: Krendl C, Shaposhnikov D et al. (2017) GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency, PNAS, doi: 10.1073/pnas.1708341114 and the Helmholtz Zentrum Muenchen Press Release